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Homo sapiens paxillin (PXN), transcript variant 1, mRNA

NCBI Reference Sequence: NM_002859.3

FASTA Graphics 

LOCUS       NM_002859               3691 bp    mRNA    linear   PRI 01-MAY-2019
DEFINITION  Homo sapiens paxillin (PXN), transcript variant 1, mRNA.
ACCESSION   NM_002859 XM_001132665 XM_001134353
VERSION     NM_002859.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3691)
  AUTHORS   Bozic J, Stoka V and Dolenc I.
  TITLE     Glucosamine prevents polarization of cytotoxic granules in NK-92
            cells by disturbing FOXO1/ERK/paxillin phosphorylation
  JOURNAL   PLoS ONE 13 (7), e0200757 (2018)
   PUBMED   30016365
  REMARK    GeneRIF: Glucosamine affects signaling pathway activation of NK-92
            immune cells, changing the phosphorylation of FOXO1, paxillin, and
            the ERK map kinase pathway
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3691)
  AUTHORS   Zhang LL, Zhang LF and Shi YB.
  TITLE     miR-24 inhibited the killing effect of natural killer cells to
            colorectal cancer cells by downregulating Paxillin
  JOURNAL   Biomed. Pharmacother. 101, 257-263 (2018)
   PUBMED   29494963
  REMARK    GeneRIF: overexpression of Paxillin significantly decreased tumor
            volume of colorectal cancer; miR-24 was overexpressed in natural
            killer cells and inhibited paxillin expression.
REFERENCE   3  (bases 1 to 3691)
  AUTHORS   Jiang H, Zhang H, Hu X and Li W.
  TITLE     Knockdown of long non-coding RNA XIST inhibits cell viability and
            invasion by regulating miR-137/PXN axis in non-small cell lung
            cancer
  JOURNAL   Int. J. Biol. Macromol. 111, 623-631 (2018)
   PUBMED   29337100
  REMARK    GeneRIF: XIST positively regulated PXN levels by sponging miR-137
            in vitro and in vivo. Collectively, our study provided the evidence
            for the cross-talk between XIST, miR-137, and PXN, shedding light
            on the therapy for non-small cell lung cancer .
REFERENCE   4  (bases 1 to 3691)
  AUTHORS   Liu Q, Wang J, Tang M, Chen L, Qi X, Li J, Yu J, Qiu H and Wang Y.
  TITLE     The overexpression of PXN promotes tumor progression and leads to
            radioresistance in cervical cancer
  JOURNAL   Future Oncol 14 (3), 241-253 (2018)
   PUBMED   29318915
  REMARK    GeneRIF: we herein demonstrated that frequent overexpression of PXN
            in cervical cancer was associated with advanced tumor stage, poor
            differentiation and metastasis, and poor predictive outcomes
REFERENCE   5  (bases 1 to 3691)
  AUTHORS   Montone R, Romanelli MG, Baruzzi A, Ferrarini F, Liboi E and
            Lievens PM.
  TITLE     Mutant FGFR3 associated with SADDAN disease causes cytoskeleton
            disorganization through PLCgamma1/Src-mediated paxillin
            hyperphosphorylation
  JOURNAL   Int. J. Biochem. Cell Biol. 95, 17-26 (2018)
   PUBMED   29242050
  REMARK    GeneRIF: Data suggest that FGFR3 with mutation found in patients
            with SADDAN (but not FGFR3 with mutation found in patients with
            TDII) affects cytoskeleton organization in chondrocytes by inducing
            tyrosine hyperphosphorylation of paxillin. (FGFR3 = fibroblast
            growth factor receptor 3; SADDAN = Severe Achondroplasia with
            Developmental Delay and Acanthosis Nigricans; TDII = Thanatophoric
            Dysplasia type II)
REFERENCE   6  (bases 1 to 3691)
  AUTHORS   Ganju RK, Munshi N, Nair BC, Liu ZY, Gill P and Groopman JE.
