LOCUS NM_009322 3977 bp mRNA linear ROD 14-FEB-2023
DEFINITION Mus musculus T-box brain transcription factor 1 (Tbr1), mRNA.
ACCESSION NM_009322
VERSION NM_009322.3
KEYWORDS RefSeq; RefSeq Select.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (bases 1 to 3977)
AUTHORS Kueh AJ, Bergamasco MI, Quaglieri A, Phipson B, Li-Wai-Suen CSN,
Lonnstedt IM, Hu Y, Feng ZP, Woodruff C, May RE, Wilcox S, Garnham
AL, Snyder MP, Smyth GK, Speed TP, Thomas T and Voss AK.
TITLE Stem cell plasticity, acetylation of H3K14, and de novo gene
activation rely on KAT7
JOURNAL Cell Rep 42 (1), 111980 (2023)
PUBMED 36641753
REFERENCE 2 (bases 1 to 3977)
AUTHORS Gerstmann K, Kindbeiter K, Telley L, Bozon M, Reynaud F, Theoulle
E, Charoy C, Jabaudon D, Moret F and Castellani V.
TITLE A balance of noncanonical Semaphorin signaling from the
cerebrospinal fluid regulates apical cell dynamics during
corticogenesis
JOURNAL Sci Adv 8 (46), eabo4552 (2022)
PUBMED 36399562
REFERENCE 3 (bases 1 to 3977)
AUTHORS de Thonel A, Ahlskog JK, Daupin K, Dubreuil V, Berthelet J, Chaput
C, Pires G, Leonetti C, Abane R, Barris LC, Leray I, Aalto AL,
Naceri S, Cordonnier M, Benasolo C, Sanial M, Duchateau A,
Vihervaara A, Puustinen MC, Miozzo F, Fergelot P, Lebigot E,
Verloes A, Gressens P, Lacombe D, Gobbo J, Garrido C, Westerheide
SD, David L, Petitjean M, Taboureau O, Rodrigues-Lima F, Passemard
S, Saberan-Djoneidi D, Nguyen L, Lancaster M, Sistonen L and Mezger
V.
TITLE CBP-HSF2 structural and functional interplay in Rubinstein-Taybi
neurodevelopmental disorder
JOURNAL Nat Commun 13 (1), 7002 (2022)
PUBMED 36385105
REMARK Publication Status: Online-Only
REFERENCE 4 (bases 1 to 3977)
AUTHORS Nguyen H, Sokpor G, Parichha A, Pham L, Saikhedkar N, Xie Y, Ulmke
PA, Rosenbusch J, Pirouz M, Behr R, Stoykova A, Brand-Saberi B,
Nguyen HP, Staiger JF, Tole S and Tuoc T.
TITLE BAF (mSWI/SNF) complex regulates mediolateral cortical patterning
in the developing forebrain
JOURNAL Front Cell Dev Biol 10, 1011109 (2022)
PUBMED 36263009
REMARK Publication Status: Online-Only
REFERENCE 5 (bases 1 to 3977)
AUTHORS Tomita H, Hines KM, Herron JM, Li A, Baggett DW and Xu L.
TITLE 7-Dehydrocholesterol-derived oxysterols cause neurogenic defects in
Smith-Lemli-Opitz syndrome
JOURNAL Elife 11, e67141 (2022)
PUBMED 36111785
REMARK Publication Status: Online-Only
REFERENCE 6 (bases 1 to 3977)
AUTHORS Bulfone A, Wang F, Hevner R, Anderson S, Cutforth T, Chen S,
Meneses J, Pedersen R, Axel R and Rubenstein JL.
TITLE An olfactory sensory map develops in the absence of normal
projection neurons or GABAergic interneurons
JOURNAL Neuron 21 (6), 1273-1282 (1998)
PUBMED 9883721
REFERENCE 7 (bases 1 to 3977)
AUTHORS Wattler S, Russ A, Evans M and Nehls M.
TITLE A combined analysis of genomic and primary protein structure
defines the phylogenetic relationship of new members if the T-box
family
JOURNAL Genomics 48 (1), 24-33 (1998)
PUBMED 9503012
REFERENCE 8 (bases 1 to 3977)
AUTHORS Acampora D, Avantaggiato V, Tuorto F and Simeone A.
