LOCUS NM_001322128 4332 bp mRNA linear PRI 17-FEB-2024
DEFINITION Homo sapiens zinc finger protein 160 (ZNF160), transcript variant
4, mRNA.
ACCESSION NM_001322128
VERSION NM_001322128.2
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4332)
AUTHORS Takahashi,K., Sugi,Y., Hosono,A. and Kaminogawa,S.
TITLE Epigenetic regulation of TLR4 gene expression in intestinal
epithelial cells for the maintenance of intestinal homeostasis
JOURNAL J Immunol 183 (10), 6522-6529 (2009)
PUBMED 19846881
REMARK GeneRIF: TLR4 gene transcription was repressed by epigenetic
regulations, which were, at least in part, dependent on ZNF160.
REFERENCE 2 (bases 1 to 4332)
AUTHORS Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
TITLE A census of human transcription factors: function, expression and
evolution
JOURNAL Nat Rev Genet 10 (4), 252-263 (2009)
PUBMED 19274049
REMARK Review article
REFERENCE 3 (bases 1 to 4332)
AUTHORS Mark,C., Looman,C., Abrink,M. and Hellman,L.
TITLE Molecular cloning and preliminary functional analysis of two novel
human KRAB zinc finger proteins, HKr18 and HKr19
JOURNAL DNA Cell Biol 20 (5), 275-286 (2001)
PUBMED 11410164
REFERENCE 4 (bases 1 to 4332)
AUTHORS Hattori,A., Okumura,K., Nagase,T., Kikuno,R., Hirosawa,M. and
Ohara,O.
TITLE Characterization of long cDNA clones from human adult spleen
JOURNAL DNA Res 7 (6), 357-366 (2000)
PUBMED 11214971
REFERENCE 5 (bases 1 to 4332)
AUTHORS Abrink,M., Aveskogh,M. and Hellman,L.
TITLE Isolation of cDNA clones for 42 different Kruppel-related zinc
finger proteins expressed in the human monoblast cell line U-937
JOURNAL DNA Cell Biol 14 (2), 125-136 (1995)
PUBMED 7865130
REFERENCE 6 (bases 1 to 4332)
AUTHORS Halford,S., Mattei,M.G., Daw,S. and Scambler,P.J.
TITLE A novel C2H2 zinc-finger protein gene (ZNF160) maps to human
chromosome 19q13.3-q13.4
JOURNAL Genomics 25 (1), 322-323 (1995)
PUBMED 7774943
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AC010328.4.
On Aug 14, 2020 this sequence version replaced NM_001322128.1.
Summary: The protein encoded by this gene is a Kruppel-related zinc
finger protein which is characterized by the presence of an
N-terminal repressor domain, the Kruppel-associated box (KRAB). The
KRAB domain is a potent repressor of transcription; thus this
protein may function in transcription regulation. Multiple
transcript variants have been found for this gene. [provided by
RefSeq, Apr 2016].
Transcript Variant: This variant (4), as well as variants 1-3 and
5-12, encodes isoform (a).
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments.
