LOCUS NM_004688 1501 bp mRNA linear PRI 04-MAY-2019
DEFINITION Homo sapiens N-myc and STAT interactor (NMI), mRNA.
ACCESSION NM_004688
VERSION NM_004688.2
KEYWORDS RefSeq; RefSeq Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1501)
AUTHORS Yu F, Tian T, Deng B, Wang T, Qi Q, Zhu M, Yan C, Ding H, Wang J,
Dai J, Ma H, Ding Y and Jin G.
TITLE Multi-marker analysis of genomic annotation on gastric cancer GWAS
data from Chinese populations
JOURNAL Gastric Cancer 22 (1), 60-68 (2019)
PUBMED 29859005
REMARK GeneRIF: NMI and RAC1 might represent two new key genes related to
gastric cancer
REFERENCE 2 (bases 1 to 1501)
AUTHORS Pruitt HC, Metge BJ, Weeks SE, Chen D, Wei S, Kesterson RA, Shevde
LA and Samant RS.
TITLE Conditional knockout of N-Myc and STAT interactor disrupts normal
mammary development and enhances metastatic ability of mammary
tumors
JOURNAL Oncogene 37 (12), 1610-1623 (2018)
PUBMED 29326438
REMARK GeneRIF: Nmi has a distinct role in the differentiation process of
mammary luminal epithelial cell compartment and developmental
aberrations resulting from Nmi absence contribute to metastasis.
REFERENCE 3 (bases 1 to 1501)
AUTHORS Song D, Zhao J, Su C, Jiang Y and Hou J.
TITLE Etoposide induced NMI promotes cell apoptosis by activating the
ARF-p53 signaling pathway in lung carcinoma
JOURNAL Biochem. Biophys. Res. Commun. 495 (1), 368-374 (2018)
PUBMED 29030066
REMARK GeneRIF: These investigations demonstrated etoposide-induced NMI
can suppress tumor proliferation and promote cell apoptosis by
activating the ARF-p53 signaling pathway in lung carcinoma. Our
results provide an alternative mechanism for etoposide in lung
carcinoma and suggest NMI has a critical role in suppressing lung
carcinoma progression.
REFERENCE 4 (bases 1 to 1501)
AUTHORS Xiahou Z, Wang X, Shen J, Zhu X, Xu F, Hu R, Guo D, Li H, Tian Y,
Liu Y and Liang H.
TITLE NMI and IFP35 serve as proinflammatory DAMPs during cellular
infection and injury
JOURNAL Nat Commun 8 (1), 950 (2017)
PUBMED 29038465
REMARK GeneRIF: Damage-associated molecular patterns (DAMP) are important
mediators of innate immunity. Here the authors show that N-myc and
STAT interactor (NMI) and interferon-induced protein 35 (IFP35) act
as DAMPs to promote inflammation by activating macrophages via the
Toll-like receptor 4 and NF-kappaB pathways.
Publication Status: Online-Only
REFERENCE 5 (bases 1 to 1501)
AUTHORS Wang J, Zou K, Feng X, Chen M, Li C, Tang R, Xuan Y, Luo M, Chen W,
Qiu H, Qin G, Li Y, Zhang C, Xiao B, Kang L, Kang T, Huang W, Yu X,
Wu X and Deng W.
TITLE Downregulation of NMI promotes tumor growth and predicts poor
prognosis in human lung adenocarcinomas
JOURNAL Mol. Cancer 16 (1), 158 (2017)
PUBMED 29025423
REMARK GeneRIF: Our study showed that NMI suppressed tumor growth by
inhibiting PI3K/AKT, MMP2/MMP9, COX-2/PGE2 signaling pathways and
p300-mediated NF-kappaB acetylation, and predicted a favorable
prognosis in human lung adenocarcinomas, suggesting that NMI was a
potential tumor suppressor in lung cancer.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 1501)
AUTHORS Bannasch D, Weis I and Schwab M.
