LOCUS NM_003884 4410 bp mRNA linear PRI 03-SEP-2024
DEFINITION Homo sapiens lysine acetyltransferase 2B (KAT2B), mRNA.
ACCESSION NM_003884 XM_001130666
VERSION NM_003884.5
KEYWORDS RefSeq; MANE Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4410)
AUTHORS Lee,S.Y., Lee,S.H., Choi,N.H., Kim,J.Y., Kweon,J.H., Miller,K.M.
and Kim,J.J.
TITLE PCAF promotes R-loop resolution via histone acetylation
JOURNAL Nucleic Acids Res 52 (15), 8643-8660 (2024)
PUBMED 38936834
REMARK GeneRIF: PCAF promotes R-loop resolution via histone acetylation.
REFERENCE 2 (bases 1 to 4410)
AUTHORS Ma,W., Zhang,J., Chen,W., Liu,N. and Wu,T.
TITLE The histone lysine acetyltransferase KAT2B inhibits
cholangiocarcinoma growth: evidence for interaction with SP1 to
regulate NF2-YAP signaling
JOURNAL J Exp Clin Cancer Res 43 (1), 117 (2024)
PUBMED 38641672
REMARK GeneRIF: The histone lysine acetyltransferase KAT2B inhibits
cholangiocarcinoma growth: evidence for interaction with SP1 to
regulate NF2-YAP signaling.
Publication Status: Online-Only
REFERENCE 3 (bases 1 to 4410)
AUTHORS Monte-Serrano,E., Morejon-Garcia,P., Campillo-Marcos,I.,
Campos-Diaz,A., Navarro-Carrasco,E. and Lazo,P.A.
TITLE The pattern of histone H3 epigenetic posttranslational
modifications is regulated by the VRK1 chromatin kinase
JOURNAL Epigenetics Chromatin 16 (1), 18 (2023)
PUBMED 37179361
REMARK Publication Status: Online-Only
REFERENCE 4 (bases 1 to 4410)
AUTHORS Zhang,J., Hu,Z., Chung,H.H., Tian,Y., Lau,K.W., Ser,Z., Lim,Y.T.,
Sobota,R.M., Leong,H.F., Chen,B.J., Yeo,C.J., Tan,S.Y.X., Kang,J.,
Tan,D.E.K., Sou,I.F., McClurg,U.L., Lakshmanan,M., Vaiyapuri,T.S.,
Raju,A., Wong,E.S.M., Tergaonkar,V., Rajarethinam,R., Pathak,E.,
Tam,W.L., Tan,E.Y. and Tee,W.W.
TITLE Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer
carcinogenesis
JOURNAL Nat Commun 14 (1), 2439 (2023)
PUBMED 37117180
REMARK GeneRIF: Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast
cancer carcinogenesis.
Publication Status: Online-Only
REFERENCE 5 (bases 1 to 4410)
AUTHORS Qiu,L., Liu,X., Xia,H. and Xu,C.
TITLE Downregulation of P300/CBP-Associated Factor Protects from Vascular
Aging via Nrf2 Signal Pathway Activation
JOURNAL Int J Mol Sci 23 (20), 12574 (2022)
PUBMED 36293441
REMARK GeneRIF: Downregulation of P300/CBP-Associated Factor Protects from
Vascular Aging via Nrf2 Signal Pathway Activation.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 4410)
AUTHORS Spencer,T.E., Jenster,G., Burcin,M.M., Allis,C.D., Zhou,J.,
Mizzen,C.A., McKenna,N.J., Onate,S.A., Tsai,S.Y., Tsai,M.J. and
O'Malley,B.W.
TITLE Steroid receptor coactivator-1 is a histone acetyltransferase
JOURNAL Nature 389 (6647), 194-198 (1997)
PUBMED 9296499
REFERENCE 7 (bases 1 to 4410)
AUTHORS Chen,H., Lin,R.J., Schiltz,R.L., Chakravarti,D., Nash,A., Nagy,L.,
Privalsky,M.L., Nakatani,Y. and Evans,R.M.
TITLE Nuclear receptor coactivator ACTR is a novel histone
acetyltransferase and forms a multimeric activation complex with
P/CAF and CBP/p300
JOURNAL Cell 90 (3), 569-580 (1997)
PUBMED 9267036
REFERENCE 8 (bases 1 to 4410)
AUTHORS Ogryzko,V.V., Schiltz,R.L., Russanova,V., Howard,B.H. and
Nakatani,Y.
