LOCUS NM_025709 5966 bp mRNA linear ROD 13-MAY-2017
DEFINITION Mus musculus GTPase activating protein and VPS9 domains 1 (Gapvd1),
mRNA.
ACCESSION NM_025709
VERSION NM_025709.2
KEYWORDS RefSeq.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (bases 1 to 5966)
AUTHORS Ng EL, Ng JJ, Liang F and Tang BL.
TITLE Rab22B is expressed in the CNS astroglia lineage and plays a role
in epidermal growth factor receptor trafficking in A431 cells
JOURNAL J. Cell. Physiol. 221 (3), 716-728 (2009)
PUBMED 19725050
REFERENCE 2 (bases 1 to 5966)
AUTHORS Lodhi IJ, Bridges D, Chiang SH, Zhang Y, Cheng A, Geletka LM,
Weisman LS and Saltiel AR.
TITLE Insulin stimulates phosphatidylinositol 3-phosphate production via
the activation of Rab5
JOURNAL Mol. Biol. Cell 19 (7), 2718-2728 (2008)
PUBMED 18434594
REMARK GeneRIF: the TC10/GAPEX-5/Rab5 axis mediates insulin-stimulated
production of PI(3)P, which regulates trafficking of Glut4 vesicles
REFERENCE 3 (bases 1 to 5966)
AUTHORS Kitano M, Nakaya M, Nakamura T, Nagata S and Matsuda M.
TITLE Imaging of Rab5 activity identifies essential regulators for
phagosome maturation
JOURNAL Nature 453 (7192), 241-245 (2008)
PUBMED 18385674
REFERENCE 4 (bases 1 to 5966)
AUTHORS Lodhi IJ, Chiang SH, Chang L, Vollenweider D, Watson RT, Inoue M,
Pessin JE and Saltiel AR.
TITLE Gapex-5, a Rab31 guanine nucleotide exchange factor that regulates
Glut4 trafficking in adipocytes
JOURNAL Cell Metab. 5 (1), 59-72 (2007)
PUBMED 17189207
REMARK GeneRIF: Insulin recruits the CIP4/Gapex-5 complex to the plasma
membrane, thus reducing Rab31 activity and permitting Glut4
vesicles to translocate to the cell surface, where Glut4 docks and
fuses to transport glucose into the cell.
REFERENCE 5 (bases 1 to 5966)
AUTHORS Okazaki N, Kikuno R, Ohara R, Inamoto S, Koseki H, Hiraoka S, Saga
Y, Nagase T, Ohara O and Koga H.
TITLE Prediction of the coding sequences of mouse homologues of KIAA
gene: III. the complete nucleotide sequences of 500 mouse
KIAA-homologous cDNAs identified by screening of terminal sequences
of cDNA clones randomly sampled from size-fractionated libraries
JOURNAL DNA Res. 10 (4), 167-180 (2003)
PUBMED 14621295
REFERENCE 6 (bases 1 to 5966)
AUTHORS Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
Babbitt PC and Ferrin TE.
TITLE BayGenomics: a resource of insertional mutations in mouse embryonic
stem cells
JOURNAL Nucleic Acids Res. 31 (1), 278-281 (2003)
PUBMED 12520002
REFERENCE 7 (bases 1 to 5966)
AUTHORS Piao Y, Ko NT, Lim MK and Ko MS.
TITLE Construction of long-transcript enriched cDNA libraries from
submicrogram amounts of total RNAs by a universal PCR amplification
method
JOURNAL Genome Res. 11 (9), 1553-1558 (2001)
PUBMED 11544199
REFERENCE 8 (bases 1 to 5966)
AUTHORS Wertz K and Herrmann BG.
TITLE Large-scale screen for genes involved in gonad development
JOURNAL Mech. Dev. 98 (1-2), 51-70 (2000)
PUBMED 11044607
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from BC060123.1.
[WARNING] On Oct 4, 2017 this sequence was replaced by NM_025709.3.
On Dec 20, 2003 this sequence version replaced NM_025709.1.
