LOCUS NM_015089 7771 bp mRNA linear PRI 30-JUN-2018
DEFINITION Homo sapiens cullin 9 (CUL9), mRNA.
ACCESSION NM_015089
VERSION NM_015089.3
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7771)
AUTHORS Li Z and Xiong Y.
TITLE Cytoplasmic E3 ubiquitin ligase CUL9 controls cell proliferation,
senescence, apoptosis and genome integrity through p53
JOURNAL Oncogene 36 (36), 5212-5218 (2017)
PUBMED 28481879
REMARK GeneRIF: Results in U2OS cells demonstrate that the functions of
CUL9 in regulating cell proliferation and maintaining genomic
integrity are mainly mediated by p53, and that CUL9 is a critical
p53 activator.
REFERENCE 2 (bases 1 to 7771)
AUTHORS Li X, Wang W, Wang J, Malovannaya A, Xi Y, Li W, Guerra R, Hawke
DH, Qin J and Chen J.
TITLE Proteomic analyses reveal distinct chromatin-associated and soluble
transcription factor complexes
JOURNAL Mol. Syst. Biol. 11 (1), 775 (2015)
PUBMED 25609649
REMARK Publication Status: Online-Only
REFERENCE 3 (bases 1 to 7771)
AUTHORS Gama V, Swahari V, Schafer J, Kole AJ, Evans A, Huang Y, Cliffe A,
Golitz B, Sciaky N, Pei XH, Xiong Y and Deshmukh M.
TITLE The E3 ligase PARC mediates the degradation of cytosolic cytochrome
c to promote survival in neurons and cancer cells
JOURNAL Sci Signal 7 (334), ra67 (2014)
PUBMED 25028717
REMARK GeneRIF: PARC-mediated ubiquitination and degradation of Cyt c is a
strategy engaged by both neurons and cancer cells to prevent
apoptosis during conditions of mitochondrial stress.
Publication Status: Online-Only
REFERENCE 4 (bases 1 to 7771)
AUTHORS Lopez J and Tait SW.
TITLE Killing the Killer: PARC/CUL9 promotes cell survival by destroying
cytochrome C
JOURNAL Sci Signal 7 (334), pe17 (2014)
PUBMED 25028716
REMARK GeneRIF: PARC (also known as CUL9) was found to be the ubiquitin
ligase responsible for the ubiquitination and proteasomal
degradation of cytochrome c, thus promoting cell survival.
Publication Status: Online-Only
REFERENCE 5 (bases 1 to 7771)
AUTHORS Li Z, Pei XH, Yan J, Yan F, Cappell KM, Whitehurst AW and Xiong Y.
TITLE CUL9 mediates the functions of the 3M complex and ubiquitylates
survivin to maintain genome integrity
JOURNAL Mol. Cell 54 (5), 805-819 (2014)
PUBMED 24793696
REFERENCE 6 (bases 1 to 7771)
AUTHORS Ko HS, Kim SW, Sriram SR, Dawson VL and Dawson TM.
TITLE Identification of far upstream element-binding protein-1 as an
authentic Parkin substrate
JOURNAL J. Biol. Chem. 281 (24), 16193-16196 (2006)
PUBMED 16672220
REMARK GeneRIF: FUBP1 is an authentic substrate of Parkin that might play
an important role in development of Parkinson disease pathology
along with aminoacyl-tRNA synthetase interacting multifunctional
protein type 2
REFERENCE 7 (bases 1 to 7771)
AUTHORS Cheng J, Kapranov P, Drenkow J, Dike S, Brubaker S, Patel S, Long
J, Stern D, Tammana H, Helt G, Sementchenko V, Piccolboni A,
Bekiranov S, Bailey DK, Ganesh M, Ghosh S, Bell I, Gerhard DS and
Gingeras TR.
