LOCUS NM_028710 3292 bp mRNA linear ROD 30-APR-2024
DEFINITION Mus musculus arylsulfatase G (Arsg), transcript variant 1, mRNA.
ACCESSION NM_028710
VERSION NM_028710.3
KEYWORDS RefSeq; RefSeq Select.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (bases 1 to 3292)
AUTHORS Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
Jackson,S.P. and Balmus,G.
CONSRTM Sanger Mouse Genetics Project
TITLE Genetic determinants of micronucleus formation in vivo
JOURNAL Nature 627 (8002), 130-136 (2024)
PUBMED 38355793
REFERENCE 2 (bases 1 to 3292)
AUTHORS Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
TITLE Mouse Models of Inherited Retinal Degeneration with Photoreceptor
Cell Loss
JOURNAL Cells 9 (4), 931 (2020)
PUBMED 32290105
REMARK Review article
Publication Status: Online-Only
REFERENCE 3 (bases 1 to 3292)
AUTHORS Ingham,N.J., Rook,V., Di Domenico,F., James,E., Lewis,M.A.,
Girotto,G., Buniello,A. and Steel,K.P.
TITLE Functional analysis of candidate genes from genome-wide association
studies of hearing
JOURNAL Hear Res 387, 107879 (2020)
PUBMED 31927188
REFERENCE 4 (bases 1 to 3292)
AUTHORS Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
White,J.K. and Steel,K.P.
TITLE Mouse screen reveals multiple new genes underlying mouse and human
hearing loss
JOURNAL PLoS Biol 17 (4), e3000194 (2019)
PUBMED 30973865
REMARK Publication Status: Online-Only
REFERENCE 5 (bases 1 to 3292)
AUTHORS Kruszewski,K., Lullmann-Rauch,R., Dierks,T., Bartsch,U. and
Damme,M.
TITLE Degeneration of Photoreceptor Cells in Arylsulfatase G-Deficient
Mice
JOURNAL Invest Ophthalmol Vis Sci 57 (3), 1120-1131 (2016)
PUBMED 26975023
REFERENCE 6 (bases 1 to 3292)
AUTHORS Ratzka,A., Mundlos,S. and Vortkamp,A.
TITLE Expression patterns of sulfatase genes in the developing mouse
embryo
JOURNAL Dev Dyn 239 (6), 1779-1788 (2010)
PUBMED 20503373
REFERENCE 7 (bases 1 to 3292)
AUTHORS Otsuki,B., Matsumura,T., Shimizu,M., Mori,M., Okudaira,S.,
Nakanishi,R., Higuchi,K., Hosokawa,M., Tsuboyama,T. and Nakamura,T.
TITLE Quantitative trait locus that determines the cross-sectional shape
of the femur in SAMP6 and SAMP2 mice
JOURNAL J Bone Miner Res 22 (5), 675-685 (2007)
PUBMED 17295603
REFERENCE 8 (bases 1 to 3292)
AUTHORS Sardiello,M., Annunziata,I., Roma,G. and Ballabio,A.
TITLE Sulfatases and sulfatase modifying factors: an exclusive and
promiscuous relationship
JOURNAL Hum Mol Genet 14 (21), 3203-3217 (2005)
PUBMED 16174644
REFERENCE 9 (bases 1 to 3292)
AUTHORS Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
TITLE Genomic analysis of mouse retinal development
JOURNAL PLoS Biol 2 (9), E247 (2004)
PUBMED 15226823
REFERENCE 10 (bases 1 to 3292)
AUTHORS Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
TITLE Prediction of the coding sequences of mouse homologues of KIAA
gene: IV. The complete nucleotide sequences of 500 mouse
KIAA-homologous cDNAs identified by screening of terminal sequences
of cDNA clones randomly sampled from size-fractionated libraries
JOURNAL DNA Res 11 (3), 205-218 (2004)
PUBMED 15368895
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AK158726.1 and BC084731.1.
On Oct 10, 2009 this sequence version replaced NM_028710.2.
