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Homo sapiens crooked neck pre-mRNA splicing factor 1 (CRNKL1), transcript variant 1, mRNA

NCBI Reference Sequence: NM_016652.6

FASTA Graphics 

LOCUS       NM_016652               4406 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens crooked neck pre-mRNA splicing factor 1 (CRNKL1),
            transcript variant 1, mRNA.
ACCESSION   NM_016652
VERSION     NM_016652.6
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4406)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4406)
  AUTHORS   Xiao,H., Wyler,E., Milek,M., Grewe,B., Kirchner,P., Ekici,A.,
            Silva,A.B.O.V., Jungnickl,D., Full,F., Thomas,M., Landthaler,M.,
            Ensser,A. and Uberla,K.
  TITLE     CRNKL1 Is a Highly Selective Regulator of Intron-Retaining HIV-1
            and Cellular mRNAs
  JOURNAL   mBio 12 (1), e02525-20 (2021)
   PUBMED   33468685
  REMARK    GeneRIF: CRNKL1 Is a Highly Selective Regulator of Intron-Retaining
            HIV-1 and Cellular mRNAs.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4406)
  AUTHORS   Bertram,K., Agafonov,D.E., Liu,W.T., Dybkov,O., Will,C.L.,
            Hartmuth,K., Urlaub,H., Kastner,B., Stark,H. and Luhrmann,R.
  TITLE     Cryo-EM structure of a human spliceosome activated for step 2 of
            splicing
  JOURNAL   Nature 542 (7641), 318-323 (2017)
   PUBMED   28076346
REFERENCE   4  (bases 1 to 4406)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 4406)
  AUTHORS   Hegele,A., Kamburov,A., Grossmann,A., Sourlis,C., Wowro,S.,
            Weimann,M., Will,C.L., Pena,V., Luhrmann,R. and Stelzl,U.
  TITLE     Dynamic protein-protein interaction wiring of the human spliceosome
  JOURNAL   Mol Cell 45 (4), 567-580 (2012)
   PUBMED   22365833
REFERENCE   6  (bases 1 to 4406)
  AUTHORS   Hillman,R.T., Green,R.E. and Brenner,S.E.
  TITLE     An unappreciated role for RNA surveillance
  JOURNAL   Genome Biol 5 (2), R8 (2004)
   PUBMED   14759258
REFERENCE   7  (bases 1 to 4406)
  AUTHORS   Chung,S., Zhou,Z., Huddleston,K.A., Harrison,D.A., Reed,R.,
            Coleman,T.A. and Rymond,B.C.
  TITLE     Crooked neck is a component of the human spliceosome and implicated
            in the splicing process
  JOURNAL   Biochim Biophys Acta 1576 (3), 287-297 (2002)
   PUBMED   12084575
  REMARK    GeneRIF: Data show that crooked neck activity appears essential as
            extracts depleted of hcrn fail to splice pre-mRNA. These and
            related data support the view that crooked neck is a
            phylogenetically conserved pre-mRNA splicing factor.
REFERENCE   8  (bases 1 to 4406)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   9  (bases 1 to 4406)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   10 (bases 1 to 4406)
  AUTHORS   Lai,C.H., Chiu,J.Y. and Lin,W.
  TITLE     Identification of the human crooked neck gene by comparative gene
            identification
  JOURNAL   Biochim Biophys Acta 1517 (3), 449-454 (2001)
   PUBMED   11342225
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF318303.1, AL035454.18,
            BC144222.1, AL832435.1 and AA255987.1.
            
            On Aug 13, 2020 this sequence version replaced NM_016652.5.