TITLE Genetic control of brain morphogenesis through Otx gene dosage
requirement
JOURNAL Development 124 (18), 3639-3650 (1997)
PUBMED 9342056
REFERENCE 9 (bases 1 to 3977)
AUTHORS Qiu M, Anderson S, Chen S, Meneses JJ, Hevner R, Kuwana E, Pedersen
RA and Rubenstein JL.
TITLE Mutation of the Emx-1 homeobox gene disrupts the corpus callosum
JOURNAL Dev Biol 178 (1), 174-178 (1996)
PUBMED 8812118
REFERENCE 10 (bases 1 to 3977)
AUTHORS Bulfone A, Smiga SM, Shimamura K, Peterson A, Puelles L and
Rubenstein JL.
TITLE T-brain-1: a homolog of Brachyury whose expression defines
molecularly distinct domains within the cerebral cortex
JOURNAL Neuron 15 (1), 63-78 (1995)
PUBMED 7619531
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from AL845291.5.
[WARNING] On Mar 18, 2023 this sequence was replaced by
NM_009322.4.
On Nov 17, 2006 this sequence version replaced NM_009322.2.
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC052737.1, U49251.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN01164131, SAMN01164132
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression,
longest protein
##RefSeq-Attributes-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-947 AL845291.5 178917-179863
948-1102 AL845291.5 180438-180592
1103-1224 AL845291.5 181096-181217
1225-1383 AL845291.5 181743-181901
1384-1445 AL845291.5 182963-183024
1446-3977 AL845291.5 186047-188578
FEATURES Location/Qualifiers
source 1..3977
/organism="Mus musculus"
/mol_type="mRNA"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="2"
/map="2 35.56 cM"
gene 1..3977
/gene="Tbr1"
/note="T-box brain transcription factor 1"
/db_xref="GeneID:21375"
/db_xref="MGI:MGI:107404"
exon 1..947
/gene="Tbr1"
/inference="alignment:Splign:2.1.0"
misc_feature 172..174
/gene="Tbr1"
/note="upstream in-frame stop codon"
CDS 256..2301
/gene="Tbr1"
/note="TBR-1; TES-56; T-brain-1; T-box brain gene 1"
/codon_start=1
/product="T-box brain protein 1"
/protein_id="NP_033348.2"
/db_xref="CCDS:CCDS16063.1"
/db_xref="GeneID:21375"
/db_xref="MGI:MGI:107404"
/translation="MQLEHCLSPSIMLSKKFLNVSSSYPHSGGSELVLHDHPIISTTD
NLERSSPLKKITRGMTNQSDTDNFPDSKDSPGDVQRSKLSPVLDGVSELRHSFDGSAA
DRYLLSQSSQPQSAATAPSAMFPYPSQHGPAHPAFSIGSPSRYMAHHPVITNGAYNSL
LSNSSPQGYPTAGYPYPQQYGHSYQGAPFYQFSSTQPGLVPGKAQVYLCNRPLWLKFH
RHQTEMIITKQGRRMFPFLSFNISGLDPTAHYNIFVDVILADPNHWRFQGGKWVPCGK
ADTNVQGNRVYMHPDSPNTGAHWMRQEISFGKLKLTNNKGASNNNGQMVVLQSLHKYQ
PRLHVVEVNEDGTEDTSQPGRVQTFTFPETQFIAVTAYQNTDITQLKIDHNPFAKGFR
DNYDTIYTGCDMDRLTPSPNDSPRSQIVPGARYAMAGSFLQDQFVSNYAKARFHPGAG
AGPGPGTDRSVPHTNGLLSPQQAEDPGAPSPQRWFVTPANNRLDFAASAYDTATDFAG
NAATLLSYAAAGVKALPLQAAGCTGRPLGYYADPSGWGARSPPQYCGAKSGSVLPCWP
NSAAAAARMAGANPYLGEEAEGLAAERSPLAPAAEDAKPKDLSDSSWIETPSSIKSID
SSDSGIYEQAKRRRISPADTPVSESSSPLKSEVLAQRDCEKNCAKDIGGYYGFYSHS"
misc_feature 382..504
/gene="Tbr1"
/note="propagated from UniProtKB/Swiss-Prot (Q64336.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 577..636
/gene="Tbr1"
/note="propagated from UniProtKB/Swiss-Prot (Q64336.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 1477..1479
/gene="Tbr1"
/note="Phosphothreonine.