Transcript Variant: This variant (1) represents the longest
transcript and encodes the longest isoform (1). Variants 1 and 3
both encode the same isoform (1).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK158726.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN00849383, SAMN01164132
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression,
longest protein
##RefSeq-Attributes-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-1678 AK158726.1 2-1679
1679-3292 BC084731.1 1369-2982
FEATURES Location/Qualifiers
source 1..3292
/organism="Mus musculus"
/mol_type="mRNA"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="11"
/map="11 71.98 cM"
gene 1..3292
/gene="Arsg"
/gene_synonym="6330406P08Rik; ASG"
/note="arylsulfatase G"
/db_xref="GeneID:74008"
/db_xref="MGI:MGI:1921258"
exon 1..48
/gene="Arsg"
/gene_synonym="6330406P08Rik; ASG"
/inference="alignment:Splign:2.1.0"
exon 49..146
/gene="Arsg"
/gene_synonym="6330406P08Rik; ASG"
/inference="alignment:Splign:2.1.0"
exon 147..198
/gene="Arsg"
/gene_synonym="6330406P08Rik; ASG"
/inference="alignment:Splign:2.1.0"
exon 199..1081
/gene="Arsg"
/gene_synonym="6330406P08Rik; ASG"
/inference="alignment:Splign:2.1.0"
misc_feature 792..794
/gene="Arsg"
/gene_synonym="6330406P08Rik; ASG"
/note="upstream in-frame stop codon"
CDS 864..2441
/gene="Arsg"
/gene_synonym="6330406P08Rik; ASG"
/EC_number="3.1.6.1"
/EC_number="3.1.6.15"
/note="isoform 1 precursor is encoded by transcript
variant 1; N-sulfoglucosamine-3-sulfatase"
/codon_start=1
/product="arylsulfatase G isoform 1 precursor"
/protein_id="NP_082986.3"
/db_xref="CCDS:CCDS25581.1"
/db_xref="GeneID:74008"
/db_xref="MGI:MGI:1921258"
/translation="MGWLFLKVLLVGMAFSGFFYPLVDFSISGKTRAPQPNIVIILAD
DMGWGDLGANWAETKDTTNLDKMASEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGV
THNFAVTSVGGLPVNETTLAEVLRQEGYVTAMIGKWHLGHHGSYHPNFRGFDYYFGIP
YSNDMGCTDAPGYNYPPCPACPQRDGLWRNPGRDCYTDVALPLYENLNIVEQPVNLSG
LAQKYAERAVEFIEQASTSGRPFLLYVGLAHMHVPLSVTPPLAHPQRQSLYRASLREM
DSLVGQIKDKVDHVARENTLLWFTGDNGPWAQKCELAGSVGPFFGLWQTHQGGSPTKQ
TTWEGGHRVPALAYWPGRVPANVTSTALLSLLDIFPTVIALAGASLPPNRKFDGRDVS
EVLFGKSQMGHRVLFHPNSGAAGEYGALQTVRLNHYKAFYITGGAKACDGSVGPEQHH
VAPLIFNLEDAADEGMPLQKGSPEYQEVLQQVTRALADVLQDIADDNSSRADYTQDPS
VIPCCNPYQTTCRCQPV"
sig_peptide 864..911
/gene="Arsg"
/gene_synonym="6330406P08Rik; ASG"
/note="/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q3TYD4.1)"
mat_peptide 912..2438
/gene="Arsg"
/gene_synonym="6330406P08Rik; ASG"
/product="Arylsulfatase G. /id=PRO_0000238663"
/note="propagated from UniProtKB/Swiss-Prot (Q3TYD4.1)"
misc_feature 1212..1214
/gene="Arsg"
/gene_synonym="6330406P08Rik; ASG"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000269|PubMed:25135642; propagated from
UniProtKB/Swiss-Prot (Q3TYD4.1); glycosylation site"
misc_feature 1506..1508
/gene="Arsg"
