LOCUS NM_001145922 5478 bp mRNA linear ROD 30-APR-2024
DEFINITION Mus musculus Rho guanine nucleotide exchange factor 40 (Arhgef40),
transcript variant 3, mRNA.
ACCESSION NM_001145922
VERSION NM_001145922.1
KEYWORDS RefSeq.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (bases 1 to 5478)
AUTHORS Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
Jackson,S.P. and Balmus,G.
CONSRTM Sanger Mouse Genetics Project
TITLE Genetic determinants of micronucleus formation in vivo
JOURNAL Nature 627 (8002), 130-136 (2024)
PUBMED 38355793
REFERENCE 2 (bases 1 to 5478)
AUTHORS Bedogni,F. and Hevner,R.F.
TITLE Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
Intermediate Progenitors Implicated in Axon Development
JOURNAL Front Mol Neurosci 14, 686034 (2021)
PUBMED 34321999
REMARK Publication Status: Online-Only
REFERENCE 3 (bases 1 to 5478)
AUTHORS Lumayag,S., Haldin,C.E., Corbett,N.J., Wahlin,K.J., Cowan,C.,
Turturro,S., Larsen,P.E., Kovacs,B., Witmer,P.D., Valle,D.,
Zack,D.J., Nicholson,D.A. and Xu,S.
TITLE Inactivation of the microRNA-183/96/182 cluster results in
syndromic retinal degeneration
JOURNAL Proc Natl Acad Sci U S A 110 (6), E507-E516 (2013)
PUBMED 23341629
REFERENCE 4 (bases 1 to 5478)
AUTHORS Tse,S.W., Broderick,J.A., Wei,M.L., Luo,M.H., Smith,D.,
McCaffery,P., Stamm,S. and Andreadis,A.
TITLE Identification, expression analysis, genomic organization and
cellular location of a novel protein with a RhoGEF domain
JOURNAL Gene 359, 63-72 (2005)
PUBMED 16143467
REFERENCE 5 (bases 1 to 5478)
AUTHORS Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
Saga,Y., Kitamura,H., Nakagawa,T., Nagase,T., Ohara,O. and Koga,H.
TITLE Prediction of the coding sequences of mouse homologues of FLJ
genes: the complete nucleotide sequences of 110 mouse
FLJ-homologous cDnas identified by screening of terminal sequences
of cDNA clones randomly sampled from size-fractionated libraries
JOURNAL DNA Res 11 (2), 127-135 (2004)
PUBMED 15449545
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AK163945.1, BC059018.1 and AK143527.1.
Transcript Variant: This variant (3) lacks an alternate in-frame
exon in the 3' coding region, compared to variant 1. The resulting
protein (isoform 3) is shorter when compared to isoform 1.
##Evidence-Data-START##
Transcript exon combination :: BC059018.1, SRR9219382.48667.1
[ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN00849374, SAMN00849375
[ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-98 AK163945.1 2-99
99-4854 BC059018.1 1-4756
4855-5478 AK143527.1 4974-5597
FEATURES Location/Qualifiers
source 1..5478
/organism="Mus musculus"
/mol_type="mRNA"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="14"
/map="14 26.75 cM"
gene 1..5478
/gene="Arhgef40"
/gene_synonym="E130112L23Rik; Gm669; Solo"
/note="Rho guanine nucleotide exchange factor 40"
/db_xref="GeneID:268739"
/db_xref="MGI:MGI:2685515"
exon 1..159
/gene="Arhgef40"