/evidence=ECO:0007744|PubMed:21183079; propagated from
UniProtKB/Swiss-Prot (Q64336.2); phosphorylation site"
misc_feature 1483..1485
/gene="Tbr1"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:21183079; propagated from
UniProtKB/Swiss-Prot (Q64336.2); phosphorylation site"
misc_feature 1594..1704
/gene="Tbr1"
/note="propagated from UniProtKB/Swiss-Prot (Q64336.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 2035..2037
/gene="Tbr1"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:21183079; propagated from
UniProtKB/Swiss-Prot (Q64336.2); phosphorylation site"
misc_feature 2044..2220
/gene="Tbr1"
/note="propagated from UniProtKB/Swiss-Prot (Q64336.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 2173..2175
/gene="Tbr1"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:21183079; propagated from
UniProtKB/Swiss-Prot (Q64336.2); phosphorylation site"
exon 948..1102
/gene="Tbr1"
/inference="alignment:Splign:2.1.0"
exon 1103..1224
/gene="Tbr1"
/inference="alignment:Splign:2.1.0"
exon 1225..1383
/gene="Tbr1"
/inference="alignment:Splign:2.1.0"
exon 1384..1445
/gene="Tbr1"
/inference="alignment:Splign:2.1.0"
exon 1446..3977
/gene="Tbr1"
/inference="alignment:Splign:2.1.0"
ORIGIN
1 cagctaacca atggcaagag ccgtttcatc ggctgcataa gcagcaagat caaaagtgag
61 ccttttctga ttgctgcata gtgtcaattg gccaatctct tctcccaggg aaaaaaaaaa
121 gtaaatcaaa cctttgagaa gcatttgctg gttgaagtgc tttctgtcta gtgaggggtc
181 tgtggattcc tagtgtatga taaacaggac tttaaaaccc agggacggga gggccagcgt
241 tcaggttcta gagctatgca gctggagcat tgcctctctc cttctatcat gctctccaag
301 aaatttctca atgtgagcag cagctaccca cattcgggcg gatctgagct tgtcttgcat
361 gatcatccca ttatctcgac cactgacaac ctggagagaa gttcaccttt gaaaaaaatt
421 accaggggga tgacgaatca gtcagataca gacaattttc ctgactccaa ggactcacca
481 ggggacgtcc agagaagtaa actctctcct gtcttggacg gggtctctga gcttcgtcac
541 agtttcgatg gctctgctgc agatcgttac ctactctctc agtccagcca gccacagtct
601 gcggccaccg ctcccagtgc catgttcccg taccccagcc agcacggacc ggcgcatccc
661 gccttctcca tcggcagccc cagtcgctac atggcccacc acccggtcat taccaacgga
721 gcttacaaca gcctgctgtc caactcttcg ccgcagggct accccacggc cggctacccc
781 tacccacagc agtacggcca ctcctaccaa ggagcccctt tctaccagtt ctcctccacc
841 cagcccgggt tggtgcccgg caaggcgcaa gtatacctgt gcaacaggcc actttggctg
901 aaatttcatc ggcatcaaac ggagatgatc atcactaaac agggaaggcg catgtttccc
961 tttttgagtt ttaacatttc tggtctcgat cccaccgctc attacaatat ttttgtggat
1021 gtgattttgg cggatcccaa tcactggagg tttcaaggag gcaaatgggt tccttgtggc
1081 aaagcggaca ccaatgtgca aggaaaccgg gtctatatgc atccggattc ccccaacact
1141 ggggctcact ggatgcggca agaaatctct tttggaaaat taaaacttac caacaacaag
1201 ggagcatcaa acaacaatgg gcagatggtg gttttacagt ccctgcacaa gtaccagccc
1261 cgtctgcacg tggtggaagt gaatgaggat ggcacagagg acaccagcca gccaggccga
1321 gtccagacgt tcacttttcc ggagactcag ttcatcgctg tcaccgccta ccagaacacg
1381 gatattacac aactaaaaat agatcataac ccctttgcaa aaggatttcg agataactat
1441 gacacgatct acacgggctg cgacatggac cgcttgaccc cgtcgcccaa cgactctccg
