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Mus musculus T-box brain transcription factor 1 (Tbr1), mRNA

NCBI Reference Sequence: NM_009322.3

FASTA Graphics 

LOCUS       NM_009322               3977 bp    mRNA    linear   ROD 14-FEB-2023
DEFINITION  Mus musculus T-box brain transcription factor 1 (Tbr1), mRNA.
ACCESSION   NM_009322
VERSION     NM_009322.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3977)
  AUTHORS   Kueh AJ, Bergamasco MI, Quaglieri A, Phipson B, Li-Wai-Suen CSN,
            Lonnstedt IM, Hu Y, Feng ZP, Woodruff C, May RE, Wilcox S, Garnham
            AL, Snyder MP, Smyth GK, Speed TP, Thomas T and Voss AK.
  TITLE     Stem cell plasticity, acetylation of H3K14, and de novo gene
            activation rely on KAT7
  JOURNAL   Cell Rep 42 (1), 111980 (2023)
   PUBMED   36641753
REFERENCE   2  (bases 1 to 3977)
  AUTHORS   Gerstmann K, Kindbeiter K, Telley L, Bozon M, Reynaud F, Theoulle
            E, Charoy C, Jabaudon D, Moret F and Castellani V.
  TITLE     A balance of noncanonical Semaphorin signaling from the
            cerebrospinal fluid regulates apical cell dynamics during
            corticogenesis
  JOURNAL   Sci Adv 8 (46), eabo4552 (2022)
   PUBMED   36399562
REFERENCE   3  (bases 1 to 3977)
  AUTHORS   de Thonel A, Ahlskog JK, Daupin K, Dubreuil V, Berthelet J, Chaput
            C, Pires G, Leonetti C, Abane R, Barris LC, Leray I, Aalto AL,
            Naceri S, Cordonnier M, Benasolo C, Sanial M, Duchateau A,
            Vihervaara A, Puustinen MC, Miozzo F, Fergelot P, Lebigot E,
            Verloes A, Gressens P, Lacombe D, Gobbo J, Garrido C, Westerheide
            SD, David L, Petitjean M, Taboureau O, Rodrigues-Lima F, Passemard
            S, Saberan-Djoneidi D, Nguyen L, Lancaster M, Sistonen L and Mezger
            V.
  TITLE     CBP-HSF2 structural and functional interplay in Rubinstein-Taybi
            neurodevelopmental disorder
  JOURNAL   Nat Commun 13 (1), 7002 (2022)
   PUBMED   36385105
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3977)
  AUTHORS   Nguyen H, Sokpor G, Parichha A, Pham L, Saikhedkar N, Xie Y, Ulmke
            PA, Rosenbusch J, Pirouz M, Behr R, Stoykova A, Brand-Saberi B,
            Nguyen HP, Staiger JF, Tole S and Tuoc T.
  TITLE     BAF (mSWI/SNF) complex regulates mediolateral cortical patterning
            in the developing forebrain
  JOURNAL   Front Cell Dev Biol 10, 1011109 (2022)
   PUBMED   36263009
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3977)
  AUTHORS   Tomita H, Hines KM, Herron JM, Li A, Baggett DW and Xu L.
  TITLE     7-Dehydrocholesterol-derived oxysterols cause neurogenic defects in
            Smith-Lemli-Opitz syndrome
  JOURNAL   Elife 11, e67141 (2022)
   PUBMED   36111785
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3977)
  AUTHORS   Bulfone A, Wang F, Hevner R, Anderson S, Cutforth T, Chen S,
            Meneses J, Pedersen R, Axel R and Rubenstein JL.
  TITLE     An olfactory sensory map develops in the absence of normal
            projection neurons or GABAergic interneurons
  JOURNAL   Neuron 21 (6), 1273-1282 (1998)
   PUBMED   9883721
REFERENCE   7  (bases 1 to 3977)
  AUTHORS   Wattler S, Russ A, Evans M and Nehls M.
  TITLE     A combined analysis of genomic and primary protein structure
            defines the phylogenetic relationship of new members if the T-box
            family
  JOURNAL   Genomics 48 (1), 24-33 (1998)
   PUBMED   9503012
REFERENCE   8  (bases 1 to 3977)
  AUTHORS   Acampora D, Avantaggiato V, Tuorto F and Simeone A.
