LOCUS NM_139308 3118 bp mRNA linear ROD 06-SEP-2023
DEFINITION Mus musculus StAR related lipid transfer domain containing 7
(Stard7), transcript variant 1, mRNA; nuclear gene for
mitochondrial product.
ACCESSION NM_139308
VERSION NM_139308.2
KEYWORDS RefSeq; RefSeq Select.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (bases 1 to 3118)
AUTHORS Horibata Y, Mitsuhashi S, Shimizu H, Maejima S, Sakamoto H, Aoyama
C, Ando H and Sugimoto H.
TITLE The phosphatidylcholine transfer protein StarD7 is important for
myogenic differentiation in mouse myoblast C2C12 cells and human
primary skeletal myoblasts
JOURNAL Sci Rep 10 (1), 2845 (2020)
PUBMED 32071354
REMARK GeneRIF: The phosphatidylcholine transfer protein StarD7 is
important for myogenic differentiation in mouse myoblast C2C12
cells and human primary skeletal myoblasts.
Publication Status: Online-Only
REFERENCE 2 (bases 1 to 3118)
AUTHORS Yang L, Na CL, Luo S, Wu D, Hogan S, Huang T and Weaver TE.
TITLE The Phosphatidylcholine Transfer Protein Stard7 is Required for
Mitochondrial and Epithelial Cell Homeostasis
JOURNAL Sci Rep 7, 46416 (2017)
PUBMED 28401922
REMARK GeneRIF: Stard7 deficiency was associated with altered
mitochondrial size and membrane organization both in vitro and in
vivo.
Publication Status: Online-Only
REFERENCE 3 (bases 1 to 3118)
AUTHORS Horibata Y, Ando H, Zhang P, Vergnes L, Aoyama C, Itoh M, Reue K
and Sugimoto H.
TITLE StarD7 Protein Deficiency Adversely Affects the Phosphatidylcholine
Composition, Respiratory Activity, and Cristae Structure of
Mitochondria
JOURNAL J Biol Chem 291 (48), 24880-24891 (2016)
PUBMED 27694445
REMARK GeneRIF: These findings indicate that StarD7 plays important roles
in maintaining the proper composition of mitochondrial
phospholipids as well as mitochondrial function and morphogenesis.
REFERENCE 4 (bases 1 to 3118)
AUTHORS Lin S, Ikegami M, Moon C, Naren AP and Shannon JM.
TITLE Lysophosphatidylcholine Acyltransferase 1 (LPCAT1) Specifically
Interacts with Phospholipid Transfer Protein StarD10 to Facilitate
Surfactant Phospholipid Trafficking in Alveolar Type II Cells
JOURNAL J Biol Chem 290 (30), 18559-18574 (2015)
PUBMED 26048993
REFERENCE 5 (bases 1 to 3118)
AUTHORS Yang L, Lewkowich I, Apsley K, Fritz JM, Wills-Karp M and Weaver
TE.
TITLE Haploinsufficiency for Stard7 is associated with enhanced allergic
responses in lung and skin
JOURNAL J Immunol 194 (12), 5635-5643 (2015)
PUBMED 25980009
REMARK GeneRIF: these data suggest that Stard7 is an important component
of a novel protective pathway in tissues exposed to the
extracellular environment.
REFERENCE 6 (bases 1 to 3118)
AUTHORS Ryder E, Wong K, Gleeson D, Keane TM, Sethi D, Vyas S, Wardle-Jones
H, Bussell JN, Houghton R, Salisbury J, Harvey N, Adams DJ and
Ramirez-Solis R.
CONSRTM Sanger Mouse Genetics Project
TITLE Genomic analysis of a novel spontaneous albino C57BL/6N mouse
strain
JOURNAL Genesis 51 (7), 523-528 (2013)
PUBMED 23620107
REFERENCE 7 (bases 1 to 3118)
AUTHORS Angeletti S, Rena V, Nores R, Fretes R, Panzetta-Dutari GM and
Genti-Raimondi S.
TITLE Expression and localization of StarD7 in trophoblast cells
JOURNAL Placenta 29 (5), 396-404 (2008)
PUBMED 18378304
REFERENCE 8 (bases 1 to 3118)
AUTHORS Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber
G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong
WH and Cepko CL.
TITLE Genomic analysis of mouse retinal development
JOURNAL PLoS Biol 2 (9), E247 (2004)
PUBMED 15226823
REFERENCE 9 (bases 1 to 3118)
AUTHORS Thomas JW and Green ED.
CONSRTM NISC Comparative Sequencing Program
TITLE Comparative sequence analysis of a single-gene conserved segment in
mouse and human
JOURNAL Mamm Genome 14 (10), 673-678 (2003)
PUBMED 14694903
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AL845368.6.
[WARNING] On Oct 5, 2023 this sequence was replaced by NM_139308.3.
On Nov 6, 2008 this sequence version replaced NM_139308.1.
Transcript Variant: This variant (1) represents the longest
transcript and encodes the longer isoform (1).
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments.
