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Homo sapiens MCTS1 re-initiation and release factor (MCTS1), transcript variant 2, mRNA

NCBI Reference Sequence: NM_001137554.2

FASTA Graphics 

LOCUS       NM_001137554            9599 bp    mRNA    linear   PRI 12-DEC-2024
DEFINITION  Homo sapiens MCTS1 re-initiation and release factor (MCTS1),
            transcript variant 2, mRNA.
ACCESSION   NM_001137554
VERSION     NM_001137554.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9599)
  AUTHORS   Bohlen,J., Zhou,Q., Philippot,Q., Ogishi,M., Rinchai,D.,
            Nieminen,T., Seyedpour,S., Parvaneh,N., Rezaei,N., Yazdanpanah,N.,
            Momenilandi,M., Conil,C., Neehus,A.L., Schmidt,C.,
            Arango-Franco,C.A., Voyer,T.L., Khan,T., Yang,R., Puchan,J.,
            Erazo,L., Roiuk,M., Vatovec,T., Janda,Z., Bagaric,I., Materna,M.,
            Gervais,A., Li,H., Rosain,J., Peel,J.N., Seeleuthner,Y., Han,J.E.,
            L'Honneur,A.S., Moncada-Velez,M., Martin-Fernandez,M., Horesh,M.E.,
            Kochetkov,T., Schmidt,M., AlShehri,M.A., Salo,E., Saxen,H.,
            ElGhazali,G., Yatim,A., Soudee,C., Sallusto,F., Ensser,A., Marr,N.,
            Zhang,P., Bogunovic,D., Cobat,A., Shahrooei,M., Beziat,V., Abel,L.,
            Wang,X., Boisson-Dupuis,S., Teleman,A.A., Bustamante,J., Zhang,Q.
            and Casanova,J.L.
  TITLE     Human MCTS1-dependent translation of JAK2 is essential for
            IFN-gamma immunity to mycobacteria
  JOURNAL   Cell 186 (23), 5114-5134 (2023)
   PUBMED   37875108
  REMARK    GeneRIF: Human MCTS1-dependent translation of JAK2 is essential for
            IFN-gamma immunity to mycobacteria.
REFERENCE   2  (bases 1 to 9599)
  AUTHORS   Ma,B., Wei,X., Zhou,S. and Yang,M.
  TITLE     MCTS1 enhances the proliferation of laryngeal squamous cell
            carcinoma via promoting OTUD6B-1 mediated LIN28B deubiquitination
  JOURNAL   Biochem Biophys Res Commun 678, 128-134 (2023)
   PUBMED   37634410
  REMARK    GeneRIF: MCTS1 enhances the proliferation of laryngeal squamous
            cell carcinoma via promoting OTUD6B-1 mediated LIN28B
            deubiquitination.
REFERENCE   3  (bases 1 to 9599)
  AUTHORS   Yang,M., Ma,B. and Liu,X.
  TITLE     MCTS1 promotes laryngeal squamous cell carcinoma cell growth via
            enhancing LARP7 stability
  JOURNAL   Clin Exp Pharmacol Physiol 49 (6), 652-660 (2022)
   PUBMED   35274760
  REMARK    GeneRIF: MCTS1 promotes laryngeal squamous cell carcinoma cell
            growth via enhancing LARP7 stability.
REFERENCE   4  (bases 1 to 9599)
  AUTHORS   de Carvalho,P.A., Bonatelli,M., Cordeiro,M.D., Coelho,R.F.,
            Reis,S., Srougi,M., Nahas,W.C., Pinheiro,C. and Leite,K.R.M.
  TITLE     MCT1 expression is independently related to shorter cancer-specific
            survival in clear cell renal cell carcinoma
  JOURNAL   Carcinogenesis 42 (12), 1420-1427 (2021)
   PUBMED   34668521
  REMARK    GeneRIF: MCT1 expression is independently related to shorter
            cancer-specific survival in clear cell renal cell carcinoma.
REFERENCE   5  (bases 1 to 9599)
  AUTHORS   Zhu,J., Wang,X., Shao,Z., Sun,W. and Wu,T.