/gene_synonym="6330406P08Rik; ASG"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000269|PubMed:25135642; propagated from
UniProtKB/Swiss-Prot (Q3TYD4.1); glycosylation site"
misc_feature 1929..1931
/gene="Arsg"
/gene_synonym="6330406P08Rik; ASG"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000269|PubMed:25135642; propagated from
UniProtKB/Swiss-Prot (Q3TYD4.1); glycosylation site"
misc_feature 2352..2354
/gene="Arsg"
/gene_synonym="6330406P08Rik; ASG"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000269|PubMed:25135642; propagated from
UniProtKB/Swiss-Prot (Q3TYD4.1); glycosylation site"
exon 1082..1269
/gene="Arsg"
/gene_synonym="6330406P08Rik; ASG"
/inference="alignment:Splign:2.1.0"
exon 1270..1317
/gene="Arsg"
/gene_synonym="6330406P08Rik; ASG"
/inference="alignment:Splign:2.1.0"
exon 1318..1429
/gene="Arsg"
/gene_synonym="6330406P08Rik; ASG"
/inference="alignment:Splign:2.1.0"
exon 1430..1567
/gene="Arsg"
/gene_synonym="6330406P08Rik; ASG"
/inference="alignment:Splign:2.1.0"
exon 1568..1764
/gene="Arsg"
/gene_synonym="6330406P08Rik; ASG"
/inference="alignment:Splign:2.1.0"
exon 1765..1845
/gene="Arsg"
/gene_synonym="6330406P08Rik; ASG"
/inference="alignment:Splign:2.1.0"
exon 1846..1954
/gene="Arsg"
/gene_synonym="6330406P08Rik; ASG"
/inference="alignment:Splign:2.1.0"
exon 1955..2075
/gene="Arsg"
/gene_synonym="6330406P08Rik; ASG"
/inference="alignment:Splign:2.1.0"
exon 2076..2166
/gene="Arsg"
/gene_synonym="6330406P08Rik; ASG"
/inference="alignment:Splign:2.1.0"
exon 2167..3278
/gene="Arsg"
/gene_synonym="6330406P08Rik; ASG"
/inference="alignment:Splign:2.1.0"
regulatory 3254..3259
/regulatory_class="polyA_signal_sequence"
/gene="Arsg"
/gene_synonym="6330406P08Rik; ASG"
/note="hexamer: AATAAA"
polyA_site 3278
/gene="Arsg"
/gene_synonym="6330406P08Rik; ASG"
/note="major polyA site"
ORIGIN
1 aaggcacgcg ccccgcctgc cggctgccgg ggctgggggt cacggaaggt taaagcgcta
61 gcacacatgg ggtgcgccaa cgatccagtg cctgggagaa ccacctttga cctcatgtgg
121 acagctggtg cccaaggccc ctcctgttca tccgaaagct tcgtttctgg aaaaccaaca
181 gagccccgag ccagcaaggg ggaagaaacc gatgaggcag ttgaacatct gaagaaggaa
241 aacatctgtt ggcatggaaa agtgattctt ttcccaagct actgagtaaa acaccacaga
301 cctggctgtt ccaactctgg tttcttgtca gattttgttc ctccaggaaa ccttacagaa
361 acctctacca tctggaactc agaaactcat ctcagggctg actgtggctt ctagaacatg
421 caggtgttct gcagatgtga gactgtatcc cgcagtcacc agatgaaatc ctaagcagat
481 gcaaggcttg ctttgtggcc ttagctcccc tgagtgcaaa gggccacttc tctgctaagt
541 ggccaagagt ggatattgac attgatgtct gaatgctgca cccagccagt catcttatta
601 agctgcgatg agaagacatc ttgaggggac caacccaact taggggtgac acattcctga
661 ctttcttgga ttaggattcc acatggggac cttgtgtctg tagccctgta gccattacta
721 actccagtgt attcttgaca actggactcc ttggagactt cctgcactga aagtgaacaa
781 agagaaaact ctaaaattcc agagattcac agtggtgctc ggttatcatt tatccaagac
841 aacgggagtc ttcgtgtctt acaatgggct ggctctttct aaaggttttg ttggttggca
