LOCUS BC146769 5396 bp mRNA linear PRI 23-JUL-2007
DEFINITION Homo sapiens leucine-rich repeat kinase 1, mRNA (cDNA clone
IMAGE:9007214), partial cds.
ACCESSION BC146769
VERSION BC146769.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5396)
AUTHORS Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
CONSRTM Mammalian Gene Collection Program Team
TITLE Generation and initial analysis of more than 15,000 full-length
human and mouse cDNA sequences
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
PUBMED 12477932
REFERENCE 2 (bases 1 to 5396)
CONSRTM NIH MGC Project
TITLE Direct Submission
JOURNAL Submitted (16-JUN-2007) National Institutes of Health, Mammalian
Gene Collection (MGC), Bethesda, MD 20892-2590, USA
REMARK NIH-MGC Project URL: http://mgc.nci.nih.gov
COMMENT Contact: MGC help desk
Email: cgapbs-r@mail.nih.gov
Tissue Procurement: Kazusa DNA Research Inst.
cDNA Library Preparation: Kazusa DNA Research Institute
cDNA Library Arrayed by: The I.M.A.G.E. Consortium (LLNL)
DNA Sequencing by: Sequencing Group at the Stanford Human Genome
Center, Stanford University School of Medicine, Stanford, CA 94305
Web site: http://www-shgc.stanford.edu
Contact: (Dickson, Mark) mcd@paxil.stanford.edu
Dickson, M., Schmutz, J., Grimwood, J., Rodriquez, A., and Myers,
R. M.
Clone distribution: MGC clone distribution information can be found
through the I.M.A.G.E. Consortium/LLNL at: http://image.llnl.gov
Series: IRCF Plate: 9 Row: b Column: 7.
FEATURES Location/Qualifiers
source 1..5396
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="IMAGE:9007214"
/tissue_type="Clones donated by Kazusa DNA Research Inst."
/clone_lib="Kazusa-KIAA-pBluescriptIISK+"
/lab_host="DH5alpha T1-resistant"
/note="Vector: pBluescript II SK+"
gene <1..5396
/gene="LRRK1"
/gene_synonym="RIPK6"
/gene_synonym="Roco1"
/db_xref="GeneID:79705"
/db_xref="HGNC:HGNC:18608"
/db_xref="MIM:610986"
CDS <1..4112
/gene="LRRK1"
/gene_synonym="RIPK6"
/gene_synonym="Roco1"
/codon_start=3
/product="LRRK1 protein"
/protein_id="AAI46770.1"
/db_xref="GeneID:79705"
/db_xref="HGNC:HGNC:18608"
/db_xref="MIM:610986"
/translation="PRQGKSTLLEILQTGRAPQVVHGEATIRTTKWELQRPAGSRAKV
ESVEFNVWDIGGPASMATVNQCFFTDKALYVVVWNLALGEEAVANLQFWLLNIEAKAP
NAVVLVVGTHLDLIEAKFRVERIATLRAYVLALCRSPSGSRATGFPDITFKHLHEISC
KSLEGQEGLRQLIFHVTCSMKDVGSTIGCQRLAGRLIPRSYLSLQEAVLAEQQRRSRD
DDVQYLTDRQLEQLVEQTPDNDIKDYEDLQSAISFLIETGTLLHFPDTSHGLRNLYFL
DPIWLSECLQRIFNIKGSRSVAKNGVIRAEDLRMLLVGTGFTQQTEEQYFQFLAKFEI
