LOCUS NM_152750 6448 bp mRNA linear PRI 05-APR-2024
DEFINITION Homo sapiens cadherin related family member 3 (CDHR3), transcript
variant 1, mRNA.
ACCESSION NM_152750 XR_108861 XR_110727 XR_114075
VERSION NM_152750.5
KEYWORDS RefSeq; MANE Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6448)
AUTHORS Eliasen,A.U., Pedersen,C.E.T., Rasmussen,M.A., Wang,N.,
Soverini,M., Fritz,A., Stokholm,J., Chawes,B.L., Morin,A.,
Bork-Jensen,J., Grarup,N., Pedersen,O., Hansen,T., Linneberg,A.,
Mortensen,P.B., Hougaard,D.M., Bybjerg-Grauholm,J.,
Baekvad-Hansen,M., Mors,O., Nordentoft,M., Borglum,A.D., Werge,T.,
Agerbo,E., Soderhall,C., Altman,M.C., Thysen,A.H., McKennan,C.G.,
Brix,S., Gern,J.E., Ober,C., Ahluwalia,T.S., Bisgaard,H.,
Pedersen,A.G. and Bonnelykke,K.
TITLE Genome-wide study of early and severe childhood asthma identifies
interaction between CDHR3 and GSDMB
JOURNAL J Allergy Clin Immunol 150 (3), 622-630 (2022)
PUBMED 35381269
REMARK GeneRIF: Genome-wide study of early and severe childhood asthma
identifies interaction between CDHR3 and GSDMB.
REFERENCE 2 (bases 1 to 6448)
AUTHORS Hirsch,S.D., Elling,C.L., Bootpetch,T.C., Scholes,M.A., Hafren,L.,
Streubel,S.O., Pine,H.S., Wine,T.M., Szeremeta,W., Prager,J.D.,
Einarsdottir,E., Yousaf,A., Baschal,E.E., Rehman,S., Bamshad,M.J.,
Nickerson,D.A., Riazuddin,S., Leal,S.M., Ahmed,Z.M., Yoon,P.J.,
Kere,J., Chan,K.H., Mattila,P.S., Friedman,N.R., Chonmaitree,T.,
Frank,D.N., Ryan,A.F. and Santos-Cortez,R.L.P.
TITLE The role of CDHR3 in susceptibility to otitis media
JOURNAL J Mol Med (Berl) 99 (11), 1571-1583 (2021)
PUBMED 34322716
REMARK GeneRIF: The role of CDHR3 in susceptibility to otitis media.
REFERENCE 3 (bases 1 to 6448)
AUTHORS Zhang,M., Chen,G., Wang,Y., Wu,S.Q., Sandford,A.J. and He,J.Q.
TITLE Polymorphisms in the airway epithelium related genes CDHR3 and EMSY
are associated with asthma susceptibility
JOURNAL BMC Pulm Med 20 (1), 305 (2020)
PUBMED 33213402
REMARK GeneRIF: Polymorphisms in the airway epithelium related genes CDHR3
and EMSY are associated with asthma susceptibility.
Publication Status: Online-Only
REFERENCE 4 (bases 1 to 6448)
AUTHORS Shigemasa,R., Masuko,H., Hyodo,K., Kitazawa,H., Kanazawa,J.,
Yatagai,Y., Iijima,H., Naito,T., Saito,T., Hirota,T., Tamari,M.,
Sakamoto,T. and Hizawa,N.
TITLE Genetic impact of CDHR3 on the adult onset of asthma and COPD
JOURNAL Clin Exp Allergy 50 (11), 1223-1229 (2020)
PUBMED 32615023
REMARK GeneRIF: Genetic impact of CDHR3 on the adult onset of asthma and
COPD.
REFERENCE 5 (bases 1 to 6448)
AUTHORS Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
TITLE Interactome Mapping Provides a Network of Neurodegenerative Disease
Proteins and Uncovers Widespread Protein Aggregation in Affected
Brains
JOURNAL Cell Rep 32 (7), 108050 (2020)
PUBMED 32814053
REFERENCE 6 (bases 1 to 6448)
AUTHORS Jamieson,K.C., Warner,S.M., Leigh,R. and Proud,D.
TITLE Rhinovirus in the Pathogenesis and Clinical Course of Asthma
JOURNAL Chest 148 (6), 1508-1516 (2015)
PUBMED 26270739
REMARK GeneRIF: CDHR3 is a susceptibility locus for early childhood Asthma
with severe exacerbations.
