LOCUS NM_001137554 9599 bp mRNA linear PRI 12-DEC-2024
DEFINITION Homo sapiens MCTS1 re-initiation and release factor (MCTS1),
transcript variant 2, mRNA.
ACCESSION NM_001137554
VERSION NM_001137554.2
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 9599)
AUTHORS Bohlen,J., Zhou,Q., Philippot,Q., Ogishi,M., Rinchai,D.,
Nieminen,T., Seyedpour,S., Parvaneh,N., Rezaei,N., Yazdanpanah,N.,
Momenilandi,M., Conil,C., Neehus,A.L., Schmidt,C.,
Arango-Franco,C.A., Voyer,T.L., Khan,T., Yang,R., Puchan,J.,
Erazo,L., Roiuk,M., Vatovec,T., Janda,Z., Bagaric,I., Materna,M.,
Gervais,A., Li,H., Rosain,J., Peel,J.N., Seeleuthner,Y., Han,J.E.,
L'Honneur,A.S., Moncada-Velez,M., Martin-Fernandez,M., Horesh,M.E.,
Kochetkov,T., Schmidt,M., AlShehri,M.A., Salo,E., Saxen,H.,
ElGhazali,G., Yatim,A., Soudee,C., Sallusto,F., Ensser,A., Marr,N.,
Zhang,P., Bogunovic,D., Cobat,A., Shahrooei,M., Beziat,V., Abel,L.,
Wang,X., Boisson-Dupuis,S., Teleman,A.A., Bustamante,J., Zhang,Q.
and Casanova,J.L.
TITLE Human MCTS1-dependent translation of JAK2 is essential for
IFN-gamma immunity to mycobacteria
JOURNAL Cell 186 (23), 5114-5134 (2023)
PUBMED 37875108
REMARK GeneRIF: Human MCTS1-dependent translation of JAK2 is essential for
IFN-gamma immunity to mycobacteria.
REFERENCE 2 (bases 1 to 9599)
AUTHORS Ma,B., Wei,X., Zhou,S. and Yang,M.
TITLE MCTS1 enhances the proliferation of laryngeal squamous cell
carcinoma via promoting OTUD6B-1 mediated LIN28B deubiquitination
JOURNAL Biochem Biophys Res Commun 678, 128-134 (2023)
PUBMED 37634410
REMARK GeneRIF: MCTS1 enhances the proliferation of laryngeal squamous
cell carcinoma via promoting OTUD6B-1 mediated LIN28B
deubiquitination.
REFERENCE 3 (bases 1 to 9599)
AUTHORS Yang,M., Ma,B. and Liu,X.
TITLE MCTS1 promotes laryngeal squamous cell carcinoma cell growth via
enhancing LARP7 stability
JOURNAL Clin Exp Pharmacol Physiol 49 (6), 652-660 (2022)
PUBMED 35274760
REMARK GeneRIF: MCTS1 promotes laryngeal squamous cell carcinoma cell
growth via enhancing LARP7 stability.
REFERENCE 4 (bases 1 to 9599)
AUTHORS de Carvalho,P.A., Bonatelli,M., Cordeiro,M.D., Coelho,R.F.,
Reis,S., Srougi,M., Nahas,W.C., Pinheiro,C. and Leite,K.R.M.
TITLE MCT1 expression is independently related to shorter cancer-specific
survival in clear cell renal cell carcinoma
JOURNAL Carcinogenesis 42 (12), 1420-1427 (2021)
PUBMED 34668521
REMARK GeneRIF: MCT1 expression is independently related to shorter
cancer-specific survival in clear cell renal cell carcinoma.
REFERENCE 5 (bases 1 to 9599)
AUTHORS Zhu,J., Wang,X., Shao,Z., Sun,W. and Wu,T.
TITLE Prognostic value of malignant T cell-amplified sequence 1 in head
and neck squamous cell carcinoma
JOURNAL Biomark Med 15 (17), 1623-1639 (2021)
PUBMED 34704820
REMARK GeneRIF: Prognostic value of malignant T cell-amplified sequence 1
in head and neck squamous cell carcinoma.
