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NCBI Reference Sequence: NM_018250.3
FASTA Graphics
LOCUS NM_018250 2764 bp mRNA linear PRI 24-JUN-2018 DEFINITION Homo sapiens integrator complex subunit 9 (INTS9), transcript variant 1, mRNA. ACCESSION NM_018250 VERSION NM_018250.3 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2764) AUTHORS Wu Y, Albrecht TR, Baillat D, Wagner EJ and Tong L. TITLE Molecular basis for the interaction between Integrator subunits IntS9 and IntS11 and its functional importance JOURNAL Proc. Natl. Acad. Sci. U.S.A. 114 (17), 4394-4399 (2017) PUBMED 28396433 REMARK GeneRIF: Functional studies demonstrate that the IntS9-IntS11 interaction is crucial for the role of INT in snRNA 3'-end processing. REFERENCE 2 (bases 1 to 2764) AUTHORS Jodoin JN, Sitaram P, Albrecht TR, May SB, Shboul M, Lee E, Reversade B, Wagner EJ and Lee LA. TITLE Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the integrator complex JOURNAL Mol. Biol. Cell 24 (18), 2954-2965 (2013) PUBMED 23904267 REFERENCE 3 (bases 1 to 2764) AUTHORS Albrecht TR and Wagner EJ. TITLE snRNA 3' end formation requires heterodimeric association of integrator subunits JOURNAL Mol. Cell. Biol. 32 (6), 1112-1123 (2012) PUBMED 22252320 REMARK GeneRIF: The specific heterodimeric interaction between IntS9 and IntS11 is mediated by a discrete domain present at the extreme C terminus of IntS9 and within the C terminus of IntS11, adjacent to the predicted active site of this endonuclease. REFERENCE 4 (bases 1 to 2764) AUTHORS Baillat D, Hakimi MA, Naar AM, Shilatifard A, Cooch N and Shiekhattar R. TITLE Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II JOURNAL Cell 123 (2), 265-276 (2005) PUBMED 16239144 REFERENCE 5 (bases 1 to 2764) AUTHORS Dominski Z, Yang XC, Purdy M, Wagner EJ and Marzluff WF. TITLE A CPSF-73 homologue is required for cell cycle progression but not cell growth and interacts with a protein having features of CPSF-100 JOURNAL Mol. Cell. Biol. 25 (4), 1489-1500 (2005) PUBMED 15684398 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC339488.1, BC025267.1 and AA825242.1. This sequence is a reference standard in the RefSeqGene project. [WARNING] On Nov 22, 2018 this sequence was replaced by NM_018250.4. On Feb 20, 2010 this sequence version replaced NM_018250.2. Summary: This gene encodes a subunit of the Integrator complex. This protein complex binds the C-terminal domain of RNA polymerase II and likely plays a role in small nuclear RNA processing. The encoded protein has similarities to the subunits of the cleavage and polyadenylation specificity factor complex. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010]. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). ##Evidence-Data-START## Transcript exon combination :: SRR1803611.170659.1, SRR1803617.206818.