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Homo sapiens melanoma associated antigen (mutated) 1 (MUM1), transcript variant 1, mRNA

NCBI Reference Sequence: NM_032853.3

FASTA Graphics 

LOCUS       NM_032853               4119 bp    mRNA    linear   PRI 14-JUL-2018
DEFINITION  Homo sapiens melanoma associated antigen (mutated) 1 (MUM1),
            transcript variant 1, mRNA.
ACCESSION   NM_032853 NM_016473
VERSION     NM_032853.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4119)
  AUTHORS   Huen MS, Huang J, Leung JW, Sy SM, Leung KM, Ching YP, Tsao SW and
            Chen J.
  TITLE     Regulation of chromatin architecture by the PWWP domain-containing
            DNA damage-responsive factor EXPAND1/MUM1
  JOURNAL   Mol. Cell 37 (6), 854-864 (2010)
   PUBMED   20347427
  REMARK    GeneRIF: report the identification of the PWWP domain-containing
            protein EXPAND1/MUM1 as an architectural component of the
            chromatin, which in response to DNA damage serves as an accessory
            factor to promote cell survival.
REFERENCE   2  (bases 1 to 4119)
  AUTHORS   Coulie PG, Lehmann F, Lethe B, Herman J, Lurquin C, Andrawiss M and
            Boon T.
  TITLE     A mutated intron sequence codes for an antigenic peptide recognized
            by cytolytic T lymphocytes on a human melanoma
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 92 (17), 7976-7980 (1995)
   PUBMED   7644523
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DN993266.1, BC110874.1, DA739708.1, AK309092.1, AC004623.2,
            AC005329.1 and BU741593.1.
            
            [WARNING] On Sep 21, 2018 this sequence was replaced by
            NM_032853.4.
            
