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Saccharomyces cerevisiae S288C alanine--tRNA ligase (ALA1), partial mRNA

NCBI Reference Sequence: NM_001183755.3

FASTA Graphics 

LOCUS       NM_001183755            2877 bp    mRNA    linear   PLN 17-DEC-2024
DEFINITION  Saccharomyces cerevisiae S288C alanine--tRNA ligase (ALA1), partial
            mRNA.
ACCESSION   NM_001183755
VERSION     NM_001183755.3
DBLINK      BioProject: PRJNA128
KEYWORDS    RefSeq.
SOURCE      Saccharomyces cerevisiae S288C
  ORGANISM  Saccharomyces cerevisiae S288C
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
            Saccharomyces.
REFERENCE   1  (bases 1 to 2877)
  AUTHORS   Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
            Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
            Weng,S. and Cherry,J.M.
  TITLE     New data and collaborations at the Saccharomyces Genome Database:
            updated reference genome, alleles, and the Alliance of Genome
            Resources
  JOURNAL   Genetics 220 (4) (2022)
   PUBMED   34897464
REFERENCE   2  (bases 1 to 2877)
  AUTHORS   Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W.,
            Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R.,
            Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G.,
            Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H.,
            Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al.
  TITLE     The nucleotide sequence of Saccharomyces cerevisiae chromosome XV
  JOURNAL   Nature 387 (6632 SUPPL), 98-102 (1997)
   PUBMED   9169874
REFERENCE   3  (bases 1 to 2877)
  AUTHORS   Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
            Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
            Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
            Oliver,S.G.
  TITLE     Life with 6000 genes
  JOURNAL   Science 274 (5287), 546 (1996)
   PUBMED   8849441
REFERENCE   4  (bases 1 to 2877)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (17-DEC-2024) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (bases 1 to 2877)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (16-JAN-2015) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   6  (bases 1 to 2877)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (04-MAY-2012) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   7  (bases 1 to 2877)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (31-MAR-2011) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Sequence update by submitter
REFERENCE   8  (bases 1 to 2877)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (27-MAY-2010) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   9  (bases 1 to 2877)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (14-DEC-2009) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by SGD. This record
            is derived from an annotated genomic sequence (NC_001147).
            
            On Jul 30, 2012 this sequence version replaced NM_001183755.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: SGD
            Annotation Status   :: Full Annotation
            Annotation Version  :: R64-4-1
            URL                 :: http://www.yeastgenome.org/
            ##Genome-Annotation-Data-END##
            COMPLETENESS: incomplete on both ends.
FEATURES             Location/Qualifiers
     source          1..2877
                     /organism="Saccharomyces cerevisiae S288C"
                     /mol_type="mRNA"
                     /strain="S288C"