Review article
REFERENCE 7 (bases 1 to 6448)
AUTHORS Bochkov,Y.A., Watters,K., Ashraf,S., Griggs,T.F., Devries,M.K.,
Jackson,D.J., Palmenberg,A.C. and Gern,J.E.
TITLE Cadherin-related family member 3, a childhood asthma susceptibility
gene product, mediates rhinovirus C binding and replication
JOURNAL Proc Natl Acad Sci U S A 112 (17), 5485-5490 (2015)
PUBMED 25848009
REMARK GeneRIF: the asthma susceptibility gene product CDHR3 mediates RV-C
entry into host cells, and suggest that rs6967330 mutation could be
a risk factor for RV-C wheezing illnesses.
REFERENCE 8 (bases 1 to 6448)
AUTHORS Bonnelykke,K., Sleiman,P., Nielsen,K., Kreiner-Moller,E.,
Mercader,J.M., Belgrave,D., den Dekker,H.T., Husby,A.,
Sevelsted,A., Faura-Tellez,G., Mortensen,L.J., Paternoster,L.,
Flaaten,R., Molgaard,A., Smart,D.E., Thomsen,P.F., Rasmussen,M.A.,
Bonas-Guarch,S., Holst,C., Nohr,E.A., Yadav,R., March,M.E.,
Blicher,T., Lackie,P.M., Jaddoe,V.W., Simpson,A., Holloway,J.W.,
Duijts,L., Custovic,A., Davies,D.E., Torrents,D., Gupta,R.,
Hollegaard,M.V., Hougaard,D.M., Hakonarson,H. and Bisgaard,H.
TITLE A genome-wide association study identifies CDHR3 as a
susceptibility locus for early childhood asthma with severe
exacerbations
JOURNAL Nat Genet 46 (1), 51-55 (2014)
PUBMED 24241537
REMARK GeneRIF: the role of CDHR3 variants in the development of asthma
with severe exacerbations based on genome-wide association study in
Denmark
REFERENCE 9 (bases 1 to 6448)
AUTHORS Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
Gibbs,R.A. and Butte,N.F.
TITLE Novel genetic loci identified for the pathophysiology of childhood
obesity in the Hispanic population
JOURNAL PLoS One 7 (12), e51954 (2012)
PUBMED 23251661
REFERENCE 10 (bases 1 to 6448)
AUTHORS Cha,P.C., Mushiroda,T., Takahashi,A., Kubo,M., Minami,S.,
Kamatani,N. and Nakamura,Y.
TITLE Genome-wide association study identifies genetic determinants of
warfarin responsiveness for Japanese
JOURNAL Hum Mol Genet 19 (23), 4735-4744 (2010)
PUBMED 20833655
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AK126338.1, BC111738.1 and AC004836.2.
On Nov 23, 2018 this sequence version replaced NM_152750.4.
Transcript Variant: This variant (1) represents the longer
transcript and encodes the longer isoform (1).
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK126338.1, SRR1660809.206702.1
[ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA2144333, SAMEA2145240
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000317716.14/ ENSP00000325954.9
RefSeq Select criteria :: based on conservation, expression,
longest protein
##RefSeq-Attributes-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-1943 AK126338.1 25-1967
1944-1953 BC111738.1 1936-1945
1954-3437 AK126338.1 1978-3461
3438-6447 AC004836.2 62309-65318
6448-6448 AC004836.2 65319-65319
FEATURES Location/Qualifiers
source 1..6448
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="7"
/map="7q22.3"
gene 1..6448
/gene="CDHR3"
/gene_synonym="CDH28"
/note="cadherin related family member 3"
/db_xref="GeneID:222256"
/db_xref="HGNC:HGNC:26308"
/db_xref="MIM:615610"