            On Oct 23, 2008 this sequence version replaced NM_032853.2.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and is protein-coding.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.123734.1,
                                           SRR1660805.255041.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                DN993266.1         8-41
            35-244              BC110874.1         1-210
            245-550             DA739708.1         235-540
            551-1224            AK309092.1         439-1112
            1225-2393           BC110874.1         1191-2359
            2394-2587           AC004623.2         36807-37000
            2588-3870           AC005329.1         527-1809
            3871-4119           BU741593.1         1-249               c
FEATURES             Location/Qualifiers
     source          1..4119
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..4119
                     /gene="MUM1"
                     /gene_synonym="EXPAND1; HSPC211; MUM-1"
                     /note="melanoma associated antigen (mutated) 1"
                     /db_xref="GeneID:84939"
                     /db_xref="HGNC:HGNC:29641"
     exon            1..44
                     /gene="MUM1"
                     /gene_synonym="EXPAND1; HSPC211; MUM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            45..170
                     /gene="MUM1"
                     /gene_synonym="EXPAND1; HSPC211; MUM-1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    108..110
                     /gene="MUM1"
                     /gene_synonym="EXPAND1; HSPC211; MUM-1"
                     /note="upstream in-frame stop codon"
     CDS             111..2246
                     /gene="MUM1"
                     /gene_synonym="EXPAND1; HSPC211; MUM-1"
                     /note="melanoma ubiquitous mutated protein; mutated
                     melanoma-associated antigen 1; protein expandere"
                     /codon_start=1
                     /product="PWWP domain-containing protein MUM1"
                     /protein_id="NP_116242.2"
                     /db_xref="CCDS:CCDS12062.1"
                     /db_xref="GeneID:84939"
                     /db_xref="HGNC:HGNC:29641"
                     /translation="MMADAKYVLCRWEKRLWPAKVLARTATSTKNKRRKEYFLAVQIL
                     SLEEKIKVKSTEVEILEKSQIEAIASSLASQNEVPAAPLEELAYRRSLRVALDVLSEG
                     SIWSQESSAGTGRADRSLRGKPMEHVSSPCDSNSSSLPRGDVLGSSRPHRRRPCVQQS
                     LSSSFTCEKDPECKVDHKKGLRKSENPRGPLVLPAGGGAQDESGSRIHHKNWTLASKR
                     GGNSAQKASLCLNGSSLSEDDTERDMGSKGGSWAAPSLPSGVREDDPCANAEGHDPGL
                     PLGSLTAPPAPEPSACSEPGECPAKKRPRLDGSQRPPAVQLEPMAAGAAPSPGPGPGP
                     RESVTPRSTARLGPPPSHASADATRCLPCPDSQKLEKECQSSEESMGSNSMRSILEED
                     EEDEEPPRVLLYHEPRSFEVGMLVWHKHKKYPFWPAVVKSVRQRDKKASVLYIEGHMN
                     PKMKGFTVSLKSLKHFDCKEKQTLLNQAREDFNQDIGWCVSLITDYRVRLGCGSFAGS
                     FLEYYAADISYPVRKSIQQDVLGTKLPQLSKGSPEEPVVGCPLGQRQPCRKMLPDRSR
                     AARDRANQKLVEYIVKAKGAESHLRAILKSRKPSRWLQTFLSSSQYVTCVETYLEDEG
                     QLDLVVKYLQGVYQEVGAKVLQRTNGDRIRFILDVLLPEAIICAISAVDEVDYKTAEE
                     KYIKGPSLSYREKEIFDNQLLEERNRRRR"
     exon            171..256
                     /gene="MUM1"
                     /gene_synonym="EXPAND1; HSPC211; MUM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            257..327
                     /gene="MUM1"
                     /gene_synonym="EXPAND1; HSPC211; MUM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            328..1224
                     /gene="MUM1"
                     /gene_synonym="EXPAND1; HSPC211; MUM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1326
                     /gene="MUM1"
                     /gene_synonym="EXPAND1; HSPC211; MUM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1397
                     /gene="MUM1"
                     /gene_synonym="EXPAND1; HSPC211; MUM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1474
                     /gene="MUM1"
                     /gene_synonym="EXPAND1; HSPC211; MUM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1535
                     /gene="MUM1"
                     /gene_synonym="EXPAND1; HSPC211; MUM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1611
                     /gene="MUM1"
                     /gene_synonym="EXPAND1; HSPC211; MUM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1662
                     /gene="MUM1"
                     /gene_synonym="EXPAND1; HSPC211; MUM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..2099
                     /gene="MUM1"
                     /gene_synonym="EXPAND1; HSPC211; MUM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2188
                     /gene="MUM1"
                     /gene_synonym="EXPAND1; HSPC211; MUM-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..4101
                     /gene="MUM1"
                     /gene_synonym="EXPAND1; HSPC211; MUM-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcggggagc ggcggcggcg gcggcggcgg cggtggcgga ggcggacaca ttggcgtgag