  TITLE     Human immunodeficiency virus tat modulates the Flk-1/KDR receptor,
            mitogen-activated protein kinases, and components of focal adhesion
            in Kaposi's sarcoma cells
  JOURNAL   J. Virol. 72 (7), 6131-6137 (1998)
   PUBMED   9621077
REFERENCE   7  (bases 1 to 3691)
  AUTHORS   Tong X and Howley PM.
  TITLE     The bovine papillomavirus E6 oncoprotein interacts with paxillin
            and disrupts the actin cytoskeleton
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 94 (9), 4412-4417 (1997)
   PUBMED   9114003
REFERENCE   8  (bases 1 to 3691)
  AUTHORS   Mazaki Y, Hashimoto S and Sabe H.
  TITLE     Monocyte cells and cancer cells express novel paxillin isoforms
            with different binding properties to focal adhesion proteins
  JOURNAL   J. Biol. Chem. 272 (11), 7437-7444 (1997)
   PUBMED   9054445
REFERENCE   9  (bases 1 to 3691)
  AUTHORS   Tachibana K, Sato T, D'Avirro N and Morimoto C.
  TITLE     Direct association of pp125FAK with paxillin, the focal
            adhesion-targeting mechanism of pp125FAK
  JOURNAL   J. Exp. Med. 182 (4), 1089-1099 (1995)
   PUBMED   7561682
REFERENCE   10 (bases 1 to 3691)
  AUTHORS   Salgia R, Li JL, Lo SH, Brunkhorst B, Kansas GS, Sobhany ES, Sun Y,
            Pisick E, Hallek M, Ernst T et al.
  TITLE     Molecular cloning of human paxillin, a focal adhesion protein
            phosphorylated by P210BCR/ABL
  JOURNAL   J. Biol. Chem. 270 (10), 5039-5047 (1995)
   PUBMED   7534286
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB472926.1, BC136794.1,
            BU500419.1, BC144410.1, BX648777.1 and AA922640.1.
            
            [WARNING] On Jun 2, 2019 this sequence was replaced by NM_002859.4.
            
            On Aug 25, 2011 this sequence version replaced NM_002859.2.
            
            Summary: This gene encodes a cytoskeletal protein involved in
            actin-membrane attachment at sites of cell adhesion to the
            extracellular matrix (focal adhesion). Alternatively spliced
            transcript variants encoding different isoforms have been described
            for this gene. These isoforms exhibit different expression pattern,
            and have different biochemical, as well as physiological properties
            (PMID:9054445). [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript, and encodes isoform 1 (also known as isoform alpha).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U14588.1, SRR1803615.120200.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                DB472926.1         3-68
            67-358              BC136794.1         1-292
            359-359             BU500419.1         292-292
            360-1962            BC136794.1         294-1896
            1963-2653           BC144410.1         1999-2689
            2654-3683           BX648777.1         2771-3800
            3684-3691           AA922640.1         1-8                 c
FEATURES             Location/Qualifiers
     source          1..3691
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.23"
     gene            1..3691
                     /gene="PXN"
                     /note="paxillin"
                     /db_xref="GeneID:5829"
                     /db_xref="HGNC:HGNC:9718"
                     /db_xref="MIM:602505"
     exon            1..155
                     /gene="PXN"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    119..121
                     /gene="PXN"
                     /note="upstream in-frame stop codon"
     CDS             143..1816
                     /gene="PXN"