            
            Summary: The crooked neck (crn) gene of Drosophila is essential for
            embryogenesis and is thought to be involved in cell cycle
            progression and pre-mRNA splicing. A protein encoded by this human
            locus has been found to localize to pre-mRNA splicing complexes in
            the nucleus and is necessary for pre-mRNA splicing. Alternatively
            spliced transcript variants have been described. [provided by
            RefSeq, Jul 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF318303.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               AF318303.1         1-121
            122-135             AL035454.18        34048-34061         c
            136-614             AF318303.1         136-614
            615-671             BC144222.1         575-631
            672-3288            AF318303.1         672-3288
            3289-4225           AL832435.1         2898-3834
            4226-4406           AA255987.1         13-193              c
FEATURES             Location/Qualifiers
     source          1..4406
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p11.23"
     gene            1..4406
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /note="crooked neck pre-mRNA splicing factor 1"
                     /db_xref="GeneID:51340"
                     /db_xref="HGNC:HGNC:15762"
                     /db_xref="MIM:610952"
     exon            1..99
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..2579
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /note="isoform a is encoded by transcript variant 1;
                     crooked neck-like 1; crooked neck-like protein 1; crooked
                     neck homolog; Crn, crooked neck-like 1; SYF3
                     pre-mRNA-splicing factor; crooked neck pre-mRNA splicing
                     factor-like 1"
                     /codon_start=1
                     /product="crooked neck-like protein 1 isoform a"
                     /protein_id="NP_057736.4"
                     /db_xref="CCDS:CCDS33446.1"
                     /db_xref="GeneID:51340"
                     /db_xref="HGNC:HGNC:15762"
                     /db_xref="MIM:610952"
                     /translation="MTATVENLTFQKDTLGNAVDKNTSRLELRSYSLAGRHGSTEPLV
                     LAWSSQFRRLTWGCALDALHRSPCVAASQHGVTHLIRSSRTPHSTRCRKEDAQPGHHG
                     NGAASVTAQARGQRSVLQVPLPVPRSCLFSESFVVSVSSQSRFLASVPGTGVQRSTAA
                     DMAASTAAGKQRIPKVAKVKNKAPAEVQITAEQLLREAKERELELLPPPPQQKITDEE
                     ELNDYKLRKRKTFEDNIRKNRTVISNWIKYAQWEESLKEIQRARSIYERALDVDYRNI
                     TLWLKYAEMEMKNRQVNHARNIWDRAITTLPRVNQFWYKYTYMEEMLGNVAGARQVFE
                     RWMEWQPEEQAWHSYINFELRYKEVDRARTIYERFVLVHPDVKNWIKYARFEEKHAYF
                     AHARKVYERAVEFFGDEHMDEHLYVAFAKFEENQKEFERVRVIYKYALDRISKQDAQE
                     LFKNYTIFEKKFGDRRGIEDIIVSKRRFQYEEEVKANPHNYDAWFDYLRLVESDAEAE
                     AVREVYERAIANVPPIQEKRHWKRYIYLWINYALYEELEAKDPERTRQVYQASLELIP
                     HKKFTFAKMWILYAQFEIRQKNLSLARRALGTSIGKCPKNKLFKVYIELELQLREFDR
                     CRKLYEKFLEFGPENCTSWIKFAELETILGDIDRARAIYELAISQPRLDMPEVLWKSY
                     IDFEIEQEETERTRNLYRRLLQRTQHVKVWISFAQFELSSGKEGSLTKCRQIYEEANK
                     TMRNCEEKEERLMLLESWRSFEEEFGTASDKERVDKLMPEKVKKRRKVQTDDGSDAGW
                     EEYFDYIFPEDAANQPNLKLLAMAKLWKKQQQEKEDAEHHPDEDVDESES"
     misc_feature    36..38
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /note="N-acetylalanine.
                     /evidence=ECO:0007744|PubMed:22814378; propagated from
                     UniProtKB/Swiss-Prot (Q9BZJ0.4); acetylation site"
     misc_feature    273..350
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BZJ0.4);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    696..794
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BZJ0.4);
                     Region: HAT 1"
     misc_feature    798..896
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BZJ0.4);
                     Region: HAT 2"
     misc_feature    900..998
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BZJ0.4);
                     Region: HAT 3"
     misc_feature    1002..1097
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BZJ0.4);
                     Region: HAT 4"
     misc_feature    1101..1196
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BZJ0.4);
                     Region: HAT 5"
     misc_feature    1200..1307
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BZJ0.4);
                     Region: HAT 6"
     misc_feature    1263..1916
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BZJ0.4);
                     Region: Mediates interaction with HSP90.