exon 1..101
/gene="CDHR3"
/gene_synonym="CDH28"
/inference="alignment:Splign:2.1.0"
misc_feature 44..46
/gene="CDHR3"
/gene_synonym="CDH28"
/note="upstream in-frame stop codon"
CDS 56..2713
/gene="CDHR3"
/gene_synonym="CDH28"
/note="isoform 1 precursor is encoded by transcript
variant 1; cadherin-like protein 28"
/codon_start=1
/product="cadherin-related family member 3 isoform 1
precursor"
/protein_id="NP_689963.2"
/db_xref="CCDS:CCDS47684.1"
/db_xref="GeneID:222256"
/db_xref="HGNC:HGNC:26308"
/db_xref="MIM:615610"
/translation="MQEAIILLALLGAMSGGEALHLILLPATGNVAENSPPGTSVHKF
SVKLSASLSPVIPGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFD
LQIYVKDEVGVTDLQVLTVQVTDVNEPPQFQGNLAEGLHLYIVERANPGFIYQVEAFD
PEDTSRNIPLSYFLISPPKSFRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKA
STELQVNIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSI
TTVSKYFMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRPYGGQENRIQITFI
VEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVG
SGSRFLQDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYIL
TSPENEFPLIFDRPSYVFDVSERRPARTRVGQVRATDKDLPQSSLLYSISTGGASLQY
PNVFWINPKTGELQLVTKVDCETTPIYILRIQATNNEDTSSVTVTVNILEENDEKPIC
TPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPRSFRYSIGPGNVNNHFTFSPNAGSN
VTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSDRKKAEALVETGTVTLSIKVIPH
PTTIITTTPRPRVTYQVLRKNVYSPSAWYVPFVITLGSILLLGLLVYLVVLLAKAIHR
HCPCKTGKNKEPLTKKGETKTAERDVVVETIQMNTIFDGEAIDPVTGETYEFNSKTGA
RKWKDPLTQMPKWKESSHQGAAPRRVTAGEGMGSLRSANWEEDELSGKAWAEDAGLGS
RNEGGKLGNPKNRNPAFMNRAYPKPHPGK"
sig_peptide 56..112
/gene="CDHR3"
/gene_synonym="CDH28"
/inference="COORDINATES: ab initio prediction:SignalP:6.0"
mat_peptide 113..2710
/gene="CDHR3"
/gene_synonym="CDH28"
/product="Cadherin-related family member 3.
/id=PRO_0000305903"
/note="propagated from UniProtKB/Swiss-Prot (Q6ZTQ4.1)"
misc_feature 611..613
/gene="CDHR3"
/gene_synonym="CDH28"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q6ZTQ4.1); glycosylation site"
misc_feature 824..826
/gene="CDHR3"
/gene_synonym="CDH28"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q6ZTQ4.1); glycosylation site"
misc_feature 1925..1927
/gene="CDHR3"
/gene_synonym="CDH28"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q6ZTQ4.1); glycosylation site"
misc_feature 2195..2257
/gene="CDHR3"
/gene_synonym="CDH28"
/note="propagated from UniProtKB/Swiss-Prot (Q6ZTQ4.1);
transmembrane region"
misc_feature 2477..2710
/gene="CDHR3"
/gene_synonym="CDH28"
/note="propagated from UniProtKB/Swiss-Prot (Q6ZTQ4.1);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
exon 102..304
/gene="CDHR3"
/gene_synonym="CDH28"
/inference="alignment:Splign:2.1.0"
exon 305..470
/gene="CDHR3"
/gene_synonym="CDH28"
/inference="alignment:Splign:2.1.0"
exon 471..568
/gene="CDHR3"
/gene_synonym="CDH28"
/inference="alignment:Splign:2.1.0"
exon 569..663
/gene="CDHR3"
/gene_synonym="CDH28"
/inference="alignment:Splign:2.1.0"
exon 664..768
/gene="CDHR3"
/gene_synonym="CDH28"
/inference="alignment:Splign:2.1.0"
exon 769..917
/gene="CDHR3"
/gene_synonym="CDH28"
/inference="alignment:Splign:2.1.0"