TITLE Transcriptional maps of 10 human chromosomes at 5-nucleotide
resolution
JOURNAL Science 308 (5725), 1149-1154 (2005)
PUBMED 15790807
REFERENCE 8 (bases 1 to 7771)
AUTHORS Nikolaev AY, Li M, Puskas N, Qin J and Gu W.
TITLE Parc: a cytoplasmic anchor for p53
JOURNAL Cell 112 (1), 29-40 (2003)
PUBMED 12526791
REMARK GeneRIF: Parc, a Parkin-like ubiquitin ligase,is a critical
regulator in controlling p53 subcellular cytoplasmic localization
and subsequent function.
REFERENCE 9 (bases 1 to 7771)
AUTHORS Nakayama M, Kikuno R and Ohara O.
TITLE Protein-protein interactions between large proteins: two-hybrid
screening using a functionally classified library composed of long
cDNAs
JOURNAL Genome Res. 12 (11), 1773-1784 (2002)
PUBMED 12421765
REFERENCE 10 (bases 1 to 7771)
AUTHORS Moynihan TP, Ardley HC, Nuber U, Rose SA, Jones PF, Markham AF,
Scheffner M and Robinson PA.
TITLE The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with
RING finger/IBR motif-containing domains of HHARI and H7-AP1
JOURNAL J. Biol. Chem. 274 (43), 30963-30968 (1999)
PUBMED 10521492
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AL133375.25, AJ318215.1, KF458162.1 and BC002879.2.
[WARNING] On Nov 23, 2018 this sequence was replaced by
NM_015089.4.
On Jan 17, 2014 this sequence version replaced NM_015089.2.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
CDS exon combination :: AJ318215.1, AY145132.1 [ECO:0000331]
RNAseq introns :: single sample supports all introns
SAMEA1965299, SAMEA1966682 [ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-2 AL133375.25 4471-4472
3-66 AL133375.25 4473-4536
67-599 AL133375.25 6589-7121
600-1223 AJ318215.1 525-1148
1224-1224 KF458162.1 164-164 c
1225-6707 AJ318215.1 1150-6632
6708-7767 BC002879.2 1974-3033
7768-7771 AL133375.25 46871-46874
FEATURES Location/Qualifiers
source 1..7771
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="6"
/map="6p21.1"
gene 1..7771
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/note="cullin 9"
/db_xref="GeneID:23113"
/db_xref="HGNC:HGNC:15982"
/db_xref="MIM:607489"
exon 1..66
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/inference="alignment:Splign:2.1.0"
misc_feature 49..51
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/note="upstream in-frame stop codon"
exon 67..670
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/inference="alignment:Splign:2.1.0"
CDS 76..7629
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/note="parkin-like cytoplasmic p53 binding protein;
p53-associated parkin-like cytoplasmic protein;
UbcH7-associated protein 1; CUL-9"
/codon_start=1
/product="cullin-9"
/protein_id="NP_055904.1"
/db_xref="CCDS:CCDS4890.1"
/db_xref="GeneID:23113"
/db_xref="HGNC:HGNC:15982"