TITLE Nmi protein interacts with regions that differ between MycN and Myc
and is localized in the cytoplasm of neuroblastoma cells in
contrast to nuclear MycN
JOURNAL Oncogene 18 (48), 6810-6817 (1999)
PUBMED 10597290
REFERENCE 7 (bases 1 to 1501)
AUTHORS Lee ND, Chen J, Shpall RL and Naumovski L.
TITLE Subcellular localization of interferon-inducible
Myc/stat-interacting protein Nmi is regulated by a novel IFP 35
homologous domain
JOURNAL J. Interferon Cytokine Res. 19 (11), 1245-1252 (1999)
PUBMED 10574616
REFERENCE 8 (bases 1 to 1501)
AUTHORS Zhu M, John S, Berg M and Leonard WJ.
TITLE Functional association of Nmi with Stat5 and Stat1 in IL-2- and
IFNgamma-mediated signaling
JOURNAL Cell 96 (1), 121-130 (1999)
PUBMED 9989503
REFERENCE 9 (bases 1 to 1501)
AUTHORS Lebrun SJ, Shpall RL and Naumovski L.
TITLE Interferon-induced upregulation and cytoplasmic localization of
Myc-interacting protein Nmi
JOURNAL J. Interferon Cytokine Res. 18 (9), 767-771 (1998)
PUBMED 9781816
REFERENCE 10 (bases 1 to 1501)
AUTHORS Bao J and Zervos AS.
TITLE Isolation and characterization of Nmi, a novel partner of Myc
proteins
JOURNAL Oncogene 12 (10), 2171-2176 (1996)
PUBMED 8668343
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from CB151555.1, BC001268.1 and
BC021987.2.
[WARNING] On May 17, 2019 this sequence was replaced by
NM_004688.3.
On May 15, 2008 this sequence version replaced NM_004688.1.
Summary: NMYC interactor (NMI) encodes a protein that interacts
with NMYC and CMYC (two members of the oncogene Myc family), and
other transcription factors containing a Zip, HLH, or HLH-Zip
motif. The NMI protein also interacts with all STATs except STAT2
and augments STAT-mediated transcription in response to cytokines
IL2 and IFN-gamma. The NMI mRNA has low expression levels in all
human fetal and adult tissues tested except brain and has high
expression in cancer cell line-myeloid leukemias. [provided by
RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC001268.1, AK291548.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
SAMEA1965299, SAMEA1966682
[ECO:0000350]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression,
longest protein
##RefSeq-Attributes-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-280 CB151555.1 1-280
281-596 BC001268.1 1-316
597-831 BC021987.2 273-507
832-1501 BC001268.1 552-1221
FEATURES Location/Qualifiers
source 1..1501
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2q23.3"
gene 1..1501
/gene="NMI"
/note="N-myc and STAT interactor"
/db_xref="GeneID:9111"
/db_xref="HGNC:HGNC:7854"
/db_xref="MIM:603525"
exon 1..324
/gene="NMI"
/inference="alignment:Splign:2.1.0"
exon 325..411
/gene="NMI"
/inference="alignment:Splign:2.1.0"
CDS 331..1254
/gene="NMI"
/codon_start=1
/product="N-myc-interactor"
/protein_id="NP_004679.2"
/db_xref="CCDS:CCDS2192.1"