REFERENCE 6 (bases 1 to 9599)
AUTHORS Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
Birchmeier,W., Lehrach,H. and Wanker,E.E.
TITLE A human protein-protein interaction network: a resource for
annotating the proteome
JOURNAL Cell 122 (6), 957-968 (2005)
PUBMED 16169070
REFERENCE 7 (bases 1 to 9599)
AUTHORS Shi,B., Levenson,V. and Gartenhaus,R.B.
TITLE Identification and characterization of a novel enhancer for the
human MCT-1 oncogene promoter
JOURNAL J Cell Biochem 90 (1), 68-79 (2003)
PUBMED 12938157
REMARK GeneRIF: demonstrated the presence of sequence-specific DNA-binding
protein in nuclear extracts designated as LMBF; the 26-mer
oligonucleotide containing the LMBF binding site is required for
maximum transcriptional activity of the MCT-1 promoter
REFERENCE 8 (bases 1 to 9599)
AUTHORS Shi,B., Hsu,H.L., Evens,A.M., Gordon,L.I. and Gartenhaus,R.B.
TITLE Expression of the candidate MCT-1 oncogene in B- and T-cell
lymphoid malignancies
JOURNAL Blood 102 (1), 297-302 (2003)
PUBMED 12637315
REMARK GeneRIF: tumor cell lines overexpressing MCT-1 exhibited increased
growth rates and displayed increased protection against apoptosis
induced by serum starvation
REFERENCE 9 (bases 1 to 9599)
AUTHORS Herbert,G.B., Shi,B. and Gartenhaus,R.B.
TITLE Expression and stabilization of the MCT-1 protein by DNA damaging
agents
JOURNAL Oncogene 20 (46), 6777-6783 (2001)
PUBMED 11709712
REFERENCE 10 (bases 1 to 9599)
AUTHORS Prosniak,M., Dierov,J., Okami,K., Tilton,B., Jameson,B.,
Sawaya,B.E. and Gartenhaus,R.B.
TITLE A novel candidate oncogene, MCT-1, is involved in cell cycle
progression
JOURNAL Cancer Res 58 (19), 4233-4237 (1998)
PUBMED 9766643
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AA375691.1, AW957695.1, AK294834.1, AC011890.4 and BM671542.1.
On May 31, 2019 this sequence version replaced NM_001137554.1.
Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
portion of the 5' coding region, and initiates translation at an
alternate start codon, compared to variant 1. The encoded isoform
(2) is longer and has a distinct N-terminus, compared to isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR1803615.134015.1,
SRR1803616.76982.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA1965299, SAMEA1966682
[ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-13 AA375691.1 3-15
14-30 AW957695.1 15-31
31-1188 AK294834.1 1-1158
1189-9150 AC011890.4 12917-20878
9151-9599 BM671542.1 17-465 c
FEATURES Location/Qualifiers
source 1..9599
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xq24"
gene 1..9599
/gene="MCTS1"
/gene_synonym="IMD118; MCT-1; MCT1"
/note="MCTS1 re-initiation and release factor"
/db_xref="GeneID:28985"
