Integrin alpha1beta1
Integrin alpha1beta1 functions as a receptor for LAMININ and COLLAGEN. It is widely expressed during development, but in the adult is the predominant laminin receptor (RECEPTORS, LAMININ) in mature SMOOTH MUSCLE CELLS, where it is important for maintenance of the differentiated phenotype of these cells. Integrin alpha1beta1 is also found in LYMPHOCYTES and microvascular endothelial cells, and may play a role in angiogenesis. In SCHWANN CELLS and neural crest cells, it is involved in cell migration. Integrin alpha1beta1 is also known as VLA-1 and CD49a-CD29.
Year introduced: 2003
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Subheadings:
Tree Number(s): D12.776.543.750.685.100, D12.776.543.750.705.408.850.099, D12.776.543.750.705.876.249
MeSH Unique ID: D039222
Entry Terms:
- alpha1beta1, Integrin
- CD49a-CD29
- alpha1beta1 Integrin
- Integrin, alpha1beta1
- Integrin alpha(1)beta(1)
- VLA-1
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