                     /db_xref="taxon:559292"
                     /chromosome="XV"
     gene            <1..>2877
                     /gene="ALA1"
                     /locus_tag="YOR335C"
                     /gene_synonym="CDC64"
                     /db_xref="GeneID:854513"
     CDS             1..2877
                     /gene="ALA1"
                     /locus_tag="YOR335C"
                     /gene_synonym="CDC64"
                     /EC_number="6.1.1.7"
                     /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
                     [PMID:16556230|PMID:14562095|PMID:11914276]"
                     /experiment="EXISTENCE:direct assay:GO:0005739
                     mitochondrion
                     [PMID:16823961|PMID:24769239|PMID:16556230|PMID:14576278]"
                     /experiment="EXISTENCE:direct assay:GO:1990825
                     sequence-specific mRNA binding [PMID:34039240]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0004813
                     alanine-tRNA ligase activity [PMID:7761427]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0006419
                     alanyl-tRNA aminoacylation [PMID:7761427]"
                     /note="Cytoplasmic and mitochondrial alanyl-tRNA
                     synthetase; required for protein synthesis; point mutation
                     (cdc64-1 allele) causes cell cycle arrest at G1; lethality
                     of null mutation is functionally complemented by human
                     homolog AARS; mutations in human homolog AARS are
                     associated with autoimmune disease
                     polymyositis/dermatomyositis and with hereditary
                     peripheral neuropathy, Charcot-Marie-Tooth (CMT) disease"
                     /codon_start=1
                     /product="alanine--tRNA ligase"
                     /protein_id="NP_014980.3"
                     /db_xref="GeneID:854513"
                     /db_xref="SGD:S000005862"
                     /translation="MTIGDKQKWTATNVRNTFLDYFKSKEHKFVKSSPVVPFDDPTLL
                     FANAGMNQYKPIFLGTVDPASDFYTLKRAYNSQKCIRAGGKHNDLEDVGKDSYHHTFF
                     EMLGNWSFGDYFKKEAITYSWTLLTEVYGIPKDRLYVTYFEGDEKLGLEPDTEARELW
                     KNVGVPDDHILPGNAKDNFWEMGDQGPCGPCSEIHYDRIGGRNAASLVNMDDPDVLEV
                     WNLVFIQFNREQDGSLKPLPAKHIDTGMGFERLVSVLQDVRSNYDTDVFTPLFERIQE
                     ITSVRPYSGNFGENDKDGIDTAYRVLADHVRTLTFALADGGVPNNEGRGYVLRRILRR
                     GARYARKYMNYPIGNFFSTLAPTLISQVQDIFPELAKDPAFLFEILDEEEASFAKTLD
                     RGERLFEKYASAASKTESKTLDGKQVWRLYDTYGFPVDLTELMAEEQGLKIDGPGFEK
                     AKQESYEASKRGGKKDQSDLIKLNVHELSELNDAKVPKTNDEFKYGSANVEGTILKLH
                     DGTNFVDEITEPGKKYGIILDKTCFYAEQGGQEYDTGKIVIDDAAEFNVENVQLYNGF
                     VFHTGSLEEGKLSVGDKIIASFDELRRFPIKNNHTGTHILNFALKETLGNDVDQKGSL
                     VAPEKLRFDFSHKKAVSNEELKKVEDICNEQIKENLQVFYKEIPLDLAKSIDGVRAVF
                     GETYPDPVRVVSVGKPIEELLANPANEEWTKYSIEFCGGTHVNKTGDIKYFVILEESG
                     IAKGIRRIVAVTGTEAFEAQRLAEQFAADLDAADKLPFSPIKEKKLKELGVKLGQLSI
                     SVITKNELKQKFNKIEKAVKDEVKSRAKKENKQTLDEVKTFFETNENAPYLVKFIDIS
                     PNAKAITEAINYMKSNDSVKDKSIYLLAGNDPEGRVAHGCYISNAALAKGIDGSALAK
                     KVSSIIGGKAGGKGNVFQGMGDKPAAIKDAVDDLESLFKEKLSI"
ORIGIN      
        1 atgacgatcg gtgataagca aaaatggacc gctactaatg tccgtaatac ctttctagac
       61 tatttcaaat ctaaagaaca caagtttgtc aaatcctctc cagtagttcc atttgatgat