                     /note="isoform 1 is encoded by transcript variant 1;
                     testicular tissue protein Li 134"
                     /codon_start=1
                     /product="paxillin isoform 1"
                     /protein_id="NP_002850.2"
                     /db_xref="CCDS:CCDS44996.1"
                     /db_xref="GeneID:5829"
                     /db_xref="HGNC:HGNC:9718"
                     /db_xref="MIM:602505"
                     /translation="MDDLDALLADLESTTSHISKRPVFLSEETPYSYPTGNHTYQEIA
                     VPPPVPPPPSSEALNGTILDPLDQWQPSSSRFIHQQPQSSSPVYGSSAKTSSVSNPQD
                     SVGSPCSRVGEEEHVYSFPNKQKSAEPSPTVMSTSLGSNLSELDRLLLELNAVQHNPP
                     GFPADEANSSPPLPGALSPLYGVPETNSPLGGKAGPLTKEKPKRNGGRGLEDVRPSVE
                     SLLDELESSVPSPVPAITVNQGEMSSPQRVTSTQQQTRISASSATRELDELMASLSDF
                     KFMAQGKTGSSSPPGGPPKPGSQLDSMLGSLQSDLNKLGVATVAKGVCGACKKPIAGQ
                     VVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPRCYYCNGPILD
                     KVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAPKCGGCARAIL
                     ENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGSLCSGCQKPI
                     TGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLKLFC"
     exon            156..382
                     /gene="PXN"
                     /inference="alignment:Splign:2.1.0"
     exon            383..498
                     /gene="PXN"
                     /inference="alignment:Splign:2.1.0"
     exon            499..635
                     /gene="PXN"
                     /inference="alignment:Splign:2.1.0"
     exon            636..837
                     /gene="PXN"
                     /inference="alignment:Splign:2.1.0"
     exon            838..973
                     /gene="PXN"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1144
                     /gene="PXN"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1318
                     /gene="PXN"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1400
                     /gene="PXN"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1549
                     /gene="PXN"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..3691
                     /gene="PXN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3660..3665
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PXN"
     polyA_site      3683
                     /gene="PXN"
ORIGIN      
        1 ggcgggcgcg ggcgcgggcg cgcgcggcgg cggcgcgttc cgttccgggc cgaggctcgc
       61 ggcggaaaag ttgcggggca tagacgagcg gccccgggac gggcagctag cgcgaccctg
      121 agccggcgcc cgtggtccgg ccatggacga cctcgacgcc ctgctggcgg acttggagtc
      181 taccacctcc cacatctcca aacggcctgt gttcttgtcg gaggagaccc cctactcata
      241 cccaactgga aaccacacat accaggagat tgccgtgcca ccccccgtcc ccccaccccc
      301 gtccagcgag gccctcaatg gcacaatcct tgacccctta gaccagtggc agcccagcag
      361 ctcccgattc atccaccagc agcctcagtc ctcatcacct gtgtacggct ccagtgccaa
      421 aacttccagt gtctccaacc ctcaggacag tgttggctct ccgtgctccc gagtgggtga
      481 ggaggagcac gtctacagct tccccaacaa gcagaaatca gctgagcctt cacccaccgt
      541 aatgagcacg tccctgggca gcaacctttc tgaactcgac cgcctgctgc tggaactgaa
      601 cgctgtacag cataacccgc caggcttccc tgcagatgag gccaactcaa gccccccgct
      661 tcctggggcc ctgagccccc tctatggtgt cccagagact aacagcccct tgggaggcaa
      721 agctgggccc ctgacgaaag agaagcctaa gcggaatggg ggccggggcc tggaggacgt
      781 gcggcccagt gtggagagtc tcttggatga actggagagc tccgtgccca gccccgtccc
      841 tgccatcact gtgaaccagg gcgagatgag cagcccgcag cgcgtcacct ccacccaaca