/db_xref="GeneID:9111"
/db_xref="HGNC:HGNC:7854"
/db_xref="MIM:603525"
/translation="MEADKDDTQQILKEHSPDEFIKDEQNKGLIDEITKKNIQLKKEI
QKLETELQEATKEFQIKEDIPETKMKFLSVETPENDSQLSNISCSFQVSSKVPYEIQK
GQALITFEKEEVAQNVVSMSKHHVQIKDVNLEVTAKPVPLNSGVRFQVYVEVSKMKIN
VTEIPDTLREDQMRDKLELSFSKSRNGGGEVDRVDYDRQSGSAVITFVEIGVADKILK
KKEYPLYINQTCHRVTVSPYTEIHLKKYQIFSGTSKRTVLLTGMEGIQMDEEIVEDLI
NIHFQRAKNGGGEVDVVKCSLGQPHIAYFEE"
misc_feature 376..378
/gene="NMI"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:23186163};
propagated from UniProtKB/Swiss-Prot (Q13287.2);
phosphorylation site"
exon 412..507
/gene="NMI"
/inference="alignment:Splign:2.1.0"
exon 508..670
/gene="NMI"
/inference="alignment:Splign:2.1.0"
exon 671..777
/gene="NMI"
/inference="alignment:Splign:2.1.0"
exon 778..964
/gene="NMI"
/inference="alignment:Splign:2.1.0"
exon 965..1071
/gene="NMI"
/inference="alignment:Splign:2.1.0"
exon 1072..1479
/gene="NMI"
/inference="alignment:Splign:2.1.0"
regulatory 1458..1463
/regulatory_class="polyA_signal_sequence"
/gene="NMI"
polyA_site 1479
/gene="NMI"
ORIGIN
1 ctgttagtga ctaatcattg gagacaacca tgtttagtat ttgagcattg gttaaatgct
61 aaagaaaaat cgccgttaaa gcagttttct ttttcactgt ctttttcttt tcgcggggaa
121 cccagctgtt cctgcgaggg ccacctcctc aggaagaccc cgcagctctc ccgcggcgct
181 tctgcaggag gcagcgacag tttcgagaac ccgggccttc ccctcccagt gcctcccggg
241 gttccggcgt ttcaggcgct gctgttttcc gggaagggca ggcgcgctgg gccttgggga
301 gctgcgctcg gcgggcggac gcgggggatc atggaagctg ataaagatga cacacaacaa
361 attcttaagg agcattcgcc agatgaattt ataaaagatg aacaaaataa gggactaatt
421 gatgaaatta caaagaaaaa tattcaacta aagaaggaga tccaaaagct tgaaacggag
481 ttacaagagg ctaccaaaga attccagatt aaagaggata ttcctgaaac aaagatgaaa
541 ttcttatcag ttgaaactcc tgagaatgac agccagttgt caaatatctc ctgttcgttt
601 caagtgagct cgaaagttcc ttatgagata caaaaaggac aagcacttat cacctttgaa
661 aaagaagaag ttgctcaaaa tgtggtaagc atgagtaaac atcatgtaca gataaaagat
721 gtaaatctgg aggttacggc caagccagtt ccattaaatt caggagtcag attccaggtt
781 tatgtagaag tttctaaaat gaaaatcaat gttactgaaa ttcctgacac attgcgtgaa
841 gatcaaatga gagacaaact agagctgagc ttttcaaagt cccgaaatgg aggcggagag
901 gtggaccgcg tggactatga cagacagtcc gggagtgcag tcatcacgtt tgtggagatt
961 ggagtggctg acaagatttt gaaaaagaaa gaataccctc tttatataaa tcaaacctgc
1021 catagagtta ctgtttctcc atacacagaa atacacttga aaaagtatca gatattttca
1081 ggaacatcta agaggacagt gcttctgaca ggaatggaag gcattcaaat ggatgaagaa
1141 attgtggagg atttaattaa cattcacttt caacgggcaa agaatggagg tggagaagta
1201 gatgtggtca agtgttctct aggtcaacct cacatagcat actttgaaga atagacttaa
1261 cagaatcatg aaaactatag ctttttaacc cggattactg taaatgtttg acaaaaatga
1321 atatgctttt ccttaaaaaa tgaaaacttt aatttttacc atccatttat gtttagatac
1381 aaaacttatt tccatgtttc tgaatcttct ttgtttcaaa tggtgctgca tgttttcaac
1441 tacaataagt gcactgtaat aaaaagtttt gtttatagaa aaaaaaaaaa aaaaaaaaaa
1501 a
//