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-176 DC339488.1 1-176 177-250 DC339488.1 178-251 251-2761 BC025267.1 1-2511 2762-2764 AA825242.1 4-6 c FEATURES Location/Qualifiers source 1..2764 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="8" /map="8p21.1" gene 1..2764 /gene="INTS9" /gene_synonym="CPSF2L; INT9; RC74" /note="integrator complex subunit 9" /db_xref="GeneID:55756" /db_xref="HGNC:HGNC:25592" /db_xref="MIM:611352" exon 1..308 /gene="INTS9" /gene_synonym="CPSF2L; INT9; RC74" /inference="alignment:Splign:2.1.0" misc_feature 270..272 /gene="INTS9" /gene_synonym="CPSF2L; INT9; RC74" /note="upstream in-frame stop codon" CDS 300..2276 /gene="INTS9" /gene_synonym="CPSF2L; INT9; RC74" /note="isoform 1 is encoded by transcript variant 1; protein related to CPSF subunits of 74 kDa" /codon_start=1 /product="integrator complex subunit 9 isoform 1" /protein_id="NP_060720.2" /db_xref="CCDS:CCDS34873.1" /db_xref="GeneID:55756" /db_xref="HGNC:HGNC:25592" /db_xref="MIM:611352" /translation="MKLYCLSGHPTLPCNVLKFKSTTIMLDCGLDMTSTLNFLPLPLV QSPRLSNLPGWSLKDGNAFLDKELKECSGHVFVDSVPEFCLPETELIDLSTVDVILIS NYHCMMALPYITEHTGFTGTVYATEPTVQIGRLLMEELVNFIERVPKAQSASLWKNKD IQRLLPSPLKDAVEVSTWRRCYTMQEVNSALSKIQLVGYSQKIELFGAVQVTPLSSGY ALGSSNWIIQSHYEKVSYVSGSSLLTTHPQPMDQASLKNSDVLVLTGLTQIPTANPDG MVGEFCSNLALTVRNGGNVLVPCYPSGVIYDLLECLYQYIDSAGLSSVPLYFISPVAN SSLEFSQIFAEWLCHNKQSKVYLPEPPFPHAELIQTNKLKHYPSIHGDFSNDFRQPCV VFTGHPSLRFGDVVHFMELWGKSSLNTVIFTEPDFSYLEALAPYQPLAMKCIYCPIDT RLNFIQVSKLLKEVQPLHVVCPEQYTQPPPAQSHRMDLMIDCQPPAMSYRRAEVLALP FKRRYEKIEIMPELADSLVPMEIKPGISLATVSAVLHTKDNKHLLQPPPRPAQPTSGK KRKRVSDDVPDCKVLKPLLSGSIPVEQFVQTLEKHGFSDIKVEDTAKGHIVLLQEAET LIQIEEDSTHIICDNDEMLRVRLRDLVLKFLQKF" exon 309..436 /gene="INTS9" /gene_synonym="CPSF2L; INT9; RC74" /inference="alignment:Splign:2.1.0" exon 437..497 /gene="INTS9" /gene_synonym="CPSF2L; INT9; RC74" /inference="alignment:Splign:2.1.0" exon 498..560 /gene="INTS9" /gene_synonym="CPSF2L; INT9; RC74" /inference="alignment:Splign:2.1.0" exon 561..700 /gene="INTS9" /gene_synonym="CPSF2L; INT9; RC74" /inference="alignment:Splign:2.1.0" exon 701..787 /gene="INTS9" /gene_synonym="CPSF2L; INT9; RC74" /inference="alignment:Splign:2.1.0" exon 788..908 /gene="INTS9" /gene_synonym="CPSF2L; INT9; RC74" /inference="alignment:Splign:2.1.0" exon 909..1043 /gene="INTS9" /gene_synonym="CPSF2L; INT9; RC74" /inference="alignment:Splign:2.1.0" exon 1044..1155 /gene="INTS9" /gene_synonym="CPSF2L; INT9; RC74" /inference="alignment:Splign:2.1.0" exon 1156..1336 /gene="INTS9" /gene_synonym="CPSF2L; INT9; RC74" /inference="alignment:Splign:2.1.0" exon 1337..1397 /gene="INTS9" /gene_synonym="CPSF2L; INT9; RC74" /inference="alignment:Splign:2.1.0" exon 1398..1569 /gene="INTS9" /gene_synonym="CPSF2L; INT9; RC74" /inference="alignment:Splign:2.1.0" exon 1570..1694 /gene="INTS9" /gene_synonym="CPSF2L; INT9; RC74" /inference="alignment:Splign:2.1.0" exon 1695..1862 /gene="INTS9" /gene_synonym="CPSF2L; INT9; RC74" /inference="alignment:Splign:2.1.0" exon 1863..1961 /gene="INTS9" /gene_synonym="CPSF2L; INT9; RC74" /inference="alignment:Splign:2.1.0" exon 1962..2099 /gene="INTS9" /gene_synonym="CPSF2L; INT9; RC74" /inference="alignment:Splign:2.1.0" exon 2100..2764 /gene="INTS9" /gene_synonym="CPSF2L; INT9; RC74" /inference="alignment:Splign:2.1.0" regulatory 2739..2744 /regulatory_class="polyA_signal_sequence" /gene="INTS9" /gene_synonym="CPSF2L; INT9; RC74" polyA_site 2761 /gene="INTS9" /gene_synonym="CPSF2L; INT9; RC74" /note="The 3'-most polyA site has not been determined. This is an internal polyA site." ORIGIN 1 aaggaagaca tgatatcatg ctggggtgga gagggaggat gcattggcgg ctgggatgaa 61 tttgagctga