/db_xref="HGNC:HGNC:23357"
/db_xref="MIM:300587"
exon 1..169
/gene="MCTS1"
/gene_synonym="IMD118; MCT-1; MCT1"
/inference="alignment:Splign:2.1.0"
misc_feature 75..77
/gene="MCTS1"
/gene_synonym="IMD118; MCT-1; MCT1"
/note="upstream in-frame stop codon"
CDS 156..704
/gene="MCTS1"
/gene_synonym="IMD118; MCT-1; MCT1"
/note="isoform 2 is encoded by transcript variant 2;
multiple copies T-cell malignancies; malignant T-cell
amplified sequence 1; multiple copies in T-cell
lymphoma-1"
/codon_start=1
/product="malignant T-cell-amplified sequence 1 isoform 2"
/protein_id="NP_001131026.1"
/db_xref="CCDS:CCDS48160.1"
/db_xref="GeneID:28985"
/db_xref="HGNC:HGNC:23357"
/db_xref="MIM:300587"
/translation="MGKGRFDEKENVSNCIQLKTSVIKGIKNQLIEQFPGIEPWLNQI
MPKKDPVKIVRCHEHIEILTVNGELLFFRQREGPFYPTLRLLHKYPFILPHQQVDKGA
IKFVLSGANIMCPGLTSPGAKLYPAAVDTIVAIMAEGKQHALCVGVMKMSAEDIEKVN
KGIGIENIHYLNDGLWHMKTYK"
exon 170..322
/gene="MCTS1"
/gene_synonym="IMD118; MCT-1; MCT1"
/inference="alignment:Splign:2.1.0"
exon 323..420
/gene="MCTS1"
/gene_synonym="IMD118; MCT-1; MCT1"
/inference="alignment:Splign:2.1.0"
exon 421..554
/gene="MCTS1"
/gene_synonym="IMD118; MCT-1; MCT1"
/inference="alignment:Splign:2.1.0"
exon 555..622
/gene="MCTS1"
/gene_synonym="IMD118; MCT-1; MCT1"
/inference="alignment:Splign:2.1.0"
exon 623..9599
/gene="MCTS1"
/gene_synonym="IMD118; MCT-1; MCT1"
/inference="alignment:Splign:2.1.0"
regulatory 805..810
/regulatory_class="polyA_signal_sequence"
/gene="MCTS1"
/gene_synonym="IMD118; MCT-1; MCT1"
/note="hexamer: AATAAA"
polyA_site 827
/gene="MCTS1"
/gene_synonym="IMD118; MCT-1; MCT1"
/note="major polyA site"
regulatory 9576..9581
/regulatory_class="polyA_signal_sequence"
/gene="MCTS1"
/gene_synonym="IMD118; MCT-1; MCT1"
/note="hexamer: AATAAA"
regulatory 9581..9586
/regulatory_class="polyA_signal_sequence"
/gene="MCTS1"
/gene_synonym="IMD118; MCT-1; MCT1"
/note="hexamer: AATATA"
polyA_site 9595
/gene="MCTS1"
/gene_synonym="IMD118; MCT-1; MCT1"
polyA_site 9599
/gene="MCTS1"
/gene_synonym="IMD118; MCT-1; MCT1"
ORIGIN
1 ctgtcatgcc tattgcctag ctgccagatt aaccttgcct tgaaaataac gattgcccca
61 taggctattc agtgtaagga agacaaaaat tccttgggaa cctactagtg ggtttgcctt
121 ccagatttgg tagacgcaaa aagcaaaggg ggaacatggg caaaggaaga tttgatgaaa
181 aagaaaatgt gtccaactgc atccagttga aaacttcagt tattaagggt attaagaatc
241 aattgataga gcaatttcca ggtattgaac catggcttaa tcaaatcatg cctaagaaag
301 atcctgtcaa aatagtccga tgccatgaac atatagaaat ccttacagta aatggagaat
361 tactcttttt tagacaaaga gaagggcctt tttatccaac cctaagatta cttcacaaat
421 atccttttat cctgccacac cagcaggttg ataaaggagc catcaaattt gtactcagtg
481 gagcaaatat catgtgtcca ggcttaactt ctcctggagc taagctttac cctgctgcag