  TITLE     Prognostic value of malignant T cell-amplified sequence 1 in head
            and neck squamous cell carcinoma
  JOURNAL   Biomark Med 15 (17), 1623-1639 (2021)
   PUBMED   34704820
  REMARK    GeneRIF: Prognostic value of malignant T cell-amplified sequence 1
            in head and neck squamous cell carcinoma.
REFERENCE   6  (bases 1 to 9599)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
REFERENCE   7  (bases 1 to 9599)
  AUTHORS   Shi,B., Levenson,V. and Gartenhaus,R.B.
  TITLE     Identification and characterization of a novel enhancer for the
            human MCT-1 oncogene promoter
  JOURNAL   J Cell Biochem 90 (1), 68-79 (2003)
   PUBMED   12938157
  REMARK    GeneRIF: demonstrated the presence of sequence-specific DNA-binding
            protein in nuclear extracts designated as LMBF; the 26-mer
            oligonucleotide containing the LMBF binding site is required for
            maximum transcriptional activity of the MCT-1 promoter
REFERENCE   8  (bases 1 to 9599)
  AUTHORS   Shi,B., Hsu,H.L., Evens,A.M., Gordon,L.I. and Gartenhaus,R.B.
  TITLE     Expression of the candidate MCT-1 oncogene in B- and T-cell
            lymphoid malignancies
  JOURNAL   Blood 102 (1), 297-302 (2003)
   PUBMED   12637315
  REMARK    GeneRIF: tumor cell lines overexpressing MCT-1 exhibited increased
            growth rates and displayed increased protection against apoptosis
            induced by serum starvation
REFERENCE   9  (bases 1 to 9599)
  AUTHORS   Herbert,G.B., Shi,B. and Gartenhaus,R.B.
  TITLE     Expression and stabilization of the MCT-1 protein by DNA damaging
            agents
  JOURNAL   Oncogene 20 (46), 6777-6783 (2001)
   PUBMED   11709712
REFERENCE   10 (bases 1 to 9599)
  AUTHORS   Prosniak,M., Dierov,J., Okami,K., Tilton,B., Jameson,B.,
            Sawaya,B.E. and Gartenhaus,R.B.
  TITLE     A novel candidate oncogene, MCT-1, is involved in cell cycle
            progression
  JOURNAL   Cancer Res 58 (19), 4233-4237 (1998)
   PUBMED   9766643
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AA375691.1, AW957695.1, AK294834.1, AC011890.4 and BM671542.1.
            
            On May 31, 2019 this sequence version replaced NM_001137554.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at an
            alternate start codon, compared to variant 1. The encoded isoform
            (2) is longer and has a distinct N-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.134015.1,
                                           SRR1803616.76982.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AA375691.1         3-15
            14-30               AW957695.1         15-31
            31-1188             AK294834.1         1-1158
            1189-9150           AC011890.4         12917-20878
            9151-9599           BM671542.1         17-465              c
FEATURES             Location/Qualifiers
     source          1..9599
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq24"
     gene            1..9599
                     /gene="MCTS1"
                     /gene_synonym="IMD118; MCT-1; MCT1"
