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NCBI Reference Sequence: NM_032853.3
FASTA Graphics
LOCUS NM_032853 4119 bp mRNA linear PRI 14-JUL-2018 DEFINITION Homo sapiens melanoma associated antigen (mutated) 1 (MUM1), transcript variant 1, mRNA. ACCESSION NM_032853 NM_016473 VERSION NM_032853.3 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 4119) AUTHORS Huen MS, Huang J, Leung JW, Sy SM, Leung KM, Ching YP, Tsao SW and Chen J. TITLE Regulation of chromatin architecture by the PWWP domain-containing DNA damage-responsive factor EXPAND1/MUM1 JOURNAL Mol. Cell 37 (6), 854-864 (2010) PUBMED 20347427 REMARK GeneRIF: report the identification of the PWWP domain-containing protein EXPAND1/MUM1 as an architectural component of the chromatin, which in response to DNA damage serves as an accessory factor to promote cell survival. REFERENCE 2 (bases 1 to 4119) AUTHORS Coulie PG, Lehmann F, Lethe B, Herman J, Lurquin C, Andrawiss M and Boon T. TITLE A mutated intron sequence codes for an antigenic peptide recognized by cytolytic T lymphocytes on a human melanoma JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (17), 7976-7980 (1995) PUBMED 7644523 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DN993266.1, BC110874.1, DA739708.1, AK309092.1, AC004623.2, AC005329.1 and BU741593.1. [WARNING] On Sep 21, 2018 this sequence was replaced by NM_032853.4. On Oct 23, 2008 this sequence version replaced NM_032853.2. Transcript Variant: This variant (1) represents the shorter transcript and is protein-coding. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The extent of this transcript is supported by transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.123734.1, SRR1660805.255041.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-34 DN993266.1 8-41 35-244 BC110874.1 1-210 245-550 DA739708.1 235-540 551-1224 AK309092.1 439-1112 1225-2393 BC110874.1 1191-2359 2394-2587 AC004623.2 36807-37000 2588-3870 AC005329.1 527-1809 3871-4119 BU741593.1 1-249 c FEATURES Location/Qualifiers source 1..4119 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="19" /map="19p13.3" gene 1..4119 /gene="MUM1" /gene_synonym="EXPAND1; HSPC211; MUM-1" /note="melanoma associated antigen (mutated) 1" /db_xref="GeneID:84939" /db_xref="HGNC:HGNC:29641" exon 1..44 /gene="MUM1" /gene_synonym="EXPAND1; HSPC211; MUM-1" /inference="alignment:Splign:2.1.0" exon 45..170 /gene="MUM1" /gene_synonym="EXPAND1; HSPC211; MUM-1" /inference="alignment:Splign:2.1.0" misc_feature 108..110 /gene="MUM1" /gene_synonym="EXPAND1; HSPC211; MUM-1" /note="upstream in-frame stop codon" CDS 111..2246 /gene="MUM1" /gene_synonym="EXPAND1; HSPC211; MUM-1" /note="melanoma ubiquitous mutated protein; mutated melanoma-associated antigen 1; protein expandere" /codon_start=1 /product="PWWP domain-containing protein MUM1" /protein_id="NP_116242.2" /db_xref="CCDS:CCDS12062.1" /db_xref="GeneID:84939" /db_xref="HGNC:HGNC:29641" /translation="MMADAKYVLCRWEKRLWPAKVLARTATSTKNKRRKEYFLAVQIL SLEEKIKVKSTEVEILEKSQIEAIASSLASQNEVPAAPLEELAYRRSLRVALDVLSEG SIWSQESSAGTGRADRSLRGKPMEHVSSPCDSNSSSLPRGDVLGSSRPHRRRPCVQQS LSSSFTCEKDPECKVDHKKGLRKSENPRGPLVLPAGGGAQDESGSRIHHKNWTLASKR GGNSAQKASLCLNGSSLSEDDTERDMGSKGGSWAAPSLPSGVREDDPCANAEGHDPGL PLGSLTAPPAPEPSACSEPGECPAKKRPRLDGSQRPPAVQLEPMAAGAAPSPGPGPGP