  TITLE     Genetic control of brain morphogenesis through Otx gene dosage
            requirement
  JOURNAL   Development 124 (18), 3639-3650 (1997)
   PUBMED   9342056
REFERENCE   9  (bases 1 to 3977)
  AUTHORS   Qiu M, Anderson S, Chen S, Meneses JJ, Hevner R, Kuwana E, Pedersen
            RA and Rubenstein JL.
  TITLE     Mutation of the Emx-1 homeobox gene disrupts the corpus callosum
  JOURNAL   Dev Biol 178 (1), 174-178 (1996)
   PUBMED   8812118
REFERENCE   10 (bases 1 to 3977)
  AUTHORS   Bulfone A, Smiga SM, Shimamura K, Peterson A, Puelles L and
            Rubenstein JL.
  TITLE     T-brain-1: a homolog of Brachyury whose expression defines
            molecularly distinct domains within the cerebral cortex
  JOURNAL   Neuron 15 (1), 63-78 (1995)
   PUBMED   7619531
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL845291.5.
            
            [WARNING] On Mar 18, 2023 this sequence was replaced by
            NM_009322.4.
            
            On Nov 17, 2006 this sequence version replaced NM_009322.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052737.1, U49251.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-947               AL845291.5         178917-179863
            948-1102            AL845291.5         180438-180592
            1103-1224           AL845291.5         181096-181217
            1225-1383           AL845291.5         181743-181901
            1384-1445           AL845291.5         182963-183024
            1446-3977           AL845291.5         186047-188578
FEATURES             Location/Qualifiers
     source          1..3977
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 35.56 cM"
     gene            1..3977
                     /gene="Tbr1"
                     /note="T-box brain transcription factor 1"
                     /db_xref="GeneID:21375"
                     /db_xref="MGI:MGI:107404"
     exon            1..947
                     /gene="Tbr1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    172..174
                     /gene="Tbr1"
                     /note="upstream in-frame stop codon"
     CDS             256..2301
                     /gene="Tbr1"
                     /note="TBR-1; TES-56; T-brain-1; T-box brain gene 1"
                     /codon_start=1
                     /product="T-box brain protein 1"
                     /protein_id="NP_033348.2"
                     /db_xref="CCDS:CCDS16063.1"
                     /db_xref="GeneID:21375"
                     /db_xref="MGI:MGI:107404"
                     /translation="MQLEHCLSPSIMLSKKFLNVSSSYPHSGGSELVLHDHPIISTTD
                     NLERSSPLKKITRGMTNQSDTDNFPDSKDSPGDVQRSKLSPVLDGVSELRHSFDGSAA
                     DRYLLSQSSQPQSAATAPSAMFPYPSQHGPAHPAFSIGSPSRYMAHHPVITNGAYNSL
                     LSNSSPQGYPTAGYPYPQQYGHSYQGAPFYQFSSTQPGLVPGKAQVYLCNRPLWLKFH
                     RHQTEMIITKQGRRMFPFLSFNISGLDPTAHYNIFVDVILADPNHWRFQGGKWVPCGK
                     ADTNVQGNRVYMHPDSPNTGAHWMRQEISFGKLKLTNNKGASNNNGQMVVLQSLHKYQ
                     PRLHVVEVNEDGTEDTSQPGRVQTFTFPETQFIAVTAYQNTDITQLKIDHNPFAKGFR
                     DNYDTIYTGCDMDRLTPSPNDSPRSQIVPGARYAMAGSFLQDQFVSNYAKARFHPGAG
                     AGPGPGTDRSVPHTNGLLSPQQAEDPGAPSPQRWFVTPANNRLDFAASAYDTATDFAG
                     NAATLLSYAAAGVKALPLQAAGCTGRPLGYYADPSGWGARSPPQYCGAKSGSVLPCWP
                     NSAAAAARMAGANPYLGEEAEGLAAERSPLAPAAEDAKPKDLSDSSWIETPSSIKSID
