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Mus musculus guanine nucleotide binding protein, alpha z subunit (Gnaz), mRNA

NCBI Reference Sequence: NM_010311.3

FASTA Graphics 

LOCUS       NM_010311               2435 bp    mRNA    linear   ROD 20-NOV-2017
DEFINITION  Mus musculus guanine nucleotide binding protein, alpha z subunit
            (Gnaz), mRNA.
ACCESSION   NM_010311
VERSION     NM_010311.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2435)
  AUTHORS   Vancura P, Abdelhadi S, Csicsely E, Baba K, Tosini G, Iuvone PM and
            Spessert R.
  TITLE     Gnaz couples the circadian and dopaminergic system to G
            protein-mediated signaling in mouse photoreceptors
  JOURNAL   PLoS ONE 12 (10), E0187411 (2017)
   PUBMED   29088301
  REMARK    GeneRIF: present study suggest that Gnaz links the circadian
            clockwork-via dopamine acting on D4 receptors-to G protein-mediated
            signaling in intact but not diabetic retina
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2435)
  AUTHORS   Fenske RJ, Cadena MT, Harenda QE, Wienkes HN, Carbajal K, Schaid
            MD, Laundre E, Brill AL, Truchan NA, Brar H, Wisinski J, Cai J,
            Graham TE, Engin F and Kimple ME.
  TITLE     The Inhibitory G Protein alpha-Subunit, Galphaz, Promotes Type 1
            Diabetes-Like Pathophysiology in NOD Mice
  JOURNAL   Endocrinology 158 (6), 1645-1658 (2017)
   PUBMED   28419211
  REMARK    GeneRIF: Galphaz plays a key role in beta-cell signaling that
            becomes dysfunctional in the type 1 diabetes setting, accelerating
            the death of beta-cells, which promotes further accumulation of
            immune cells in the pancreatic islets, and inhibiting a restorative
            proliferative response.
REFERENCE   3  (bases 1 to 2435)
  AUTHORS   Jin S, Martinelli DC, Zheng X, Tessier-Lavigne M and Fan CM.
  TITLE     Gas1 is a receptor for sonic hedgehog to repel enteric axons
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 112 (1), E73-E80 (2015)
   PUBMED   25535338
REFERENCE   4  (bases 1 to 2435)
  AUTHORS   Regard JB, Malhotra D, Gvozdenovic-Jeremic J, Josey M, Chen M,
            Weinstein LS, Lu J, Shore EM, Kaplan FS and Yang Y.
  TITLE     Activation of Hedgehog signaling by loss of GNAS causes heterotopic
            ossification
  JOURNAL   Nat. Med. 19 (11), 1505-1512 (2013)
   PUBMED   24076664
REFERENCE   5  (bases 1 to 2435)
  AUTHORS   Kimple ME, Moss JB, Brar HK, Rosa TC, Truchan NA, Pasker RL,
            Newgard CB and Casey PJ.
  TITLE     Deletion of GalphaZ protein protects against diet-induced glucose
            intolerance via expansion of beta-cell mass
  JOURNAL   J. Biol. Chem. 287 (24), 20344-20355 (2012)
   PUBMED   22457354
  REMARK    GeneRIF: Deletion of GalphaZ protein protects against diet-induced
            glucose intolerance via expansion of beta-cell mass.
REFERENCE   6  (bases 1 to 2435)
  AUTHORS   Zigman JM, Westermark GT, LaMendola J and Steiner DF.
  TITLE     Expression of cone transducin, Gz alpha, and other G-protein
            alpha-subunit messenger ribonucleic acids in pancreatic islets
  JOURNAL   Endocrinology 135 (1), 31-37 (1994)
   PUBMED   8013366
REFERENCE   7  (bases 1 to 2435)
  AUTHORS   Wilkie TM, Gilbert DJ, Olsen AS, Chen XN, Amatruda TT, Korenberg
            JR, Trask BJ, de Jong P, Reed RR, Simon MI et al.
  TITLE     Evolution of the mammalian G protein alpha subunit multigene family
  JOURNAL   Nat. Genet. 1 (2), 85-91 (1992)
   PUBMED   1302014
  REMARK    Review article
REFERENCE   8  (bases 1 to 2435)
  AUTHORS   Strathmann M, Wilkie TM and Simon MI.
  TITLE     Diversity of the G-protein family: sequences from five additional
            alpha subunits in the mouse
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 86 (19), 7407-7409 (1989)
   PUBMED   2508088
REFERENCE   9  (bases 1 to 2435)
  AUTHORS   Fong HK, Yoshimoto KK, Eversole-Cire P and Simon MI.
  TITLE     Identification of a GTP-binding protein alpha subunit that lacks an
            apparent ADP-ribosylation site for pertussis toxin
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 85 (9), 3066-3070 (1988)
   PUBMED   3129724
REFERENCE   10 (bases 1 to 2435)
  AUTHORS   Tanabe,T., Nukada,T., Nishikawa,Y., Sugimoto,K., Suzuki,H.,
            Takahashi,H., Noda,M., Haga,T., Ichiyama,A., Kangawa,K. et al.
  TITLE     Primary structure of the alpha-subunit of transducin and its
            relationship to ras proteins
  JOURNAL   Nature 315 (6016), 242-245 (1985)
   PUBMED   3923359
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC142500.23.
            