exon 918..1107
/gene="CDHR3"
/gene_synonym="CDH28"
/inference="alignment:Splign:2.1.0"
exon 1108..1279
/gene="CDHR3"
/gene_synonym="CDH28"
/inference="alignment:Splign:2.1.0"
exon 1280..1382
/gene="CDHR3"
/gene_synonym="CDH28"
/inference="alignment:Splign:2.1.0"
exon 1383..1481
/gene="CDHR3"
/gene_synonym="CDH28"
/inference="alignment:Splign:2.1.0"
exon 1482..1708
/gene="CDHR3"
/gene_synonym="CDH28"
/inference="alignment:Splign:2.1.0"
exon 1709..1880
/gene="CDHR3"
/gene_synonym="CDH28"
/inference="alignment:Splign:2.1.0"
exon 1881..2131
/gene="CDHR3"
/gene_synonym="CDH28"
/inference="alignment:Splign:2.1.0"
exon 2132..2313
/gene="CDHR3"
/gene_synonym="CDH28"
/inference="alignment:Splign:2.1.0"
exon 2314..2327
/gene="CDHR3"
/gene_synonym="CDH28"
/inference="alignment:Splign:2.1.0"
exon 2328..2359
/gene="CDHR3"
/gene_synonym="CDH28"
/inference="alignment:Splign:2.1.0"
exon 2360..2408
/gene="CDHR3"
/gene_synonym="CDH28"
/inference="alignment:Splign:2.1.0"
exon 2409..6448
/gene="CDHR3"
/gene_synonym="CDH28"
/inference="alignment:Splign:2.1.0"
regulatory 3065..3070
/regulatory_class="polyA_signal_sequence"
/gene="CDHR3"
/gene_synonym="CDH28"
/note="hexamer: CATAAA"
polyA_site 3088
/gene="CDHR3"
/gene_synonym="CDH28"
regulatory 3767..3772
/regulatory_class="polyA_signal_sequence"
/gene="CDHR3"
/gene_synonym="CDH28"
/note="hexamer: AATAAA"
polyA_site 3793
/gene="CDHR3"
/gene_synonym="CDH28"
/note="major polyA site"
regulatory 6425..6430
/regulatory_class="polyA_signal_sequence"
/gene="CDHR3"
/gene_synonym="CDH28"
/note="hexamer: AATAAA"
polyA_site 6448
/gene="CDHR3"
/gene_synonym="CDH28"
ORIGIN
1 gggattcagg ctgtggctaa tgtgctggaa gcacgcacag ttgtgaccat caagtatgca
61 ggaagcaatc attctcctgg ctctcctggg tgccatgtca gggggagaag cactacacct
121 aatcctctta cctgctacag gcaatgtggc agagaattct ccacctggga cttcagtgca
181 caagttttct gtgaagttat cagcatcatt gtcacctgtg atcccaggat ttccccagat
241 agtcaactca aatcccctca ctgaagcttt tagggtgaat tggctgtcag gcacctactt
301 tgaggttgtc accactggga tggaacaact agattttgaa acaggaccaa acatatttga
361 tttgcagatt tatgtgaagg atgaggttgg tgtcacagac ctgcaagtcc tgactgtcca
421 ggtaacagat gtgaacgagc cacctcagtt tcaaggcaac ttggcagaag gtctacacct
481 ctacatagta gaaagagcaa accctggatt catttaccag gttgaggcct tcgatccaga
541 agacacaagc cgaaacattc ccctcagtta tttcctgatt tctcccccaa agagcttcag
601 aatgtctgct aatggcaccc tcttctccac aacagaattg gactttgaag caggacacag
661 aagtttccat ctcatcgtgg aggtgaggga cagtggaggc ctcaaagcct ccacagagct
721 ccaggtgaac atcgtgaacc tcaacgacga agtccctcgc tttaccagcc cgacacgagt
781 gtacacagtc ctggaggaac tgagtccagg aaccatcgtg gccaatatca cagcggagga
841 tcctgatgat gaaggttttc ccagccacct cctctacagc attaccactg ttagcaaata
901 tttcatgata aatcagttga ctggtacaat ccaagtggcc caaaggatag accgagatgc
961 aggtgaattg agacaaaatc ccaccatttc cctggaagtt ctagtgaagg acagaccata
1021 tgggggtcag gagaatcgca tccagataac cttcattgtg gaagacgtca acgacaatcc
1081 tgccacatgc caaaagttca ccttcagcat tatggtgccg gaaagaacag ccaaggggac
1141 gttgcttctt gacctaaaca agttctgctt tgatgatgac agtgaggcac caaacaacag
1201 attcaacttc accatgccat ctggagtggg gagcggcagc agatttttac aggatccagc