##Evidence-Data-START##
Transcript exon combination :: BC060123.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
SAMN00849374, SAMN00849375
[ECO:0000350]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..5966
/organism="Mus musculus"
/mol_type="mRNA"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="2"
/map="2"
gene 1..5966
/gene="Gapvd1"
/gene_synonym="2010005B09Rik; 4432404J10Rik; AW108497;
Gapex-5; mKIAA1521; RAP6; RME-6"
/note="GTPase activating protein and VPS9 domains 1"
/db_xref="GeneID:66691"
/db_xref="MGI:MGI:1913941"
misc_feature 550..552
/gene="Gapvd1"
/gene_synonym="2010005B09Rik; 4432404J10Rik; AW108497;
Gapex-5; mKIAA1521; RAP6; RME-6"
/note="upstream in-frame stop codon"
CDS 583..4896
/gene="Gapvd1"
/gene_synonym="2010005B09Rik; 4432404J10Rik; AW108497;
Gapex-5; mKIAA1521; RAP6; RME-6"
/note="rab5-activating protein 6"
/codon_start=1
/product="GTPase-activating protein and VPS9
domain-containing protein 1"
/protein_id="NP_079985.2"
/db_xref="CCDS:CCDS15949.1"
/db_xref="GeneID:66691"
/db_xref="MGI:MGI:1913941"
/translation="MVKLDIHTLAHHLKQERLYVSSEKQLIQRLNADVLKTAEKLYRT
AWIAKQQRINLDRLIITSAEASPAECCQHAKILEDTQFVDGYKQLGFQETAYGEFLSR
LRENPRLIASSLVAGEKLNQENTQSVIYTVFTSLYGNCIMQEDESYLLQVLRYLIEFE
LKESDNPRRLLRRGTCAFSILFKLFSEGLFSAKLFLTATLHEPIMQLLVEDEDHLETD
PNKLIERFSPAQQEKLFGEKGSDRFRQKVQEMVDSNEAKLVALVNKFIGYLKQNTYCF
PHSLRWIVSQMYKTLSCVDRLEVGEVRAMCTDLLLACFICPAVVNPEQYGIISDAPIN
EVARFNLMQVGRLLQQLAMTGTEEGDPRTKNSLGKFDKGCVAAFLDVVIGGRAVETPP
MSSVNLLEGLSRTVVYISYSQLITLVNFMKSVMSGDQLKEDRMALDNLLANLPQAKPG
KSSSLDMTPYSTPQMSPATTPANKKNRLPIATRSRSRSNMLMDLHMDHEGSSQETIQE
VQPEEVLVISLGTGPQLTPGMMSENEVLNMQLSDGGQGDVPVDENKLHGPSNRSNSVS
SLDLEGESVSELGAGPSGSNGVEALQLLEHEQATTQDNLDDKLRKFEIRDMMGLTDDR
DISETVSETWSTDVLGSDFDPNVDEDRLQEIAGAAAENVLGSLLCLPGSGSVLLDPCT
GSTISETTSEAWSVEVLPSDSEAPDLKQEERLQELESCSGLGSTSDDTDVREVSSRPS
TPGLSVVSGISATSEDIPNKIEDLRSECSSDFGGKDSVTSPDMDDIAHGAHQLTSPPS
QSESLLAMFDPLSSHEGASAVVRPKVHYARPSHPPPDPPILEGAVGGNEARLPNFGSH
VLTAAEMEAFKQRHSYPERLVRSRSSDIVSSVRRPMSDPSWNRRPGNEELPPAAATGA
TSLVAAPHSSSSSPSKDSSRGETEERKDSDDERSDRSRPWWRKRFVSAMPKAPIPFRK
KEKQEKDKDDLGPDRFSTLTDEPSPRLSAQAQVAEDILDKYRNAIKRTSPSEGAMAND
ESAEVMGDGESAHDSPREEALQNISADDLPDSASQAAHPQDSAFSYRDVKKKLRLALC
SADSVAFPVLTHSTRNGLPDHTDPEDNEIVCFLKVQIAEAINLQDKSLMAQLQETMRC
VCRFDNRTCRKLLASIAEDYRKRAPYIAYLTRCRQGLQTTQAHLERLLQRVLRDKEVA
NRYFTTVCVRLLLESKEKKIREFIQDFQKLTAADDKTAQVEDFLQFLYGVMAQDVIWQ
NASEEQLQDAQLAIERSVMNRIFKLAFYPNQDGDILRDQVLHEHIQRLSKVVTANHRA
LQIPEVYLREAPWPSAQSEIRTISAYKTPRDKVQCILRMCSTIMNLLSLANEDSVPGA
DDFVPVLVFVLIKANPPCLLSTVQYISSFYASCLSGEESYWWMQFTAAVEFIKTIDDR
K"
misc_feature 1261..1263
/gene="Gapvd1"
/gene_synonym="2010005B09Rik; 4432404J10Rik; AW108497;
Gapex-5; mKIAA1521; RAP6; RME-6"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000250|UniProtKB:Q14C86};
propagated from UniProtKB/Swiss-Prot (Q6PAR5.2);
phosphorylation site"
misc_feature 1750..1752
/gene="Gapvd1"
/gene_synonym="2010005B09Rik; 4432404J10Rik; AW108497;
