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NCBI Reference Sequence: NM_134130.1
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LOCUS NM_134130 1903 bp mRNA linear ROD 01-JUN-2024 DEFINITION Mus musculus abhydrolase domain containing 3 (Abhd3), mRNA. ACCESSION NM_134130 VERSION NM_134130.1 KEYWORDS RefSeq; RefSeq Select. SOURCE Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. REFERENCE 1 (bases 1 to 1903) AUTHORS Lui,J.H., Nowakowski,T.J., Pollen,A.A., Javaherian,A., Kriegstein,A.R. and Oldham,M.C. TITLE Radial glia require PDGFD-PDGFRbeta signalling in human but not mouse neocortex JOURNAL Nature 515 (7526), 264-268 (2014) PUBMED 25391964 REFERENCE 2 (bases 1 to 1903) AUTHORS Long,J.Z., Cisar,J.S., Milliken,D., Niessen,S., Wang,C., Trauger,S.A., Siuzdak,G. and Cravatt,B.F. TITLE Metabolomics annotates ABHD3 as a physiologic regulator of medium-chain phospholipids JOURNAL Nat Chem Biol 7 (11), 763-765 (2011) PUBMED 21926997 REMARK GeneRIF: This study descrbed a cell-based screen for enzyme substrate discovery and its application to identify the protein alpha/beta-hydrolase domain-containing 3 as a lipase that selectively cleaves medium-chain and oxidatively truncated phospholipids. Publication Status: Online-Only REFERENCE 3 (bases 1 to 1903) AUTHORS Edgar,A.J. and Polak,J.M. TITLE Cloning and tissue distribution of three murine alpha/beta hydrolase fold protein cDNAs JOURNAL Biochem Biophys Res Commun 292 (3), 617-625 (2002) PUBMED 11922611 REMARK GeneRIF: a member of a novel family of membrane bound enzymes whose function has yet to be determined; highest expression level in the liver [LABH3] COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF429302.1. ##Evidence-Data-START## Transcript exon combination :: AF429302.1, AK134676.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## FEATURES Location/Qualifiers source 1..1903 /organism="Mus musculus" /mol_type="mRNA" /strain="BALB/c" /db_xref="taxon:10090" /chromosome="18" /map="18 5.28 cM" gene 1..1903 /gene="Abhd3" /gene_synonym="LABH3" /note="abhydrolase domain containing 3" /db_xref="GeneID:106861" /db_xref="MGI:MGI:2147183" exon 1..167 /gene="Abhd3" /gene_synonym="LABH3" /inference="alignment:Splign:2.1.0" CDS 6..1241 /gene="Abhd3" /gene_synonym="LABH3" /EC_number="3.1.1.4" /EC_number="3.1.1.32" /note="lung alpha/beta hydrolase 3; abhydrolase domain-containing protein 3; mmLABH3" /codon_start=1 /product="phospholipase ABHD3" /protein_id="NP_598891.1" /db_xref="CCDS:CCDS29057.1" /db_xref="GeneID:106861" /db_xref="MGI:MGI:2147183" /translation="MQRLAMDLRVLSRELALYLEHQVRVGFFGSGVGLSLILGFSVAY ACYYLSSIAKKPQLVIGGESFSRFLQDHCPVVTETYYPTVWCWESRGQTLLRPFITSK PPVQYRNELIKTADGGQISLDWFDNNNSAYYVDASTRPTILLLPGLTGTSKESYILHM IHLSEELGYRCVVFNNRGVAGESLLTPRTYCCANTEDLEAVVHHVHSLYPGAPFLAAG VSMGGMLLLNYLGKIGSKTPLMAAATFSVGWNTFACSESLERPLNWLLFNYYLTTCLQ SSVKKHRHMFVEQIDMDQVMKAKSIREFDKRFTAVMFGYRTLDDYYTDASPNRRLKSV GIPVLCLNATDDVFSPSHAIPIETAKQNPNVALVLTAYGGHIGFLEGIWPRQCTYMDR VFKQFVQAMVEHGHELSNM" misc_feature 78..140 /gene="Abhd3" /gene_synonym="LABH3" /note="propagated from UniProtKB/Swiss-Prot (Q91ZH7.1); transmembrane region" exon 168..331 /gene="Abhd3" /gene_synonym="LABH3" /inference="alignment:Splign:2.1.0" exon 332..514 /gene="Abhd3" /gene_synonym="LABH3" /inference="alignment:Splign:2.1.0" exon 515..560 /gene="Abhd3" /gene_synonym="LABH3" /inference="alignment:Splign:2.1.0" exon 561..673 /gene="Abhd3" /gene_synonym="LABH3" /inference="alignment:Splign:2.1.0" exon 674..847 /gene="Abhd3" /gene_synonym="LABH3" /inference="alignment:Splign:2.1.0" exon 848..896 /gene="Abhd3" /gene_synonym="LABH3" /inference="alignment:Splign:2.1.0" exon 897..1062 /gene="Abhd3" /gene_synonym="LABH3" /inference="alignment:Splign:2.1.0" exon 1063..1887 /gene="Abhd3" /gene_synonym="LABH3" /inference="alignment:Splign:2.1.0" regulatory 1868..1873 /regulatory_class="polyA_signal_sequence" /gene="Abhd3" /gene_synonym="LABH3" /note="hexamer: AATAAA" polyA_site 1887 /gene="Abhd3" /gene_synonym="LABH3" /note="major polyA site" ORIGIN 1 gcactatgca gcgcctggcc atggacctgc gggtgctgtc ccgggagctg gcgctctacc 61 tggagcacca ggttcgcgtc ggcttcttcg gctcgggcgt gggcttgtca ctgatcttgg 121 gattcagcgt tgcctatgct tgctactacc tgagtagcat tgccaagaaa ccccagttag 181 tgattggagg ggagagtttc agccgcttcc tacaggacca ctgtcccgtg gtgacagaaa 241 cctattaccc gacggtctgg tgctgggaga gccgaggaca gacattgctg agacccttca 301 tcacttccaa acccccggtg caatacagga acgaactcat taaaactgca gacggaggac 361 agatctcact ggactggttt gataacaata acagtgcgta ctatgtggat gccagcacca 421 gacctactat cttgctcttg cctggcctca ctggaacaag caaggaatcc tacatccttc 481 atatgatcca tctcagtgaa gaattaggat acaggtgtgt ggtttttaat aacagaggag 541 tagcaggaga aagtctcttg acaccacgga cttactgctg tgcgaacact gaagacttgg 601 aggccgtcgt ccaccacgtg cacagcctgt accctggggc tccttttctg gcagcaggcg 661 tatcaatggg aggaatgctg cttctgaatt acttgggtaa aattgggtcc aaaacccctc 721 tgatggctgc tgcaacgttt tcggttggct ggaacacttt cgcttgctca gagtctctgg 781 agaggccgct gaactggcta ctttttaatt actacttaac aacttgcctc cagtcatcag 841 ttaagaagca ccggcatatg tttgtggagc agattgacat ggatcaggtc atgaaggcca 901 agtcgatcag agagtttgat aagcggttca cggcggtcat gtttgggtac cgcacactcg 961 atgattacta caccgatgcc agtccaaacc gcaggctgaa gtcagtggga atccctgttc 1021 tgtgcctgaa tgctacggac gacgtgttct cacccagcca tgctatccca atagaaactg 1081 ctaaacaaaa ccctaacgtg gctttggtcc ttacagccta tggaggccat attggttttc 1141 tggagggaat ctggcctagg caatgcactt acatggatcg agtcttcaag caatttgtac 1201 aggccatggt tgagcacgga catgaactct ccaacatgta gcttcttggc tgcattcagc 1261 ctgagccact gttgttaaag cagctcagct tggagcacag gtttcaacag ctgagggtag 1321 agctgacaag ccggcagatg ggtgaagagg tccagcatga catgcaaaac tacttcttag 1381 ggaaacacaa caactttgta gtaagaaact aaagatagtt tagattgtta ctgtagtaga 1441 tcttattttt cctatgcctt accaaatatg accttaaaat taagtagtcc ttatgtaaca 1501 gaattgcact taaccaaaac tattgtgtaa aacgatttta attcctcagg gttttaattt 1561 aggctagtat ttttaattac tcagtttagg tgacttaata atactttaat aactgttaag 1621 agattttaat gatttgaata taagttagaa gaggggtatt catggtaaca agaaactgaa 1681 aaggataaat tatattgttc taagtgtttc ttctgattta aaaggcaaat gcaacaatgt 1741 tagactgact tctatatttg ctctcttctc tgataatatt aaattagggc tgatttatgt 1801 tttataattg ttatcattta catgcttatt tttaaaatag tatttgtgaa tacatatatc 1861 atattaaaat aaattctatc attttaaaaa aaaaaaaaaa aaa //
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