                     /note="MCTS1 re-initiation and release factor"
                     /db_xref="GeneID:28985"
                     /db_xref="HGNC:HGNC:23357"
                     /db_xref="MIM:300587"
     exon            1..169
                     /gene="MCTS1"
                     /gene_synonym="IMD118; MCT-1; MCT1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    75..77
                     /gene="MCTS1"
                     /gene_synonym="IMD118; MCT-1; MCT1"
                     /note="upstream in-frame stop codon"
     CDS             156..704
                     /gene="MCTS1"
                     /gene_synonym="IMD118; MCT-1; MCT1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     multiple copies T-cell malignancies; malignant T-cell
                     amplified sequence 1; multiple copies in T-cell
                     lymphoma-1"
                     /codon_start=1
                     /product="malignant T-cell-amplified sequence 1 isoform 2"
                     /protein_id="NP_001131026.1"
                     /db_xref="CCDS:CCDS48160.1"
                     /db_xref="GeneID:28985"
                     /db_xref="HGNC:HGNC:23357"
                     /db_xref="MIM:300587"
                     /translation="MGKGRFDEKENVSNCIQLKTSVIKGIKNQLIEQFPGIEPWLNQI
                     MPKKDPVKIVRCHEHIEILTVNGELLFFRQREGPFYPTLRLLHKYPFILPHQQVDKGA
                     IKFVLSGANIMCPGLTSPGAKLYPAAVDTIVAIMAEGKQHALCVGVMKMSAEDIEKVN
                     KGIGIENIHYLNDGLWHMKTYK"
     exon            170..322
                     /gene="MCTS1"
                     /gene_synonym="IMD118; MCT-1; MCT1"
                     /inference="alignment:Splign:2.1.0"
     exon            323..420
                     /gene="MCTS1"
                     /gene_synonym="IMD118; MCT-1; MCT1"
                     /inference="alignment:Splign:2.1.0"
     exon            421..554
                     /gene="MCTS1"
                     /gene_synonym="IMD118; MCT-1; MCT1"
                     /inference="alignment:Splign:2.1.0"
     exon            555..622
                     /gene="MCTS1"
                     /gene_synonym="IMD118; MCT-1; MCT1"
                     /inference="alignment:Splign:2.1.0"
     exon            623..9599
                     /gene="MCTS1"
                     /gene_synonym="IMD118; MCT-1; MCT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      805..810
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MCTS1"
                     /gene_synonym="IMD118; MCT-1; MCT1"
                     /note="hexamer: AATAAA"
     polyA_site      827
                     /gene="MCTS1"
                     /gene_synonym="IMD118; MCT-1; MCT1"
                     /note="major polyA site"
     regulatory      9576..9581
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MCTS1"
                     /gene_synonym="IMD118; MCT-1; MCT1"
                     /note="hexamer: AATAAA"
     regulatory      9581..9586
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MCTS1"
                     /gene_synonym="IMD118; MCT-1; MCT1"
                     /note="hexamer: AATATA"