      901 gcagacacgc atctcggcct cctctgccac cagggagctg gacgagctga tggcttcgct
      961 gtcggatttc aagttcatgg cccaggggaa gacagggagc agctcacccc ctggggggcc
     1021 cccgaagccc gggagccagc tggacagcat gctggggagc ctgcagtctg acctgaacaa
     1081 gctgggggtc gccacagtcg ccaaaggagt ctgcggggcc tgcaagaagc ccatcgccgg
     1141 gcaggttgtg accgccatgg ggaagacgtg gcaccccgag cacttcgtct gcacccactg
     1201 ccaggaggag atcggatccc ggaacttctt cgagcgggat ggacagccct actgtgaaaa
     1261 ggactaccac aacctcttct ccccgcgctg ctactactgc aacggcccca tcctggataa
     1321 agtggtgaca gcccttgacc ggacgtggca ccctgaacac ttcttctgtg cacagtgtgg
     1381 agccttcttt ggtcccgaag ggttccacga gaaggacggc aaggcctact gtcgcaagga
     1441 ctacttcgac atgttcgcac ccaagtgtgg cggctgcgcc cgggccatcc tggagaacta
     1501 tatctcagcc ctcaacacgc tgtggcatcc tgagtgcttt gtgtgccggg aatgcttcac
     1561 gccattcgtg aacggcagct tcttcgagca cgacgggcag ccctactgtg aggtgcacta
     1621 ccacgagcgg cgcggctcgc tgtgttctgg ctgccagaag cccatcaccg gccgctgcat
     1681 caccgccatg gccaagaagt tccaccccga gcacttcgtc tgtgccttct gcctcaagca
     1741 gctcaacaag ggcaccttca aggagcagaa cgacaagcct tactgtcaga actgcttcct
     1801 caagctcttc tgctaggtgc cctgcccctg tctctgcccc ccttccccag ccagcatccc
     1861 caactgcgac tgtgacctag agacttcacc cgggggtgaa ggggtaaacc cgactgaaac
     1921 tggaaccctt gtcctccgct ggtgcgggat ggacagaggg ccgtgagggg tccccctgct
     1981 tgtcttcacc cctgccagag cctctgggcc ccctcctccc tcctgtagct ctccctaggc
     2041 tgcccactct ccatcctccc caggggtaga ggctgggggc tccaccccag cccatgtacg
     2101 tccccacgaa ctggcctggc cagcacccca cactggagcc atctcttcct catatttcag
     2161 cagtgcagcc ggggggcagg gaagggcagg cagggtctgt tggggtctct ttttatcctt
     2221 attcctcccc cgacctaatt gtctttgttc tgtgattatt gggggacacc cggctccctc
     2281 cagacaatgc cagcataaat ccatccatcc aaaggcagag aaccaaaggg gccatggaag
     2341 gttctctgtg ctcctcctac ccttccagtg ccctaggcct ggcgactgcc cctgcctttt
     2401 agacccgccc tcccctttta tacctgctct tgttctactg agaaaagcct ctccagcaat
     2461 aatgttttct agtcacttcc tccgtctccg ggacggcgtg cctggacact gtaccgactt
     2521 tgatagattt ctacactgag gtttgaattc atatcgcctg agttgctttt acttctctat
     2581 acaaaatgat tttgaagaga ttttaaagac gttccctttt gtattctctt cctcatccac
     2641 cgccactggg cctgtcactg atggtggctc tggtgtgaag tttgctttgt actgagggtt
     2701 ggggtgggga agcaatttgt attttattgt ttcttagcac aagcaggtga actgggagca
     2761 gctctgtgac tccccctctt tcacttcata gctcaccagg actgttttat aaactgctgt
     2821 atttggaaac cccttcttta cttcccaggc cagcaagctc ttcactgaaa ctggttgaag
     2881 ggtgttgcac ccttttgggc ctagaattct gaactttatc tgttctgttt ctgtgggagg
     2941 agaaggggaa gtatgttttg gggggctgct tcctgtctga gtaagccctc aggagcctct
     3001 gctcccctgt gaacccactg aaccttctga gcccccactg cttctatggg gctctctctt
     3061 ctgccttctc aggaaagctg gtgtctgatt ttggccatca ggactctgac gtctctttgg
     3121 tcttgttgat ttcctctggg catatccctt ccccagatct gctcctcccc tttcacaggt
     3181 gggatcggca ctcagggggt ctggaaagaa ggtcataagg gagcatgata ggatttgggg
     3241 cagagggaca ggctcctctg gggaaacccc ccagagctct ttaccaagga tgaaagagga
     3301 gccaggcctt gggctcctga tgaggagaaa ggggccccac cggggtctaa tggtgacagt
     3361 ccaaaccact ccactggcct cctggcagaa gccgagtgtg ctggggtctc cgaagagggt
     3421 ccctcctttt tgggggaagg tcagcccagc ccctccaaag gtctgatgtc tccactttca
     3481 cccgcaggcc ttaccgctct gtttatagtg acccacccta gatcttcccc aagagggact
     3541 ggggtttctg gggtccattc tctgagtcag tggttatttg aaaatttgat tttgatttta
     3601 ttttttctct gtaaacttcc aagctggctt ttcccatttc aattcctgtg atttatgcca
     3661 ataaagtttg cccatgattt tcacctgtgc t
//
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