##Evidence-Data-START##
Transcript exon combination :: SRR14038195.847008.1,
SRR14038193.1627453.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMEA1965299,
SAMEA1966682 [ECO:0006172]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-158 AC010328.4 42779-42936
159-242 AC010328.4 54481-54564
243-367 AC010328.4 55536-55660
368-427 AC010328.4 59880-59939
428-554 AC010328.4 71018-71144
555-683 AC010328.4 71933-72061
684-4332 AC010328.4 75939-79587
FEATURES Location/Qualifiers
source 1..4332
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="19"
/map="19q13.41-q13.42"
gene 1..4332
/gene="ZNF160"
/gene_synonym="F11; HKr18; HZF5; KR18"
/note="zinc finger protein 160"
/db_xref="GeneID:90338"
/db_xref="HGNC:HGNC:12948"
/db_xref="MIM:600398"
exon 1..158
/gene="ZNF160"
/gene_synonym="F11; HKr18; HZF5; KR18"
/inference="alignment:Splign:2.1.0"
exon 159..242
/gene="ZNF160"
/gene_synonym="F11; HKr18; HZF5; KR18"
/inference="alignment:Splign:2.1.0"
exon 243..367
/gene="ZNF160"
/gene_synonym="F11; HKr18; HZF5; KR18"
/inference="alignment:Splign:2.1.0"
misc_feature 365..367
/gene="ZNF160"
/gene_synonym="F11; HKr18; HZF5; KR18"
/note="upstream in-frame stop codon"
exon 368..427
/gene="ZNF160"
/gene_synonym="F11; HKr18; HZF5; KR18"
/inference="alignment:Splign:2.1.0"
CDS 413..2869
/gene="ZNF160"
/gene_synonym="F11; HKr18; HZF5; KR18"
/note="isoform a is encoded by transcript variant 4; KRAB
zinc finger protein KR18; zinc finger protein 5; zinc
finger protein Kr18; zinc finger protein HZF5"
/codon_start=1
/product="zinc finger protein 160 isoform a"
/protein_id="NP_001309057.1"
/db_xref="CCDS:CCDS12859.1"
/db_xref="GeneID:90338"
/db_xref="HGNC:HGNC:12948"
/db_xref="MIM:600398"
/translation="MALTQVRLTFRDVAIEFSQEEWKCLDPAQRILYRDVMLENYWNL
VSLGLCHFDMNIISMLEEGKEPWTVKSCVKIARKPRTPECVKGVVTDIPPKCTIKDLL
PKEKSSTEAVFHTVVLERHESPDIEDFSFKEPQKNVHDFECQWRDDTGNYKGVLMAQK
EGKRDQRDRRDIENKLMNNQLGVSFHSHLPELQLFQGEGKMYECNQVEKSTNNGSSVS
PLQQIPSSVQTHRSKKYHELNHFSLLTQRRKANSCGKPYKCNECGKAFTQNSNLTSHR
RIHSGEKPYKCSECGKTFTVRSNLTIHQVIHTGEKPYKCHECGKVFRHNSYLATHRRI
HTGEKPYKCNECGKAFRGHSNLTTHQLIHTGEKPFKCNECGKLFTQNSHLISHWRIHT
GEKPYKCNECGKAFSVRSSLAIHQTIHTGEKPYKCNECGKVFRYNSYLGRHRRVHTGE
KPYKCNECGKAFSMHSNLATHQVIHTGTKPFKCNECSKVFTQNSQLANHRRIHTGEKP
YKCNECGKAFSVRSSLTTHQAIHSGEKPYKCIECGKSFTQKSHLRSHRGIHSGEKPYK
CNECGKVFAQTSQLARHWRVHTGEKPYKCNDCGRAFSDRSSLTFHQAIHTGEKPYKCH
ECGKVFRHNSYLATHRRIHTGEKPYKCNECGKAFSMHSNLTTHKVIHTGEKPYKCNQC
GKVFTQNSHLANHQRTHTGEKPYRCNECGKAFSVRSSLTTHQAIHTGKKPYKCNECGK
VFTQNAHLANHRRIHTGEKPYRCTECGKAFRVRSSLTTHMAIHTGEKRYKCNECGKVF
RQSSNLASHHRMHTGEKPYK"
exon 428..554
/gene="ZNF160"
/gene_synonym="F11; HKr18; HZF5; KR18"
/inference="alignment:Splign:2.1.0"
exon 555..683
/gene="ZNF160"
/gene_synonym="F11; HKr18; HZF5; KR18"
/inference="alignment:Splign:2.1.0"