     polyA_site      9595
                     /gene="MCTS1"
                     /gene_synonym="IMD118; MCT-1; MCT1"
     polyA_site      9599
                     /gene="MCTS1"
                     /gene_synonym="IMD118; MCT-1; MCT1"
ORIGIN      
        1 ctgtcatgcc tattgcctag ctgccagatt aaccttgcct tgaaaataac gattgcccca
       61 taggctattc agtgtaagga agacaaaaat tccttgggaa cctactagtg ggtttgcctt
      121 ccagatttgg tagacgcaaa aagcaaaggg ggaacatggg caaaggaaga tttgatgaaa
      181 aagaaaatgt gtccaactgc atccagttga aaacttcagt tattaagggt attaagaatc
      241 aattgataga gcaatttcca ggtattgaac catggcttaa tcaaatcatg cctaagaaag
      301 atcctgtcaa aatagtccga tgccatgaac atatagaaat ccttacagta aatggagaat
      361 tactcttttt tagacaaaga gaagggcctt tttatccaac cctaagatta cttcacaaat
      421 atccttttat cctgccacac cagcaggttg ataaaggagc catcaaattt gtactcagtg
      481 gagcaaatat catgtgtcca ggcttaactt ctcctggagc taagctttac cctgctgcag
      541 tagataccat tgttgctatc atggcagaag gaaaacagca tgctctatgt gttggagtca
      601 tgaagatgtc tgcagaagac attgagaaag tcaacaaagg aattggcatt gaaaatatcc
      661 attatttaaa tgatgggctg tggcatatga agacatataa atgagcctca gaaggaatgc
      721 acttgggcta aatatggata ttgtgctgta tctgtgtttg tgtctgtgtg tgacagcatg
      781 aagataatgc ctgtggttat gctgaataaa ttcaccagat gctaaaattc tgttagcttc
      841 agaaattatt ttaagttttc ttaaactcaa gttaaaattg ggtagcaaac ttggacatta
      901 aaaggtatct ggtaagtaag caaactcata caactaatgt cctttcttag gctaatgata
      961 taagagtgaa gagcaggact tggtcaatgg attgccattt tatggtagac ctctagagaa
     1021 actgtctagt taaatggggc tagaaactag actaggaatt ttattctatt actccagggg
     1081 acccagcagt gctcattctc gtgtgtgtgt gtgtgtgtgt gtgtgtatgt gtgtgtgtgt
     1141 gtgtgtgtgt gttttgttga ttgttttttt aaaaaaaact tcaatggaaa attctaaaca
     1201 tattaagaag tctggagaat agtataatgg acctctccat atccatcacc cagtttcagt
     1261 ttatggtcag tcttatttca tctatacctc aattatttct ccccaccccc caattatttt
     1321 gaagcaaatc ccagacatcc tatcatttca tccataacta ctttattctt tttttttttt
     1381 ttttgaaaca gggtcttgct ctgttgccca ggctggagtg cagtggtacg atcttggctc
     1441 actgtaacct ccacctcccg ggttcaagcg attcttgtgc ctcagcctcc tgagtagctg
     1501 ggattacagg cacgtgccac catgcccggc taattttgta tttttggtag agatggggtt
     1561 tcgctatgtt ggccagactg gtcttgaact cttggcctca agtgatccgt ccccctctgc
     1621 ctcccaaagt gctgggatta caggcatgag ccaccgtgcc cagctaattt ttatatattt
     1681 tatagttggc caggctggtc ttgaactcct ggcctcaagt gatcagcctc ccaaagtgct
     1741 gggattatag gcatgagtca ccatgcctgg cgtcataact actttagtgt gtatctttaa
     1801 aaattagaaa aaccccacaa taccattatc acacctaaaa agttgaactg tttcttaata
     1861 tgatcaactg tctagactgt taattctctt taactgttgg tttgcttgaa ataggtacca
     1921 cacaaggttc atacattgca tttggttgtt atttattgaa gtctgtttaa tttataagtt
     1981 accttttctt ttccccctta aattatttaa gaaatctagt tgttttgtct ttaaagtttc
     2041 cacacatatt ctggattttg ttgattgtat cactgtgaag tcattaactt gtttttatgc
     2101 ctcctgtata tcctgtaaac aaataagatt gatcagattc aggttcagtt tttttagtgc
     2161 cttcttttga gtaaagtcat accaaacaga tgcccagaac atctggattt gggtccccac
     2221 tagactcctt aaataatgta tatcttctat aagtggaata tgagggacat ggacctgctt