1261 tggctctggg aagattgtgc tgattggtga tctagactac gaaaatccaa gtaacctagc
1321 agccggcaat aaatatacgg tgataatcca ggtgcaggat gtggcccccc cttactataa
1381 aaataacgtc tacgtttata tcctaacaag cccagaaaat gagtttcctc tcatttttga
1441 taggccatcc tatgtatttg atgtgtcaga aagaaggccc gccagaaccc gagtgggaca
1501 ggtgcgagcc actgataaag acctccccca gagcagcctc ctgtactcca tctccactgg
1561 aggggccagc ctccagtatc caaatgtatt ttggattaat cccaagacag gagaactcca
1621 gctggtaact aaagtggact gtgaaacaac ccccatctat attctcagaa tccaggccac
1681 caacaacgaa gacacaagct ctgtcactgt tactgtgaac atccttgaag aaaatgatga
1741 aaagccaatt tgtactccaa actcttattt cctggccctc ccagtggatc tgaaagttgg
1801 cacaaatatt cagaatttca agctgacatg taccgacctt gattccagcc ccagatcttt
1861 ccgttattcc attggcccag gtaacgtcaa caatcatttc accttctctc ccaatgctgg
1921 ttccaatgtc acacgcctgc tgcttacatc tcgctttgac tatgctggtg ggtttgataa
1981 gatctgggac tacaagctac ttgtctacgt aactgatgac aacttgatgt ctgacaggaa
2041 gaaagcggag gctcttgttg agacaggaac agtgacactg agtattaaag tcattcccca
2101 cccaaccact atcatcacca cgacccccag gcccagggtc acctatcagg tcctgaggaa
2161 aaacgtttac tctccatctg catggtacgt gccgtttgtc atcactttgg gctccatatt
2221 gcttctgggt ctcctcgtgt acctggtcgt cctattggcc aaagccatcc acagacactg
2281 cccctgcaag actgggaaga acaaggaacc tctgacaaag aaaggagaaa cgaagactgc
2341 agagagagac gtcgtggtgg aaactatcca gatgaacact atctttgatg gagaagccat
2401 agatccagtg accggggaaa catatgaatt caactcaaaa actggagcca gaaagtggaa
2461 agatccacta acccaaatgc caaaatggaa agagtccagc caccagggag ctgccccacg
2521 cagagtcact gctggggaag ggatggggtc actgagaagt gccaactggg aagaagatga
2581 gctgagtggc aaagcgtggg ctgaggatgc tggtctgggt tccagaaatg agggtggcaa
2641 gctgggcaac ccaaagaaca gaaatccagc cttcatgaac agggcttacc ccaaaccaca
2701 cccaggaaag taaacggggt ctaaggaggg gcctgtcaat cactgagatg ctgcctcacc
2761 ctaaattcta tggggatggt gtgggcatgg tgtagggggg aaaatgtggg ctgaggggat
2821 tcagacatcc agggtcaaac atgggatgtt tgacaaattt ttaaacaaat agaaaggggt
2881 ttgatcacat agttgcgtgt tctgaaatga tacaggaaca ttttctatca gatttcagaa
2941 ctacctgtgc ttctgataag caagactgtt aactttgggg tgtggaattg ttgtgtttct
3001 tctttgcatt gactgctagg aagctctatt ctgttcacca tagaaagttt gtaggaattc
3061 ctgacataaa tagtgaagac tatccttaca tctggtttcc accttatttt cctgccctcg
3121 ttttaacatc acccagattt cttcagttat aaatatgcca tacacctttg taagtcacct
3181 caaatcttct tcaaaagaag cagaacagtg aaaaaaacag atgagtaagt taagagttgg
3241 tcatctggaa agaagaaaac tcagtaggca ccttcttttg ttttttcttg tggtgtccgg
3301 atcagcatcc tgcatgtgag attcatccac gttgtcctgt ctagcagtag ttcagttctc
3361 ttcatggtta tgtctggttt cattctatga ttatatcaca atttatctat tctacacttg
3421 ggtggcagct gcttcagatt ttttactttt aaaaaatata cttaaaagtg aactacaggc
3481 agggcatgat ggctcatgcc tgtaatgcca gcactttgcc aaggtgggca gatcacctaa
3541 ggtcaggagt tcaagatcag cctggcctag atggcaaaac cctgtctcta ctaaaaaata
3601 caaaaattag cttggtgtgg tggtgggcac atgtaatccc agctacttgg gaggctgagg
3661 tagggagaac tgcttaaacc tgagaggtgg aggttacagt gagttgagat tgtgccactg
3721 cactctagcc tgggtgacaa agcaagactc catctcagaa aaaaaaaata aaagtgaatt
3781 acaacactat gaactttctt gtacatgtct tttggtgaac ataaacactc acttttttgc