/db_xref="MIM:607489"
/translation="MVGERHAGDLMVPLGPRLQAYPEELIRQRPGHDGHPEYLIRWSV
LKCGEVGKVGVEEGKAEHILMWLSAPEVYANCPGLLGERALSKGLQHEPAGVSGSFPR
DPGGLDEVAMGEMEADVQALVRRAARQLAESGTPSLTAAVLHTIHVLSAYASIGPLTG
VFRETGALDLLMHMLCNPEPQIRRSAGKMLQALAAHDAGSRAHVLLSLSQQDGIEQHM
DFDSRYTLLELFAETTSSEEHCMAFEGIHLPQIPGKLLFSLVKRYLCVTSLLDQLNSS
PELGAGDQSSPCATREKSRGQRELEFSMAVGNLISELVRSMGWARNLSEQGMSPPRPT
RSIFQPYISGPSLLLPTIVTTPRRQGWVFRQRSEFSSRSGYGEYVQQTLQPGMRVRML
DDYEEISAGDEGEFRQSNNGIPPVQVFWQSTGRTYWVHWHMLEILGPEEATEDKASAA
VEKGAGATVLGTAFPSWDWNPMDGLYPLPYLQPEPQKNERVGYLTQAEWWELLFFIKK
LDLCEQQPIFQNLWKNLDETLGEKALGEISVSVEMAESLLQVLSSRFEGSTLNDLLNS
QIYTKYGLLSNEPSSSSTSRNHSCTPDPEEESKSEASFSEEETESLKAKAEAPKTEAE
PTKTRTETPMAQSDSQLFNQLLVTEGMTLPTEMKEAASEMARALRGPGPRSSLDQHVA
AVVATVQISSLDTNLQLSGLSALSQAVEEVTERDHPLVRPDRSLREKLVKMLVELLTN
QVGEKMVVVQALRLLYLLMTKHEWRPLFAREGGIYAVLVCMQEYKTSVLVQQAGLAAL
KMLAVASSSEIPTFVTGRDSIHSLFDAQMTREIFASIDSATRPGSESLLLTVPAAVIL
MLNTEGCSSAARNGLLLLNLLLCNHHTLGDQIITQELRDTLFRHSGIAPRTEPMPTTR
TILMMLLNRYSEPPGSPERAALETPIIQGQDGSPELLIRSLVGGPSAELLLDLERVLC
REGSPGGAVRPLLKRLQQETQPFLLLLRTLDAPGPNKTLLLSVLRVITRLLDFPEAMV
LPWHEVLEPCLNCLSGPSSDSEIVQELTCFLHRLASMHKDYAVVLCCLGAKEILSKVL
DKHSAQLLLGCELRDLVTECEKYAQLYSNLTSSILAGCIQMVLGQIEDHRRTHQPINI
PFFDVFLRHLCQGSSVEVKEDKCWEKVEVSSNPHRASKLTDHNPKTYWESNGSTGSHY
ITLHMHRGVLVRQLTLLVASEDSSYMPARVVVFGGDSTSCIGTELNTVNVMPSASRVI
LLENLNRFWPIIQIRIKRCQQGGIDTRVRGVEVLGPKPTFWPLFREQLCRRTCLFYTI
RAQAWSRDIAEDHRRLLQLCPRLNRVLRHEQNFADRFLPDDEAAQALGKTCWEALVSP
LVQNITSPDAEGVSALGWLLDQYLEQRETSRNPLSRAASFASRVRRLCHLLVHVEPPP
GPSPEPSTRPFSKNSKGRDRSPAPSPVLPSSSLRNITQCWLSVVQEQVSRFLAAAWRA
PDFVPRYCKLYEHLQRAGSELFGPRAAFMLALRSGFSGALLQQSFLTAAHMSEQFARY
IDQQIQGGLIGGAPGVEMLGQLQRHLEPIMVLSGLELATTFEHFYQHYMADRLLSFGS
SWLEGAVLEQIGLCFPNRLPQLMLQSLSTSEELQRQFHLFQLQRLDKLFLEQEDEEEK
RLEEEEEEEEEEEAEKELFIEDPSPAISILVLSPRCWPVSPLCYLYHPRKCLPTEFCD
ALDRFSSFYSQSQNHPVLDMGPHRRLQWTWLGRAELQFGKQILHVSTVQMWLLLKFNQ
TEEVSVETLLKDSDLSPELLLQALVPLTSGNGPLTLHEGQDFPHGGVLRLHEPGPQRS
GEALWLIPPQAYLNVEKDEGRTLEQKRNLLSCLLVRILKAHGEKGLHIDQLVCLVLEA
WQKGPNPPGTLGHTVAGGVACTSTDVLSCILHLLGQGYVKRRDDRPQILMYAAPEPMG
PCRGQADVPFCGSQSETSKPSPEAVATLASLQLPAGRTMSPQEVEGLMKQTVRQVQET
LNLEPDVAQHLLAHSHWGAEQLLQSYSEDPEPLLLAAGLCVHQAQAVPVRPDHCPVCV
SPLGCDDDLPSLCCMHYCCKSCWNEYLTTRIEQNLVLNCTCPIADCPAQPTGAFIRAI
VSSPEVISKYEKALLRGYVESCSNLTWCTNPQGCDRILCRQGLGCGTTCSKCGWASCF
NCSFPEAHYPASCGHMSQWVDDGGYYDGMSVEAQSKHLAKLISKRCPSCQAPIEKNEG
CLHMTCAKCNHGFCWRCLKSWKPNHKDYYNCSAMVSKAARQEKRFQDYNERCTFHHQA
REFAVNLRNRVSAIHEVPPPRSFTFLNDACQGLEQARKVLAYACVYSFYSQDAEYMDV
VEQQTENLELHTNALQILLEETLLRCRDLASSLRLLRADCLSTGMELLRRIQERLLAI
LQHSAQDFRVGLQSPSVEAWEAKGPNMPGSQPQASSGPEAEEEEEDDEDDVPEWQQDE
FDEELDNDSFSYDESENLDQETFFFGDEEEDEDEAYD"
misc_feature 3001..3003
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:23186163};
propagated from UniProtKB/Swiss-Prot (Q8IWT3.2);
