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Saccharomyces cerevisiae S288C adenosylmethionine decarboxylase SPE2 (SPE2), partial mRNA

NCBI Reference Sequence: NM_001183306.1

FASTA Graphics 

LOCUS       NM_001183306            1191 bp    mRNA    linear   PLN 17-DEC-2024
DEFINITION  Saccharomyces cerevisiae S288C adenosylmethionine decarboxylase
            SPE2 (SPE2), partial mRNA.
ACCESSION   NM_001183306
VERSION     NM_001183306.1
DBLINK      BioProject: PRJNA128
KEYWORDS    RefSeq.
SOURCE      Saccharomyces cerevisiae S288C
  ORGANISM  Saccharomyces cerevisiae S288C
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
            Saccharomyces.
REFERENCE   1  (bases 1 to 1191)
  AUTHORS   Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
            Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
            Weng,S. and Cherry,J.M.
  TITLE     New data and collaborations at the Saccharomyces Genome Database:
            updated reference genome, alleles, and the Alliance of Genome
            Resources
  JOURNAL   Genetics 220 (4) (2022)
   PUBMED   34897464
REFERENCE   2  (bases 1 to 1191)
  AUTHORS   Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W.,
            Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R.,
            Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G.,
            Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H.,
            Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al.
  TITLE     The nucleotide sequence of Saccharomyces cerevisiae chromosome XV
  JOURNAL   Nature 387 (6632 SUPPL), 98-102 (1997)
   PUBMED   9169874
REFERENCE   3  (bases 1 to 1191)
  AUTHORS   Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
            Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
            Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
            Oliver,S.G.
  TITLE     Life with 6000 genes
  JOURNAL   Science 274 (5287), 546 (1996)
   PUBMED   8849441
REFERENCE   4  (bases 1 to 1191)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (17-DEC-2024) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (bases 1 to 1191)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (16-JAN-2015) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   6  (bases 1 to 1191)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (04-MAY-2012) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   7  (bases 1 to 1191)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (31-MAR-2011) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Sequence update by submitter
REFERENCE   8  (bases 1 to 1191)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (27-MAY-2010) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   9  (bases 1 to 1191)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (14-DEC-2009) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by SGD. This record
            is derived from an annotated genomic sequence (NC_001147).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: SGD
            Annotation Status   :: Full Annotation
            Annotation Version  :: R64-4-1
            URL                 :: http://www.yeastgenome.org/
            ##Genome-Annotation-Data-END##
            COMPLETENESS: incomplete on both ends.
FEATURES             Location/Qualifiers
     source          1..1191
                     /organism="Saccharomyces cerevisiae S288C"
                     /mol_type="mRNA"
                     /strain="S288C"
                     /db_xref="taxon:559292"
                     /chromosome="XV"
     gene            <1..>1191
                     /gene="SPE2"
                     /locus_tag="YOL052C"
                     /db_xref="GeneID:854105"
     CDS             1..1191
                     /gene="SPE2"
                     /locus_tag="YOL052C"
                     /EC_number="4.1.1.50"
                     /experiment="EXISTENCE:direct assay:GO:0004014
                     adenosylmethionine decarboxylase activity [PMID:2266128]"
                     /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
                     [PMID:14562095]"
                     /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
                     [PMID:14562095]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0006597
                     spermine biosynthetic process [PMID:7929015]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0008295
                     spermidine biosynthetic process [PMID:7929015]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0015940
                     pantothenate biosynthetic process [PMID:11154694]"
                     /note="S-adenosylmethionine decarboxylase; required for
                     the biosynthesis of spermidine and spermine; cells lacking
                     Spe2p require spermine or spermidine for growth in the
                     presence of oxygen but not when grown anaerobically"
                     /codon_start=1
                     /product="adenosylmethionine decarboxylase SPE2"
                     /protein_id="NP_014590.1"
                     /db_xref="GeneID:854105"
                     /db_xref="SGD:S000005412"
                     /translation="MTVTIKELTNHNYIDHELSATLDSTDAFEGPEKLLEIWFFPHKK
                     SITTEKTLRNIGMDRWIEILKLVKCEVLSMKKTKELDAFLLSESSLFVFDHKLTMKTC
                     GTTTTLFCLEKLFQIVEQELSWAFRTTQGGKYKPFKVFYSRRCFLFPCKQAAIHQNWA
                     DEVDYLNKFFDNGKSYSVGRNDKSNHWNLYVTETDRSTPKGKEYIEDDDETFEVLMTE
                     LDPECASKFVCGPEASTTALVEPNEDKGHNLGYQMTKNTRLDEIYVNSAQDSDLSFHH
                     DAFAFTPCGYSSNMILAEKYYYTLHVTPEKGWSYASFESNIPVFDISQGKQDNLDVLL
                     HILNVFQPREFSMTFFTKNYQNQSFQKLLSINESLPDYIKLDKIVYDLDDYHLFYMKL
                     QKKI"
ORIGIN      
        1 atgactgtca ccataaaaga attgactaac cacaactaca ttgaccacga actatcagcc
       61 actttagact caacggatgc gttcgagggt cccgagaagt tgctggaaat ctggttcttc
      121 cctcacaaga agtccatcac gaccgaaaag acattaagaa atattggcat ggatagatgg
      181 atcgagattt tgaaattagt gaaatgcgaa gttctttcca tgaagaagac taaagaactg
      241 gatgcctttt tgttgagtga gtcttccctc ttcgtcttcg atcacaaatt gacgatgaag
      301 acgtgcggta ctacaaccac attgttctgt ctcgaaaagc ttttccagat cgttgagcaa
      361 gagttatcgt gggctttccg cacaacacaa gggggcaagt acaaaccatt taaagtgttt
      421 tattctagac gatgtttcct tttcccctgt aagcaagccg ctatccatca aaactgggct
      481 gacgaagtcg actatttgaa caaatttttc gacaatggta aaagttattc cgtgggaaga
      541 aatgacaaga gcaaccactg gaacctgtac gtcaccgaga cggaccgctc cacacctaag
      601 ggaaaggagt acatcgagga tgacgacgaa actttcgaag tactgatgac ggagctggac
      661 ccagaatgcg ctagtaagtt tgtttgcggg cctgaggcat ccacaaccgc tctcgtggag
      721 ccaaacgaag ataagggcca caacctcggc taccaaatga ctaaaaatac aaggcttgac
      781 gaaatatatg tcaactcggc ccaagactcc gatttatcat ttcaccacga tgcatttgcg
      841 ttcacgccat gtggatactc atccaatatg attctcgctg aaaaatacta ttacaccctg
      901 cacgtgactc cggaaaaggg ttggtcttac gcctctttcg aaagtaacat acccgtattt
      961 gacatttccc aagggaagca agacaacttg gacgttcttc tacatattct gaacgttttt
     1021 caaccaagag agttctcgat gacctttttt accaaaaatt atcagaacca atccttccaa
     1081 aaactactaa gcatcaacga gtcactgccc gactacatca agttagacaa aattgtttat
     1141 gatctggacg actaccacct tttctatatg aaattgcaga agaaaatatg a
//
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Reference sequence information

  • RefSeq protein product
    See the reference protein sequence for adenosylmethionine decarboxylase SPE2 (NP_014590.1).

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