Aortic Valve, Calcification of [Supplementary Concept]

Condition where calcium deposits form on the aortic valve and is often observed in younger patients with bicuspid aortic valve (OMIM: 109730), as a result of inappropriate activation of OSTEOBLAST-specific gene expression. Germline mutations in the NOTCH1 gene have been identified.

Date introduced: November 5, 2012

MeSH Unique ID: C562942

Heading Mapped to:

• Aortic Valve/pathology
• Aortic Valve Stenosis
• Calcinosis

Entry Terms:

• Aortic Stenosis, Calcific