RESVTPRSTARLGPPPSHASADATRCLPCPDSQKLEKECQSSEESMGSNSMRSILEED EEDEEPPRVLLYHEPRSFEVGMLVWHKHKKYPFWPAVVKSVRQRDKKASVLYIEGHMN PKMKGFTVSLKSLKHFDCKEKQTLLNQAREDFNQDIGWCVSLITDYRVRLGCGSFAGS FLEYYAADISYPVRKSIQQDVLGTKLPQLSKGSPEEPVVGCPLGQRQPCRKMLPDRSR AARDRANQKLVEYIVKAKGAESHLRAILKSRKPSRWLQTFLSSSQYVTCVETYLEDEG QLDLVVKYLQGVYQEVGAKVLQRTNGDRIRFILDVLLPEAIICAISAVDEVDYKTAEE KYIKGPSLSYREKEIFDNQLLEERNRRRR" exon 171..256 /gene="MUM1" /gene_synonym="EXPAND1; HSPC211; MUM-1" /inference="alignment:Splign:2.1.0" exon 257..327 /gene="MUM1" /gene_synonym="EXPAND1; HSPC211; MUM-1" /inference="alignment:Splign:2.1.0" exon 328..1224 /gene="MUM1" /gene_synonym="EXPAND1; HSPC211; MUM-1" /inference="alignment:Splign:2.1.0" exon 1225..1326 /gene="MUM1" /gene_synonym="EXPAND1; HSPC211; MUM-1" /inference="alignment:Splign:2.1.0" exon 1327..1397 /gene="MUM1" /gene_synonym="EXPAND1; HSPC211; MUM-1" /inference="alignment:Splign:2.1.0" exon 1398..1474 /gene="MUM1" /gene_synonym="EXPAND1; HSPC211; MUM-1" /inference="alignment:Splign:2.1.0" exon 1475..1535 /gene="MUM1" /gene_synonym="EXPAND1; HSPC211; MUM-1" /inference="alignment:Splign:2.1.0" exon 1536..1611 /gene="MUM1" /gene_synonym="EXPAND1; HSPC211; MUM-1" /inference="alignment:Splign:2.1.0" exon 1612..1662 /gene="MUM1" /gene_synonym="EXPAND1; HSPC211; MUM-1" /inference="alignment:Splign:2.1.0" exon 1663..2099 /gene="MUM1" /gene_synonym="EXPAND1; HSPC211; MUM-1" /inference="alignment:Splign:2.1.0" exon 2100..2188 /gene="MUM1" /gene_synonym="EXPAND1; HSPC211; MUM-1" /inference="alignment:Splign:2.1.0" exon 2189..4101 /gene="MUM1" /gene_synonym="EXPAND1; HSPC211; MUM-1" /inference="alignment:Splign:2.1.0" ORIGIN 1 cgcggggagc ggcggcggcg gcggcggcgg cggtggcgga ggcggacaca ttggcgtgag 61 acctgggagt acgttgtgcc aaatcattgc cacttgccac atgagtgtaa atgatggcgg 121 atgccaagta tgtcctctgc cgatgggaaa agcgattatg gcctgcgaag gttttggccc 181 gaaccgcgac ttcaacaaaa aataagagaa gaaaggaata ttttctagct gtgcaaatcc 241 tctctctaga ggaaaaaatt aaggtgaaaa gcactgaagt tgagatccta gagaagtctc 301 aaattgaagc cattgcttcc tcgttagcct cacagaatga ggttcctgcg gcacccctgg 361 aagaactggc ctacagacgg tcgcttcgcg tggctctgga cgttctgagc gagggctcga 421 tttggagtca agaaagctct gcagggacag gtagagctga ccggtctctg cgagggaagc 481 ccatggagca tgtctcctcg ccctgtgatt cgaactcctc atctcttccc cgcggagacg 541 tgttgggcag ttccagacct cacaggagga ggccatgtgt gcaacaaagc ctgtcaagtt 601 cgttcacttg tgaaaaggac cccgagtgca aagtggacca caagaagggg ctcaggaaaa 661 gtgaaaaccc aagaggcccg ttggtcctcc cagctggagg tggtgcccaa gatgagagtg 721 ggtccagaat ccaccacaaa aattggactc ttgcaagtaa gaggggagga aactcagcgc 781 agaaggctag cttgtgcctg aatggatctt ccctttcaga ggacgacacg gagagagaca 841 tggggagcaa aggaggcagc tgggcagccc cgtccttgcc ctccggggtc agggaggacg 901 atccctgtgc caacgctgag ggacacgacc ccggtctgcc gttgggcagc ctcactgcgc 961 ccccagcccc tgagccctcg gcctgctcag agcctggaga atgccctgcg aaaaagaggc 1021 cgcgcctgga tggcagccaa aggccgcctg ccgtgcagct ggagcccatg gcagcagggg 1081 ccgcaccatc ccccgggccg gggccagggc ccagagagtc tgtgaccccg cgcagcaccg 1141 ccaggctggg cccgcctccc tcccacgcct ctgcggatgc aaccagatgt cttccttgcc 1201 cggattccca gaagctggag aaagagtgcc agtcttccga agagtccatg gggtctaatt 1261 ccatgcgttc tatcctggag gaagacgagg aagacgagga gccaccaaga gtccttttat 1321 accacgaacc acgttcgttt gaagtaggaa tgctagtctg gcataaacat aaaaaatacc 1381 ccttctggcc