Gapex-5; mKIAA1521; RAP6; RME-6"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine. {ECO:0000250|UniProtKB:Q14C86};
propagated from UniProtKB/Swiss-Prot (Q6PAR5.2);
phosphorylation site"
misc_feature 1954..1956
/gene="Gapvd1"
/gene_synonym="2010005B09Rik; 4432404J10Rik; AW108497;
Gapex-5; mKIAA1521; RAP6; RME-6"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine. {ECO:0000250|UniProtKB:Q14C86};
propagated from UniProtKB/Swiss-Prot (Q6PAR5.2);
phosphorylation site"
misc_feature 1978..1980
/gene="Gapvd1"
/gene_synonym="2010005B09Rik; 4432404J10Rik; AW108497;
Gapex-5; mKIAA1521; RAP6; RME-6"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000250|UniProtKB:Q14C86};
propagated from UniProtKB/Swiss-Prot (Q6PAR5.2);
phosphorylation site"
misc_feature 1990..1992
/gene="Gapvd1"
/gene_synonym="2010005B09Rik; 4432404J10Rik; AW108497;
Gapex-5; mKIAA1521; RAP6; RME-6"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine. {ECO:0000250|UniProtKB:Q14C86};
propagated from UniProtKB/Swiss-Prot (Q6PAR5.2);
phosphorylation site"
misc_feature 2743..2745
/gene="Gapvd1"
/gene_synonym="2010005B09Rik; 4432404J10Rik; AW108497;
Gapex-5; mKIAA1521; RAP6; RME-6"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:21183079};
propagated from UniProtKB/Swiss-Prot (Q6PAR5.2);
phosphorylation site"
misc_feature 2755..2757
/gene="Gapvd1"
/gene_synonym="2010005B09Rik; 4432404J10Rik; AW108497;
Gapex-5; mKIAA1521; RAP6; RME-6"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000250|UniProtKB:Q14C86};
propagated from UniProtKB/Swiss-Prot (Q6PAR5.2);
phosphorylation site"
misc_feature 2788..2790
/gene="Gapvd1"
/gene_synonym="2010005B09Rik; 4432404J10Rik; AW108497;
Gapex-5; mKIAA1521; RAP6; RME-6"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:21183079};
propagated from UniProtKB/Swiss-Prot (Q6PAR5.2);
phosphorylation site"
misc_feature 2803..2805
/gene="Gapvd1"
/gene_synonym="2010005B09Rik; 4432404J10Rik; AW108497;
Gapex-5; mKIAA1521; RAP6; RME-6"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine. {ECO:0000250|UniProtKB:Q14C86};
propagated from UniProtKB/Swiss-Prot (Q6PAR5.2);
phosphorylation site"
misc_feature 2815..2817
/gene="Gapvd1"
/gene_synonym="2010005B09Rik; 4432404J10Rik; AW108497;
Gapex-5; mKIAA1521; RAP6; RME-6"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000250|UniProtKB:Q14C86};
propagated from UniProtKB/Swiss-Prot (Q6PAR5.2);
phosphorylation site"
misc_feature 3145..3147
/gene="Gapvd1"
/gene_synonym="2010005B09Rik; 4432404J10Rik; AW108497;
Gapex-5; mKIAA1521; RAP6; RME-6"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000250|UniProtKB:Q14C86};
propagated from UniProtKB/Swiss-Prot (Q6PAR5.2);
phosphorylation site"
misc_feature 3223..3225
/gene="Gapvd1"
/gene_synonym="2010005B09Rik; 4432404J10Rik; AW108497;
Gapex-5; mKIAA1521; RAP6; RME-6"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:19131326,
ECO:0000244|PubMed:19144319, ECO:0000244|PubMed:21183079};
