Immunoreceptor Tyrosine-Based Inhibition Motif

A conserved AMINO ACID SEQUENCE located in the intracellular domains of a family of transmembrane proteins that negatively regulate the signal transduction processes emanating from transmembrane proteins containing IMMUNORECEPTOR TYROSINE-BASED ACTIVATION MOTIFS. The CONSENSUS SEQUENCE of this motif is I(or V)LXYXXL(or V) (where X denotes any amino acid). Also known as ITIM motifs.

Year introduced: 2013

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Tree Number(s): G02.111.570.820.709.275.500.480

MeSH Unique ID: D061626

Entry Terms:

• Immunoreceptor Tyrosine Based Inhibition Motif
• Immuno-Receptor Tyrosine-Based Inhibition Motif
• Immuno Receptor Tyrosine Based Inhibition Motif
• Immune Receptor Tyrosine-Based Inhibition Motif
• Immune Receptor Tyrosine Based Inhibition Motif

All MeSH Categories
Phenomena and Processes Category
Chemical Phenomena
Biochemical Phenomena
Molecular Structure
Molecular Conformation
Protein Conformation
Protein Structural Elements
Amino Acid Motifs
Immunoreceptor Tyrosine-Based Inhibition Motif