LOCUS NM_001302082 1775 bp mRNA linear PRI 10-JUN-2024
DEFINITION Homo sapiens BEN domain containing 5 (BEND5), transcript variant 2,
mRNA.
ACCESSION NM_001302082 XM_005271199
VERSION NM_001302082.2
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1775)
AUTHORS Shi,Y., Zhang,D., Chen,J., Jiang,Q., Song,S., Mi,Y., Wang,T. and
Ye,Q.
TITLE Interaction between BEND5 and RBPJ suppresses breast cancer growth
and metastasis via inhibiting Notch signaling
JOURNAL Int J Biol Sci 18 (10), 4233-4244 (2022)
PUBMED 35844785
REMARK GeneRIF: Interaction between BEND5 and RBPJ suppresses breast
cancer growth and metastasis via inhibiting Notch signaling.
Publication Status: Online-Only
REFERENCE 2 (bases 1 to 1775)
AUTHORS Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
TITLE A reference map of the human binary protein interactome
JOURNAL Nature 580 (7803), 402-408 (2020)
PUBMED 32296183
REFERENCE 3 (bases 1 to 1775)
AUTHORS Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
and Yu,H.
TITLE An interactome perturbation framework prioritizes damaging missense
mutations for developmental disorders
JOURNAL Nat Genet 50 (7), 1032-1040 (2018)
PUBMED 29892012
REFERENCE 4 (bases 1 to 1775)
AUTHORS Corominas,R., Yang,X., Lin,G.N., Kang,S., Shen,Y., Ghamsari,L.,
Broly,M., Rodriguez,M., Tam,S., Wanamaker,S.A., Fan,C., Yi,S.,
Tasan,M., Lemmens,I., Kuang,X., Zhao,N., Malhotra,D.,
Michaelson,J.J., Vacic,V., Calderwood,M.A., Roth,F.P.,
Tavernier,J., Horvath,S., Salehi-Ashtiani,K., Korkin,D., Sebat,J.,
Hill,D.E., Hao,T., Vidal,M. and Iakoucheva,L.M.
TITLE Protein interaction network of alternatively spliced isoforms from
brain links genetic risk factors for autism
JOURNAL Nat Commun 5, 3650 (2014)
PUBMED 24722188
REMARK Erratum:[Nat Commun. 2023 Feb 2;14(1):569. doi:
10.1038/s41467-023-36264-y. PMID: 36732511]
Publication Status: Online-Only
REFERENCE 5 (bases 1 to 1775)
AUTHORS Dai,Q., Ren,A., Westholm,J.O., Serganov,A.A., Patel,D.J. and
Lai,E.C.
TITLE The BEN domain is a novel sequence-specific DNA-binding domain
conserved in neural transcriptional repressors
JOURNAL Genes Dev 27 (6), 602-614 (2013)
PUBMED 23468431
REFERENCE 6 (bases 1 to 1775)
AUTHORS Wistow,G., Bernstein,S.L., Ray,S., Wyatt,M.K., Behal,A.,
Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
TITLE Expressed sequence tag analysis of adult human iris for the NEIBank
Project: steroid-response factors and similarities with retinal
pigment epithelium
JOURNAL Mol Vis 8, 185-195 (2002)
PUBMED 12107412
REMARK Publication Status: Online-Only
REFERENCE 7 (bases 1 to 1775)
AUTHORS Bussow,K., Cahill,D., Nietfeld,W., Bancroft,D., Scherzinger,E.,
Lehrach,H. and Walter,G.
TITLE A method for global protein expression and antibody screening on
high-density filters of an arrayed cDNA library
JOURNAL Nucleic Acids Res 26 (21), 5007-5008 (1998)
PUBMED 9776767
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BC007932.2, AK021650.1, CD579580.2, BX096297.1 and AC097062.2.
On Aug 13, 2020 this sequence version replaced NM_001302082.1.
Transcript Variant: This variant (2) uses an alternate splice site
at an internal exon, and initiates translation at a downstream
start codon, compared to variant 1. The encoded isoform (2) has a
shorter N-terminus compared to isoform 1. Variants 2, 3, and 4 all
encode the same isoform (2).