ALPVANDSYLLPHLLPSKPGLDTHGMRHPTANTIQRVFKMSFVPVGFWQRFIARMLIS
LAEMDLQLFENKKNTKSRNRKVTIYSFTGNQRNRCSTFRVKRNQTIYWQEGLLVTFDG
GYLSVESSDVNWKKKKSGGMKIVCQSEVRDFSAMAFITDHVNSLIDQWFPALTATESD
GTPLMEQYVPCPVCETAWAQHTDPSEKSEDVQYFDMEDCVLTAIERDFISCPRHPDLP
VPLQELVPELFMTDFPARLFLENSKLEHSEDEGSVLGQGGSGTVIYRARYQGQPVAVK
RFHIKKFKNFANVPADTMLRHLRATDAMKNFSEFRQEASMLHALQHPCIVALIGISIH
PLCFALELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKKNIIFCD
LKSDNILVWSLDVKEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEIRPRIVYDEK
VDMFSYGMVLYELLSGQRPALGHHQLQIAKKLSKGIRPVLGQPEEVQFRRLQALMMEC
WDTKPEKRPLALSVVSQMKDPTFATFMYELCCGKQTAFFSSQGQEYTVVFWDGKEESR
NYTVVNTEKGLMEVQRMCCPGMKVSCQLQVQRSLWTATEDQKIYIYTLKGMCPLNTPQ
QALDTPAVVTCFLAVPVIKKNSYLVLAGLADGLVAVFPVVRGTPKDSCSYLCSHTANR
SKFSIADEDARQNPYPVKAMEVVNSGSEVWYSNGPGLLVIDCASLEICRRLEPYMAPS
MVTSVVCSSEGRGEEVVWCLDDKANSLVMYHSTTYQLCARYFCGVPSPLRDMFPVRPL
DTEPPAASHTANPKVPEGDSIADVSIMYSEELGTQILIHQESLTDYCSMSSYSSSPPR
QAARSPSSLPSSPASSSSVPFSTDCEDSDMLHTPGAASDRSEHDLTPMDGETFSQHLQ
AVKILAVRDLIWVPRRGGDVIVIGLEKDSEAQRGRVIAVLKARELTPHGVLVDAAVVA
KDTVVCTFENENTEWCLAVWRGWGAREFDIFYQSYEELGRLEACTRKRR"
ORIGIN
1 ccccgcgcca gggcaagtcc accctcctgg agatcttaca gacggggagg gccccccagg
61 tggtgcatgg agaggccacc atcaggacca ccaagtggga gctccagagg ccggctggct
121 caagagccaa ggttgagtcc gtggagttca acgtctggga catcggggga ccggccagca
181 tggccactgt caaccagtgc ttcttcacgg acaaggccct gtacgtggtg gtctggaacc
241 tggcgctggg ggaggaggcc gtggccaacc tccagttctg gctgctcaac atcgaggcca
301 aggccccaaa cgccgtggtg ctggtggtcg ggacgcacct ggatttaatt gaagccaagt
361 tccgtgtgga aaggattgca acgctgcgtg cctatgtgct ggcactctgc cgctccccct
421 ccggctccag ggccacaggc ttcccagaca tcaccttcaa acacttacat gagatttcct
481 gcaagagcct ggaaggtcag gaagggctgc gacagctgat tttccacgtc acgtgcagca
541 tgaaggacgt gggcagcacc atcggctgcc agcgactggc agggcggctg atccccagga
601 gctacctgag cctgcaggag gccgtgctgg cagagcagca gcgccgcagc cgggacgacg
661 acgtgcagta cctgacggac aggcagctgg agcagctggt ggagcagacg cccgacaacg
721 acatcaagga ctacgaggac ctgcagtcag ccatcagctt cctcatagaa accggcaccc
781 tgctccattt cccggacacc agccacggcc tgaggaacct ctacttcctc gaccctattt
841 ggctctccga atgtctgcag aggatcttta atattaaggg ctctcggtca gtggccaaga
901 atggggtgat cagagcagaa gacctcagga tgctgctggt ggggactggc ttcacgcagc
961 agacggaaga gcagtacttc cagttcctgg ccaagtttga gatcgccctg cccgtcgcca
1021 atgacagcta cctcctgccc catctccttc catctaaacc tggcctggac acccacggta
1081 tgcggcaccc cacagccaac accattcaga gggtatttaa gatgagcttc gttcccgttg
1141 gcttctggca aaggtttata gcacggatgc tgatcagcct ggcggagatg gacctgcagc