TITLE The transcriptional coactivators p300 and CBP are histone
acetyltransferases
JOURNAL Cell 87 (5), 953-959 (1996)
PUBMED 8945521
REFERENCE 9 (bases 1 to 4410)
AUTHORS Yang,X.J., Ogryzko,V.V., Nishikawa,J., Howard,B.H. and Nakatani,Y.
TITLE A p300/CBP-associated factor that competes with the adenoviral
oncoprotein E1A
JOURNAL Nature 382 (6589), 319-324 (1996)
PUBMED 8684459
REFERENCE 10 (bases 1 to 4410)
AUTHORS Dawson,S.J. and White,L.A.
TITLE Treatment of Haemophilus aphrophilus endocarditis with
ciprofloxacin
JOURNAL J Infect 24 (3), 317-320 (1992)
PUBMED 1602151
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AC099057.3.
On Nov 23, 2018 this sequence version replaced NM_003884.4.
Summary: CBP and p300 are large nuclear proteins that bind to many
sequence-specific factors involved in cell growth and/or
differentiation, including c-jun and the adenoviral oncoprotein
E1A. The protein encoded by this gene associates with p300/CBP. It
has in vitro and in vivo binding activity with CBP and p300, and
competes with E1A for binding sites in p300/CBP. It has histone
acetyl transferase activity with core histones and nucleosome core
particles, indicating that this protein plays a direct role in
transcriptional regulation. [provided by RefSeq, Jul 2008].
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC060823.1, SRR1803611.10333.1
[ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA1965299, SAMEA1966682
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000263754.5/ ENSP00000263754.4
RefSeq Select criteria :: based on conservation, expression,
longest protein
##RefSeq-Attributes-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-335 AC099057.3 17529-17863
336-462 AC099057.3 49416-49542
463-608 AC099057.3 72346-72491
609-701 AC099057.3 76945-77037
702-883 AC099057.3 78370-78551
884-1075 AC099057.3 88679-88870
1076-1182 AC099057.3 91965-92071
1183-1308 AC099057.3 96681-96806
1309-1445 AC099057.3 99751-99887
1446-1654 AC099057.3 102988-103196
1655-1781 AC099057.3 104506-104632
1782-1892 AC099057.3 114025-114135
1893-2036 AC099057.3 117304-117447
2037-2151 AC099057.3 123399-123513
2152-2188 AC099057.3 125046-125082
2189-2252 AC099057.3 125326-125389
2253-2337 AC099057.3 125486-125570
2338-4410 AC099057.3 129415-131487
FEATURES Location/Qualifiers
source 1..4410
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3p24.3"
gene 1..4410
/gene="KAT2B"
/gene_synonym="CAF; P/CAF; PCAF"
/note="lysine acetyltransferase 2B"
/db_xref="GeneID:8850"
/db_xref="HGNC:HGNC:8638"
/db_xref="MIM:602303"
exon 1..335
/gene="KAT2B"
/gene_synonym="CAF; P/CAF; PCAF"
/inference="alignment:Splign:2.1.0"
CDS 33..2531
/gene="KAT2B"
/gene_synonym="CAF; P/CAF; PCAF"
/EC_number="2.3.1.57"
/EC_number="2.3.1.48"
/note="CREBBP-associated factor; K(lysine)
acetyltransferase 2B; p300/CBP-associated factor; histone
acetylase PCAF; histone acetyltransferase PCAF; spermidine
acetyltransferase KAT2B"
/codon_start=1