exon 684..4332
/gene="ZNF160"
/gene_synonym="F11; HKr18; HZF5; KR18"
/inference="alignment:Splign:2.1.0"
regulatory 4308..4313
/regulatory_class="polyA_signal_sequence"
/gene="ZNF160"
/gene_synonym="F11; HKr18; HZF5; KR18"
/note="hexamer: AATAAA"
polyA_site 4332
/gene="ZNF160"
/gene_synonym="F11; HKr18; HZF5; KR18"
/note="major polyA site"
ORIGIN
1 agacccggaa gtggatcgtg cggagcaagc atcacaccat ggcgtatgag tgttcctctg
61 tgtagactca acctgcgcct cgccgtcccc cattcgcaca cccgatgccc gggggtcgct
121 acggacttaa aatctccgca ccgcaccctc cacctcagaa acgttcctgg atccgaacac
181 tgccccctga cgacctagag agatcccggc tcccagccca ctgagtggct tcagcctcgc
241 tggcctcccc ctcataagca tggcttcctc tgacccagcg ttgaaggagg tgacttgggc
301 ctgtctgttc acctccaatg ttcttttgtc ccagattcca ctccactagg aaaagtgctt
361 tcagtaggaa gaagtctgga agaagaggaa gaggaaagaa aaggagtcag ggatggccct
421 tactcaggta cggttgacat ttagggatgt ggccatagaa ttctctcagg aggagtggaa
481 atgcctggac cctgctcaga ggatcttata cagggacgtg atgttggaga actactggaa
541 ccttgtttct ctgggactgt gtcattttga tatgaatatt atctccatgt tggaggaagg
601 gaaagagccc tggactgtga agagctgtgt gaaaatagca agaaaaccaa gaacgccgga
661 atgtgtcaaa ggcgtggtca cagatatccc tcctaaatgt acaatcaagg atttgctacc
721 aaaagagaag agcagtacag aagcagtatt ccacacagtg gtgttggaaa gacacgaaag
781 ccctgacatt gaagactttt ccttcaagga accccagaaa aatgtgcatg attttgagtg
841 tcaatggaga gatgacacag gaaattacaa gggagtgctt atggcccaga aagaaggtaa
901 aagagatcaa cgcgacagaa gagacataga aaacaagctt atgaacaatc agcttggagt
961 aagctttcat tctcatctgc ctgaactgca gctatttcaa ggtgagggga aaatgtatga
1021 atgtaatcaa gttgagaagt ctaccaacaa tggttcctca gtgtcaccac ttcaacaaat
1081 tccttctagt gtccaaaccc acaggtctaa aaaatatcat gaacttaacc atttttcatt
1141 actcacacaa agacgaaaag caaacagttg tggaaaacct tataaatgta atgaatgtgg
1201 caaggcgttc actcagaatt cgaaccttac aagtcatagg agaattcata gtggagagaa
1261 gccttacaaa tgcagtgagt gcggcaaaac ctttactgtt cgttcaaatc taactattca
1321 tcaggtcatc catactggag aaaaacctta caaatgtcat gagtgtggca aggtcttcag
1381 gcacaattca taccttgcaa ctcatcggcg aattcatact ggagagaaac cttacaagtg
1441 taatgagtgt ggaaaagcct ttagaggaca ttcaaaccta actacccatc agttaattca
1501 tactggagaa aaaccgttca aatgtaatga atgtggcaag ctcttcactc aaaattcaca
1561 ccttataagt cattggagaa ttcacactgg agagaaacct tacaagtgca atgagtgcgg
1621 caaagccttt agtgttcgtt caagcctagc aatccatcag acaatccaca ctggagaaaa
1681 accttacaaa tgtaatgaat gtggcaaagt ctttaggtac aattcatacc tcggaaggca
1741 tcggagagtt catactggtg agaaacctta caagtgtaat gaatgtggca aagccttcag
1801 tatgcattca aacctagcta cccatcaggt catccatact ggaacaaaac ctttcaaatg
1861 caatgaatgc agcaaggttt tcactcaaaa ttcacaactt gcaaatcatc gaagaattca
1921 tactggagag aaaccttaca agtgtaatga gtgtgggaaa gccttcagtg ttcgttcaag
1981 tctgactacc catcaggcaa tccattctgg agagaaacct tacaaatgta ttgaatgtgg