phosphorylation site"
misc_feature 4444..4446
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:23186163};
propagated from UniProtKB/Swiss-Prot (Q8IWT3.2);
phosphorylation site"
misc_feature 7381..7383
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine. {ECO:0000244|PubMed:23186163};
propagated from UniProtKB/Swiss-Prot (Q8IWT3.2);
phosphorylation site"
exon 671..825
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/inference="alignment:Splign:2.1.0"
exon 826..1326
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/inference="alignment:Splign:2.1.0"
exon 1327..1462
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/inference="alignment:Splign:2.1.0"
exon 1463..1656
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/inference="alignment:Splign:2.1.0"
exon 1657..2062
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/inference="alignment:Splign:2.1.0"
exon 2063..2255
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/inference="alignment:Splign:2.1.0"
exon 2256..2463
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/inference="alignment:Splign:2.1.0"
exon 2464..2660
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/inference="alignment:Splign:2.1.0"
exon 2661..2878
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/inference="alignment:Splign:2.1.0"
exon 2879..3125
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/inference="alignment:Splign:2.1.0"
exon 3126..3231
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/inference="alignment:Splign:2.1.0"
exon 3232..3459
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/inference="alignment:Splign:2.1.0"
exon 3460..3550
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/inference="alignment:Splign:2.1.0"
exon 3551..3722
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/inference="alignment:Splign:2.1.0"
exon 3723..3828
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/inference="alignment:Splign:2.1.0"
exon 3829..3924
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/inference="alignment:Splign:2.1.0"
exon 3925..4100
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/inference="alignment:Splign:2.1.0"
exon 4101..4234
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/inference="alignment:Splign:2.1.0"
exon 4235..4414
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/inference="alignment:Splign:2.1.0"
exon 4415..4524
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/inference="alignment:Splign:2.1.0"
exon 4525..4707
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/inference="alignment:Splign:2.1.0"
exon 4708..4868
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/inference="alignment:Splign:2.1.0"
exon 4869..5097