541 tagataccat tgttgctatc atggcagaag gaaaacagca tgctctatgt gttggagtca
601 tgaagatgtc tgcagaagac attgagaaag tcaacaaagg aattggcatt gaaaatatcc
661 attatttaaa tgatgggctg tggcatatga agacatataa atgagcctca gaaggaatgc
721 acttgggcta aatatggata ttgtgctgta tctgtgtttg tgtctgtgtg tgacagcatg
781 aagataatgc ctgtggttat gctgaataaa ttcaccagat gctaaaattc tgttagcttc
841 agaaattatt ttaagttttc ttaaactcaa gttaaaattg ggtagcaaac ttggacatta
901 aaaggtatct ggtaagtaag caaactcata caactaatgt cctttcttag gctaatgata
961 taagagtgaa gagcaggact tggtcaatgg attgccattt tatggtagac ctctagagaa
1021 actgtctagt taaatggggc tagaaactag actaggaatt ttattctatt actccagggg
1081 acccagcagt gctcattctc gtgtgtgtgt gtgtgtgtgt gtgtgtatgt gtgtgtgtgt
1141 gtgtgtgtgt gttttgttga ttgttttttt aaaaaaaact tcaatggaaa attctaaaca
1201 tattaagaag tctggagaat agtataatgg acctctccat atccatcacc cagtttcagt
1261 ttatggtcag tcttatttca tctatacctc aattatttct ccccaccccc caattatttt
1321 gaagcaaatc ccagacatcc tatcatttca tccataacta ctttattctt tttttttttt
1381 ttttgaaaca gggtcttgct ctgttgccca ggctggagtg cagtggtacg atcttggctc
1441 actgtaacct ccacctcccg ggttcaagcg attcttgtgc ctcagcctcc tgagtagctg
1501 ggattacagg cacgtgccac catgcccggc taattttgta tttttggtag agatggggtt
1561 tcgctatgtt ggccagactg gtcttgaact cttggcctca agtgatccgt ccccctctgc
1621 ctcccaaagt gctgggatta caggcatgag ccaccgtgcc cagctaattt ttatatattt
1681 tatagttggc caggctggtc ttgaactcct ggcctcaagt gatcagcctc ccaaagtgct
1741 gggattatag gcatgagtca ccatgcctgg cgtcataact actttagtgt gtatctttaa
1801 aaattagaaa aaccccacaa taccattatc acacctaaaa agttgaactg tttcttaata
1861 tgatcaactg tctagactgt taattctctt taactgttgg tttgcttgaa ataggtacca
1921 cacaaggttc atacattgca tttggttgtt atttattgaa gtctgtttaa tttataagtt
1981 accttttctt ttccccctta aattatttaa gaaatctagt tgttttgtct ttaaagtttc
2041 cacacatatt ctggattttg ttgattgtat cactgtgaag tcattaactt gtttttatgc
2101 ctcctgtata tcctgtaaac aaataagatt gatcagattc aggttcagtt tttttagtgc
2161 cttcttttga gtaaagtcat accaaacaga tgcccagaac atctggattt gggtccccac
2221 tagactcctt aaataatgta tatcttctat aagtggaata tgagggacat ggacctgctt
2281 tagtaagaac agtaatctgt ttggggagtt aaaagagcag ttgtggattt atttattgat
2341 aaagaccatt tttcttccta ataaccttgc tgttattcta gtgtcttagc catcttcatt
2401 tggttgttta ccaatatatg acatgtgatt ttatttttca gatggataca gacatataca
2461 agattgtggt gacctgtgtt acagttagaa gttggtgaga aaggtgaggg tggatagcaa
2521 aaagagagag atcatttggc tggctgttcc agctgggtct cccaggatgt aacataggtg
2581 gacatagatc cagggtctga ccctcagctt gagaaaccat ttcccactga tgaaacttga
2641 gagacttgga gattccccag ttagaatata aatgtattaa ttcatagtga taggtctgcc
2701 tatggtaaac aattaggaaa caggaagtta cttggtaaac acaggtatga gcaaaggaag
2761 attgataaat tggggtaata tttcagttgt gctgaggtaa gacttggaga atttttcctg