            [WARNING] On Dec 12, 2017 this sequence was replaced by
            NM_010311.4.
            
            On Nov 17, 2006 this sequence version replaced NM_010311.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK080716.1, SRR1660813.162991.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               AC142500.23        121728-121879
            153-218             AC142500.23        133288-133353
            219-1425            AC142500.23        145431-146637
            1426-2435           AC142500.23        169365-170374
FEATURES             Location/Qualifiers
     source          1..2435
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 38.48 cM"
     gene            1..2435
                     /gene="Gnaz"
                     /gene_synonym="AI847979; Gz"
                     /note="guanine nucleotide binding protein, alpha z
                     subunit"
                     /db_xref="GeneID:14687"
                     /db_xref="MGI:MGI:95780"
     misc_feature    625..627
                     /gene="Gnaz"
                     /gene_synonym="AI847979; Gz"
                     /note="upstream in-frame stop codon"
     CDS             703..1770
                     /gene="Gnaz"
                     /gene_synonym="AI847979; Gz"
                     /note="gz-alpha; g(x) alpha chain"
                     /codon_start=1
                     /product="guanine nucleotide-binding protein G(z) subunit
                     alpha"
                     /protein_id="NP_034441.1"
                     /db_xref="CCDS:CCDS23922.1"
                     /db_xref="GeneID:14687"
                     /db_xref="MGI:MGI:95780"
                     /translation="MGCRQSSEEKEAARRSRRIDRHLRSESQRQRREIKLLLLGTSNS
                     GKSTIVKQMKIIHSGGFNLDACKEYKPLIIYNAIDSLTRIIRALAALKIDFHNPDRAY
                     DAVQLFALTGPAESKGEITPELLGVMRRLWADPGAQACFGRSSEYHLEDNAAYYLNDL
                     ERIAAPDYIPTVEDILRSRDMTTGIVENKFTFKELTFKMVDVGGQRSERKKWIHCFEG
                     VTAIIFCVELSGYDLKLYEDNQTSRMAESLRLFDSICNNNWFINTSLILFLNKKDLLA
                     EKIRRIPLSVCFPEYKGQNTYEEAAVYIQRQFEDLNRNKETKEIYSHFTCATDTSNIQ
                     FVFDAVTDVIIQNNLKYIGLC"
ORIGIN      
        1 gcggcggagc gtgtgtgcca cccgcggacc ggtcacgtcc tcgcgcggcc gccggcaccc
       61 gcttcgtgca gaaccagggc gccacagccc tacgctcgcg gccccgcccc gccgggtgca
      121 gctcgaccga cgcacgaagc cgcgcccggg agtttcaggc atttgcaggg ctgatgagga
      181 gtgaaatgca aagtccttcg caagccttat gaaaactggt gaagggccgg atgcaaggca
      241 gggagccgga gcagcctgag gcaggggggc ctcagggagc gctgggccct ccagccgtgc
      301 ttagaaacat cgccacagca accagcgagc agacagcagt agcctgggca gacgcaagcg