                     /evidence=ECO:0000250|UniProtKB:P63154"
     misc_feature    1539..1541
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q9BZJ0.4); phosphorylation site"
     misc_feature    1890..1988
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BZJ0.4);
                     Region: HAT 12"
     misc_feature    1992..2096
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BZJ0.4);
                     Region: HAT 13"
     misc_feature    2100..2195
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BZJ0.4);
                     Region: HAT 14"
     misc_feature    2208..2333
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BZJ0.4);
                     Region: HAT 15"
     misc_feature    2337..2453
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BZJ0.4);
                     Region: HAT 16"
     misc_feature    2457..2534
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BZJ0.4);
                     Region: HAT 17"
     misc_feature    2511..2576
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BZJ0.4);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            100..566
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /inference="alignment:Splign:2.1.0"
     exon            567..719
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /inference="alignment:Splign:2.1.0"
     exon            720..811
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /inference="alignment:Splign:2.1.0"
     exon            812..970
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1137
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1316
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1487
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1679
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1739
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1820
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..2060
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2162
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /inference="alignment:Splign:2.1.0"
     exon            2163..2411
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /inference="alignment:Splign:2.1.0"
     exon            2412..4406
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2613..2618
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /note="hexamer: TATAAA"
     polyA_site      2632
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /note="major polyA site"
     regulatory      3408..3413
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /note="hexamer: CATAAA"
     polyA_site      3429
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
     regulatory      3967..3972
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /note="hexamer: AATAAA"
     polyA_site      3997
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
     regulatory      4378..4383
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /note="hexamer: AGTAAA"
     polyA_site      4406
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
ORIGIN      
        1 ctttccgaca ctctttggga agagaatctc taatgacggc aacagtggag aacctaacgt
       61 tccagaagga cactttggga aatgctgttg acaaaaacac atccagattg gagctccgtt
      121 cttactccct tgcagggcgc cacggctcga cagagccact cgtcctcgcc tggtcatccc
      181 agttccggag gctgacctgg ggatgcgccc tggacgccct gcaccgcagt ccttgcgtcg
      241 ctgctagtca gcacggcgtt acccacctca tccgcagctc caggacgccg cactccacgc
      301 gctgccgcaa ggaggacgcg cagcctggtc accatggaaa cggtgccgcc tccgtcacgg
      361 ctcaagcgag aggtcaaagg tcagtcctgc aagttccgct tccggttccg agatcctgtt
      421 tgttttctga aagctttgtg gtttcggtga gctctcagag ccgatttcta gcgtccgtgc
      481 cggggacagg tgtccagagg tcgactgctg cagacatggc ggcctccacc gcggccggga
      541 agcagcggat tcccaaagtg gccaaggtga aaaacaaagc cccggctgag gtacagataa
      601 ctgctgaaca actcttaaga gaggctaaag aaagagaact tgagcttctt ccacctccac
      661 ctcaacagaa gatcacagat gaagaagaat taaatgatta taaactaagg aaaaggaaga
      721 cttttgaaga taatataaga aaaaacagga ctgtgattag taactggata aaatacgcac
      781 aatgggaaga aagcctaaag gagattcaaa gggctcgatc catatacgag cgtgctttag
      841 atgtagacta ccgaaatatt acactctggc tgaaatacgc agaaatggaa atgaagaatc
      901 gccaagtcaa ccatgctcga aatatctggg accgggccat aacaacgctg cctcgagtta
      961 atcagttctg gtacaagtac acgtacatgg aggaaatgtt gggaaacgtt gccggtgccc