/gene_synonym="E130112L23Rik; Gm669; Solo"
/inference="alignment:Splign:2.1.0"
CDS 157..4566
/gene="Arhgef40"
/gene_synonym="E130112L23Rik; Gm669; Solo"
/note="isoform 3 is encoded by transcript variant 3;
protein SOLO; Rho guanine nucleotide exchange factor (GEF)
40"
/codon_start=1
/product="rho guanine nucleotide exchange factor 40
isoform 3"
/protein_id="NP_001139394.1"
/db_xref="CCDS:CCDS59616.1"
/db_xref="GeneID:268739"
/db_xref="MGI:MGI:2685515"
/translation="MEPEPVEDCVQSTLAALYPPFEATAPTLLGQVFQVVERTYQEDA
LRYTLDFLVPAKHLLAKVQQEACAQYSGFLFFHEGWPLCLHEQVVVQLAALPWQLLRP
GDFYLQVVPSAAQAPRLALKCLAPGGGRVQELPVPSEACAYLFTPEWLQGINKDRPTG
RLSTCLLSAPSGIQRLPWAELVCPRFVHKEGLMVGHQPSTLPPELPSGPPGLPSSPLP
EEVLGTRSPGDGHNAPAEGPEGEYVELLEVTLPVRGSPVDAEASGLSRTRTVPARKST
GGKGRHRRHRAWMNQKGLGSRDQDGTRPPGEGSSTGASSDSPSGAEADPDATALQASE
PPAEALGEAPESCLLSGEAVGGVGQGAEGPPGTPRRTGKGNRRKKRAAGRGAGSRGGE
GTSLSPRDKEETRQQEVLVSLPSPSEQEPAECSLVKEKEDSGKQESESKEELKPADEK
EPARPEDYEPPEEEIRESEKEELTPQCTAGSTGPEWFPSEPSTQPLETVQNVKGDSLP
EETPPVSVLDDPVVAWDLMASGFFVLTGGVDQTGRALLTITPPPPCLPEESSPSQETL
STALRYLHSLLRPDLQLLGLTILLDLRKAPPLPPALLPALSQLQDSGEPPLIQRLVIL
IHEDPPAELCGFQGAELLSEKDLKRVAKPEELQWDLGGHRDLSPNHWAEIHQEVARLC
TLCQGVLTSVRQAIEELEGTAEPKEEEAVGMPEPLQKVLADPRLTALQRNGGAILMRL
RSAHSSKLEGPGPAELYQEVDEAIHQLVRLSNLRVQQQEERQRLRQVQQVLQWLSGPG
EEQLASFSMPGNSLSVLQETELRFRAFSTEVQERLVQAREALALEEDLTSQKVLDIFE
QRLEQAESGLHRALRLQRFFQQAHEWVDEGSARLAGAGSGREALLAALALRRAPEPSA
GTFQEMRALALDLGSPAALREWGRCRARCQELERRIQQQLGEEASPRSHRRRRADSAS
SAGAQHGAHSPSPSLSSLLLPSSPGPRAAPSHCSLTPCGEDYEEEGLELAPETDGRPP
RAVLIRGLEVTSTEVVDRTCSPREHVLLGRAGGPDGPWGIGTPRMERKRSISAQQRLV
SELIACEQEYVTTLNEPVPLPGPELTPELRCTWAAALSVRERLRSFHGTHFLQELQGC
AAHPLRIGACFLRHGDQFNLYAQFVKHRHKLESGLAALTPSVKGSMESSPCLPRALQQ
PLEQLARYGQLLEELLREAGPELSSERQALRAAVQLLQEQEARGRDLLAVEAVRGCEI
DLKEQGQLLHRDPFTVICGRKKCLRHVFLFEDLLLFSKLKGSEGGSETFVYKQAFKTA
DMGLTENIGDSGLCFELWFRRRRAREAYTLQATSPETKLKWTSSIAQLLWRQAAHNKE
LRVQQMVSMGIGNKPFLDIKALGERTLSALLTGRASETLDSSGDVSPGPRNSPSLQPP
SPGSSTPALTSGGILGLSRQSHSRALSDPTTPL"
exon 160..357
/gene="Arhgef40"
/gene_synonym="E130112L23Rik; Gm669; Solo"
/inference="alignment:Splign:2.1.0"
exon 358..1594
/gene="Arhgef40"
/gene_synonym="E130112L23Rik; Gm669; Solo"
/inference="alignment:Splign:2.1.0"
exon 1595..1762
/gene="Arhgef40"
/gene_synonym="E130112L23Rik; Gm669; Solo"
/inference="alignment:Splign:2.1.0"
exon 1763..1889
/gene="Arhgef40"
/gene_synonym="E130112L23Rik; Gm669; Solo"
/inference="alignment:Splign:2.1.0"
exon 1890..1986
/gene="Arhgef40"
/gene_synonym="E130112L23Rik; Gm669; Solo"
/inference="alignment:Splign:2.1.0"
exon 1987..2067
/gene="Arhgef40"
/gene_synonym="E130112L23Rik; Gm669; Solo"
/inference="alignment:Splign:2.1.0"
exon 2068..2184
/gene="Arhgef40"
/gene_synonym="E130112L23Rik; Gm669; Solo"
/inference="alignment:Splign:2.1.0"
exon 2185..2280
/gene="Arhgef40"
/gene_synonym="E130112L23Rik; Gm669; Solo"
/inference="alignment:Splign:2.1.0"
exon 2281..2396
/gene="Arhgef40"