/product="histone acetyltransferase KAT2B"
/protein_id="NP_003875.3"
/db_xref="CCDS:CCDS2634.1"
/db_xref="GeneID:8850"
/db_xref="HGNC:HGNC:8638"
/db_xref="MIM:602303"
/translation="MSEAGGAGPGGCGAGAGAGAGPGALPPQPAALPPAPPQGSPCAA
AAGGSGACGPATAVAAAGTAEGPGGGGSARIAVKKAQLRSAPRAKKLEKLGVYSACKA
EESCKCNGWKNPNPSPTPPRADLQQIIVSLTESCRSCSHALAAHVSHLENVSEEEMNR
LLGIVLDVEYLFTCVHKEEDADTKQVYFYLFKLLRKSILQRGKPVVEGSLEKKPPFEK
PSIEQGVNNFVQYKFSHLPAKERQTIVELAKMFLNRINYWHLEAPSQRRLRSPNDDIS
GYKENYTRWLCYCNVPQFCDSLPRYETTQVFGRTLLRSVFTVMRRQLLEQARQEKDKL
PLEKRTLILTHFPKFLSMLEEEVYSQNSPIWDQDFLSASSRTSQLGIQTVINPPPVAG
TISYNSTSSSLEQPNAGSSSPACKASSGLEANPGEKRKMTDSHVLEEAKKPRVMGDIP
MELINEVMSTITDPAAMLGPETNFLSAHSARDEAARLEERRGVIEFHVVGNSLNQKPN
KKILMWLVGLQNVFSHQLPRMPKEYITRLVFDPKHKTLALIKDGRVIGGICFRMFPSQ
GFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKHDILNFLTYADEYAIGYFKKQGFSK
EIKIPKTKYVGYIKDYEGATLMGCELNPRIPYTEFSVIIKKQKEIIKKLIERKQAQIR
KVYPGLSCFKDGVRQIPIESIPGIRETGWKPSGKEKSKEPRDPDQLYSTLKSILQQVK
SHQSAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLKNRYYVSKKLFMADLQRVFTN
CKEYNPPESEYYKCANILEKFFFSKIKEAGLIDK"
misc_feature 33..194
/gene="KAT2B"
/gene_synonym="CAF; P/CAF; PCAF"
/note="propagated from UniProtKB/Swiss-Prot (Q92831.3);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 1215..1340
/gene="KAT2B"
/gene_synonym="CAF; P/CAF; PCAF"
/note="propagated from UniProtKB/Swiss-Prot (Q92831.3);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 2148..2207
/gene="KAT2B"
/gene_synonym="CAF; P/CAF; PCAF"
/note="propagated from UniProtKB/Swiss-Prot (Q92831.3);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
exon 336..462
/gene="KAT2B"
/gene_synonym="CAF; P/CAF; PCAF"
/inference="alignment:Splign:2.1.0"
exon 463..608
/gene="KAT2B"
/gene_synonym="CAF; P/CAF; PCAF"
/inference="alignment:Splign:2.1.0"
exon 609..701
/gene="KAT2B"
/gene_synonym="CAF; P/CAF; PCAF"
/inference="alignment:Splign:2.1.0"
exon 702..883
/gene="KAT2B"
/gene_synonym="CAF; P/CAF; PCAF"
/inference="alignment:Splign:2.1.0"
exon 884..1075
/gene="KAT2B"
/gene_synonym="CAF; P/CAF; PCAF"
/inference="alignment:Splign:2.1.0"
exon 1076..1182
/gene="KAT2B"
/gene_synonym="CAF; P/CAF; PCAF"
/inference="alignment:Splign:2.1.0"
exon 1183..1308
/gene="KAT2B"
/gene_synonym="CAF; P/CAF; PCAF"
/inference="alignment:Splign:2.1.0"
exon 1309..1445
/gene="KAT2B"
/gene_synonym="CAF; P/CAF; PCAF"
/inference="alignment:Splign:2.1.0"
exon 1446..1654
/gene="KAT2B"
/gene_synonym="CAF; P/CAF; PCAF"
/inference="alignment:Splign:2.1.0"
exon 1655..1781
/gene="KAT2B"
/gene_synonym="CAF; P/CAF; PCAF"
/inference="alignment:Splign:2.1.0"
exon 1782..1892
/gene="KAT2B"
/gene_synonym="CAF; P/CAF; PCAF"
/inference="alignment:Splign:2.1.0"
exon 1893..2036
/gene="KAT2B"
/gene_synonym="CAF; P/CAF; PCAF"
/inference="alignment:Splign:2.1.0"
exon 2037..2151
/gene="KAT2B"
/gene_synonym="CAF; P/CAF; PCAF"
/inference="alignment:Splign:2.1.0"
exon 2152..2188
/gene="KAT2B"
/gene_synonym="CAF; P/CAF; PCAF"
/inference="alignment:Splign:2.1.0"
exon 2189..2252