                     SSDSGIYEQAKRRRISPADTPVSESSSPLKSEVLAQRDCEKNCAKDIGGYYGFYSHS"
     misc_feature    382..504
                     /gene="Tbr1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64336.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    577..636
                     /gene="Tbr1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64336.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1477..1479
                     /gene="Tbr1"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q64336.2); phosphorylation site"
     misc_feature    1483..1485
                     /gene="Tbr1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q64336.2); phosphorylation site"
     misc_feature    1594..1704
                     /gene="Tbr1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64336.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2035..2037
                     /gene="Tbr1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q64336.2); phosphorylation site"
     misc_feature    2044..2220
                     /gene="Tbr1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64336.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2173..2175
                     /gene="Tbr1"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q64336.2); phosphorylation site"
     exon            948..1102
                     /gene="Tbr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1224
                     /gene="Tbr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1383
                     /gene="Tbr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1445
                     /gene="Tbr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..3977
                     /gene="Tbr1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagctaacca atggcaagag ccgtttcatc ggctgcataa gcagcaagat caaaagtgag
       61 ccttttctga ttgctgcata gtgtcaattg gccaatctct tctcccaggg aaaaaaaaaa
      121 gtaaatcaaa cctttgagaa gcatttgctg gttgaagtgc tttctgtcta gtgaggggtc
      181 tgtggattcc tagtgtatga taaacaggac tttaaaaccc agggacggga gggccagcgt
      241 tcaggttcta gagctatgca gctggagcat tgcctctctc cttctatcat gctctccaag
      301 aaatttctca atgtgagcag cagctaccca cattcgggcg gatctgagct tgtcttgcat
      361 gatcatccca ttatctcgac cactgacaac ctggagagaa gttcaccttt gaaaaaaatt
      421 accaggggga tgacgaatca gtcagataca gacaattttc ctgactccaa ggactcacca
      481 ggggacgtcc agagaagtaa actctctcct gtcttggacg gggtctctga gcttcgtcac
      541 agtttcgatg gctctgctgc agatcgttac ctactctctc agtccagcca gccacagtct
      601 gcggccaccg ctcccagtgc catgttcccg taccccagcc agcacggacc ggcgcatccc
      661 gccttctcca tcggcagccc cagtcgctac atggcccacc acccggtcat taccaacgga
      721 gcttacaaca gcctgctgtc caactcttcg ccgcagggct accccacggc cggctacccc
      781 tacccacagc agtacggcca ctcctaccaa ggagcccctt tctaccagtt ctcctccacc
      841 cagcccgggt tggtgcccgg caaggcgcaa gtatacctgt gcaacaggcc actttggctg
      901 aaatttcatc ggcatcaaac ggagatgatc atcactaaac agggaaggcg catgtttccc
      961 tttttgagtt ttaacatttc tggtctcgat cccaccgctc attacaatat ttttgtggat
     1021 gtgattttgg cggatcccaa tcactggagg tttcaaggag gcaaatgggt tccttgtggc
     1081 aaagcggaca ccaatgtgca aggaaaccgg gtctatatgc atccggattc ccccaacact
     1141 ggggctcact ggatgcggca agaaatctct tttggaaaat taaaacttac caacaacaag
     1201 ggagcatcaa acaacaatgg gcagatggtg gttttacagt ccctgcacaa gtaccagccc
     1261 cgtctgcacg tggtggaagt gaatgaggat ggcacagagg acaccagcca gccaggccga
