LOCUS NM_001183306 1191 bp mRNA linear PLN 17-DEC-2024
DEFINITION Saccharomyces cerevisiae S288C adenosylmethionine decarboxylase
SPE2 (SPE2), partial mRNA.
ACCESSION NM_001183306
VERSION NM_001183306.1
DBLINK BioProject: PRJNA128
KEYWORDS RefSeq.
SOURCE Saccharomyces cerevisiae S288C
ORGANISM Saccharomyces cerevisiae S288C
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
Saccharomyces.
REFERENCE 1 (bases 1 to 1191)
AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
Weng,S. and Cherry,J.M.
TITLE New data and collaborations at the Saccharomyces Genome Database:
updated reference genome, alleles, and the Alliance of Genome
Resources
JOURNAL Genetics 220 (4) (2022)
PUBMED 34897464
REFERENCE 2 (bases 1 to 1191)
AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W.,
Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R.,
Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G.,
Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H.,
Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al.
TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV
JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997)
PUBMED 9169874
REFERENCE 3 (bases 1 to 1191)
AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
Oliver,S.G.
TITLE Life with 6000 genes
JOURNAL Science 274 (5287), 546 (1996)
PUBMED 8849441
REFERENCE 4 (bases 1 to 1191)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (17-DEC-2024) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
REFERENCE 5 (bases 1 to 1191)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Protein update by submitter
REFERENCE 6 (bases 1 to 1191)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Protein update by submitter
REFERENCE 7 (bases 1 to 1191)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Sequence update by submitter
REFERENCE 8 (bases 1 to 1191)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Protein update by submitter
REFERENCE 9 (bases 1 to 1191)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
COMMENT REVIEWED REFSEQ: This record has been curated by SGD. This record
is derived from an annotated genomic sequence (NC_001147).
##Genome-Annotation-Data-START##
Annotation Provider :: SGD
Annotation Status :: Full Annotation
Annotation Version :: R64-4-1
URL :: http://www.yeastgenome.org/
##Genome-Annotation-Data-END##
COMPLETENESS: incomplete on both ends.
FEATURES Location/Qualifiers
source 1..1191
/organism="Saccharomyces cerevisiae S288C"
/mol_type="mRNA"
/strain="S288C"
/db_xref="taxon:559292"
/chromosome="XV"
gene <1..>1191
/gene="SPE2"
/locus_tag="YOL052C"
/db_xref="GeneID:854105"
CDS 1..1191
/gene="SPE2"
/locus_tag="YOL052C"
/EC_number="4.1.1.50"
/experiment="EXISTENCE:direct assay:GO:0004014
adenosylmethionine decarboxylase activity [PMID:2266128]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:mutant phenotype:GO:0006597
spermine biosynthetic process [PMID:7929015]"
/experiment="EXISTENCE:mutant phenotype:GO:0008295
spermidine biosynthetic process [PMID:7929015]"
/experiment="EXISTENCE:mutant phenotype:GO:0015940
pantothenate biosynthetic process [PMID:11154694]"
/note="S-adenosylmethionine decarboxylase; required for
the biosynthesis of spermidine and spermine; cells lacking
Spe2p require spermine or spermidine for growth in the
presence of oxygen but not when grown anaerobically"
/codon_start=1
/product="adenosylmethionine decarboxylase SPE2"
/protein_id="NP_014590.1"
/db_xref="GeneID:854105"
/db_xref="SGD:S000005412"
/translation="MTVTIKELTNHNYIDHELSATLDSTDAFEGPEKLLEIWFFPHKK
SITTEKTLRNIGMDRWIEILKLVKCEVLSMKKTKELDAFLLSESSLFVFDHKLTMKTC
GTTTTLFCLEKLFQIVEQELSWAFRTTQGGKYKPFKVFYSRRCFLFPCKQAAIHQNWA
DEVDYLNKFFDNGKSYSVGRNDKSNHWNLYVTETDRSTPKGKEYIEDDDETFEVLMTE
LDPECASKFVCGPEASTTALVEPNEDKGHNLGYQMTKNTRLDEIYVNSAQDSDLSFHH
DAFAFTPCGYSSNMILAEKYYYTLHVTPEKGWSYASFESNIPVFDISQGKQDNLDVLL
HILNVFQPREFSMTFFTKNYQNQSFQKLLSINESLPDYIKLDKIVYDLDDYHLFYMKL
QKKI"
ORIGIN
1 atgactgtca ccataaaaga attgactaac cacaactaca ttgaccacga actatcagcc
61 actttagact caacggatgc gttcgagggt cccgagaagt tgctggaaat ctggttcttc
121 cctcacaaga agtccatcac gaccgaaaag acattaagaa atattggcat ggatagatgg
181 atcgagattt tgaaattagt gaaatgcgaa gttctttcca tgaagaagac taaagaactg
241 gatgcctttt tgttgagtga gtcttccctc ttcgtcttcg atcacaaatt gacgatgaag
301 acgtgcggta ctacaaccac attgttctgt ctcgaaaagc ttttccagat cgttgagcaa
361 gagttatcgt gggctttccg cacaacacaa gggggcaagt acaaaccatt taaagtgttt
421 tattctagac gatgtttcct tttcccctgt aagcaagccg ctatccatca aaactgggct
481 gacgaagtcg actatttgaa caaatttttc gacaatggta aaagttattc cgtgggaaga
541 aatgacaaga gcaaccactg gaacctgtac gtcaccgaga cggaccgctc cacacctaag
601 ggaaaggagt acatcgagga tgacgacgaa actttcgaag tactgatgac ggagctggac
661 ccagaatgcg ctagtaagtt tgtttgcggg cctgaggcat ccacaaccgc tctcgtggag
721 ccaaacgaag ataagggcca caacctcggc taccaaatga ctaaaaatac aaggcttgac
781 gaaatatatg tcaactcggc ccaagactcc gatttatcat ttcaccacga tgcatttgcg
841 ttcacgccat gtggatactc atccaatatg attctcgctg aaaaatacta ttacaccctg
901 cacgtgactc cggaaaaggg ttggtcttac gcctctttcg aaagtaacat acccgtattt
961 gacatttccc aagggaagca agacaacttg gacgttcttc tacatattct gaacgttttt
1021 caaccaagag agttctcgat gacctttttt accaaaaatt atcagaacca atccttccaa
1081 aaactactaa gcatcaacga gtcactgccc gactacatca agttagacaa aattgtttat
1141 gatctggacg actaccacct tttctatatg aaattgcaga agaaaatatg a
//