/gene="KAT2B"
/gene_synonym="CAF; P/CAF; PCAF"
/inference="alignment:Splign:2.1.0"
exon 2253..2337
/gene="KAT2B"
/gene_synonym="CAF; P/CAF; PCAF"
/inference="alignment:Splign:2.1.0"
exon 2338..4410
/gene="KAT2B"
/gene_synonym="CAF; P/CAF; PCAF"
/inference="alignment:Splign:2.1.0"
regulatory 4357..4362
/regulatory_class="polyA_signal_sequence"
/gene="KAT2B"
/gene_synonym="CAF; P/CAF; PCAF"
/note="hexamer: AATATA"
regulatory 4388..4393
/regulatory_class="polyA_signal_sequence"
/gene="KAT2B"
/gene_synonym="CAF; P/CAF; PCAF"
/note="hexamer: ATTATA"
polyA_site 4407
/gene="KAT2B"
/gene_synonym="CAF; P/CAF; PCAF"
polyA_site 4410
/gene="KAT2B"
/gene_synonym="CAF; P/CAF; PCAF"
/note="major polyA site"
ORIGIN
1 actcggcgcc tcctgccgtg ctccggggcg gcatgtccga ggctggcggg gccgggccgg
61 gcggctgcgg ggcaggagcc ggggcagggg ccgggcccgg ggcgctgccc ccgcagcctg
121 cggcgcttcc gcccgcgccc ccgcagggct ccccctgcgc cgctgccgcc gggggctcgg
181 gcgcctgcgg tccggcgacg gcagtggctg cagcgggcac ggccgaagga ccgggaggcg
241 gtggctcggc ccgaatcgcc gtgaagaaag cgcaactacg ctccgctccg cgggccaaga
301 aactggagaa actcggagtg tactccgcct gcaaggccga ggagtcttgt aaatgtaatg
361 gctggaaaaa ccctaacccc tcacccactc cccccagagc cgacctgcag caaataattg
421 tcagtctaac agaatcctgt cggagttgta gccatgccct agctgctcat gtttcccacc
481 tggagaatgt gtcagaggaa gaaatgaaca gactcctggg aatagtattg gatgtggaat
541 atctctttac ctgtgtccac aaggaagaag atgcagatac caaacaagtt tatttctatc
601 tatttaagct cttgagaaag tctattttac aaagaggaaa acctgtggtt gaaggctctt
661 tggaaaagaa acccccattt gaaaaaccta gcattgaaca gggtgtgaat aactttgtgc
721 agtacaaatt tagtcacctg ccagcaaaag aaaggcaaac aatagttgag ttggcaaaaa
781 tgttcctaaa ccgcatcaac tattggcatc tggaggcacc atctcaacga agactgcgat
841 ctcccaatga tgatatttct ggatacaaag agaactacac aaggtggctg tgttactgca
901 acgtgccaca gttctgcgac agtctacctc ggtacgaaac cacacaggtg tttgggagaa
961 cattgcttcg ctcggtcttc actgttatga ggcgacaact cctggaacaa gcaagacagg
1021 aaaaagataa actgcctctt gaaaaacgaa ctctaatcct cactcatttc ccaaaatttc
1081 tgtccatgct agaagaagaa gtatatagtc aaaactctcc catctgggat caggattttc
1141 tctcagcctc ttccagaacc agccagctag gcatccaaac agttatcaat ccacctcctg
1201 tggctgggac aatttcatac aattcaacct catcttccct tgagcagcca aacgcaggga
1261 gcagcagtcc tgcctgcaaa gcctcttctg gacttgaggc aaacccagga gaaaagagga
1321 aaatgactga ttctcatgtt ctggaggagg ccaagaaacc ccgagttatg ggggatattc
1381 cgatggaatt aatcaacgag gttatgtcta ccatcacgga ccctgcagca atgcttggac
1441 cagagaccaa ttttctgtca gcacactcgg ccagggatga ggcggcaagg ttggaagagc
1501 gcaggggtgt aattgaattt cacgtggttg gcaattccct caaccagaaa ccaaacaaga
1561 agatcctgat gtggctggtt ggcctacaga acgttttctc ccaccagctg ccccgaatgc
1621 caaaagaata catcacacgg ctcgtctttg acccgaaaca caaaaccctt gctttaatta
1681 aagatggccg tgttattggt ggtatctgtt tccgtatgtt cccatctcaa ggattcacag
1741 agattgtctt ctgtgctgta acctcaaatg agcaagtcaa gggctatgga acacacctga
1801 tgaatcattt gaaagaatat cacataaagc atgacatcct gaacttcctc acatatgcag
1861 atgaatatgc aattggatac tttaagaaac agggtttctc caaagaaatt aaaataccta