      121 ccaactttac ttttcgctaa tgccggtatg aaccaataca agcctatctt tttaggtact
      181 gtcgatccag cttccgattt ctacaccttg aaaagggctt acaactctca aaagtgtatc
      241 agagctggtg gtaaacacaa cgatttagaa gatgtcggta aggattctta tcatcatacc
      301 ttttttgaaa tgctgggtaa ctggtcgttt ggcgactatt tcaagaagga agctattact
      361 tactcatgga ctttgttgac tgaagtatac ggcattccaa aggatagatt atacgttacc
      421 tattttgaag gtgatgaaaa gttaggcttg gaacctgata ctgaagcccg tgaactatgg
      481 aaaaatgttg gtgttcccga tgaccatata ttacctggta atgcaaagga caacttttgg
      541 gaaatgggtg accaaggccc atgtggtcct tgttctgaaa ttcactacga tagaataggt
      601 ggtagaaatg ctgcttcctt ggttaatatg gacgaccctg atgtcttgga agtttggaat
      661 ttggttttca ttcaattcaa cagagaacaa gacgggtctt tgaagccttt acctgccaag
      721 catatcgaca caggtatggg gttcgaaaga ttggtttctg ttctgcaaga tgttagatct
      781 aactatgata ccgatgtttt cacacctttg ttcgagcgta tccaagaaat cacttcagtt
      841 agaccatatt ctggcaattt tggtgagaat gacaaggacg gtatcgatac tgcctacaga
      901 gttttagctg atcatgtccg tacattgact tttgccttag ctgacggtgg cgttccaaac
      961 aatgaaggta gaggatatgt tttgagacgc attctaagaa gaggtgcccg ttacgcccgt
     1021 aaatacatga attacccaat cggtaacttt ttctccactt tggctccaac tttaatttct
     1081 caggttcaag atatctttcc cgaattagcc aaggatcctg cattcctctt tgaaatcttg
     1141 gatgaagaag aagcttcttt cgctaagacc ttggatcgtg gtgaaagact atttgaaaaa
     1201 tatgcttctg ctgcttctaa gactgaatct aagactttag acggtaaaca agtttggaga
     1261 ctttacgaca cttatggttt cccagtcgac ttgactgaat tgatggctga agaacaaggc
     1321 ttgaagattg atggacccgg tttcgaaaag gccaaacaag agtcatacga agcatccaaa
     1381 agaggtggta agaaggacca aagtgatttg attaagttaa acgtccatga attatccgag
     1441 ttgaacgatg ctaaggtgcc caagactaat gatgaattca aatacggcag cgccaacgtc
     1501 gaaggtacca ttttgaaact gcatgacggt accaactttg ttgatgagat cactgaacca
     1561 ggtaagaagt acggtattat tttggataaa acatgtttct acgccgaaca aggtggtcaa
     1621 gaatatgaca ctggtaaaat tgttattgat gacgctgctg agtttaatgt tgaaaatgtt
     1681 caattgtata acggttttgt tttccacacc gggtctttag aagaaggtaa gttgtctgtc
     1741 ggtgacaaga ttatcgcttc attcgatgaa ctacgtcgtt tccctattaa gaacaatcat
     1801 actggtacac atatcttaaa ctttgctctg aaggaaactt tgggtaatga tgtcgatcaa
     1861 aagggttctt tggttgcccc agaaaaattg agattcgatt tctctcataa aaaggctgtg
     1921 tcaaatgaag aattgaaaaa agttgaagat atctgtaatg agcaaattaa agaaaactta
     1981 caagtgtttt acaaggaaat tccattggac ttggccaaat ccattgatgg tgttcgtgct
     2041 gtctttggtg agacttaccc agatccagtt cgtgtagttt ctgttggtaa gccaatcgaa
     2101 gaattgttgg ccaacccagc taacgaagag tggaccaagt attctattga attttgcggt
     2161 ggtacccatg tcaacaagac aggcgatatt aaatacttcg tcattttaga agagagcggt
     2221 attgcaaagg gtatcagaag aattgttgct gttactggaa ctgaagcctt tgaagctcaa
     2281 agattggctg aacagtttgc tgctgatttg gatgctgcag acaagctgcc gttctctcca
     2341 atcaaagaaa agaagttgaa ggaacttggt gtcaaacttg gtcaactttc aatttctgtt
     2401 atcacaaaaa atgaactgaa gcagaaattt aacaaaattg aaaaagcagt gaaggatgaa
     2461 gttaagtcaa gggccaaaaa agaaaacaaa caaactcttg atgaagtgaa gacatttttc
     2521 gaaaccaatg agaatgctcc atacctagtt aaattcattg atatttctcc aaatgctaaa
     2581 gctatcactg aagcgatcaa ctacatgaaa tccaatgatt ctgtcaaaga caagtcaatc
     2641 tatttattgg caggtaatga ccctgaaggt cgtgttgctc acggttgtta catctccaat
     2701 gctgctttag ccaagggtat tgatggttct gcgcttgcca aaaaggtgtc cagtatcatc
     2761 ggcggtaagg ctggtggtaa aggtaatgtt ttccaaggta tgggtgataa accagccgct
     2821 ataaaggatg cagttgatga tttggaaagt ttgttcaagg agaagctttc catttaa
//
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