/gene_synonym="E130112L23Rik; Gm669; Solo"
/inference="alignment:Splign:2.1.0"
exon 2397..2523
/gene="Arhgef40"
/gene_synonym="E130112L23Rik; Gm669; Solo"
/inference="alignment:Splign:2.1.0"
exon 2524..2646
/gene="Arhgef40"
/gene_synonym="E130112L23Rik; Gm669; Solo"
/inference="alignment:Splign:2.1.0"
exon 2647..2790
/gene="Arhgef40"
/gene_synonym="E130112L23Rik; Gm669; Solo"
/inference="alignment:Splign:2.1.0"
exon 2791..3401
/gene="Arhgef40"
/gene_synonym="E130112L23Rik; Gm669; Solo"
/inference="alignment:Splign:2.1.0"
exon 3402..3636
/gene="Arhgef40"
/gene_synonym="E130112L23Rik; Gm669; Solo"
/inference="alignment:Splign:2.1.0"
exon 3637..3723
/gene="Arhgef40"
/gene_synonym="E130112L23Rik; Gm669; Solo"
/inference="alignment:Splign:2.1.0"
exon 3724..3939
/gene="Arhgef40"
/gene_synonym="E130112L23Rik; Gm669; Solo"
/inference="alignment:Splign:2.1.0"
exon 3940..4110
/gene="Arhgef40"
/gene_synonym="E130112L23Rik; Gm669; Solo"
/inference="alignment:Splign:2.1.0"
exon 4111..4288
/gene="Arhgef40"
/gene_synonym="E130112L23Rik; Gm669; Solo"
/inference="alignment:Splign:2.1.0"
exon 4289..4393
/gene="Arhgef40"
/gene_synonym="E130112L23Rik; Gm669; Solo"
/inference="alignment:Splign:2.1.0"
exon 4394..4524
/gene="Arhgef40"
/gene_synonym="E130112L23Rik; Gm669; Solo"
/inference="alignment:Splign:2.1.0"
exon 4525..4571
/gene="Arhgef40"
/gene_synonym="E130112L23Rik; Gm669; Solo"
/inference="alignment:Splign:2.1.0"
exon 4572..5478
/gene="Arhgef40"
/gene_synonym="E130112L23Rik; Gm669; Solo"
/inference="alignment:Splign:2.1.0"
regulatory 4835..4840
/regulatory_class="polyA_signal_sequence"
/gene="Arhgef40"
/gene_synonym="E130112L23Rik; Gm669; Solo"
/note="hexamer: ATTAAA"
regulatory 4839..4844
/regulatory_class="polyA_signal_sequence"
/gene="Arhgef40"
/gene_synonym="E130112L23Rik; Gm669; Solo"
/note="hexamer: AATATA"
polyA_site 4854
/gene="Arhgef40"
/gene_synonym="E130112L23Rik; Gm669; Solo"
/note="major polyA site"
polyA_site 4888
/gene="Arhgef40"
/gene_synonym="E130112L23Rik; Gm669; Solo"
regulatory 5455..5460
/regulatory_class="polyA_signal_sequence"
/gene="Arhgef40"
/gene_synonym="E130112L23Rik; Gm669; Solo"
/note="hexamer: AATAAA"
polyA_site 5476
/gene="Arhgef40"
/gene_synonym="E130112L23Rik; Gm669; Solo"
ORIGIN
1 cccgcggcct gggctgccga acgagcgggg agagccgcgg tcgccgcgcg agttgtcctg
61 cagctagacc cggcgagact gagcgcccgg agggaggcgg tggctcaccc gccccgcccg
121 cccgccggag agtgggacac ctcccgacgc cgagccatgg agcctgaacc agtggaggac
181 tgtgtgcaga gcacgcttgc tgccttgtac ccgccctttg aagccacagc cccaaccctg
241 ttgggccagg tgttccaggt ggtggagagg acgtaccagg aggatgcgct gaggtacacg
301 ctggacttcc tggtacctgc taaacacctg cttgccaagg tccagcagga agcctgtgcc
361 cagtatagtg gattcctctt cttccacgag ggctggccac tctgcttgca tgagcaggtg
421 gtagtgcagc tagcggccct tccctggcag ctgctgcgcc ctggagactt ctacctgcag
481 gtagtgcctt cagcagccca ggcaccccgg ctggcactga aatgcctggc cccaggaggt
541 gggcgggtac aggagctccc agtgcccagt gaagcctgtg cctacctctt cacacctgag