##Evidence-Data-START##
Transcript exon combination :: KU178777.1, AK021650.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA1970526, SAMEA2153031
[ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-60 BC007932.2 31-90
61-874 AK021650.1 1-814
875-875 CD579580.2 696-696
876-1423 BC007932.2 824-1371
1424-1571 BX096297.1 46-193
1572-1572 AC097062.2 48673-48673 c
1573-1771 BX096297.1 195-393
1772-1775 AC097062.2 48470-48473 c
FEATURES Location/Qualifiers
source 1..1775
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1p33"
gene 1..1775
/gene="BEND5"
/gene_synonym="C1orf165"
/note="BEN domain containing 5"
/db_xref="GeneID:79656"
/db_xref="HGNC:HGNC:25668"
exon 1..286
/gene="BEND5"
/gene_synonym="C1orf165"
/inference="alignment:Splign:2.1.0"
exon 287..420
/gene="BEND5"
/gene_synonym="C1orf165"
/inference="alignment:Splign:2.1.0"
exon 421..887
/gene="BEND5"
/gene_synonym="C1orf165"
/inference="alignment:Splign:2.1.0"
misc_feature 476..478
/gene="BEND5"
/gene_synonym="C1orf165"
/note="upstream in-frame stop codon"
CDS 650..1408
/gene="BEND5"
/gene_synonym="C1orf165"
/note="isoform 2 is encoded by transcript variant 2; BEN
domain-containing protein 5"
/codon_start=1
/product="BEN domain-containing protein 5 isoform 2"
/protein_id="NP_001289011.1"
/db_xref="GeneID:79656"
/db_xref="HGNC:HGNC:25668"
/translation="MDSLEDAVVPRALYEELLRNYQQQQEEMRHLQQELERTRRQLVQ
QAKKLKEYGALVSEMKELRDLNRRLQDVLLLRLGSGPAIDLEKVKSECLEPEPELRST
FSEEANTSSYYPAPAPVMDKYILDNGKVHLGSGIWVDEEKWHQLQVTQGDSKYTKNLA
VMIWGTDVLKNRSVTGVATKKKKDAVPKPPLSPHKLSIVRECLYDRIAQETVDETEIA
QRLSKVNKYICEKIMDINKSCKNEERREAKYNLQ"
exon 888..1036
/gene="BEND5"
/gene_synonym="C1orf165"
/inference="alignment:Splign:2.1.0"
exon 1037..1250
/gene="BEND5"
/gene_synonym="C1orf165"
/inference="alignment:Splign:2.1.0"
exon 1251..1775
/gene="BEND5"
/gene_synonym="C1orf165"
/inference="alignment:Splign:2.1.0"
regulatory 1404..1409
/regulatory_class="polyA_signal_sequence"
/gene="BEND5"
/gene_synonym="C1orf165"
/note="hexamer: AATAAA"
polyA_site 1427
/gene="BEND5"
/gene_synonym="C1orf165"
/note="major polyA site"
regulatory 1748..1753
/regulatory_class="polyA_signal_sequence"
/gene="BEND5"
/gene_synonym="C1orf165"
/note="hexamer: AATAAA"
polyA_site 1775
/gene="BEND5"
/gene_synonym="C1orf165"
ORIGIN
1 acctccgcgc ccgccccgcg ggctgagctg cccgaccggg gcccgccccc ggcgcccacc
61 atgtacgcct ttgtgcggtt cctggaggac aacgtctgct acgcgctgcc cgtgtcgtgc
121 gtgcgcgact tcagcccccg ctcgcggctg gattttgaca accagaaggt gtacgccgtg
181 taccggggcc cggaggaatt gggcgccggg cccgagagcc ccccgcgcgc cccccgcgac
241 tggggcgcgc tgttgctcca caaggcccag atcctggcgc tggcagaaga caaatctgac
301 cttgaaaaca gtgtgatgca gaagaaaata aaaatcccca agctttctct taatcatgta
361 gaagaagatg gagaggttaa agattatggg gaagaagatt tacagcttag acacatcaag
421 gattgtctgg ggaaatattg atctgcagtc caagaaaatc ccagctgccc ttgcctgaac
481 tgattctcgt tgtcctacac agagacctga ggggcggaag ccgagcgaag tggcgcacaa
541 gagcatcgag gcagtggtgg ctcggctaga gaagcagaac ggcctgagcc tgggccatag
601 cacgtgtccg gaagaggtct tcgtggaggc ctcgccaggc acagaggaca tggacagtct
661 agaagatgct gtggtgcccc gggctctgta tgaggagctg ctgcgcaact accagcagca
721 acaggaagag atgcgccacc tccagcagga gctggagcgg actcggaggc agctggtaca
781 acaggccaag aagctcaagg agtacggggc acttgtgtct gaaatgaagg agctccgtga
841 ccttaaccgg aggctccagg acgtgctgct cctgcggctt ggcagcggtc ccgccattga
901 tctggaaaaa gtaaagtcag aatgtctcga gcccgagccg gagttacgga gcactttcag
961 tgaggaagca aatacgtcgt cctattaccc cgctcctgcg cctgtcatgg acaagtatat
1021 cctagacaat ggcaaggtcc atctgggaag cgggatttgg gttgatgagg agaaatggca
1081 ccagctacaa gtaacccaag gagattccaa gtacacgaag aacttggcag ttatgatttg
1141 gggaacagat gttctgaaaa acagaagcgt cacaggcgtc gccacaaaaa aaaagaaaga
1201 tgcagtccct aaaccacccc tctcgcctca caaactaagc atcgtcagag agtgtttgta
1261 tgacagaata gcacaagaaa ctgtggatga aactgaaatt gcacagagac tctccaaagt
1321 caacaagtac atctgtgaaa aaatcatgga tatcaataaa tcctgtaaaa atgaagaacg
1381 aagggaagca aaatacaatt tgcaataaac tttggatttt tcataaagct ttcgtgtttt
1441 ccttgtgtgg catgtgattt gcgagcgatg gtgccgtcca aatcagaccc caccgtgcat
1501 ggtggtgtgt gtgcagggat ccatcgggtt ctggggtcag cggcttgttc tgaatgtgga
1561 cactccaaag acgacagatg gctttgctga gactcaggag cagcctggca ctggtgtcct
1621 tctgggaatg gggaaaacac tcttcttgga gggggataag gttgcctgag ttgcctgtca
1681 cttgactggg gtttgaatgg atatttttac tatccaagga cttctttgtt gctctatttt
1741 gttctataat aaattttcat taattctttg atgta
//