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HES1 protein, human [Supplementary Concept]
RefSeq NM_005524
Date introduced: January 2, 1993
Basic Helix-Loop-Helix Transcription Factors
A family of DNA-binding transcription factors that contain a basic HELIX-LOOP-HELIX MOTIF.
Year introduced: 2006
Transcription Factors
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
Year introduced: 1977
Proteins
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
Year introduced: /metabolism was PROTEIN METABOLISM 1963-1965
DNA-Binding Proteins
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
Year introduced: 1984
Amino Acids, Peptides, and Proteins
Amino acids and chains of amino acids connected by peptide linkages.
Year introduced: 1998
Transcription Factor HES-1
A basic-helix-loop-helix transcription factor that functions as a transcriptional repressor for genes transcribed by bHLH proteins. For example, it may negatively regulate MYOGENESIS by inhibiting MyoD1 and ASH1 proteins. It is also required for the stability of FANCONI ANEMIA COMPLEMENTATION GROUP PROTEINS and their localization to the cell nucleus in response to DNA DAMAGE.
Year introduced: 2017