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/inference="alignment:Splign:2.1.0"
exon 5098..5287
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/inference="alignment:Splign:2.1.0"
exon 5288..5433
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/inference="alignment:Splign:2.1.0"
exon 5434..5563
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/inference="alignment:Splign:2.1.0"
exon 5564..5763
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/inference="alignment:Splign:2.1.0"
exon 5764..6011
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/inference="alignment:Splign:2.1.0"
exon 6012..6357
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/inference="alignment:Splign:2.1.0"
exon 6358..6498
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/inference="alignment:Splign:2.1.0"
exon 6499..6663
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/inference="alignment:Splign:2.1.0"
exon 6664..6827
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/inference="alignment:Splign:2.1.0"
exon 6828..6921
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/inference="alignment:Splign:2.1.0"
exon 6922..6996
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/inference="alignment:Splign:2.1.0"
exon 6997..7107
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/inference="alignment:Splign:2.1.0"
exon 7108..7225
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/inference="alignment:Splign:2.1.0"
exon 7226..7359
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/inference="alignment:Splign:2.1.0"
exon 7360..7433
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/inference="alignment:Splign:2.1.0"
exon 7434..7771
/gene="CUL9"
/gene_synonym="H7AP1; PARC"
/inference="alignment:Splign:2.1.0"
ORIGIN
1 gaggcggggc caggacggcg ggaccggccg ctgggtccca gcgagggctg agccgggcgg
61 tgggaggagg tcaggatggt gggggaacgg catgctgggg acctcatggt gcccttaggg
121 cctcggctgc aggcatatcc tgaagaactc attcgacaga ggcctgggca tgacgggcat
181 cctgaatacc tgatccgatg gagtgtcctg aagtgtgggg aagtgggcaa agtgggtgtg
241 gaagaaggca aagcagagca catcctcatg tggctgtcgg ctcctgaggt ctacgccaac
301 tgccctgggc tgttaggtga gcgggcacta tctaagggac ttcagcacga accagctggg
361 gtttcaggaa gctttcctcg agatccagga ggcctggatg aagtggcaat gggagagatg
421 gaggctgatg ttcaggcgct ggtacgcagg gcggccaggc agctggcaga aagtgggacc
481 ccaagcctca cggccgctgt gcttcacacc atccacgtgc tcagtgccta cgccagcatc
541 gggcccctca ctggtgtctt cagggagaca ggagccctgg acctgctcat gcacatgtta
601 tgcaatcctg agcctcagat ccgccggagt gcaggcaaaa tgctgcaggc tctggcagcc
661 cacgatgctg ggagtcgggc tcacgtcctt ctatcactga gccagcaaga tggcatcgag
721 cagcacatgg attttgacag tcgctataca ttgctggagc tgtttgcaga aaccacatcc
781 tctgaagaac actgcatggc ctttgagggc attcatctgc ctcagatccc aggaaagctg