1921 aaaccaaata tgttggctat atcaaggatt atgaaggagc cactttaatg ggatgtgagc
1981 taaatccacg gatcccgtac acagaatttt ctgtcatcat taaaaagcag aaggagataa
2041 ttaaaaaact gattgaaaga aaacaggcac aaattcgaaa agtttaccct ggactttcat
2101 gttttaaaga tggagttcga cagattccta tagaaagcat tcctggaatt agagagacag
2161 gctggaaacc gagtggaaaa gagaaaagta aagagcccag agaccctgac cagctttaca
2221 gcacgctcaa gagcatcctc cagcaggtga agagccatca aagcgcttgg cccttcatgg
2281 aacctgtgaa gagaacagaa gctccaggat attatgaagt tataaggttc cccatggatc
2341 tgaaaaccat gagtgaacgc ctcaagaata ggtactacgt gtctaagaaa ttattcatgg
2401 cagacttaca gcgagtcttt accaattgca aagagtacaa cccccctgag agtgaatact
2461 acaaatgtgc caatatcctg gagaaattct tcttcagtaa aattaaggaa gctggattaa
2521 ttgacaagtg attttttttc ccctctgctt cttagaaact caccaagcag tgtgcctaaa
2581 gcaaggtggt ttagtttttt acaaagaatt ggacatgatg tattgaagag acttgtaaat
2641 gtaataatta gcacttttga aaaaacaaaa aacctccttt tagcttttca gatatgtatt
2701 taaattgaag tcataggaca tttttatttt atggaataga ttttaatcta tttactacta
2761 ttaaggtaaa ttttctatgg catgtccatt agctatttca tgatagatga ttaggggttt
2821 cctcaaaacc tgtgtgtgag gaaattgcac acagtagcaa aatttgggga aatccataac
2881 attttcagac catgaatgaa tgtttccatt tttttctaat ggaatgtgag agtttacttt
2941 tattttattc tgaaggactt taaggaaggg atacatgatt ttaaaaaagc ctgtaagagg
3001 tgaaatatgt gatgtttgaa gtctctttat agacttttta tatatatttt ttaaaacact
3061 catctagatg aggtgctttg agcagttctg aaaaatgcag ttccaggaaa gcaactgctt
3121 tggttcctaa ggaagaaatt ctaaataatg caaactttta aaataagcat ctaggttttt
3181 gataattctg tctacttaca acaaacttgt tagtacataa ccactatttt aataattatt
3241 ttctctacac aaatgtgtaa tatcatattt gactttgctt atgcaggcca taagttccaa
3301 aagataattt ccctgcccac aaaggcataa acttgaaaac acatgagatt gaatcaacat
3361 gctttaatag gaaaagatgt atggtctata tatgtatcaa tctggtgaat cctcgttcta
3421 ataaaggttc tttttctttt ctatgataca cacagccacg ctgataatat gcaaatgaac
3481 attttccttt atgtctctcc agataatgtt tattgtctga ggtaaattaa attcccacca
3541 gggtttgctg tcagtatttt aacacccaca ttagtatatg cgtccagggt cataaccccc
3601 taaaatccat catgcaacct tattaatctg tcttgggatt ccagtttagt gcttggattt
3661 atttcctgat tacactacat agaaaagtga gacatctgcc attcccaact ctgggaaaac
3721 caactaatat acaaccatat aaatgaaggc catcttgatg gtctcaacac taatttttat
3781 gatgcaaatt tatacactga tttttgtaaa ggacaaagtt ttaaaagcgt atttaacttg
3841 atgttttcta tcagcataaa taaaatggtc atgaatagtc attaaaaaca gttgccagtg
3901 ataatctgca tgaaggaaaa agaaccctgc aaatggctat tgagttggaa gtattgtttt
3961 tgatatgtaa gagatattca gaatgctcac actgaaaatg cctcaacttt ttaaagtgta
4021 agaaaccacc atgagtggtg tctagatttc taatgaagaa tcatgataca gtttggatta
4081 agtatcttgg actggtttta aacagtgctt tgtaccggat ctgctgaagc atctgtccag
4141 ctggtatcct gtgaaagttt gttattttct gagtagacat tcttatagag tattgtcttt
4201 aaaatcagat tgtctcttct atattgaaag catttttatg ttttctaatt taaaaattaa
4261 tattttctta tagatattgt gcaataaagc tgaagtagaa tgtgtggttt ttgcaaatgc
4321 tttaacagct gataaaaatt ttacatttgt aaaattaata tattgtactg gtacaaaata
4381 gttttaaatt atattttaaa aagcttccaa
//