     2281 tagtaagaac agtaatctgt ttggggagtt aaaagagcag ttgtggattt atttattgat
     2341 aaagaccatt tttcttccta ataaccttgc tgttattcta gtgtcttagc catcttcatt
     2401 tggttgttta ccaatatatg acatgtgatt ttatttttca gatggataca gacatataca
     2461 agattgtggt gacctgtgtt acagttagaa gttggtgaga aaggtgaggg tggatagcaa
     2521 aaagagagag atcatttggc tggctgttcc agctgggtct cccaggatgt aacataggtg
     2581 gacatagatc cagggtctga ccctcagctt gagaaaccat ttcccactga tgaaacttga
     2641 gagacttgga gattccccag ttagaatata aatgtattaa ttcatagtga taggtctgcc
     2701 tatggtaaac aattaggaaa caggaagtta cttggtaaac acaggtatga gcaaaggaag
     2761 attgataaat tggggtaata tttcagttgt gctgaggtaa gacttggaga atttttcctg
     2821 cttcatcatt aattagaatg cttatctctg ccaaaatctc atctctttcc tagcccatag
     2881 aggtgccctg atattttatt tcctatatcc ttttcaagtt ccatgtagtt ttccttatgt
     2941 tatgacagtt ttattctgca gcttaccata ttatttattc ctggtccacg aaagtataaa
     3001 tagtctcatc aggaactcat ttgtaagtca tctcccaggg gggtttcttc aacagatagt
     3061 ttaatttttt gctgacttac tggcttcaaa ttcagatgtc tccctatttg ggggaggagg
     3121 caccctattt gaggcctgta gctccttatg ttcttaaaaa gaatatacaa gtcatttatg
     3181 tcagaatcaa actttgaacc tttatttttg ttgctaagag aatgtttttt gaccaagact
     3241 gcctatggag tattagcaat gaaaaacaaa gcacacatat acatacatta gagaagtaaa
     3301 aacttttaat agcttggttt ttgaaataat tcatctttgt gtctaaccac tgttacagtg
     3361 ggtgtaagga acacttttta aatattcaac atcaacatct gtgcttgttt ttctactgtg
     3421 ctgaggtaca ctgtgttgcc ttggtgatat ggactaaata tgtatgttct ctgcttcccc
     3481 tgggtctgag gcctctgctc atcactgtta atcagggatg tcactctaca tgtgtgatcc
     3541 ttgtcatttt ctaaacatta ggtcatacat gaaaggcaat tcaaagagat taaactagca
     3601 gatgtgtcag catctttaga tactgtgctt aatggaaact tagtttacct atattcgtga
     3661 gaataggaat acagggatag agagcctgct tctctcaggc agtgtgtctt tagttcattt
     3721 ttagtttcaa aattaagttt gtgtcaaacc aacctacaat ctagtaactt gtgtattgga
     3781 ctcactttta ctcagacaag gtcagttcag ctcaataggt atttattgag tatctactag
     3841 gttctaagtg acgtggcatg aagatgaata atacagaagt agcccttgct cttaaggagc
     3901 ttccaatcta gtgagtaaag aaaatttaca ttttaaataa tctgggtaat ggtgacagcc
     3961 caatactaat atgtaaagcc agtaggaatg tactaatcct tttccaattt tagtcatcaa
     4021 aaattgtaaa ttacaaatga actaaatgta gtaatattcc atagattgta tccaatgtga
     4081 gggtaaaaaa aaaatcccag atgtcttgga gttgccgtga ttcagcatcc caactcagat
     4141 gattgtcctg ttgtccggtg acataatggc ctgatcagtt ctcttctagc agactgtctg
     4201 ttatggtggt ttggtagtgg tctgttggga agctgcattt ttccttttct gtttttatgc
     4261 tctggacccc aaacaaaaac agctggattt atcccatggg tagtcatgaa catttccaat
     4321 ttgagggatt ttatattccc caaacagaag gttatatggc atatatcaaa taataatgat
     4381 atccagccag gttccctgtc gtacccaaat cagtaactga agatacgtat ttctaagtat
     4441 aatacttcag aggaagagat aagaattaca attcactaaa ttcgtggagg tgtttcatta
     4501 taataaatat gtcacttatt aataatgtag caattatata ttaatggaaa tatgaatgta
     4561 tgcccaagca aaatgtcata aatattttaa ctttgtttgt ctaggttcct taattttgag
     4621 actataatta tcaaggctct tcaagaaact caaaatgatt ctaatttcta agtagtatgc
     4681 attaaaactg atatataatg aaagaaaaac agtgaaaatg tatgcatcag tttctaaaga