841 cttttctcct tggtgaagcg ctacctttgt gtcacgtccc tcctggatca gctgaatagc
901 agtccagagc tgggagctgg agaccaaagc tccccatgtg ccacaagaga gaaaagccgg
961 ggacagcggg aactggagtt cagcatggct gtgggcaacc tcatctctga gcttgtgcgg
1021 agcatgggct gggcccggaa cctcagcgaa cagggcatgt cacctccccg gccaacccgg
1081 tccatctttc agccctacat ttcaggcccc agccttttac tccccaccat tgtcaccacc
1141 cccagaagac aagggtgggt cttccgccag cgctctgaat tctccagccg tagtggctat
1201 ggagaatatg tgcagcagac actgcagcca gggatgcgag tgcggatgct ggatgattat
1261 gaggagatca gtgctgggga cgagggcgag ttccggcaga gcaacaacgg cattccccct
1321 gtgcaggttt tctggcagtc gacaggccgc acttactggg tgcactggca catgctggag
1381 atcctgggcc ctgaggaagc cactgaggat aaggcttcag cagctgtgga gaagggggca
1441 ggggctactg tgttgggcac agcatttccc tcctgggact ggaatcctat ggatgggctg
1501 taccctttgc cgtacctcca gcccgaacct cagaagaatg agagagtggg atatctgacc
1561 caggctgaat ggtgggagct gcttttcttt atcaaaaagt tggacttgtg tgagcagcag
1621 ccaattttcc agaatctttg gaagaacctg gatgagaccc tgggtgaaaa ggccctaggt
1681 gagatctctg tgtccgtgga aatggccgag agtctgctgc aggttctcag tagtcgattt
1741 gagggcagca ctctcaatga cctgctcaac tcccagatct acaccaagta tgggctgctg
1801 tctaatgaac caagcagctc gtctacttca cgaaatcact cctgtacccc agatccagaa
1861 gaggagtcca agtcggaggc cagcttctca gaggaagaga ctgagtccct caaagcaaag
1921 gccgaggccc ctaagacaga ggccgagccc accaagacaa ggaccgagac ccccatggca
1981 cagagtgatt ctcagctgtt taaccagctt ctggtgactg aggggatgac cctgcccact
2041 gagatgaagg aggcagccag tgaaatggcc agagccttgc ggggtcccgg tcctcgcagc
2101 tccctggatc agcatgtggc agcggtcgtg gccactgtgc agatatccag cttggacaca
2161 aacctgcagc tttcagggct ctctgccctc tctcaggctg tggaggaggt cactgagcgg
2221 gaccaccctc tggtccgtcc tgacagatcg ctgagagaga agctagtgaa gatgctggtg
2281 gagctgctga ccaaccaggt gggagagaag atggtggtcg tgcaggccct gcgcctcctt
2341 tacctgctca tgaccaagca cgagtggcgg ccgctctttg ccagggaggg tggcatctat
2401 gctgtgctgg tctgcatgca agaatataag acttctgtct tggtgcagca ggctgggctg
2461 gcggcactga agatgctggc cgtcgccagc tcctcggaga tccccacttt tgttactggc
2521 cgagattcta tccactcttt gtttgatgct cagatgacca gagagatctt cgccagcatc
2581 gactcagcca cacgcccggg ctctgagagc ctgctcctca ctgtccctgc agccgtgatc
2641 ctgatgctga atactgaggg gtgctcttct gcagcgagaa atggcttact cctgctcaac
2701 ctacttttgt gcaaccacca cactctggga gaccagatta taacccaaga gctgagagac
2761 acgttgttta ggcactcagg gatagcacca agaacagaac ctatgcctac cacacgcacc
2821 atcctcatga tgcttctcaa tcgctactca gagccgccgg gcagccctga gcgtgcagca
2881 ctagagaccc ccatcatcca gggtcaggat gggtcccctg agctactgat tcgatccctg
2941 gttgggggcc catctgcaga actactcctg gacttggagc gtgtgctgtg ccgtgagggc
3001 agccccggag gtgccgtgag gcccctcctc aagcgcctcc agcaggagac ccagcctttc
3061 ctcctgttgc tgcggactct ggatgctccg gggcccaaca agactctgct gctgtctgtg
3121 ctgagggtca taacccgact gctggatttc cctgaggcaa tggtcctccc ctggcacgag