      361 gacagcttcc taccgtggca gagtacaggg aatgactacg gcaaatcagg ccacactgct
      421 gacaagggag gtggagtgtc actagagggg agggtgtggt ctctgcccca ctgcaccaag
      481 cgccatgccc acaggagaag cggtactggg gcagggattg ctctgtgaca cagcctcgcc
      541 ccaaagccag tgctgagcac ggccgggtca gctgcctctc tcatctgccc gtcacaccag
      601 cccacgtttg agcatccctc gttgtgacca ttctgtttgg cgagggggag aggcgcccac
      661 cctgtgttct gcatctgggg ggtggcccgc tgctgccgga ccatgggatg tcggcaaagc
      721 tcagaggaaa aagaggcagc gaggcggtcc cggagaattg accgccacct gcgctccgaa
      781 agccagcggc agcgccgtga aatcaaactt ctcctgctgg gcaccagcaa ctcgggcaag
      841 agcaccatcg tcaagcagat gaagatcatc cacagcgggg gcttcaacct ggacgcctgc
      901 aaggagtaca agcccctcat catctacaac gccatcgact cgctgacccg gatcatccgg
      961 gccctggctg ccctcaagat cgatttccac aaccctgacc gtgcctacga cgctgtgcag
     1021 ctctttgctc tgactggccc agcagagagc aagggtgaga ttacacctga gctgctgggt
     1081 gtcatgcgac ggctctgggc tgacccaggg gcccaggcct gctttggccg ctctagcgag
     1141 taccacctgg aggacaatgc agcctactac ctgaacgacc tggagcgcat cgcagcgccc
     1201 gactacatcc ccacggtgga ggatatccta cgctcccggg acatgaccac gggcattgtg
     1261 gagaacaagt tcaccttcaa ggagcttacc ttcaagatgg tggacgtggg cgggcagagg
     1321 tcagaacgca aaaagtggat ccattgcttt gaaggcgtca cagccatcat cttctgtgtg
     1381 gagctcagtg gctatgacct gaagctctat gaggacaacc agacgagccg gatggcggag
     1441 agcctgcgcc tctttgactc catctgcaac aacaactggt tcatcaacac ctcgctcatc
     1501 ctcttcctga acaagaagga cctcctggca gagaagatcc ggcgtatccc gctcagcgtc
     1561 tgcttcccag agtacaaggg tcagaacacg tacgaggaag ccgcggtcta catccaacgt
     1621 cagttcgagg acctcaaccg caacaaggag accaaggaga tctattcgca cttcacttgt
     1681 gccaccgaca ccagtaacat ccagtttgtg tttgacgcag tgacagatgt catcatacag
     1741 aacaatctca agtacatcgg cctttgctga ggagccgggc gcagcctgct cgcctgtggt
     1801 gaaacccatg gggtgtcaca ccccacacct catgctcgag aggcccgacc caggggcaga
     1861 aaacggggct tgaagagtgt gtccccatcc cacccccagc ctctgccttc ttggccccac
     1921 atctctgcaa acataaatat atttggatag attgctaggt aggtagacac acagacacac
     1981 acacagacac acacacacac agacacacgc acgcacgcac atctggagag ggcatagttc
     2041 tccagagcgt caaggtttcc tgaagttttc aaaagctgct gtcacaattt cattccgagg
     2101 ccatcttgcc cctccccctt cactctgcct tcctgagttg gccccactct gcacgggagg
     2161 gagggcccac cttagactgc tggggagagg ccacagggct gggggccagg tccggccagc
     2221 tgtgcccatc gcctgggaga aggccagctc accaactgag ctctggactg gggactaccg
     2281 ctgaccagga gggaagcctg gagccgcacc cgactcagcc actctgcgtc acattcgtcc
     2341 tgtacctagg accggaggaa agacgtgact gctctaaccg gacctctgac taccggtggc
     2401 ttttacaaaa aaaaaacagc taaaacgtac tcagc
//
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