##Evidence-Data-START##
Transcript exon combination :: BC017524.1, SRR1660813.148864.1
[ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN00849374, SAMN00849375
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression,
longest protein
##RefSeq-Attributes-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-652 AL845368.6 75329-75980
653-861 AL845368.6 89195-89403
862-911 AL845368.6 89632-89681
912-1022 AL845368.6 95872-95982
1023-1105 AL845368.6 96058-96140
1106-1205 AL845368.6 97251-97350
1206-1290 AL845368.6 100584-100668
1291-3118 AL845368.6 102207-104034
FEATURES Location/Qualifiers
source 1..3118
/organism="Mus musculus"
/mol_type="mRNA"
/db_xref="taxon:10090"
/chromosome="2"
/map="2 61.88 cM"
gene 1..3118
/gene="Stard7"
/note="StAR related lipid transfer domain containing 7"
/db_xref="GeneID:99138"
/db_xref="MGI:MGI:2139090"
exon 1..652
/gene="Stard7"
/inference="alignment:Splign:2.1.0"
misc_feature 210..212
/gene="Stard7"
/note="upstream in-frame stop codon"
CDS 354..1475
/gene="Stard7"
/note="isoform 1 precursor is encoded by transcript
variant 1; stAR-related lipid transfer protein 7,
mitochondrial; START domain-containing protein 7; START
domain containing 7"
/codon_start=1
/product="stAR-related lipid transfer protein 7,
mitochondrial isoform 1 precursor"
/protein_id="NP_647469.2"
/db_xref="CCDS:CCDS16698.2"
/db_xref="GeneID:99138"
/db_xref="MGI:MGI:2139090"
/translation="MFPRRPPATLAAWLAGARGGGLLSALANQCRFVTGLRVRRAQQI
AQLYGRLYSESSRCALLGRFWRRLRGRPGHASVLMAALSGVFVWDEERIQEEELQRSI
NEMKRLEEMSNIFQSSGVENYPPEPKSPAGGNEKSKDKEEPWEMVMDKKHFKLWRRPI
TGTHLYQYRVFGTYTDVTPRQFFNVQLDTEYRKKWDALVIKLEVIERDAVSGSEVLHW
VTHFPYPMYSRDYVYVRRYSVDQENNVMVLVSRAVEHPSVPESPEFVRVRSYESQMVI
RPHKSFDENGFDYLLTYSDNPQTVFPRYCVSWMVSSGMPDFLEKLHMATLKAKNMEIK
VKDYISAKPLEMSSEAKATAPSPERKNEGSCGPARIEYA"
transit_peptide 354..536
/gene="Stard7"
/note="Mitochondrion. /evidence=ECO:0000255; propagated
from UniProtKB/Swiss-Prot (Q8R1R3.2)"
misc_feature 591..596
/gene="Stard7"
/note="Cleavage, by PARL.
/evidence=ECO:0000250|UniProtKB:Q9NQZ5; propagated from
UniProtKB/Swiss-Prot (Q8R1R3.2); cleavage site"
misc_feature 705..776
/gene="Stard7"
/note="propagated from UniProtKB/Swiss-Prot (Q8R1R3.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 1392..1472
/gene="Stard7"
/note="propagated from UniProtKB/Swiss-Prot (Q8R1R3.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
exon 653..861
/gene="Stard7"
/inference="alignment:Splign:2.1.0"
exon 862..911
/gene="Stard7"
/inference="alignment:Splign:2.1.0"
exon 912..1022
/gene="Stard7"
/inference="alignment:Splign:2.1.0"
exon 1023..1105
/gene="Stard7"
/inference="alignment:Splign:2.1.0"
exon 1106..1205
/gene="Stard7"
/inference="alignment:Splign:2.1.0"
exon 1206..1290
/gene="Stard7"
/inference="alignment:Splign:2.1.0"
exon 1291..3118
/gene="Stard7"
/inference="alignment:Splign:2.1.0"
regulatory 3096..3101
/regulatory_class="polyA_signal_sequence"
/gene="Stard7"
regulatory 3104..3109
/regulatory_class="polyA_signal_sequence"
/gene="Stard7"
polyA_site 3117
/gene="Stard7"
ORIGIN
1 actcggcgcg agaggcggac acaggcgcac gggaccgctt ctgctgtggc ctgggacggc
61 caccgctttg cttcccgcgc cctggccgcg ggggccccgc gagttcccgc cgtacacaca
121 gacgggcggg ctgtcgggac cgagagggcc tcgtgcaacg gcgctctcct cggaagccac
181 gctacctcag ccgcttctgc aaaaaggcat gagggacggc tcctggcttc tggagcgtga
241 ggtggcctcg gggtcaaccc gttaagggga ctgcgcggac ggcccggcct gccttccccc