3181 gtcttggagc cctgcctcaa ctgcctgagt ggccctagca gtgactccga gattgttcag
3241 gagctgacct gcttcctaca tcgcctggcc tcgatgcata aggactatgc tgtggtgctc
3301 tgctgcctgg gagcaaaaga gatcctctcc aaagtcctgg acaagcactc agctcagctg
3361 ctgctgggct gtgagcttcg ggacctggtg acagagtgtg agaagtacgc acagctctat
3421 agcaacctca cctccagcat cctggccggc tgcattcaga tggtgctggg ccagatcgaa
3481 gaccacagac gaacccacca acccatcaat atccccttct ttgatgtgtt cctcaggcat
3541 ctctgccagg gctccagtgt ggaagtgaag gaggacaagt gctgggagaa ggtggaggtg
3601 tcctccaacc cgcaccgagc cagcaagctg acggaccaca accccaagac ctactgggag
3661 tccaacggca gcaccggctc ccactacatc accctgcaca tgcaccgtgg tgttcttgtt
3721 aggcagctca ctttgctggt ggccagtgag gactcaagct acatgccagc cagggtggtg
3781 gtgtttgggg gtgacagcac cagctgcatc ggcactgagc tcaacacggt gaatgtgatg
3841 ccctctgcca gccgggtgat cctcttggag aacctgaacc gcttctggcc catcatccag
3901 atccgcataa agcgctgcca gcagggcggc attgacaccc gggttcgggg tgtggaggtc
3961 ctgggcccta agcccacatt ctggccactg ttccgggagc agctgtgtcg ccgaacatgt
4021 ctcttctaca caattcgggc acaagcctgg agccgggaca tagcagagga ccaccggcgc
4081 ctcctccagc tctgtcccag actgaacagg gttttgcgcc acgagcagaa ttttgctgac
4141 cgcttcctcc ctgatgatga ggccgcccag gcactgggca agacctgctg ggaggccctg
4201 gtcagccccc tggtgcagaa catcacctct cccgatgcgg aaggcgtgag tgccctggga
4261 tggctgctgg atcagtactt agaacagaga gagacctctc ggaacccctt gagtcgagca
4321 gcgtcctttg cttctcgagt tcgtcgcctt tgccacttgc tggtgcatgt ggaacctcct
4381 cctgggcctt ctcctgagcc atccactcgg cccttcagca agaacagcaa gggtcgggac
4441 cggagcccgg cgccttcgcc agtgcttcca agcagcagcc tgaggaacat aacccagtgc
4501 tggctgagcg tggtgcagga gcaggtcagc agattcctgg ctgcagcttg gagggcccca
4561 gactttgtgc ctcgttactg taaactctat gagcacttgc agagagcagg ctccgagctg
4621 tttgggcctc gggcagcctt catgctggct ctgcgcagtg gcttctctgg cgccttgctg
4681 cagcagtcct tcctcactgc tgctcacatg agtgagcagt ttgccaggta cattgaccaa
4741 cagatccagg gtggcctgat tggtggagcc cctggagtgg aaatgctggg gcagcttcag
4801 cggcacctgg aacccattat ggtcctttct ggtctggaac tggccacaac ttttgagcac
4861 ttctatcagc attatatggc ggaccgtctc ctgagctttg gttcgagctg gctggagggg
4921 gctgtgctag agcagattgg cctctgtttt cccaaccgcc tcccacagct gatgctgcag
4981 agcctgagca cctctgagga gctgcagcgc cagttccacc tcttccagct ccagcggctc
5041 gacaagttgt tcttggagca ggaagatgag gaggaaaaga gactagagga agaggaggag
5101 gaagaggagg aagaggaagc tgagaaagaa ttatttatcg aagatccaag tccagccatt
5161 tctatactgg tcctgtcacc acgctgctgg cccgtctccc cactctgcta cctgtaccat
5221 cccagaaagt gccttcccac agaattctgt gatgcccttg accgtttctc cagtttctac
5281 agccagagtc agaaccatcc agtcctggac atgggaccac atcggcgact gcagtggacg
5341 tggctgggcc gggctgagct gcagtttggg aagcagatac tgcatgtgtc caccgtgcag
5401 atgtggctgc tgctgaaatt caatcagaca gaggaggtgt cagtagagac cttgctgaag