2821 cttcatcatt aattagaatg cttatctctg ccaaaatctc atctctttcc tagcccatag
2881 aggtgccctg atattttatt tcctatatcc ttttcaagtt ccatgtagtt ttccttatgt
2941 tatgacagtt ttattctgca gcttaccata ttatttattc ctggtccacg aaagtataaa
3001 tagtctcatc aggaactcat ttgtaagtca tctcccaggg gggtttcttc aacagatagt
3061 ttaatttttt gctgacttac tggcttcaaa ttcagatgtc tccctatttg ggggaggagg
3121 caccctattt gaggcctgta gctccttatg ttcttaaaaa gaatatacaa gtcatttatg
3181 tcagaatcaa actttgaacc tttatttttg ttgctaagag aatgtttttt gaccaagact
3241 gcctatggag tattagcaat gaaaaacaaa gcacacatat acatacatta gagaagtaaa
3301 aacttttaat agcttggttt ttgaaataat tcatctttgt gtctaaccac tgttacagtg
3361 ggtgtaagga acacttttta aatattcaac atcaacatct gtgcttgttt ttctactgtg
3421 ctgaggtaca ctgtgttgcc ttggtgatat ggactaaata tgtatgttct ctgcttcccc
3481 tgggtctgag gcctctgctc atcactgtta atcagggatg tcactctaca tgtgtgatcc
3541 ttgtcatttt ctaaacatta ggtcatacat gaaaggcaat tcaaagagat taaactagca
3601 gatgtgtcag catctttaga tactgtgctt aatggaaact tagtttacct atattcgtga
3661 gaataggaat acagggatag agagcctgct tctctcaggc agtgtgtctt tagttcattt
3721 ttagtttcaa aattaagttt gtgtcaaacc aacctacaat ctagtaactt gtgtattgga
3781 ctcactttta ctcagacaag gtcagttcag ctcaataggt atttattgag tatctactag
3841 gttctaagtg acgtggcatg aagatgaata atacagaagt agcccttgct cttaaggagc
3901 ttccaatcta gtgagtaaag aaaatttaca ttttaaataa tctgggtaat ggtgacagcc
3961 caatactaat atgtaaagcc agtaggaatg tactaatcct tttccaattt tagtcatcaa
4021 aaattgtaaa ttacaaatga actaaatgta gtaatattcc atagattgta tccaatgtga
4081 gggtaaaaaa aaaatcccag atgtcttgga gttgccgtga ttcagcatcc caactcagat
4141 gattgtcctg ttgtccggtg acataatggc ctgatcagtt ctcttctagc agactgtctg
4201 ttatggtggt ttggtagtgg tctgttggga agctgcattt ttccttttct gtttttatgc
4261 tctggacccc aaacaaaaac agctggattt atcccatggg tagtcatgaa catttccaat
4321 ttgagggatt ttatattccc caaacagaag gttatatggc atatatcaaa taataatgat
4381 atccagccag gttccctgtc gtacccaaat cagtaactga agatacgtat ttctaagtat
4441 aatacttcag aggaagagat aagaattaca attcactaaa ttcgtggagg tgtttcatta
4501 taataaatat gtcacttatt aataatgtag caattatata ttaatggaaa tatgaatgta
4561 tgcccaagca aaatgtcata aatattttaa ctttgtttgt ctaggttcct taattttgag
4621 actataatta tcaaggctct tcaagaaact caaaatgatt ctaatttcta agtagtatgc
4681 attaaaactg atatataatg aaagaaaaac agtgaaaatg tatgcatcag tttctaaaga
4741 aatcatactt gtcattgtag agatgcatgt aaattaaatg tattatacat ttttatactt
4801 gtatgtattt tatactttgt atgaatactt ttattacact ttttaaggca ggtaaaagaa
4861 tgagtagatg ttatcaacta taacaacaat ttgttgaata ctgtgttaaa accaagtaaa
4921 ggaccacaac tccacgagat caggaatgaa tgaagaaaat tgagggccag tttttaaatc
4981 attgttgaga ctattaggtt catctgtctg tttaagagtc tggccttagg gaatataatt
5041 tatgcatgta aaaaaataca ggagatgatt cactggaatg tctcttaata ataccatgtt