901 tggctttttc tggatttttc taccctctcg tggatttctc tatcagtggg aaaacaagag
961 ccccccaacc aaacatcgtg atcattttgg ctgatgacat gggatggggt gatctgggag
1021 caaactgggc agaaacaaag gacaccacca atcttgacaa gatggcttcc gaaggaatga
1081 ggtttgtaga cttccacgca gctgcttcta cctgctcccc atcccgagcc tccctgctca
1141 ctggccggct gggtctacgg aacggagtca cgcacaactt cgcagtcacc tctgtagggg
1201 ggcttccagt caacgagacc accttggcag aggtgctgcg acaggagggt tacgtcactg
1261 ccatgatagg caagtggcat cttgggcatc atggctctta tcatcccaat ttccgtggct
1321 tcgattacta ctttggaatc ccatatagca atgacatggg ttgcactgat gctccaggct
1381 acaactaccc tccttgtcca gcgtgtccac agagagatgg cctatggagg aaccctggga
1441 gggactgtta cacagatgtt gcccttcctc tctatgaaaa cctgaacatc gtggagcagc
1501 ctgtgaacct gagcggcctt gcacagaagt acgcagaaag ggcagtggag ttcattgagc
1561 aggcaagcac cagtggaaga cccttcctgc tctacgtggg cctggctcac atgcatgtgc
1621 ctttgtctgt aactccacca ttggcacacc cacagcgcca aagcctgtac cgtgcaagtc
1681 tccgggagat ggacagtctg gtagggcaga tcaaggacaa agttgaccat gtggcaagag
1741 aaaacacact cctctggttt acaggagaca atggcccatg ggctcagaag tgtgagctgg
1801 caggcagcgt gggtcccttc ttcgggttgt ggcaaaccca tcaaggggga agtccaacca
1861 agcagaccac ctgggaaggt gggcatcggg ttccagcact ggcttactgg cctggcagag
1921 ttccagccaa cgtcactagc accgccttgt taagcttgct agacatcttc cccaccgtga
1981 tagctctggc aggagccagc ttgcccccaa accggaaatt tgatggacgg gatgtctctg
2041 aggtgctctt tggcaagtca cagatggggc acagggtgct attccacccc aacagtgggg
2101 ctgctggaga gtatggcgcc ctgcagactg tccgcctaaa ccattacaaa gctttctaca
2161 tcactggtgg agccaaagct tgtgatggga gcgtgggtcc tgagcagcac cacgtggccc
2221 ctctcatttt caacctagaa gatgctgctg atgaagggat gcctctacag aaggggagcc
2281 ccgagtacca ggaggtgctg cagcaggtca ccagggctct cgcagatgtc ctccaagaca
2341 tcgctgatga caacagctcc cgagcagact acactcagga tccttcagtg attccttgct
2401 gtaaccccta tcaaactacc tgccgttgcc aaccggtctg agggctcatt gttcccccca
2461 tgagaaacac tacctgaaaa ctgtagacag gtgggtttac ttccaaactt gggtgtggtc
2521 atggatgtct gctttagaaa ggaagctgca gcatttggtt agaaagcaac ggcgttacct
2581 ctgtgtgtgt ggactgtctc ctctgcatgc agacttgaga agccctgagt gctggtacag
2641 tggacacggc atggttaagc actagcgagt aatggggtca ggtctgagcc ctgggtttaa
2701 agctcaggca atgccttaaa cctcaattgc aagttgaagg ttaaagtaac ccacgaaact
2761 gtgtgtaacc cacgaactga caccaggcag attctcgatc ggtattttag tttctatctc
2821 gtgtccccag tttcaggggc cattttggca cagactcgtc tggtttgctg gtgggtaggg
2881 gtccgggagc ctacactgtt gcctttgaga tgacttgagc aagctaaacc aaagtgaggt
2941 tttcccaggc cttggaccct tctctcctgt aaatgtcaag tggatgtatt ataaagatgt
3001 aagcattcag ggctgaagtg gtggcccgtt ggttaagagc ttggcccact tgctcagttc
3061 ccagcaccta catggtagca taaactgtct gcaactctag ctctagggga accttgtcct
3121 cttctctggc ctctgagaat gccagacaca cacgtggtgt atatacatgt aggtaaaaca
3181 ctcatatatt aaaacatact cttttcaaaa aaattgggat ttcttcccag cccctaaaac
3241 ttctaagaaa caaaataaaa atgtaaacaa ctcacaaaaa aaaaaaaaaa aa
//