1501 cgctcgcaga tcgtgcccgg cgcccgctac gccatggccg gctctttcct gcaagaccag
1561 ttcgtgagca actacgccaa ggcccgcttc cacccgggcg ccggcgcggg tcccgggccg
1621 ggcacggacc gcagcgtgcc gcacaccaac gggctgctgt ccccgcagca ggccgaggac
1681 ccgggcgcgc cgtcgccgca gcgctggttc gtcacgccgg ccaacaaccg gctggacttc
1741 gcggcctcgg cctacgacac ggccacggac ttcgccggca acgcggccac gctgctgtcg
1801 tatgcggccg cgggcgtgaa ggcgctgccc ttgcaggccg cgggctgcac gggccgcccg
1861 ctcggctact acgccgaccc ttcgggctgg ggcgcgcgca gccccccgca gtactgcggc
1921 gccaagtcgg gctccgtgct cccctgctgg cccaacagcg ccgcggccgc cgcgcgcatg
1981 gccggcgcca acccctatct gggcgaggag gccgagggcc tggcggccga gcgctcgccg
2041 ctggcgcccg ccgccgagga cgccaagccc aaggacctgt ccgactccag ctggatcgag
2101 acgccctcct ccatcaaatc catcgactcc agcgactcgg ggatttacga gcaggccaag
2161 cggaggcgga tctcgccggc tgacacgccg gtgtctgaga gctcgtcccc gctcaagagc
2221 gaggtgctgg cccagcggga ctgcgagaag aactgcgcca aggacatagg cggctactat
2281 ggcttctact cgcacagcta ggccgccagc ccgctcgccc gcccgcccgt gcccccggcc
2341 ccccagctcg gccccacgtc ctccttccca ggcccgttct agcgcactcg ctctttcact
2401 tgaccctcga tgaccgtctg cggggataag tgcaggtctc tcactatgat tttaaaactc
2461 ttcttttttc tttctttctt tctctctaca cagccttctc tgcagttagc gcaccgacct
2521 tgaacctggc tgtaaacctt gtggttttcc aacttttcgt ctgtgaggtt atgatcctcc
2581 ctgtcttttt tccaccccct tctccttgcc ccactcatcc tctcctttct cttggaatga
2641 aactcttcaa ctttaggaga cctgggcaat cctgccaggc agcagcgatt ccgacccgcc
2701 ttgtcttggc ctccctattt aaccatagga tgttgactct agaacctgca cccacccagc
2761 gcgtcctttc ttatacccga gtggatggat ggatggatgg atggatggta gggatgttaa
2821 tacttttagt ggaacaaagc ctgtgaaatg attgtatata gtgttaattt attgtaacga
2881 atggctagtt tttattctca ttgtcaaggc acaaaaccag ttcacgctta actttttatt
2941 cctttccttt cttctccttt tctttttctc ctctcattct ttctcttctc ccacaccctt
3001 tgttttcttg tgagttatta aagatattct aagaggctct ggaaacacga agcacttcat
3061 agtggtggct ttctcacttc tcagttcgtt gcatgatgta accactgtgt gccctggtgc
3121 acacaatgta gctaaggaga atccacctga acacctgtaa aagctagttg tctgttccta
3181 ggcgagtcga gtaagtgaca cgatgcctgc caggcggact taactggagt tctatgtgtt
3241 tctcccttcc ttctaaatgg aatggcccca catcagcaat attattttgc cttatttgtt
3301 tttccccaaa gtgccaaatc cattactggt ctgtgcaggt gccaaatatg ctgataaact
3361 gtttctgact atcttttcag accccactcc acctttatat gctgtaaatc tttgtaatga
3421 gtaatctact aatgatatag atgactgaat tgttggtaac tatagtgtag tctagtgaag
3481 atgaattgtg tgagttgtat attttactgc attttagttt gaaaaacgat tcccccacca
3541 cttagagaca gctgaaattt gactttcttg ggaaaacact agcattattg caagtaagac
3601 tgattccccc caagtcttgt tatatttgat aaggagcatt aatccccctg gaaatagatt
3661 agtaggattt ctaatgttgt gtagcaaact tatacttttt ttgtacttta aaatcaatgt
3721 gaaatatgca tcatacacaa tattcaatct agattccagt ctatgggggg atttgtccta
3781 ataggaattc agggtctaaa cgtgggtata ctttggctct cctgtaaatc aaatgttgtg
3841 attttttata tttgttttgt tttgtctgtg aattgaataa tttatacaag tacacactcc
3901 actgagaatc gttttgtttt ctgctcgttt gtatcgtctg tgtataacaa gtaaaataaa
3961 tctggtaaaa tgctaaa
//