5101 cattaagaat aggtcattgg gaggaaaaat aaataaaaac atctgaactc attagtataa
5161 ttaatacttg cctcttagaa tgaaaattaa agaactccaa attttagcct tgaatacttt
5221 gagaaataaa agatgaatta gtgaaataat ttctacttaa aatcttagtt gttacagaga
5281 atgacatgcc tcactattaa tgtccaattc taattaatgg attgttttag aaatgtattt
5341 gtgaaatata gcaaacatag ctagtaatac taacaggtga aaactgatat ttcaaatgac
5401 taaatagact taagattaga ggaaggtagg aaaaggtgtg caactaacag aagcagttaa
5461 ccaaaaaatg agcttcaggc atcagtctta tttggaagac tgtaaatcaa caggctaacg
5521 ttcaaaatat ggcagacatc ttaatatcaa tatatgctaa attggtttat ctttaggcag
5581 aaacagaaag caaaaaatta aactcatcca actcatacat ttgttgttgt tgttgttgtt
5641 gttgtttttg agatggagtc ttgcttcatt gcccaggctg gagtgcaatg gcacgatctc
5701 ggctcactgc aacctctgtc ttccgggttc aagcgattct cctgcctcag cctcccgagt
5761 agctgggatc ccatgcgtgt gccaccacac ctagctaatt tttgtatttt tagtagagac
5821 agggtttcac catgttggcc aggctggtct caaactcctg acctcaggtg atgcacccgc
5881 cttggcctcc caaagtgctg ggattacagg tgtgaaccac cacacccgac ccaactaata
5941 catttttaaa atcccatttt aaaagtaaaa ccacagtttt catataacaa atgttattgc
6001 tcttcatttc attctccaat tttaaaatgc tttactttca gccaatatgt gaatatagga
6061 gacttcaaaa gcataatcaa ttactccctt aaagttcatt gtaagtgttc tcagaactct
6121 accacctaga atttaaagac gggaagattt actttataat tttaatttct tatcacaaga
6181 ctcgattgtc aataactgtt aacgtccatt taataatcta tggtgaaata ggtaatttct
6241 tcttattttc acaagcgtgt gagtaaaaga ctgggtttta agcaataaat catttgttct
6301 aactaagcac atgcttggaa aaagtgctat ttttccaaac gtatgccttg aaaacaaata
6361 caattcaatt gcctttttgg ttcatgggaa gccatactgc ggtggcttcc aaggttggcc
6421 aacctgtttt tattcttacc acctctttca aaaagggatg ttgtctttgt ccccaaattc
6481 tggtgttgtc ctatgctgat gcataatgaa gccctgaggc ttggaaactt gcaaaccaat
6541 aagatgattt aatgatgaaa cggcatgtca gtttgacact gtctattaat agtccttgag
6601 tgagcttaaa tttgagacac ttttaaaagc ggcatgtagt tccagttttg cttcccttat
6661 cagtggagct tgagatgtct gttcctgccg actgatgttt taacaaattt ttagtttctc
6721 atgatgtgaa agattttgta tgcacgtctt agtctggata ctgttttcat tagttctaat
6781 gctgctgcat gcaaattttg tttaaaacca aaattgactc ttcacatctg gactagattg
6841 gacatggtga ggaggctgga aggaaagtcc tttttgctct gtaggctctg gacagctttc
6901 ttagagttga cttatccagg attaagaaaa agttttcttt tgcgtgacta aattctttcc
6961 acagtttgct tgtgtaagca ttttagattt aagcaagttc aacttgaaat atatttgaat
7021 atgaagtaga aacagcttca tttaatggga taatagcaat ctctaaccca tcaaattaat
7081 atctactaaa tagcttccaa aaagcactga ctggaaaata tttttcacta tcatggcttt
7141 attcagtttc aaaaacagta ggggctaaaa tgtttggaca tttatcctgc atttattttg
7201 tgtttcacaa ggttaaaatt ttgtattttg taaagtgtct gaaaaggagt ccacaaagta
7261 tttctgcttt cttgctcctg aatgcaaagg tctgagagaa ggcacatcct cattagcttc
7321 tgggtgttgt caaacccaat cctctctcaa gtaccaaatg cccagataca tttattggga