301 agcccttcct ctccggggcc ccgcggcagg cgcgggaatc cacagaggcc gacatgttcc
361 cgaggaggcc accggccacc ctggccgcct ggctggcggg cgcgcggggc gggggcctgc
421 tgtccgcgct ggccaatcag tgccgcttcg tgacgggcct gcgcgtgcgg cgagcgcagc
481 agatcgcgca gctctacggc cgcctgtatt ccgagagctc gcgctgcgcc ctgctcggac
541 gcttctggcg ccggctgcga ggccgccccg gccatgcctc tgttttgatg gcggcgctct
601 ccggtgtttt cgtatgggac gaggagagaa tccaggagga ggagttgcag aggtccatta
661 atgagatgaa acggttggaa gaaatgtcaa atatatttca gagctctgga gttgagaatt
721 accctcccga accaaagtcc ccagcaggag ggaatgaaaa gtcaaaagac aaggaagaac
781 cctgggaaat ggtgatggac aagaaacact tcaagctgtg gcgccgccca attacaggca
841 cccaccttta ccagtaccga gtttttggaa catacacaga tgtgactccc cgacagttct
901 tcaatgttca gctggataca gagtacagga aaaaatggga tgcccttgtg atcaagctag
961 aggtgattga gagagatgct gttagtggtt ctgaggttct tcattgggta acccattttc
1021 cttatccaat gtactctcgt gattatgttt atgttcggcg gtatagtgtg gatcaggaaa
1081 acaatgtgat ggtcttggtg tcacgtgcgg tggaacaccc cagtgtgcca gagtctccag
1141 agtttgtcag ggtcagatct tacgaatccc aaatggttat ccgtcctcac aagtcgtttg
1201 atgagaatgg ctttgactac ttactgacat acagtgacaa tccacagaca gtgttccctc
1261 gatactgtgt cagttggatg gtttctagtg gcatgccaga tttcttggag aagctgcaca
1321 tggccactct gaaagccaag aacatggaga tcaaagtgaa agactacatc tcggctaagc
1381 ctctggaaat gagcagtgag gccaaggcca ctgctccatc ccctgagcgg aagaatgagg
1441 gtagctgtgg ccctgctcgg attgagtatg cttaaaggcc tttgggataa ggaaagacag
1501 gcacttccag ccctgccttg ctccttcagc tctgctgcag gacagggaca agtcacacat
1561 gttagaagac atctgctgta actgtcagtg caagaggatt tagaactgga gttagatttc
1621 atctggagcc ctattgctct ttaccaaaca gaggagcatg acattgtgga gttgtcatgt
1681 tctcaggcca gcagttgtga aatccagtat cgtgcttacc tactctggaa caacctctca
1741 tgttaggcca gaaggagatg actcctatcc gcctcctacg agaagcttcc ttgctgacat
1801 tccaaatgcc actgttggtt atgcaatgct ctggatatcc ttcagttctg taggtcactt
1861 ggagagtggt tggcccctgg ttctcactaa gtggtttttt ggagtgctct tggtaacagt
1921 cctgtggtgg tgtgaacaat tctggctgag ctaagtgcct tgtcctcacc ttgctttatc
1981 tttaaagaca tgaagtttgt accaagggat ccttccccct gcagactacc atgacattga
2041 ctcatctggt ggaggcagct ttcatcttaa ctggcctttc tgttttcatg ggctgtgctc
2101 actgtgtcat ggcctctgcc gtagccttag cccatttgct gggagcacca gagacaaact
2161 cctctagacg gtagcttcct aaatgatgtc atcagtgttt tgataggatc agtggaagtg
2221 tgcacaaaac atcttactta aaaatagatt tctttttaac ccttgtagca aatggagtta
2281 ggtggttgag cacaactctt cccttagtct tgtttgtttt ggcactattt tcccactgca
2341 gattgactgc gctgtcctgg aaggataaag gtggtagatg gtggttgtgc catttcctca
2401 gagttttcaa aactgtaagc tgacatatgg gccaacagat ggagtcttgc ccaataccag
2461 tatggtaggg atggggcttt tgtgacctct tggtcttgta aagcatttct ctccagagct
2521 gacatagaag taatagacac agtttggata agatcacaac cagatgctag gtgcctggcc
2581 ttgctggttt ctttatggtg aatagggatc aagtttcaca tccttctctc tcttttcctg
2641 gaattaatag agctgacatt ttcttttctt gcttgctacc taccctgttg tggtgttaaa
2701 agagactaaa cccaaggtga acataatctt taaccttctg ttgcctattc agttctgtgc
2761 caaggaaaca gctaactccc cagtgtttct gtcttttcgg ttgttggcag agcagagagt
2821 ggcattgaga agccccagtg tctctcagtg agcatttttc ccttcttccc aggacctgac
2881 aggaaaagaa aaaatcttta tttgacttta acatctgtag ctgactgcct gtgaatctgt
2941 gagcaagtgt aagcatgtat gtgtgcgtgt gtgtgctggg gctcagggac tgagcagtta
3001 cgtttaccct ttgttttgtg atttgactct gtacagttaa cttgtgtcat cataatgagt
3061 ttgctcttaa ctgtgacatt tttatcaaag gtgtgaataa atgcataaag attggtac
//