cggaaggagg cgttcggaga ggaaagggag gaaaaggaaa ggcgaccaca 121 gttcccatga tgcctggagg ggagactaca tttcccatta ttcccctgga agggacgtga 181 ggatgaaaga ctgcaagtcc cgcgatgctc tcggctggca ggtggcggag attgcaccgg 241 aagacgcttc ctgggtttga ggagttcagt gactgctatt gaaccaccaa aagtccatta 301 tgaaactgta ttgcctgtca gggcacccaa ccttaccatg caatgtgctc aaattcaaat 361 caaccaccat tatgttggac tgcggactgg acatgacttc taccctcaat ttccttcctt 421 tgccacttgt tcaaagtccc aggctgtcca atcttcctgg ctggtccctg aaggatggaa 481 atgctttctt ggacaaggag ctaaaggagt gctcgggtca tgtatttgtg gattctgtgc 541 cggaattctg tttaccagag acggagctaa tagatctgtc tacagtagat gtgattctca 601 tctctaacta tcactgtatg atggcgctgc catacatcac cgagcacacc ggcttcacag 661 gcacagtgta tgccacggaa cccaccgtcc agatcggcag gcttctcatg gaagagctgg 721 tgaatttcat tgaaagagtg ccaaaggctc agtctgcctc cttgtggaag aataaggaca 781 ttcagaggct gttaccttct cctctcaagg atgcagtgga agtctcaacc tggagaagat 841 gctatacaat gcaagaggtg aactctgccc ttagtaaaat ccagctggtg ggatattctc 901 agaaaattga gctttttggt gcggtccagg tgactcctct gagctctggc tatgcccttg 961 ggagctccaa ctggatcatc cagtctcatt acgagaaagt gtcttatgtc tctggatcct 1021 ccttgcttac cacacacccc cagcccatgg accaagcttc tctcaaaaac agcgatgttc 1081 ttgttctgac agggcttacc cagatcccca ctgcaaaccc agatggaatg gtgggagagt 1141 tctgcagcaa cctagctctg acagtccgga atggaggaaa cgtgttggtt ccctgctacc 1201 cttctggagt gatctatgac ctcctggagt gcctatatca gtacatcgac tcagccgggc 1261 tttccagcgt ccccctctac ttcatctccc ctgtggccaa cagttcactg gagttttccc 1321 agatctttgc tgagtggctt tgtcacaaca aacagagtaa ggtgtatctt ccagaaccac 1381 cttttcctca tgcagagctc attcagacca ataagctgaa gcactacccc agcatccacg 1441 gagacttcag caacgacttt agacagccct gtgtggtgtt caccgggcac ccttccctcc 1501 gcttcgggga cgtggtccac ttcatggagc tctggggaaa atctagtctc aataccgtca 1561 tattcacgga accagacttc tcctacctgg aagccctggc tccttaccag ccgctggcca 1621 tgaaatgcat ctactgcccc atcgacaccc ggctgaactt catccaggtg tcaaagctgc 1681 ttaaagaagt gcagcccctg cacgtggtgt gtcctgagca gtacactcag ccgcccccag 1741 cccagtccca caggatggac ctcatgatcg actgccagcc ccccgccatg tcctatcggc 1801 gggctgaggt tctcgccctg cccttcaaac gtcggtacga gaagatcgag atcatgccag 1861 agctcgcaga ttcactggtg cccatggaga tcaagcctgg catctccttg gcaactgtct 1921 cggccgtgct gcacaccaaa gataacaagc acttgcttca gccccctcct cggcccgccc 1981 agcccacgag cgggaagaag agaaagcggg tgagcgatga cgtaccagac tgcaaagtcc 2041 tgaagccttt gttgagcggt tccatccctg tggagcagtt cgtgcagacc ctggagaagc 2101 atggcttcag tgatattaag gtggaggaca cagccaaggg ccatatcgtc ctgctccagg 2161 aggctgagac gctcatccag attgaagaag actcgaccca tatcatctgc gacaatgacg 2221 agatgctcag agtgcgactg cgggaccttg tcctcaaatt cttacagaag ttctgagtgg 2281 gccatctgag ctacttccct gaaatcctgc agtccctcac tggctgccct cacaagccac 2341 ctgaggagtg gcatgagagg ccattaactg tgtctttgtg gtgtcctctg gcttaaggag 2401 tgaagaggtg gctcttgagg gaaatggtct ggacttattc ccagcactgt ttcaggcaag 2461 aactttccct ttcaacttca ggctcatttt cttctcaact ctggctctct caaggagctg 2521 gagggtggca gaagtgggac aggagaagtt ttccaagagg ttcatgggag gcggaggtga 2581 ctggctggct gtcttgcatc agtcccaggc ctcggccagg ggagccagcc tttggtttcg 2641 tttacttgcc tacagtgctg tacgcaataa gatgatgatc ccaaaatatg gtaaagtgaa 2701 cccatctgtc tgcattttct actctgagcc catttgttaa taaacactta tttttatata 2761 atta //
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