5461 gattctgacc tctccccaga gctgctgctc caggcactcg tgcccctcac ctcagggaat
5521 ggccctttga ccctgcatga gggccaggac tttccacacg ggggtgtgct gcggcttcat
5581 gagcctgggc cccagcgcag tggggaggcc ctgtggctga tacctcccca ggcatacctg
5641 aacgtagaga aggatgaagg ccgaaccctg gaacagaaga ggaatctctt gagctgtctt
5701 cttgttcgta ttctcaaagc ccatggggaa aagggcctcc acattgatca gctggtttgt
5761 ctggtgctgg aggcctggca gaagggtcca aatcctcctg gaaccctggg ccacactgtt
5821 gctgggggtg tggcctgtac cagtacagat gtcctctctt gcatcctgca cctcttaggc
5881 cagggctacg tgaaacggcg tgatgaccgg ccccagatcc tgatgtatgc cgctccagag
5941 cccatggggc cctgccgggg tcaggcagat gtccctttct gtggcagcca gagcgaaacc
6001 tccaagccca gcccagaagc tgtggctacc ctggcatctc tacagctgcc tgcaggccgc
6061 accatgagcc cccaggaagt agaagggttg atgaagcaga cggtgcgtca ggtgcaggag
6121 acgctgaact tagagccaga tgtcgctcag caccttttgg ctcattccca ctggggcgct
6181 gaacagctgc tgcagagcta cagtgaggac cctgagccac tgctgctggc agctgggctg
6241 tgcgtacacc aggctcaggc tgtacccgta cggcctgacc actgccccgt ctgtgtgagc
6301 cccctggggt gtgacgacga cctgccctct ctctgctgca tgcactattg ctgtaagtct
6361 tgctggaatg agtacctgac aactcggatc gagcagaacc ttgttttgaa ttgcacctgc
6421 cccattgccg actgccccgc ccagcccacc ggagccttca ttcgtgccat cgtctcctcg
6481 ccagaggtca tctccaagta tgagaaggcg ctcctgcgtg gctatgtgga gagctgctcc
6541 aacctgacct ggtgcaccaa cccccagggc tgcgaccgca tcctgtgccg ccagggcctg
6601 ggctgtggga ccacctgctc caagtgtggc tgggcctctt gcttcaactg tagcttccct
6661 gaggcacact accctgctag ctgtggccat atgtctcagt gggtcgacga cggtggctac
6721 tatgacggca tgagcgtgga ggcgcagagc aagcacctgg ccaagctcat ctccaagcgc
6781 tgtcccagct gtcaggctcc catcgagaag aacgaggggt gcctgcacat gacctgtgcc
6841 aaatgtaacc atggattctg ctggcgctgc ctcaagtcct ggaagccaaa tcacaaagac
6901 tattacaact gctctgccat ggtaagcaag gcagctcgcc aggagaagcg gtttcaggac
6961 tataatgaga ggtgcacttt ccatcaccag gcgcgggagt ttgctgtgaa cttgcggaac
7021 cgggtgtctg ccatccatga agtgcccccg cccagatcct tcaccttcct caatgatgcc
7081 tgccagggac tggagcaggc tcggaaggtg ctggcctacg cctgcgtgta cagcttctac
7141 agccaggacg cagagtacat ggatgtggtg gagcagcaga cagagaacct ggagctgcac
7201 accaatgccc tgcagatcct cctggaggaa accctgctgc ggtgcagaga cctggcctcc
7261 tccctgcgcc tcctgcgggc cgactgcctc agcacgggca tggagctgct ccggcggatc
7321 caggagaggc tgcttgccat cctgcagcat tctgcccagg atttccgggt tggtcttcag
7381 agtccatcag tagaggcctg ggaggcaaaa ggacccaaca tgcctggcag tcagccccag
7441 gcctcctcag ggccagaggc agaagaggag gaggaagacg atgaggatga tgtgcccgag
7501 tggcagcagg atgagtttga tgaggagctg gacaatgaca gcttctccta cgatgagtct
7561 gagaacctgg accaagagac tttcttcttt ggtgatgagg aagaggatga agatgaggcc
7621 tatgactgag ggggcagatg caggaaacac ctagagcagc cccagagtca cggggctgag
7681 ggggcgggag ctgcccctgt catagggagg gggattccca gcgtctgtag tgcttcctgt
7741 ttgctgaata aaggtctctt tctcacacac a
//