7381 tgcaggaatc tcacttaagt agcggttttt gctgatataa agacaaacat cttgattaaa
7441 gtgtagggag atagaaacta taccaatttg ggcaattttg gctctaatgt ctaatttgtt
7501 gtgaaagggg aagatgttct aagctaatgt tcttaaaagt aacttatgaa tttcttaaaa
7561 atagttttta aaaagctgtt tcaggaaaag ctgttttatt gcatggcaca gattaaatgt
7621 acagatgtta tcttaaaaca atgaaagagt tcccctaatt tgaatattca ataccagctg
7681 ttattcacat caatatttta acattttacc atcaagatat ttaatacaaa ggattgatac
7741 atatttaact gtttagaatt ctagttaaac ttgtccagat gagtaagagg gaaggagaaa
7801 taacattctc caagtaccta ccatgtgcac aagctctact tatatatctt gcttaatctt
7861 agcaatgatt ccatgaggta gattttaact ctcattttac aaacgaggag actaaggctc
7921 agagaggtca tacaacttca ggaaagttgt atgacctctc tgaggtaata aatggcagaa
7981 ctggaatttg aacctaagtc tccttgtctg caaatcctgt gttttgcaga aaactctcct
8041 cttgtatttc ataaaatgtt aaatcttggc ccaaattcaa atcaccatct ttatgggtta
8101 ttggagagag gtataagttg gcaagactct gttccacgat gggaaaaaat gggtaggatt
8161 tgaatgagta agagtgggat acttgcacag tatcatattt gtgtggctgg agtaatgttt
8221 ttctgtttcc ctcttagcaa agtggagtgg gagaatcttg aaattgaact cagtcctgag
8281 gtctgatttt cctattatta gtcactttca agccaggtga tttgtgacca tttaaatgtt
8341 atgctatttc aaagtcttct acatctttag aaaaggacat gagggagggt tagttaagtg
8401 gggcaatgag aatgtagagt gtaatgtgca aaagcaggac tagcagttgc tttgaagata
8461 tctggggaag gccgggcacg gtggttcacg cctgtaatcc cagtactttg ggaggccaag
8521 gtgggcggat cacgaggtca ggagatcgag accatcctgg ctaacgtgaa accccgtcta
8581 tactaaaaat acaaaaaatt aaccggacgc agtggtgggc gcctgtagtc ccagctactc
8641 gggaggctga ggcaggagag tggcatgaac ccgggaggcg gagcttgcag tgagctgaga
8701 tcgcaccact gcattccagc ctggacaaca gagcgaaact ccgtctcaaa aaccaaccaa
8761 acaaaaaaca aaaattagct gggcatggtg gcgcgtgcct gtaatcccag cactttggga
8821 gccaaggtgg gtggatcatg aggtcagaag attgagacca ccctggccaa catggtgaaa
8881 tcctgtctct actaaaaata caaaaaaaaa aaaaaaaaaa aaaattagcc gggcgtggtg
8941 gcgcgtgcct gtaatcccag ctacacagga ggctgaggca ggagatttgc ttgaacctgg
9001 gaggcggagg ttgcagtgag ccgagattgt gccactgcac tccagcctgg gcgacagagc
9061 aagactccgt ctaaaaaaaa aaaaaagata ttaaaattaa tgacaggaag agtttgggtt
9121 cagttataat ttaagggaaa aaacattgag gggcctaatc tacattttgc tccggatcca
9181 atgatttaat ttttgggaag aaaaatccag tgattaaagt catgcaagga gatggcctgg
9241 ggcttgctaa aagtcaggtt gcagtttcca ttgcattcaa gaaaatcaga aaaataaata
9301 caacttttag aagaaactaa gttttctccc attcatgttt agctattggg gggtctcata
9361 cttctggact tgcttagacc tatgctatct aatatggtag cctctgccca tccatatgtg
9421 gccactgaga acttgaaatg tgactagttt gaattaagat gtgctgtaac taaaatacac
9481 cctggatttc aaagacttaa taaataatgt aaattatcta ttctttcctg ttgattatat
9541 attgaaatga taatattttg gatatgtttg ggttaaataa aatatattac taaaagtaa
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