     4741 aatcatactt gtcattgtag agatgcatgt aaattaaatg tattatacat ttttatactt
     4801 gtatgtattt tatactttgt atgaatactt ttattacact ttttaaggca ggtaaaagaa
     4861 tgagtagatg ttatcaacta taacaacaat ttgttgaata ctgtgttaaa accaagtaaa
     4921 ggaccacaac tccacgagat caggaatgaa tgaagaaaat tgagggccag tttttaaatc
     4981 attgttgaga ctattaggtt catctgtctg tttaagagtc tggccttagg gaatataatt
     5041 tatgcatgta aaaaaataca ggagatgatt cactggaatg tctcttaata ataccatgtt
     5101 cattaagaat aggtcattgg gaggaaaaat aaataaaaac atctgaactc attagtataa
     5161 ttaatacttg cctcttagaa tgaaaattaa agaactccaa attttagcct tgaatacttt
     5221 gagaaataaa agatgaatta gtgaaataat ttctacttaa aatcttagtt gttacagaga
     5281 atgacatgcc tcactattaa tgtccaattc taattaatgg attgttttag aaatgtattt
     5341 gtgaaatata gcaaacatag ctagtaatac taacaggtga aaactgatat ttcaaatgac
     5401 taaatagact taagattaga ggaaggtagg aaaaggtgtg caactaacag aagcagttaa
     5461 ccaaaaaatg agcttcaggc atcagtctta tttggaagac tgtaaatcaa caggctaacg
     5521 ttcaaaatat ggcagacatc ttaatatcaa tatatgctaa attggtttat ctttaggcag
     5581 aaacagaaag caaaaaatta aactcatcca actcatacat ttgttgttgt tgttgttgtt
     5641 gttgtttttg agatggagtc ttgcttcatt gcccaggctg gagtgcaatg gcacgatctc
     5701 ggctcactgc aacctctgtc ttccgggttc aagcgattct cctgcctcag cctcccgagt
     5761 agctgggatc ccatgcgtgt gccaccacac ctagctaatt tttgtatttt tagtagagac
     5821 agggtttcac catgttggcc aggctggtct caaactcctg acctcaggtg atgcacccgc
     5881 cttggcctcc caaagtgctg ggattacagg tgtgaaccac cacacccgac ccaactaata
     5941 catttttaaa atcccatttt aaaagtaaaa ccacagtttt catataacaa atgttattgc
     6001 tcttcatttc attctccaat tttaaaatgc tttactttca gccaatatgt gaatatagga
     6061 gacttcaaaa gcataatcaa ttactccctt aaagttcatt gtaagtgttc tcagaactct
     6121 accacctaga atttaaagac gggaagattt actttataat tttaatttct tatcacaaga
     6181 ctcgattgtc aataactgtt aacgtccatt taataatcta tggtgaaata ggtaatttct
     6241 tcttattttc acaagcgtgt gagtaaaaga ctgggtttta agcaataaat catttgttct
     6301 aactaagcac atgcttggaa aaagtgctat ttttccaaac gtatgccttg aaaacaaata
     6361 caattcaatt gcctttttgg ttcatgggaa gccatactgc ggtggcttcc aaggttggcc
     6421 aacctgtttt tattcttacc acctctttca aaaagggatg ttgtctttgt ccccaaattc
     6481 tggtgttgtc ctatgctgat gcataatgaa gccctgaggc ttggaaactt gcaaaccaat
     6541 aagatgattt aatgatgaaa cggcatgtca gtttgacact gtctattaat agtccttgag
     6601 tgagcttaaa tttgagacac ttttaaaagc ggcatgtagt tccagttttg cttcccttat
     6661 cagtggagct tgagatgtct gttcctgccg actgatgttt taacaaattt ttagtttctc
     6721 atgatgtgaa agattttgta tgcacgtctt agtctggata ctgttttcat tagttctaat
     6781 gctgctgcat gcaaattttg tttaaaacca aaattgactc ttcacatctg gactagattg
     6841 gacatggtga ggaggctgga aggaaagtcc tttttgctct gtaggctctg gacagctttc
     6901 ttagagttga cttatccagg attaagaaaa agttttcttt tgcgtgacta aattctttcc
     6961 acagtttgct tgtgtaagca ttttagattt aagcaagttc aacttgaaat atatttgaat
     7021 atgaagtaga aacagcttca tttaatggga taatagcaat ctctaaccca tcaaattaat
     7081 atctactaaa tagcttccaa aaagcactga ctggaaaata tttttcacta tcatggcttt
     7141 attcagtttc aaaaacagta ggggctaaaa tgtttggaca tttatcctgc atttattttg