1201 tttttgaaaa caagaagaat actaaaagca ggaacaggaa agtcaccatt tacagtttta
1261 caggaaacca gagaaatcgc tgtagcacat tcagagtgaa aagaaatcag accatctatt
1321 ggcaggaagg gctcctggtc acttttgatg ggggctacct cagtgtggaa tcttccgacg
1381 tgaactggaa aaagaagaaa agcggaggaa tgaaaattgt ttgccaatca gaagtgaggg
1441 acttctcagc catggctttc atcacggacc acgtcaattc cttgattgat cagtggtttc
1501 ccgccctgac ggccacagag agcgacggga cgccactcat ggagcagtac gtgccctgcc
1561 cggtctgcga gacagcctgg gcccagcaca cggaccccag tgagaaatca gaggatgtgc
1621 agtacttcga catggaagac tgtgtcctga cggccatcga gcgggacttc atctcctgcc
1681 ccagacaccc ggacctcccc gtgccgctgc aggagctggt ccctgaactg ttcatgaccg
1741 acttcccggc caggctcttc ctggagaaca gcaagctgga gcacagcgag gacgagggca
1801 gcgtcctggg ccagggcggc agtggcaccg tcatctaccg ggcccggtac cagggccagc
1861 ctgtggccgt caagcgcttc cacatcaaaa aattcaagaa ctttgctaac gtaccggcag
1921 acaccatgct gaggcacctg cgggccaccg atgccatgaa gaacttctcc gagttccggc
1981 aggaggccag catgctgcac gcgctgcagc acccctgcat cgtggcgctc atcggcatca
2041 gcatccaccc gctctgcttc gccctggagc tcgcgccgct cagcagcctc aacaccgtgc
2101 tgtccgagaa cgccagagat tcttccttta tacccctggg acacatgctc acccaaaaaa
2161 tagcctacca gatcgcctcg ggcctggcct acctgcacaa gaaaaacatc atcttctgtg
2221 acctgaagtc ggacaacatt ctggtgtggt cccttgacgt caaggagcac atcaacatca
2281 agctatctga ctacgggatt tcgaggcagt cattccatga gggcgcccta ggcgtggagg
2341 gcactcctgg ctaccaggcc ccagagatca ggcctcgcat tgtatatgat gagaaggtag
2401 atatgttctc ctatggaatg gtgctctacg agttgctgtc aggacagcgc cctgcactgg
2461 gccaccacca gctccagatt gccaagaagc tgtccaaggg catccgcccg gttctggggc
2521 agccggagga agtgcagttc cggcgactgc aggcgctcat gatggagtgc tgggacacta
2581 agccagagaa gcgaccgctg gccctgtcgg tggtgagcca gatgaaggac ccgacttttg
2641 ccaccttcat gtatgaactg tgctgtggga agcagacagc cttcttctca tcccagggcc
2701 aggagtacac cgtggtgttt tgggatggaa aagaggagtc caggaactac acggtggtga
2761 acacagagaa gggcctcatg gaggtgcaga ggatgtgctg ccctgggatg aaggtgagct
2821 gccagctcca ggtccagaga tccctgtgga cagccaccga ggaccagaaa atctacatct
2881 acaccctcaa gggcatgtgc cccttaaaca caccccaaca ggccttggat actccagctg
2941 tcgtcacctg cttcttggcc gtgcctgtta ttaaaaagaa ttcctacctg gtcttagcgg
3001 gcctcgccga tgggcttgtg gctgtgtttc ccgtggtgcg gggcacccca aaggacagct
3061 gctcctacct gtgctcacac acagccaaca ggtccaagtt cagcatcgcg gatgaagacg
3121 cacggcagaa cccctaccca gtgaaggcca tggaggtggt caacagcggc tctgaggtct
3181 ggtacagcaa tgggccgggc ctccttgtca tcgactgtgc ctccctggag atctgcaggc
3241 ggctggagcc ctacatggcc ccctccatgg ttacgtcagt cgtgtgcagc tctgagggca