601 tggctacaag gcattaacaa ggaccggcca acagggcgcc tcagcacctg ccttctgtcc
661 gccccctccg ggatccagcg gctgccctgg gctgagctcg tctgcccacg atttgtgcac
721 aaagagggcc tcatggtggg acatcaacca agtacattgc ctccagaact gccctctgga
781 cctccaggtc ttcccagctc tccactccct gaggaggtac ttggtacccg gagtcctggg
841 gatggacaca acgctcccgc agaaggtccc gagggtgaat atgtggagct gttggaggtg
901 acactgcctg tgaggggaag ccctgtagat gctgaggcct cgggcctctc ccggacccgc
961 acagtacccg cccgtaagag cactggaggg aagggccggc accggagaca cagggcgtgg
1021 atgaatcaga aaggcctggg atctcgggat caggatggga cgcggccgcc tggtgaggga
1081 agtagcaccg gggcctcttc cgactcacct tcaggggctg aggcagaccc agatgccacc
1141 gccctccagg catctgagcc cccggcagag gctctcgggg aagcccctga atcctgcctc
1201 ctgtcagggg aggctgtggg aggagtgggc cagggggctg aaggaccacc tggtacccct
1261 cgaagaaccg gcaaaggaaa cagaagaaag aagcgagctg cgggcagagg cgctggaagc
1321 cggggagggg agggtacctc actcagcccc agggacaaag aagagaccag acagcaggaa
1381 gtccttgtca gtctgccctc acccagtgaa caggaacctg cagaatgcag cctggttaag
1441 gagaaagagg attctgggaa gcaagagtct gaatcaaaag aggaactcaa gccagcagat
1501 gaaaaagagc ctgcacgccc agaagactat gagcctccag aagaggagat cagagagagt
1561 gagaaagagg agttgacccc gcagtgtacg gcaggatcca caggtccaga gtggttccca
1621 tctgagccct caacacagcc cctggagact gtgcagaatg ttaaaggaga cagcctccca
1681 gaggaaactc ccccagtttc tgttttggat gacccagttg tagcttggga cttgatggca
1741 tctggattct tcgttctgac tggaggggta gatcagactg ggcgagctct gctgacaatc
1801 acgcctccac ctccgtgcct tcctgaggag tcctcaccct cccaagagac actgagcact
1861 gctctccgtt acctccactc actgcttagg cctgatctgc agttactggg gctgaccatc
1921 ctccttgacc ttcgcaaggc acctccactg cctccagcac ttcttcctgc cttgagtcag
1981 cttcaggact caggcgagcc tccgctcatt cagcggctgg tgatcctcat tcatgaagac
2041 cctccagctg aactctgtgg atttcaggga gctgagttgc tgtcagagaa ggatctgaaa
2101 agagtggcca agccagagga gctacagtgg gacttaggag gtcacaggga cctctccccc
2161 aaccactggg cagagataca tcaggaagtg gcaaggctat gcaccttgtg ccaaggcgtg
2221 ttgacctccg tacggcaggc cattgaggag ctagagggaa cagcagaacc caaagaagag
2281 gaggccgtgg gaatgcctga gcctctgcaa aaggtgctgg cagatcctcg gctgacagca
2341 ctacagagga acggaggagc catcctgatg cgcctgcgct ccgcccacag cagcaagcta
2401 gagggcccag gcccagctga gctataccag gaggtagatg aggccattca ccaacttgtg
2461 cgtctgtcca acctacgagt gcagcagcag gaagaacggc agcgcctgcg ccaagtccag
2521 caggtgttgc agtggctgtc tggcccagga gaagagcagc tggcaagctt ctccatgccg
2581 gggaactcac tgtcagtctt gcaagagaca gaacttcgat tcagggcttt tagcacagaa
2641 gtgcaggagc gcctagtcca agcccgggaa gctttggctc tggaggagga ccttacctcc
2701 cagaaagttc tagacatctt tgaacaacgg ttggagcagg ctgagagcgg cctccaccgg
2761 gccctcaggc tacagcgctt cttccagcag gcacacgaat gggtagatga gggctctgct
2821 cggctggcag gagctgggtc tggtcgtgaa gctctgctgg cagccctagc cctgcggagg
2881 gccccagaac ccagtgcagg caccttccaa gagatgcgag ccctggccct ggacttgggc
2941 agccccgcag cccttcgaga gtggggccga tgtcgggcac gctgccagga gctggaaaga
3001 aggattcagc agcagctggg agaggaggcc agtcctagaa gccaccgacg acgtcgggca