agcagtggtc aaaagcgtca ggcagagaga taagaaagca agtgtgctat 1441 acatcgaagg acacatgaac ccgaaaatga aaggtttcac agtgtctctt aaaagtttaa 1501 agcactttga ttgtaaagag aaacagacgc ttctgaatca agccagggag gacttcaacc 1561 aggacatcgg ctggtgtgtc tccctcatca ccgactacag ggtccggtta ggctgcgggt 1621 cttttgctgg ctctttcctg gaatattacg cggctgatat aagctatcct gtccgaaaat 1681 ccatccagca ggacgtcttg gggaccaagc ttcctcaact gagcaagggg agccccgagg 1741 agcccgtggt ggggtgcccc ctggggcaga ggcagccctg ccggaaaatg ctccccgacc 1801 gctcgcgggc cgcccgggac cgggccaacc agaagctggt ggagtacatt gtgaaggcca 1861 agggcgcgga gagccacctg cgggccatcc taaagagcag gaagccatct cgctggctgc 1921 agaccttcct gagctccagc cagtacgtga cctgtgtgga gacctacctg gaggatgagg 1981 ggcagctgga cctggtggtg aagtacctgc agggcgtcta ccaggaggtg ggggccaagg 2041 tgctccagcg caccaacggc gaccggatcc ggttcattct ggacgtgctt ctgcccgagg 2101 ccatcatctg tgcgatctct gcggtggacg aggtggacta caagacggct gaggagaagt 2161 acatcaaggg gccttcgctg agctaccggg aaaaagaaat atttgacaac cagctccttg 2221 aagagcggaa ccggcgccgt cggtgaggga gcagccggct gtgctgtcag cggggcctgg 2281 cggtggaagc gcctccagtg tgcatgagcg tgtctgaaga tggggggctc agggggcacg 2341 tttgcgtttg gacctgtctg tgcgttctcc tgcgtggcag tcctgatttc catgcttctg 2401 gagaatccat ttcgttaaca ctgaaagcca gttctctttt cctggcagtt tttttcattt 2461 tatttttggc attttttaca agataccgtt cgggaaaggc ttttgaaagg acggaagcgt 2521 attcactgtg cgccagtact cctggctgtg ctgtggtttc tcccgacgtg cacatcgatc 2581 tcgtatgtgt ggcatctgat attaaacggg aggttttaag aagcgtctgc cgtgatcatg 2641 gagcttcgga agcgggaatg gttcttccgg gtttgctgtt ttgtctgttt cccccttgtg 2701 tggtttccgc ctgcgacagt tccagaattt gctctcccac tcagtgtgct ctgcagctgt 2761 gaggaaacag ccttcgttag aggcgggagc agagacgagc cgctgctctg tgtcgtgttt 2821 gctgtggccg cagggagagg agcaggacac gcacctttcc aggggcctct gtgtcccgca 2881 ctgtgtgtga gtggaccgca gcgcgcagcc acatgccctg gctgccatgg gccagaccgc 2941 ctccacctcc cccgcccgcc tggcctgtcc tgagtgcatt tccctgcact gtgtcgtcac 3001 tgcacagcca gtcaccgcgg tctcagtcat cggcgcggat ggctatgctg gggtcccagg 3061 gtggccgcag cagtcagggt cactgtggga gccctggggt ggagtgacaa accgcattgt 3121 cctgtgcccg ccatggcaga agcgcagcct ttgtatggag gcccaaccgc gctcccgtct 3181 ggagaagcgg cttccggggt gtggctgccg ggtcggctct ggtccacagc acggtgccgg 3241 ggctgcaggt tgttgagggc tgtgactccg tggggctcag ccaggctcca gcagggtcag 3301 acgtgctgtt aagagcaaag ccacagacga tgacttgtcc attctcagtg gatgctccag 3361 gctgtgccta cacagcagtg ctggtgacat gtccagggtt ccagggcccg gtggcctggg 3421 agctgctttc tccccactgg ctgggctgca tctggccctg gctggaggcc ttgctttgag 3481 gggctgtgac cctcttcccc caggccctcc ccagccgacg acagccaccg gagaggagat 3541 cggaacacga ttgtctcaga tgcagggcgc tgtgcgggac gaagccgcaa ggactctcgt 3601 atcgggccct tgggactcgg gaggtgccag aggcggcggc tgctctggac ctcggtgttc 3661 actgaccttt gtttcacttg cctctgctcg actccgagag caggaaaccc ggccgtggcc 3721 tggcagctcc gcctcccatg cccgcacgct ggggtctgtc ttgtctggag cagtggggca 3781 caccccggag gaggcggggg tcagggctgt cggccttggc cccctgctgg tcgctgtttc 3841 ggggactcgg ggcggccagt accaccgcct gaggcggggc tcagcagcgt tgcatgtacg 3901 ggcctcgtac tgcctcatgg aaaatcctcc ggagccgccc tccattgtgg gttcctgaga 3961 gtaggacaca ttgccatggt tttgtgggaa tcacgcgccc ctgatggaac ttttctgctg 4021 ttgtgaagta cttttatcca tttgcttctc tgctgacctt gccaagttgt tcgaggtgga 4081 attaaacacc tcccagacct caaaaaaaaa aaaaaaaaa //
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