3841 tcatatatct aagagtggga ttgctggagc aattgctgga tctgccaaag agttccaaag
3901 tggtggctct gattcacatt ccagcagcaa acactgagag ttgcaattgc tctctatcct
3961 tgccaacact tgggattgtc aatcctttta actttagcca ttctggttaa aattactatt
4021 gaagtgaaat cactttttcc tcaaagctga aacaccatca gccttacaac ctacctgcct
4081 tgctccttcc cacttcctat gattggaagg aactgcagga ctctgagtgg ggacatactg
4141 gaagccccat ctagacataa aactcagact tccacctgta ggcatgagca atgaactggg
4201 aataaatggt attatgatgg aataggaaat gtaactttcc aatgtgtgcc tagcagagcc
4261 tgagcaagct tcactcgagc tctatgccct gctgcccagc tgctgcgacc ctagtccagt
4321 aaccctaaga aaggtccagg tgagtgttca ttagggaagc actcccttcc caactgggga
4381 gtcaggtgag agcctaccag gtccacaagg tcctgtggga gacagactgg atccagcaaa
4441 tgtagagctt cagagagagc agcagcttgt ttactgtgtg cctagtgcca gtgtcacttc
4501 tcaagcaaaa gaagcatttg caaaatgcct gtcctggcct agattgagcg tgatttatta
4561 ataagggttg gttgccaggg aactcccttg aatggattta aactttgcaa aagaaggcag
4621 aactgttcat ttatgcaggt taaagtgagt gaagtggctg attgcccatt taaggcattg
4681 caaatctgtg gggcccggag tcaaatgctt tccttggaag ctctcagctt caatgcaagt
4741 aaaatgaggt tctgagaagg ctgaaggggg acttaataac tgcttataag cccattaaga
4801 atgattaaaa gggccgggtg aggtggctca tgcctgtaat cccagcactc tgggaggctg
4861 aggcaggtgg atcacctgag gtcaggagtt tgagaccagc ctggccaaca tggtgaaacc
4921 ctgtctctac taaaaaatag aaaaattagc tggacgtgtt agcaggcacc tgtaatccca
4981 gctactcagg aggctgaggc aagagaatcg cttgaaccca ggaggcagaa gttgcagtgg
5041 gctgagattg cgccactgca ctccagcctg ggtgacaagg gcaaaactct gtgtcaagaa
5101 aaaaaaaaaa aaaagaataa ttaaaaggag agagtggtga gcagctggtc tttcttctcc
5161 agtgatgaca gggcaagagg gaattgtgct taatggccag agaagagatt taagtcaggc
5221 accaagaggg acttcctgaa gcctggggcc tctctgaaga gctcagtgtc ttctctggtg
5281 ataggcagga agagctgagt gtcttcctag tcgcaaggca agcctcgaga aactcaagaa
5341 ataggggcaa gagtgcgcca ggaggagaga acacctgctg ccccgtttct tttgtatatc
5401 cggctatttg gttcggggaa atccagaagt caaagtgtca ccggtggagg gtcttgactg
5461 caagttgtcc aagttcttgg agttttgaac aaagaatgga acaaaatgcc cagcaaagca
5521 gagaaagaat gaggcaacga aagaatgaaa gcagggattt attgaaaacc aaagtacact
5581 ccacagtgtg ggaacgggcc tgagcaagtg actcaagggc ccagatacag tcttctcagt
5641 ccaaataccc cttggaggtt tccccttggc cacttcatgc tcacctcatg gaaatgaagt
5701 agtggaccac aattggtctg attggttgca ggaagcaacc aatcagagac tgaagtggag
5761 ttacaaaggt cacgctcctg tgcaaacatc tgattggttg caaaaagcaa ccaatcagag
5821 gctaaggtga agttacaacg ttgcaacgaa gactcggctg gcaatcagtc tgattggtta
5881 cagacagcca atttcccagc gttgaccagg ttttgggggg aacaaaatta tctgaataaa
5941 atgaagacag caaccgtcgt ggatttggtg aaagttttct cccatctccc tctcaaggcc
6001 ttaaacaggt atgagttgat tatagccaat gtttactttt ctcattctga ttcattataa
6061 aactggggta aatacgttca ggaattagac cacgtaacaa ttataattgt cgaagacttt
6121 gaaactgcat agtagattgt gacattggag ctttttgttg tgctcattag aaagcagggt
6181 ctgaaactca gcctgtgtag caagcacggg tggctcacaa gcagaactgg gaaatgacac
6241 ttctgctccc cagagccccc tttcacatct ggggttctca ttgtttgcct ttttacttaa
6301 tgtattttgt aatggctgtg aaaattaagc tacaaaatga gtgaacattg aagacaatga
6361 ttgctattga aacttaggat ttctcatttc aaacttagcg tgtgtttatc cttcgtattc
6421 attcaataaa tatctgtgga gcaactac
//