       61 acctgggagt acgttgtgcc aaatcattgc cacttgccac atgagtgtaa atgatggcgg
      121 atgccaagta tgtcctctgc cgatgggaaa agcgattatg gcctgcgaag gttttggccc
      181 gaaccgcgac ttcaacaaaa aataagagaa gaaaggaata ttttctagct gtgcaaatcc
      241 tctctctaga ggaaaaaatt aaggtgaaaa gcactgaagt tgagatccta gagaagtctc
      301 aaattgaagc cattgcttcc tcgttagcct cacagaatga ggttcctgcg gcacccctgg
      361 aagaactggc ctacagacgg tcgcttcgcg tggctctgga cgttctgagc gagggctcga
      421 tttggagtca agaaagctct gcagggacag gtagagctga ccggtctctg cgagggaagc
      481 ccatggagca tgtctcctcg ccctgtgatt cgaactcctc atctcttccc cgcggagacg
      541 tgttgggcag ttccagacct cacaggagga ggccatgtgt gcaacaaagc ctgtcaagtt
      601 cgttcacttg tgaaaaggac cccgagtgca aagtggacca caagaagggg ctcaggaaaa
      661 gtgaaaaccc aagaggcccg ttggtcctcc cagctggagg tggtgcccaa gatgagagtg
      721 ggtccagaat ccaccacaaa aattggactc ttgcaagtaa gaggggagga aactcagcgc
      781 agaaggctag cttgtgcctg aatggatctt ccctttcaga ggacgacacg gagagagaca
      841 tggggagcaa aggaggcagc tgggcagccc cgtccttgcc ctccggggtc agggaggacg
      901 atccctgtgc caacgctgag ggacacgacc ccggtctgcc gttgggcagc ctcactgcgc
      961 ccccagcccc tgagccctcg gcctgctcag agcctggaga atgccctgcg aaaaagaggc
     1021 cgcgcctgga tggcagccaa aggccgcctg ccgtgcagct ggagcccatg gcagcagggg
     1081 ccgcaccatc ccccgggccg gggccagggc ccagagagtc tgtgaccccg cgcagcaccg
     1141 ccaggctggg cccgcctccc tcccacgcct ctgcggatgc aaccagatgt cttccttgcc
     1201 cggattccca gaagctggag aaagagtgcc agtcttccga agagtccatg gggtctaatt
     1261 ccatgcgttc tatcctggag gaagacgagg aagacgagga gccaccaaga gtccttttat
     1321 accacgaacc acgttcgttt gaagtaggaa tgctagtctg gcataaacat aaaaaatacc
     1381 ccttctggcc agcagtggtc aaaagcgtca ggcagagaga taagaaagca agtgtgctat
     1441 acatcgaagg acacatgaac ccgaaaatga aaggtttcac agtgtctctt aaaagtttaa
     1501 agcactttga ttgtaaagag aaacagacgc ttctgaatca agccagggag gacttcaacc
     1561 aggacatcgg ctggtgtgtc tccctcatca ccgactacag ggtccggtta ggctgcgggt
     1621 cttttgctgg ctctttcctg gaatattacg cggctgatat aagctatcct gtccgaaaat
     1681 ccatccagca ggacgtcttg gggaccaagc ttcctcaact gagcaagggg agccccgagg
     1741 agcccgtggt ggggtgcccc ctggggcaga ggcagccctg ccggaaaatg ctccccgacc
     1801 gctcgcgggc cgcccgggac cgggccaacc agaagctggt ggagtacatt gtgaaggcca
     1861 agggcgcgga gagccacctg cgggccatcc taaagagcag gaagccatct cgctggctgc
     1921 agaccttcct gagctccagc cagtacgtga cctgtgtgga gacctacctg gaggatgagg
     1981 ggcagctgga cctggtggtg aagtacctgc agggcgtcta ccaggaggtg ggggccaagg
     2041 tgctccagcg caccaacggc gaccggatcc ggttcattct ggacgtgctt ctgcccgagg
     2101 ccatcatctg tgcgatctct gcggtggacg aggtggacta caagacggct gaggagaagt
     2161 acatcaaggg gccttcgctg agctaccggg aaaaagaaat atttgacaac cagctccttg
     2221 aagagcggaa ccggcgccgt cggtgaggga gcagccggct gtgctgtcag cggggcctgg
     2281 cggtggaagc gcctccagtg tgcatgagcg tgtctgaaga tggggggctc agggggcacg
     2341 tttgcgtttg gacctgtctg tgcgttctcc tgcgtggcag tcctgatttc catgcttctg
     2401 gagaatccat ttcgttaaca ctgaaagcca gttctctttt cctggcagtt tttttcattt
     2461 tatttttggc attttttaca agataccgtt cgggaaaggc ttttgaaagg acggaagcgt
     2521 attcactgtg cgccagtact cctggctgtg ctgtggtttc tcccgacgtg cacatcgatc
     2581 tcgtatgtgt ggcatctgat attaaacggg aggttttaag aagcgtctgc cgtgatcatg
     2641 gagcttcgga agcgggaatg gttcttccgg gtttgctgtt ttgtctgttt cccccttgtg
     2701 tggtttccgc ctgcgacagt tccagaattt gctctcccac tcagtgtgct ctgcagctgt
     2761 gaggaaacag ccttcgttag aggcgggagc agagacgagc cgctgctctg tgtcgtgttt
     2821 gctgtggccg cagggagagg agcaggacac gcacctttcc aggggcctct gtgtcccgca
     2881 ctgtgtgtga gtggaccgca gcgcgcagcc acatgccctg gctgccatgg gccagaccgc
     2941 ctccacctcc cccgcccgcc tggcctgtcc tgagtgcatt tccctgcact gtgtcgtcac
     3001 tgcacagcca gtcaccgcgg tctcagtcat cggcgcggat ggctatgctg gggtcccagg
     3061 gtggccgcag cagtcagggt cactgtggga gccctggggt ggagtgacaa accgcattgt
     3121 cctgtgcccg ccatggcaga agcgcagcct ttgtatggag gcccaaccgc gctcccgtct
     3181 ggagaagcgg cttccggggt gtggctgccg ggtcggctct ggtccacagc acggtgccgg
     3241 ggctgcaggt tgttgagggc tgtgactccg tggggctcag ccaggctcca gcagggtcag
     3301 acgtgctgtt aagagcaaag ccacagacga tgacttgtcc attctcagtg gatgctccag
     3361 gctgtgccta cacagcagtg ctggtgacat gtccagggtt ccagggcccg gtggcctggg
     3421 agctgctttc tccccactgg ctgggctgca tctggccctg gctggaggcc ttgctttgag
     3481 gggctgtgac cctcttcccc caggccctcc ccagccgacg acagccaccg gagaggagat
     3541 cggaacacga ttgtctcaga tgcagggcgc tgtgcgggac gaagccgcaa ggactctcgt
     3601 atcgggccct tgggactcgg gaggtgccag aggcggcggc tgctctggac ctcggtgttc
     3661 actgaccttt gtttcacttg cctctgctcg actccgagag caggaaaccc ggccgtggcc
     3721 tggcagctcc gcctcccatg cccgcacgct ggggtctgtc ttgtctggag cagtggggca
     3781 caccccggag gaggcggggg tcagggctgt cggccttggc cccctgctgg tcgctgtttc
     3841 ggggactcgg ggcggccagt accaccgcct gaggcggggc tcagcagcgt tgcatgtacg
     3901 ggcctcgtac tgcctcatgg aaaatcctcc ggagccgccc tccattgtgg gttcctgaga
     3961 gtaggacaca ttgccatggt tttgtgggaa tcacgcgccc ctgatggaac ttttctgctg
     4021 ttgtgaagta cttttatcca tttgcttctc tgctgacctt gccaagttgt tcgaggtgga
     4081 attaaacacc tcccagacct caaaaaaaaa aaaaaaaaa
//
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