     7201 tgtttcacaa ggttaaaatt ttgtattttg taaagtgtct gaaaaggagt ccacaaagta
     7261 tttctgcttt cttgctcctg aatgcaaagg tctgagagaa ggcacatcct cattagcttc
     7321 tgggtgttgt caaacccaat cctctctcaa gtaccaaatg cccagataca tttattggga
     7381 tgcaggaatc tcacttaagt agcggttttt gctgatataa agacaaacat cttgattaaa
     7441 gtgtagggag atagaaacta taccaatttg ggcaattttg gctctaatgt ctaatttgtt
     7501 gtgaaagggg aagatgttct aagctaatgt tcttaaaagt aacttatgaa tttcttaaaa
     7561 atagttttta aaaagctgtt tcaggaaaag ctgttttatt gcatggcaca gattaaatgt
     7621 acagatgtta tcttaaaaca atgaaagagt tcccctaatt tgaatattca ataccagctg
     7681 ttattcacat caatatttta acattttacc atcaagatat ttaatacaaa ggattgatac
     7741 atatttaact gtttagaatt ctagttaaac ttgtccagat gagtaagagg gaaggagaaa
     7801 taacattctc caagtaccta ccatgtgcac aagctctact tatatatctt gcttaatctt
     7861 agcaatgatt ccatgaggta gattttaact ctcattttac aaacgaggag actaaggctc
     7921 agagaggtca tacaacttca ggaaagttgt atgacctctc tgaggtaata aatggcagaa
     7981 ctggaatttg aacctaagtc tccttgtctg caaatcctgt gttttgcaga aaactctcct
     8041 cttgtatttc ataaaatgtt aaatcttggc ccaaattcaa atcaccatct ttatgggtta
     8101 ttggagagag gtataagttg gcaagactct gttccacgat gggaaaaaat gggtaggatt
     8161 tgaatgagta agagtgggat acttgcacag tatcatattt gtgtggctgg agtaatgttt
     8221 ttctgtttcc ctcttagcaa agtggagtgg gagaatcttg aaattgaact cagtcctgag
     8281 gtctgatttt cctattatta gtcactttca agccaggtga tttgtgacca tttaaatgtt
     8341 atgctatttc aaagtcttct acatctttag aaaaggacat gagggagggt tagttaagtg
     8401 gggcaatgag aatgtagagt gtaatgtgca aaagcaggac tagcagttgc tttgaagata
     8461 tctggggaag gccgggcacg gtggttcacg cctgtaatcc cagtactttg ggaggccaag
     8521 gtgggcggat cacgaggtca ggagatcgag accatcctgg ctaacgtgaa accccgtcta
     8581 tactaaaaat acaaaaaatt aaccggacgc agtggtgggc gcctgtagtc ccagctactc
     8641 gggaggctga ggcaggagag tggcatgaac ccgggaggcg gagcttgcag tgagctgaga
     8701 tcgcaccact gcattccagc ctggacaaca gagcgaaact ccgtctcaaa aaccaaccaa
     8761 acaaaaaaca aaaattagct gggcatggtg gcgcgtgcct gtaatcccag cactttggga
     8821 gccaaggtgg gtggatcatg aggtcagaag attgagacca ccctggccaa catggtgaaa
     8881 tcctgtctct actaaaaata caaaaaaaaa aaaaaaaaaa aaaattagcc gggcgtggtg
     8941 gcgcgtgcct gtaatcccag ctacacagga ggctgaggca ggagatttgc ttgaacctgg
     9001 gaggcggagg ttgcagtgag ccgagattgt gccactgcac tccagcctgg gcgacagagc
     9061 aagactccgt ctaaaaaaaa aaaaaagata ttaaaattaa tgacaggaag agtttgggtt
     9121 cagttataat ttaagggaaa aaacattgag gggcctaatc tacattttgc tccggatcca
     9181 atgatttaat ttttgggaag aaaaatccag tgattaaagt catgcaagga gatggcctgg
     9241 ggcttgctaa aagtcaggtt gcagtttcca ttgcattcaa gaaaatcaga aaaataaata
     9301 caacttttag aagaaactaa gttttctccc attcatgttt agctattggg gggtctcata
     9361 cttctggact tgcttagacc tatgctatct aatatggtag cctctgccca tccatatgtg
     9421 gccactgaga acttgaaatg tgactagttt gaattaagat gtgctgtaac taaaatacac
     9481 cctggatttc aaagacttaa taaataatgt aaattatcta ttctttcctg ttgattatat
     9541 attgaaatga taatattttg gatatgtttg ggttaaataa aatatattac taaaagtaa
//
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