propagated from UniProtKB/Swiss-Prot (Q6PAR5.2);
phosphorylation site"
misc_feature 3226..3228
/gene="Gapvd1"
/gene_synonym="2010005B09Rik; 4432404J10Rik; AW108497;
Gapex-5; mKIAA1521; RAP6; RME-6"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000250|UniProtKB:Q14C86};
propagated from UniProtKB/Swiss-Prot (Q6PAR5.2);
phosphorylation site"
misc_feature 3241..3243
/gene="Gapvd1"
/gene_synonym="2010005B09Rik; 4432404J10Rik; AW108497;
Gapex-5; mKIAA1521; RAP6; RME-6"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:21183079};
propagated from UniProtKB/Swiss-Prot (Q6PAR5.2);
phosphorylation site"
misc_feature 3409..3411
/gene="Gapvd1"
/gene_synonym="2010005B09Rik; 4432404J10Rik; AW108497;
Gapex-5; mKIAA1521; RAP6; RME-6"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000250|UniProtKB:Q14C86};
propagated from UniProtKB/Swiss-Prot (Q6PAR5.2);
phosphorylation site"
misc_feature 3568..3570
/gene="Gapvd1"
/gene_synonym="2010005B09Rik; 4432404J10Rik; AW108497;
Gapex-5; mKIAA1521; RAP6; RME-6"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000250|UniProtKB:Q14C86};
propagated from UniProtKB/Swiss-Prot (Q6PAR5.2);
phosphorylation site"
misc_feature 3649..3651
/gene="Gapvd1"
/gene_synonym="2010005B09Rik; 4432404J10Rik; AW108497;
Gapex-5; mKIAA1521; RAP6; RME-6"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:21183079};
propagated from UniProtKB/Swiss-Prot (Q6PAR5.2);
phosphorylation site"
misc_feature 3745..3747
/gene="Gapvd1"
/gene_synonym="2010005B09Rik; 4432404J10Rik; AW108497;
Gapex-5; mKIAA1521; RAP6; RME-6"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000250|UniProtKB:Q14C86};
propagated from UniProtKB/Swiss-Prot (Q6PAR5.2);
phosphorylation site"
ORIGIN
1 attttaaagg gctgtcaagt gggaaccaat tctccttgct tccaggcaga ataactacct
61 gcaaagggag gaaagacaag ggaagcagat ttcagctcag cagaaggcag aactttctaa
121 catttagagc tgtgcaacag agaggagcag gctgtactcc tgagaggtag tgagctgata
181 ctggaacatc cgaaacagaa gtgagacgtg gaggccattc ctgcttgggt gggagctgca
241 ccgatgacct ttaagcacca ggtacacgga gacgtgaggg cggaggatcg gcgtacaggt
301 cctggcaagg cggttcgcga ccgggagcgg aagggcggcc gtggtccgga ccaccgatcc
361 caggggcccc cgcggcgccg cgcacgcgca ctgctgaggg ggcagcgccg ccgcaggagg
421 cagggaaacc gactggcgat ctgtggcggc ggctgggcgg cggtggcagt tcgcagcgag
481 ggcgacggct ccgaggccga gaggcagtcc agcgaggacc tgggcgccgt cctccgcatg
541 acctcaccgt gatcaacttt tgtacctttt ccgaattcaa agatggtgaa gctagatatt
601 cacacattgg cccaccacct caagcaggaa cgcttatatg tgagctctga gaaacagctc
661 attcagaggc taaatgccga tgtactgaag acagctgaaa agctgtatcg aacagcgtgg
721 attgcaaagc aacagaggat taatttggat cgtcttatta taaccagtgc tgaagcttcc
781 cctgctgagt gttgccagca tgccaagatt ttggaagata cacagtttgt tgatggatat
841 aagcaactgg gatttcagga aacagcttat ggagaattcc tgagtcggtt aagagaaaat
901 ccacgactta ttgcctcctc tttggttgct ggagaaaaac tcaatcagga gaacacacaa
961 agtgttatct acactgtttt tacctccttg tatggcaact gtattatgca agaagatgaa