2041 caagagcttc actcaaaaat cacaccttag aagtcatcgg ggaattcatt ctggagagaa
2101 accttacaag tgtaatgaat gtggtaaagt cttcgctcaa acatcacaac ttgcaaggca
2161 ttggagagtt catactggag aaaaacctta caagtgtaat gactgtggca gagcctttag
2221 tgatcgttca agcctaactt ttcatcaggc aatacatact ggagagaaac cttacaaatg
2281 tcatgaatgc ggcaaggttt ttaggcacaa ttcatacctt gcaactcatc ggcgaattca
2341 tactggagag aaaccttaca agtgtaatga gtgtgggaaa gcctttagta tgcattcaaa
2401 cctaactacc cataaggtca tccatactgg agagaagcct tacaaatgta atcaatgtgg
2461 caaggtcttc actcagaact cacaccttgc aaatcatcaa aggactcaca ccggagagaa
2521 accttaccga tgcaatgagt gtgggaaagc cttcagtgtt cgttcaagcc taaccaccca
2581 tcaggcaatc catactggga aaaaacctta caaatgtaat gaatgtggca aggtctttac
2641 tcaaaatgct cacctggcaa atcaccgaag aattcatact ggggagaaac cttacaggtg
2701 tacagagtgt gggaaagcct ttagggtaag atcaagtcta actacccata tggcaatcca
2761 cactggagaa aagcgttaca aatgtaatga gtgtggcaag gtcttcaggc agagttcaaa
2821 tcttgcaagt catcacagaa tgcataccgg agagaaacct tacaaatgag tgtggtgagg
2881 tcattaggta caattcactc ctttcacatc agttaatttc attcttgaca gaatccttac
2941 aaatgtagtg acagtggcca atccctcatg agttgaagca ttaatagata tgagaggcca
3001 taagcaagag acatcatgta aacatatgtg gcagagggtc tatccaggcc tcgcaggtta
3061 ctaggcatca agatttatat ctttgatgaa acgaaacaaa tgtaatatgc atcctgaggc
3121 cattacccag tgaccgatgg taagtgagga ttcctaggag gaataacagt ctctggtttc
3181 cctgtttgcc tttgatatta tacactgtag aatactcaca agtccaaata tgctaaaaat
3241 tatatatttt taactcacat acgaaaaggt tgcaggatat ttgtaggcag tcagttacct
3301 tcaccttatg aaatgtttca ctgagttatt tgaggttttt tggaaagcct actattgcgt
3361 ttcaatgtga actttgaaat cttattgtgc atccttacac accttccatg gtgctttctt
3421 ggaaagatca ttgggatgga aggatcattg attgggtgaa gatcattgat taggtgaagg
3481 attatttcta tccaatttgt gaagaaggag gactttgctt ttaaaattaa gtatcatctg
3541 aattagcatt tgggagtggc gaaaaacaat gtaaaactat gatgtcactc accattctga
3601 taatgttcag ggtgcctttc tcctaccagg agagtactgt ggcttagagg aaagaaatgg
3661 tctatcaact gaacatgaaa tggagcaggc caagacctta ggacattggg atttttgtgg
3721 gaggagagta ataggtaatt agacactgat tgtgtggtag aaatactgca ggggaaaagg
3781 tcgccctctt atgcatcaaa gagcaatacc tgttgtttag caaagagtga tgaaaaattg
3841 atcttgtttt gaaattgaag agagaggcca ggcgcggtgg ctcacacctg taatcccagc
3901 actttgggag gctgaggcag gtggatcacc tgaggtcggg agttcgagac cagcctgacc
3961 aacatggaga aaccccaatt gtactaaaaa tacaaaatta gccgggcgtg gtggcaggtg
4021 cctgtaatcc cagctacttg ggaggctgag gcaggagagt gcttgaaccc aggaggcgga
4081 ggttgtggtg agccaagatc atgccactgc actccagcct gggcaacaag aacaaaactc
4141 catctaaaga agaaaaagaa aaactgaaga gagagtagtt gtcagagtga agagtttaat
4201 caacagaagt agagtaacat attctttagt agaactcaca ttatctgctt gaagcacatt
4261 ttgctaatgt tttattcaga atgtatcata gatataatgt tttaactaat aaaatagaat
4321 ggtttttctc ta
//