3061 gacagtgcca gcagcgcagg ggcccagcac ggagcccata gcccttcacc cagcctcagt
3121 tccctgctgc ttcccagcag ccctgggcca cgggcagccc catcacattg ctctctgacc
3181 ccatgtgggg aggattatga ggaagaaggc cttgagctag ctccagaaac agatggaaga
3241 cccccaaggg ctgtgctaat ccgaggactg gaggtcacca gtactgaagt ggtagacagg
3301 acatgttcgc cccgagaaca cgtactattg ggccgggctg gagggccaga tggaccctgg
3361 ggaataggta cccctcgaat ggaacgcaaa cgaagcatca gcgcccagca gcgtctagtg
3421 tctgaactga ttgcctgtga gcaggagtac gtaaccaccc tgaatgagcc agtgccgctg
3481 cctgggcctg agctaacgcc tgagcttcga tgcacctggg ctgcagccct gagtgtccga
3541 gagaggcttc gcagcttcca cgggacacac tttctacaag agcttcaggg ctgcgccgcc
3601 caccccctgc gcattggggc ctgcttcctt cgccatgggg atcagttcaa cctctatgca
3661 cagttcgtga agcacaggca taaactggag agtggtctgg ctgcgctcac cccctcggtc
3721 aagggttcca tggagagcag cccttgcttg ccccgggccc tgcagcagcc actggagcag
3781 ctggctcggt atggacagct cctggaggag ctcctgaggg aagccgggcc tgagctaagc
3841 tctgaacgcc aggccctcag ggccgctgta cagttgctcc aggaacaaga ggcccgaggc
3901 agagatctgc ttgctgtgga agctgttcga ggctgtgaga tagatctaaa ggaacaggga
3961 cagctcttgc atcgggaccc tttcactgtc atctgtggcc ggaaaaagtg cctccgccac
4021 gtcttcctgt ttgaggacct gctcttattc agcaagctca agggatctga aggaggatcc
4081 gagaccttcg tttacaagca ggctttcaag accgctgaca tggggctgac agaaaacatc
4141 ggggacagtg gactctgttt cgaactatgg tttcgacgac ggcgtgcaag agaagcatac
4201 acgttgcagg ctacttcgcc agagaccaaa ctcaagtgga caagttctat tgcccagctg
4261 ctgtggagac aggcagccca caacaaggaa ctccgagtgc agcagatggt ttccatgggc
4321 attgggaata aacctttcct ggacattaaa gcccttgggg aacggacact gagtgccctg
4381 ctcactggaa gagcctcaga aacacttgat tcttctggag atgtgtcccc aggaccacga
4441 aacagcccca gcctgcagcc ccccagccct gggagcagta ctcccgctct gaccagtgga
4501 gggatcttag ggctctctcg gcagagtcat tcccgagccc tgagtgaccc caccacgcct
4561 ctgtgagcta ggaaccggag tggccctgtt caattgcctt tatgctccga gggcagggaa
4621 atgtcccctt gctgtgctac tgcacacccc cgggacactg ctctgcggac acccactact
4681 cttctcatcc caactctccc agaagattca tctctgccag gtcgaatgga attccattct
4741 gggagatcat gagaaatatg ttgtaagcca ctgaaggaga cggggtgggc actgcagact
4801 ttatatgtaa ttactgttat tatactattg ttacattaaa tatatttact ctcactgtga
4861 ctctgaggag ctcgcgcagg cctctggatt aaggtggttg aactgacttc attacttccc
4921 tataaccact aagtaggact cagaagataa aaccaaggtc agaaagtagc tgttccttcc
4981 tccccttgct ggccccaaca ctgcaggtct gggtctgagt gtgggagaat gcctccccct
5041 caggctctgg gaagctcaat gaactctgaa gtccctcctc cattctgcac ccacttcttg
5101 aggcctgaga tggtcggatg ggtccagcac aatgcagcac ttatctatga tgtcctcggg
5161 cctcagtgca agagaggcca cggctattta ttacaaacgc tagctttagg gcctcatcca
5221 gagttactga atcaaagatt tgcatcctta tcgacctcgt tgataacgaa gtgcccagga
5281 ggagtgaaac acaggcagac acacacaggg ccttgtgcct caagacacct gtttattggg
5341 gacatgactc ttcaacaggg atgacaggaa tcgtaccaaa aatagcaacg tctacaaggg
5401 cccctgatag ggctagaagg gtacagtgcc ccccaccccc accccttata caaaaataaa
5461 ctctcatgcc tatggacc
//