     1321 gtccagacgt tcacttttcc ggagactcag ttcatcgctg tcaccgccta ccagaacacg
     1381 gatattacac aactaaaaat agatcataac ccctttgcaa aaggatttcg agataactat
     1441 gacacgatct acacgggctg cgacatggac cgcttgaccc cgtcgcccaa cgactctccg
     1501 cgctcgcaga tcgtgcccgg cgcccgctac gccatggccg gctctttcct gcaagaccag
     1561 ttcgtgagca actacgccaa ggcccgcttc cacccgggcg ccggcgcggg tcccgggccg
     1621 ggcacggacc gcagcgtgcc gcacaccaac gggctgctgt ccccgcagca ggccgaggac
     1681 ccgggcgcgc cgtcgccgca gcgctggttc gtcacgccgg ccaacaaccg gctggacttc
     1741 gcggcctcgg cctacgacac ggccacggac ttcgccggca acgcggccac gctgctgtcg
     1801 tatgcggccg cgggcgtgaa ggcgctgccc ttgcaggccg cgggctgcac gggccgcccg
     1861 ctcggctact acgccgaccc ttcgggctgg ggcgcgcgca gccccccgca gtactgcggc
     1921 gccaagtcgg gctccgtgct cccctgctgg cccaacagcg ccgcggccgc cgcgcgcatg
     1981 gccggcgcca acccctatct gggcgaggag gccgagggcc tggcggccga gcgctcgccg
     2041 ctggcgcccg ccgccgagga cgccaagccc aaggacctgt ccgactccag ctggatcgag
     2101 acgccctcct ccatcaaatc catcgactcc agcgactcgg ggatttacga gcaggccaag
     2161 cggaggcgga tctcgccggc tgacacgccg gtgtctgaga gctcgtcccc gctcaagagc
     2221 gaggtgctgg cccagcggga ctgcgagaag aactgcgcca aggacatagg cggctactat
     2281 ggcttctact cgcacagcta ggccgccagc ccgctcgccc gcccgcccgt gcccccggcc
     2341 ccccagctcg gccccacgtc ctccttccca ggcccgttct agcgcactcg ctctttcact
     2401 tgaccctcga tgaccgtctg cggggataag tgcaggtctc tcactatgat tttaaaactc
     2461 ttcttttttc tttctttctt tctctctaca cagccttctc tgcagttagc gcaccgacct
     2521 tgaacctggc tgtaaacctt gtggttttcc aacttttcgt ctgtgaggtt atgatcctcc
     2581 ctgtcttttt tccaccccct tctccttgcc ccactcatcc tctcctttct cttggaatga
     2641 aactcttcaa ctttaggaga cctgggcaat cctgccaggc agcagcgatt ccgacccgcc
     2701 ttgtcttggc ctccctattt aaccatagga tgttgactct agaacctgca cccacccagc
     2761 gcgtcctttc ttatacccga gtggatggat ggatggatgg atggatggta gggatgttaa
     2821 tacttttagt ggaacaaagc ctgtgaaatg attgtatata gtgttaattt attgtaacga
     2881 atggctagtt tttattctca ttgtcaaggc acaaaaccag ttcacgctta actttttatt
     2941 cctttccttt cttctccttt tctttttctc ctctcattct ttctcttctc ccacaccctt
     3001 tgttttcttg tgagttatta aagatattct aagaggctct ggaaacacga agcacttcat
     3061 agtggtggct ttctcacttc tcagttcgtt gcatgatgta accactgtgt gccctggtgc
     3121 acacaatgta gctaaggaga atccacctga acacctgtaa aagctagttg tctgttccta
     3181 ggcgagtcga gtaagtgaca cgatgcctgc caggcggact taactggagt tctatgtgtt
     3241 tctcccttcc ttctaaatgg aatggcccca catcagcaat attattttgc cttatttgtt
     3301 tttccccaaa gtgccaaatc cattactggt ctgtgcaggt gccaaatatg ctgataaact
     3361 gtttctgact atcttttcag accccactcc acctttatat gctgtaaatc tttgtaatga
     3421 gtaatctact aatgatatag atgactgaat tgttggtaac tatagtgtag tctagtgaag
     3481 atgaattgtg tgagttgtat attttactgc attttagttt gaaaaacgat tcccccacca
     3541 cttagagaca gctgaaattt gactttcttg ggaaaacact agcattattg caagtaagac
     3601 tgattccccc caagtcttgt tatatttgat aaggagcatt aatccccctg gaaatagatt
     3661 agtaggattt ctaatgttgt gtagcaaact tatacttttt ttgtacttta aaatcaatgt
     3721 gaaatatgca tcatacacaa tattcaatct agattccagt ctatgggggg atttgtccta
     3781 ataggaattc agggtctaaa cgtgggtata ctttggctct cctgtaaatc aaatgttgtg
     3841 attttttata tttgttttgt tttgtctgtg aattgaataa tttatacaag tacacactcc
     3901 actgagaatc gttttgtttt ctgctcgttt gtatcgtctg tgtataacaa gtaaaataaa
     3961 tctggtaaaa tgctaaa
//
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