LOCUS NM_001013735 1299 bp mRNA linear PRI 29-JUL-2024
DEFINITION Homo sapiens forkhead box B2 (FOXB2), mRNA.
ACCESSION NM_001013735 XM_498331
VERSION NM_001013735.1
KEYWORDS RefSeq; MANE Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1299)
AUTHORS Moparthi,L., Pizzolato,G. and Koch,S.
TITLE Wnt activator FOXB2 drives the neuroendocrine differentiation of
prostate cancer
JOURNAL Proc Natl Acad Sci U S A 116 (44), 22189-22195 (2019)
PUBMED 31611391
REMARK GeneRIF: FOXB2 strongly activates Wnt signaling via the neurogenic
ligand WNT7B and imposes a neuronal differentiation program on
prostate cancer cells.
REFERENCE 2 (bases 1 to 1299)
AUTHORS Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
Dunham,I.
TITLE DNA sequence and analysis of human chromosome 9
JOURNAL Nature 429 (6990), 369-374 (2004)
PUBMED 15164053
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AL353637.21.
On Mar 30, 2005 this sequence version replaced XM_498331.1.
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments.
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000376708.1/ ENSP00000365898.1
RefSeq Select criteria :: based on single protein-coding transcript
##RefSeq-Attributes-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-1299 AL353637.21 107130-108428
FEATURES Location/Qualifiers
source 1..1299
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="9"
/map="9q21.2"
gene 1..1299
/gene="FOXB2"
/gene_synonym="bA159H20.4; FKH4"
/note="forkhead box B2"
/db_xref="GeneID:442425"
/db_xref="HGNC:HGNC:23315"
/db_xref="MIM:619962"
CDS 1..1299
/gene="FOXB2"
/gene_synonym="bA159H20.4; FKH4"
/codon_start=1
/product="forkhead box protein B2"
/protein_id="NP_001013757.1"
/db_xref="CCDS:CCDS35045.1"
/db_xref="GeneID:442425"
/db_xref="HGNC:HGNC:23315"
/db_xref="MIM:619962"
/translation="MPRPGKSSYSDQKPPYSYISLTAMAIQHSAEKMLPLSDIYKFIM
ERFPYYREHTQRWQNSLRHNLSFNDCFIKIPRRPDQPGKGSFWALHPDCGDMFENGSF
LRRRKRFKVLRADHTHLHAGSTKSAPGAGPGGHLHPHHHHHPHHHHHHHAAAHHHHHH
HPPQPPPPPPPPPPHMVHYFHQQPPTAPQPPPHLPSQPPQQPPQQSQPQQPSHPGKMQ
EAAAVAAAAAAAAAAAVGSVGRLSQFPPYGLGSAAAAAAAAAASTSGFKHPFAIENII
GRDYKGVLQAGGLPLASVMHHLGYPVPGQLGNVVSSVWPHVGVMDSVAAAAAAAAAAG
VPVGPEYGAFGVPVKSLCHSASQSLPAMPVPIKPTPALPPVSALQPGLTVPAASQQPP
APSTVCSAAAASPVASLLEPTAPTSAESKGGSLHSVLVHS"
misc_feature 352..660
/gene="FOXB2"
/gene_synonym="bA159H20.4; FKH4"
/note="propagated from UniProtKB/Swiss-Prot (Q5VYV0.1);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 1237..1296
/gene="FOXB2"
/gene_synonym="bA159H20.4; FKH4"
/note="propagated from UniProtKB/Swiss-Prot (Q5VYV0.1);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
exon 1..1299
/gene="FOXB2"
/gene_synonym="bA159H20.4; FKH4"
/inference="alignment:Splign:2.1.0"
ORIGIN
1 atgccgcggc cggggaagag ctcgtacagc gaccaaaaac cgccctactc ttacatctcg
61 ctgaccgcca tggcaatcca gcactcggcc gagaagatgc tgccgctgag cgacatctac
121 aagttcatca tggagcgctt cccctactac cgcgagcaca cacagcgctg gcagaacagc
181 ctgcgccaca acctctcctt caacgactgc ttcatcaaga ttccgcggag gcccgaccag
241 cctggcaagg gtagcttctg ggcgctgcac cccgactgcg gggacatgtt cgagaacggc
301 agcttcctgc ggcgtcgcaa gcgcttcaag gtgctgcgcg ccgaccatac tcacttgcac
361 gcgggaagca ccaagagcgc gccgggcgcc ggtccgggag ggcaccttca cccccatcac
421 caccaccacc cccaccacca ccatcatcac cacgctgccg cacaccacca ccatcaccac
481 cacccacccc agccgccgcc gccgccgccc ccgccgccgc cgcacatggt acactatttc
541 catcagcaac cgcctactgc tccgcagccg cctccgcacc tcccgtcaca gcccccgcag
601 caaccgcccc agcagtcgca gcctcagcag ccgtctcacc ccggcaagat gcaggaggcg
661 gcggccgtgg cggcggcggc ggcggcggcc gcggcagccg cggtgggcag cgtgggacgc
721 ctgtctcagt tcccacccta cgggctgggc tcggccgccg ccgctgccgc cgcggccgcg
781 gcgtccacgt caggcttcaa gcaccccttt gccattgaga acattattgg ccgggactac
841 aagggcgtgc tgcaggctgg agggctgccc ttggcgtccg tcatgcacca cctgggctac
901 cccgtgcccg gccagcttgg caacgtcgtc agctccgtgt ggccgcacgt tggcgtcatg
961 gattcggtgg ccgccgccgc ggccgccgca gccgcagccg gagtccctgt aggcccggag
1021 tatggggcct tcggggtccc ggtcaagtcc ctgtgccact cggcaagcca gagcctgcct
1081 gccatgccgg tgcccatcaa gcccacgcct gcgctgccgc ccgtgtccgc gctgcagccg
1141 gggctcactg tccccgcggc ttcgcagcag cctccggcgc catccaccgt gtgctccgcg
1201 gccgcggcct cgcccgttgc ctctctgctg gagcccacag cccctacctc ggccgaaagc
1261 aagggcggct ccttgcactc ggtgctagtg cactcctag
//