1021 agctacctcc ttcaggtttt acgatacttg attgaatttg aacttaaaga aagtgacaac
1081 cccaggcgcc ttttgaggag aggaacttgt gccttcagca tcttatttaa acttttttct
1141 gaaggactgt tttctgccaa acttttcctt acggctactt tgcatgagcc aatcatgcag
1201 ctcctcgtag aggatgaaga ccacctggaa acagatccaa acaagctgat agagagattc
1261 tctccagctc agcaagaaaa actctttgga gagaaaggct cagatagatt taggcaaaag
1321 gttcaagaaa tggtagattc caatgaggct aaactagtgg ctttggtgaa caaatttatt
1381 ggttatctta aacagaatac atactgcttt ccacatagtt tgaggtggat tgtgtcacag
1441 atgtacaaaa ctctttcttg tgtagacaga ttggaggttg gggaagtcag agcaatgtgt
1501 accgatcttc tgctggcttg cttcatttgt cctgcagttg tcaatccaga gcagtatggg
1561 ataatatctg atgctcctat taatgaggtg gcaagattta acctgatgca ggttggccgc
1621 cttttgcagc agctagcaat gactggcact gaagaaggag atccccggac caaaaatagc
1681 cttggaaaat ttgacaaagg ctgtgtcgct gctttccttg atgttgtaat tgggggccgt
1741 gcagtggaga ctccgccaat gtcctctgtt aatcttctgg aaggcttgag cagaactgtg
1801 gtgtatataa gttacagtca gcttattact ctggtaaatt ttatgaagag tgtgatgtct
1861 ggagatcaac tgaaagaaga tagaatggct cttgacaatt tgttggcaaa cctgccccag
1921 gctaagccag ggaagagcag cagtctggac atgactccct atagcactcc tcagatgtct
1981 ccagcaacca ctccagccaa caagaagaat cgattaccta tagcaactcg gagcagaagc
2041 cgaagtaata tgttaatgga cctacatatg gatcatgaag gatcatctca agaaaccatc
2101 caggaggtac agccagaaga ggtgctggtc atttccttag ggacaggccc tcagctcact
2161 ccagggatga tgtcagaaaa tgaggttcta aacatgcagc tttcggatgg aggacaagga
2221 gatgtccctg ttgatgaaaa caaactccac ggtccttcca atcgctccaa ttcggtgtct
2281 tctctcgacc tggagggaga gtctgtatct gaacttgggg caggaccttc tgggagtaac
2341 ggagttgaag cactgcagct gttagagcac gagcaagcta caacacaaga taatcttgat
2401 gataaactga ggaagtttga gattcgtgac atgatgggac taacagatga cagggacata
2461 tccgagactg tgagtgagac ctggagcact gatgtcctgg gaagtgactt cgacccgaac
2521 gttgatgaag atcgtttgca agagattgca ggtgcagcag cagagaacgt gttaggtagt
2581 ttgctgtgcc ttccaggttc agggtcagtt ctccttgacc cttgcactgg ctctaccata
2641 tcagagacca caagtgaagc ttggagtgta gaggtattgc caagtgactc agaggctcca
2701 gacttaaagc aggaagagcg cctccaagag ctggagagct gttctggact gggcagcaca
2761 tctgatgata cggatgtcag ggaggtcagt tcccgcccca gcacaccagg cctcagtgtt
2821 gtgtccggta taagtgctac atcggaggat attcccaata agatcgaaga cctgagatct
2881 gagtgcagct ctgattttgg gggcaaagat tctgtaacta gtccagatat ggatgacata
2941 gcccatggcg ctcatcagct gacctctcct ccctctcagt cagagtctct gcttgccatg
3001 tttgatccac tgtcctcaca tgaaggggcc tctgctgtgg taaggccaaa ggttcactat
3061 gcccgaccct cgcatccacc tccggatcct ccaatcctgg aaggtgcagt gggaggaaat
3121 gaggccaggt tgccaaactt tggctctcac gttttaactg cagctgaaat ggaggcgttc
3181 aagcagagac actcataccc tgagagattg gttcgcagca gaagctctga tatagtgtct
3241 tctgtgcggc ggcccatgag tgaccccagc tggaaccgac gtccagggaa tgaagaactt
3301 cctccagctg cagccactgg tgctacttct ttggtggctg cacctcactc gtcatcttcg
3361 tccccgagta aggactcttc tagaggagag actgaggaac gcaaggacag tgacgatgag
3421 aggtcagaca ggagcaggcc ttggtggagg aagcgctttg tttcagctat gcctaaagct