3301 gaggggagga ggtcgtctgg tgcctggatg acaaggccaa ctccttggtg atgtaccact
3361 ccaccaccta ccagctgtgt gcccggtact tctgcggggt ccccagcccc ctcagggaca
3421 tgtttcccgt gcggcccttg gacacggaac ccccggcagc cagccacacg gccaacccaa
3481 aggtgcctga gggggactcc atcgcggacg tgagcatcat gtacagtgag gagctgggca
3541 cgcagatcct gatccaccag gaatcactca ctgactactg ctccatgtcc tcctactcct
3601 catccccacc ccgccaggct gccaggtccc cctcaagcct ccccagctcc ccagcaagtt
3661 cttccagtgt gcctttctcc accgactgcg aggactcaga catgctacat acgcccggtg
3721 ctgcctccga caggtctgag catgacctga cccccatgga cggggagacc ttcagccagc
3781 acctgcaggc cgtgaagatc ctcgccgtca gagacctcat ttgggtcccc aggcgcggtg
3841 gagatgttat cgtcattggc ctggagaagg attctgaagc ccagcggggc cgagtcattg
3901 ccgtcttaaa agcccgagag ctgactccgc atggggtgct ggtggatgct gccgtggtgg
3961 caaaggacac tgttgtgtgc acctttgaaa atgaaaacac agagtggtgc ctggccgtct
4021 ggaggggctg gggcgccagg gagttcgaca ttttctacca gtcctacgag gagctgggcc
4081 ggctggaggc ttgcactcgc aagagaaggt aattcctgtg gaatgactgt cacacatcag
4141 agctggctgg cccggggctg cagcctgacc cctctgccat cggcctctag ttctccaagg
4201 acctagaaga cagatggagt tctcccctga actccttgct gctaagaagt gctgagaagt
4261 tactcgcctg gcggtggctc cagggttctc tggttctctg gagcagagtt ctctgaatac
4321 cccatccccc aactgctgat tttacagccc cagggaagac agtggtatca ggctgggagc
4381 ggcctcctct ggcctccccc atcagtttgc aggagcaggg gtgcaggatc ctgttctgag
4441 ctgggtcaaa caaagcaggg ccgggccttc ctgccatccc caggtctcag atggaattac
4501 actagaggcc ctccgctggg aagcacttga ggtagggcag gaggggggct gtgacccctg
4561 ccctttcccc gccagagacc tcgggctctc agcacattcc acaggctcct gagtccccga
4621 ggcctgggcc agcttgggca agccaagatc agatgtctct gtgttcggga aggtctccgt
4681 gtgggaaagc ccttggggga tcccgggtga ggagtgttgc cccatccaga gaatgaatga
4741 gttcctttaa gtgccaccgc cagcaagccc agaggcacac agtccgagtg cacccgctta
4801 gcctttacat tcctctccac cgacaaaagg aaggggaaac tcaatcagca ggacttcaga
4861 aagggccttg tgtttatagc tttgtcaagt aaatttggac gcagctggag cacaggccct
4921 gtttgtttgc acataataat cttgtttatc actttaaaaa attcagtaat atctcagcag
4981 tcaggcttct ggttgtgaaa tcacattgta tgggatttat accaaattat gtatttgcta
5041 aacattcact gcacacgtgt acagcggagt acgaaaagga acgttgtcca caggggattt
5101 atggatacaa cagcaaacat tttataaact atgcacatgc attacacaca tgcacacaca
5161 tatgcacaca catgtgcaaa catagccact tttttgtcaa gagttaccct ttggggctcc
5221 ttaaaccaga atgggagttt gaaagagaga tcatactcca gctgaagttt gttgaccctt
5281 ttctaaaatt aaaaagatca aatttagtat ttgctggata tgcagggaga tgagactctt
5341 ttaatctcaa aataaacaga ttctttcaag aaaaaaaaaa aaaaaaaaaa aaaaaa
//