     1021 ggcaggtgtt tgagcgctgg atggagtggc agcctgagga gcaagcctgg cactcctaca
     1081 tcaactttga gctgagatac aaagaggtgg atcgggcccg caccatttat gagcgatttg
     1141 tcctcgtgca ccctgatgtt aagaactgga tcaagtatgc ccgctttgaa gaaaaacatg
     1201 cttattttgc ccatgcacgg aaagtgtatg agagagctgt ggaattcttt ggagatgaac
     1261 atatggatga gcacctttat gttgcctttg ccaagtttga agaaaatcag aaagagtttg
     1321 aaagggtacg agtgatttac aagtatgccc tggacagaat ttcaaaacaa gatgcccaag
     1381 aactctttaa aaattatacc atctttgaga agaagtttgg tgataggcgg ggtattgaag
     1441 atatcattgt gagcaaacgg agattccagt acgaagaaga agtgaaggcg aatccacaca
     1501 attatgatgc atggtttgat tacttgcgct tggtagaaag tgacgcagaa gctgaagccg
     1561 tgagagaagt ctatgaaagg gccattgcca atgtcccacc cattcaggag aagaggcact
     1621 ggaagcgcta catttatctt tggatcaact atgcactcta tgaagaattg gaggcaaagg
     1681 atcctgagag gacaagacag gtgtatcaag cctctttgga actaattcct cacaaaaagt
     1741 tcacatttgc caaaatgtgg atactgtatg cacagtttga aatacgacag aagaatctgt
     1801 cattagccag aagagcattg ggaacttcca taggcaaatg tccaaagaac aaattattta
     1861 aagtttacat agaattggag ctacagcttc gagaatttga cagatgccgg aagctttatg
     1921 aaaagttcct ggaatttgga cctgaaaatt gtacctcatg gattaaattc gctgaattag
     1981 agacaatcct tggtgatatt gacagagcac gggcaatcta tgaattagcc atcagtcagc
     2041 cacgtttaga catgccagag gtgctttgga aatcatatat tgattttgaa attgagcagg
     2101 aagaaacaga aagaacacga aacctttacc ggcggttgct tcaacggacg cagcatgtca
     2161 aggtatggat cagctttgct cagtttgagt tgtcttcagg aaaagaagga agtttgacta
     2221 aatgcagaca aatttatgaa gaagctaaca aaaccatgcg aaactgtgaa gaaaaggaag
     2281 agagacttat gctgctggaa tcttggcgaa gttttgaaga agaatttgga acagcttcag
     2341 ataaggagag agtagacaaa ctcatgccag agaaagtcaa gaagagaaga aaggtccaga
     2401 ctgatgatgg gtctgatgca ggctgggaag aatactttga ttacatcttt ccagaagatg
     2461 ctgccaacca acctaacctc aaactcctgg ccatggccaa actgtggaag aaacagcagc
     2521 aggaaaagga ggatgctgag caccatccag atgaggacgt cgatgagagt gaatcctgat
     2581 ctttttttca tagacaaatg ttttgttatt tttataaatt aattgtttgg aactcttgtg
     2641 actcctggaa gttcttatat atttcaccag taagaaattg attggtatct ttgatggcta
     2701 ctttttaagt tattttttaa atgctcttgg gttagctagg ggtagggatt gcaagtaaag
     2761 gactttttta actgctggat ttgtttttcc aactgagtcc aaacttttct aatgtctgtc
     2821 cacatcatgc attaggaaat gtaattaagg taacattcta cagttacttt tcatgtcata
     2881 cccataaaga tagtttatgc attcatctga aatgtgtaac tttttcatgt cttcagagtc
     2941 acagacttga gttcatttcc cagctctgcc actcatgatt atataactta attttcattt
     3001 tcctcattca caaaatgggc caatagtttg acagctcatt ttgaagatta cattataaaa
     3061 ggaatatacc tggtgggtgc atagtaagtg ctcagtaaat tgtttgttct aagccacttt
     3121 taaaaatggt ttcattcctt gtagaattga atgcgagtgg attaataatt taccttactt
     3181 tcttactagt gtccagttat attgtttttt agaacaacac ttggaaaata atttgcagtg
     3241 attatatttc tgaacaaggt tcagaaaaca ttgtttacta agaatttagt ctaataattt
     3301 cagttaggcg ctcatcagtt ctccagagtg gttgagtttg taataccttg tttaaagaat
     3361 aatggcttgt tcacgtgtgt gctatgaaaa atgatgtccc atgttcacat aaatttggga
     3421 aattctggac taagacttaa gtctcgttaa tcaaatctct ttatagttag gcttctgtac
     3481 attatgtatc tccagtagca atgttgccat attatttatt tcccaaactt agtggacaat
     3541 ggagtcattt ctacctagag taccagtaaa catctcccag tgtgctatag tagaaaatgt
     3601 ctactcctca ctgctgacat gttaaactta ctcttggttt agagcatgtg tagaaacacc
     3661 taaggtagct ctatgctaaa taatgaagag tagcacaaga atgaatgtat ttgctgatac
     3721 gttgctcaca ttctcaagca aaaattcaac tgcattaacc gatctgagag ttttccttta
     3781 acctggactg tgtttctcaa gcacattttt tctttgttca ctgcccaagg actagaactg
     3841 tatttttaag gttgttttcc cctaaaagga cctttagtaa gcaaatttat tattaaatgt
     3901 gcacatctta ttcacccaag ggaataaaag ctacttcgta atgttgttac taaattttat
     3961 cttgaaaata aataacagtg tttgaggaca gaagaaacta ggactgttgt tgagataaaa
     4021 tctgttttca gcctgactgc tttagtcact ggacgagcat cagctactgc ggtgtcagat
     4081 cacttctcga gtagaggtct gcctagtgag tgagcaggag aacatcatct taatagcctt
     4141 tggctcaccc agagtcaggg agagatgaaa ataataggtc agaatgcaag tgacttaatc
     4201 acagtcttcc tagaattatc tgtttatgtt gcatgaatgc ataagaaaaa aattctgtca
     4261 tgttcccaag gtagaattgt aataagcatg tgccagtgtg aaagctggaa ggaaaaaagc
     4321 tattctctaa caggagaaca taaagattca tttctctccc accctcaact ccaccaaagt
     4381 aaatcctttc gatagtaaaa gtttaa
//
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