3481 cctataccat ttagaaagaa agaaaaacaa gaaaaagaca aagatgatct gggtcctgac
3541 agattctcaa cactcacaga tgagcccagc cctaggctca gtgctcaagc tcaggttgct
3601 gaagatattc tggacaagta ccggaatgcc attaaacgga ccagccccag tgaaggagca
3661 atggcaaatg atgagagtgc agaggtcatg ggtgatggtg aaagtgccca cgactctcct
3721 cgtgaggaag cactgcagaa catctcagcc gacgacctcc cggactccgc cagccaggca
3781 gcccaccctc aggactctgc tttctcttac agagatgtaa aaaagaagct gaggctcgca
3841 ctttgctctg cagactctgt ggccttccca gtgctaactc attcaacaag gaatggattg
3901 ccagaccaca cagacccaga agacaatgaa attgtatgct tcttaaaagt tcaaatagct
3961 gaagcaatta atttacaaga taagagctta atggctcaac ttcaagaaac aatgcgttgt
4021 gtgtgccgct ttgacaatag gacttgtagg aagttgctgg catccattgc tgaagactac
4081 agaaaaagag ctccgtatat tgcttatctt acccgctgcc gacaaggact gcagaccaca
4141 caggctcact tggaaaggct cttgcaaaga gttttgcggg acaaagaggt ggccaatcgg
4201 tacttcacca ctgtctgtgt gcggttactg cttgagagca aagaaaagaa aatcagggag
4261 ttcattcaag actttcagaa acttactgct gctgatgata aaacggctca ggtggaggat
4321 tttctacagt tcctgtatgg tgtgatggct caggatgtca tatggcagaa tgccagtgag
4381 gagcagctgc aggatgccca gctggccatc gagcggagtg tgatgaatcg gatcttcaag
4441 cttgctttct accctaacca ggatggggac atacttcgtg accaggttct gcatgaacat
4501 atccagagat tatctaaagt agtgactgca aaccacagag ctctgcagat ccctgaggtt
4561 tatctccgtg aggcaccatg gccatctgca cagtcagaaa tcaggacaat aagtgcttac
4621 aaaacgcccc gcgacaaagt gcagtgcatc ctgaggatgt gctccaccat catgaacctc
4681 ttgagcctgg ccaacgagga ctctgtcccc ggggcagatg actttgttcc tgtgttggtg
4741 tttgtgttaa taaaggcaaa cccaccctgc ctgctgtcca ctgtgcagta catcagcagc
4801 ttctatgcca gctgtctgtc tggagaggag tcctactggt ggatgcagtt cacagcagcc
4861 gtggagttta ttaaaaccat cgatgacaga aagtgaccaa gaccaggccc accaagacag
4921 cagactgtag ccaggaaaca gatctctagg aacatgtagc agcttctttg aaagctgaac
4981 attgttttgt ctaatgctct acagcttcca gacgtttcca catggctctt cctaagcaga
5041 ttaacaagct acacgcaggt cctcgttcct ttcggccttt ctgagttgca tattttattt
5101 cctgacccca agtagagagt agtactgcaa aagggaccat gtttttcagg tgttttaaat
5161 ttttaaaaac cagaacagaa atcttttagg aaacgtctag atcttggttc atgaattccc
5221 tgttcgtcct tctcattttt agaaagaaca gtgtgcccct tccaagttgc tgtgtgagcg
5281 ttcggtcgtg aggcacctgc acggagggtc tcaggagatg cgcaatacgg gctccctaga
5341 tacactctcc taaggaagag ctaagaagga aatgtaaatc taatatatat ttatatttga
5401 tgtactatgg gcatcttcag actctaataa acaacaagga cagttgctga gagtaggctg
5461 tgacattccc tcttgtgaaa tggtttcctt gacaaaattt aagctgagct taaaagcaaa
5521 agcagaaata tttattagtc tggagtagag tttatcgctc tgcatgtgtg gagtttgatg
5581 gggaagtcat gaaggcgtgt accaccatgg acatgtgttg agcctgcgca ttggggcaga
5641 ctccaccatg tggacaagca gtacgtggca tggcaggtgt gctcatgcgt ccttcctttg
5701 cacctgcgca ctgagtggaa gccaggaagg gctccttacc gagcctcagc tatcatctgt
5761 ctctgatgat ggttcacatt gaatgcacag accaggaatt cagtgaatgt cattttttaa
5821 aactaatttg tatcgtctgc tctactgatc caggtcttac tagtgttaaa ctattttgat
5881 cagccacact attcttatgg aaaaaaatct attttggcag gttcctgtgc ctttattgcc
5941 ctcttctgaa aaaaaaaaaa aaaaaa
//