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Rattus norvegicus claudin 8 (Cldn8), mRNA

NCBI Reference Sequence: NM_001037774.1

FASTA Graphics 

LOCUS       NM_001037774            2285 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus claudin 8 (Cldn8), mRNA.
ACCESSION   NM_001037774 XM_221709
VERSION     NM_001037774.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2285)
  AUTHORS   Molina-Jijon E, Rodriguez-Munoz R, Gonzalez-Ramirez R,
            Namorado-Tonix C, Pedraza-Chaverri J and Reyes JL.
  TITLE     Aldosterone signaling regulates the over-expression of claudin-4
            and -8 at the distal nephron from type 1 diabetic rats
  JOURNAL   PLoS One 12 (5), e0177362 (2017)
   PUBMED   28493961
  REMARK    GeneRIF: the participation of aldosterone (ALD), and the effect of
            spironolactone (SPL), a mineralocorticoid receptor antagonist, on
            the expressions of claudin-2, -4, -5 and -8, and occludin in
            glomeruli, proximal and distal tubules isolated from diabetic rats,
            was evaluated.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2285)
  AUTHORS   Krause G, Winkler L, Mueller SL, Haseloff RF, Piontek J and Blasig
            IE.
  TITLE     Structure and function of claudins
  JOURNAL   Biochim Biophys Acta 1778 (3), 631-645 (2008)
   PUBMED   18036336
  REMARK    Review article
REFERENCE   3  (bases 1 to 2285)
  AUTHORS   Fujita H, Chiba H, Yokozaki H, Sakai N, Sugimoto K, Wada T, Kojima
            T, Yamashita T and Sawada N.
  TITLE     Differential expression and subcellular localization of claudin-7,
            -8, -12, -13, and -15 along the mouse intestine
  JOURNAL   J Histochem Cytochem 54 (8), 933-944 (2006)
   PUBMED   16651389
REFERENCE   4  (bases 1 to 2285)
  AUTHORS   Hu YH, Warnatz HJ, Vanhecke D, Wagner F, Fiebitz A, Thamm S, Kahlem
            P, Lehrach H, Yaspo ML and Janitz M.
  TITLE     Cell array-based intracellular localization screening reveals novel
            functional features of human chromosome 21 proteins
  JOURNAL   BMC Genomics 7, 155 (2006)
   PUBMED   16780588
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2285)
  AUTHORS   Ohta H, Adachi H and Inaba M.
  TITLE     Developmental changes in the expression of tight junction protein
            claudins in murine metanephroi and embryonic kidneys
  JOURNAL   J Vet Med Sci 68 (2), 149-155 (2006)
   PUBMED   16520537
REFERENCE   6  (bases 1 to 2285)
  AUTHORS   Morita K, Furuse M, Fujimoto K and Tsukita S.
  TITLE     Claudin multigene family encoding four-transmembrane domain protein
            components of tight junction strands
  JOURNAL   Proc Natl Acad Sci U S A 96 (2), 511-516 (1999)
   PUBMED   9892664
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC099804.1.
            
            On Dec 16, 2005 this sequence version replaced XM_221709.3.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC099804.1, DN932765.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2285
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..2285
                     /gene="Cldn8"
                     /note="claudin 8"
                     /db_xref="GeneID:304124"
                     /db_xref="RGD:1308575"
     exon            1..2250
                     /gene="Cldn8"
                     /inference="alignment:Splign:2.1.0"
     CDS             3..680
                     /gene="Cldn8"
                     /codon_start=1
                     /product="claudin-8"
                     /protein_id="NP_001032863.1"
                     /db_xref="GeneID:304124"
                     /db_xref="RGD:1308575"
                     /translation="MATYALQMAALVLGGVGMVGTVAVTIMPQWRVSAFIESNIVVFE
                     NRWEGLWMNCMRHANIRMQCKVYDSLLALSPDLQASRGLMCAASVLSFLAFMTAILGM
                     KCTRCTGEDENVKSRILLTAGIIFFITGLVVLIPVSWVANAIIRDFYNPLVDVAQKRE
                     LGEALYIGWTTALVLIAGGALFCCVFCCTERSNSYKYSVPSHRTTQRSFHAEKRSPSI
                     YSKSQYV"
ORIGIN      
        1 ccatggcaac ctacgctctt caaatggctg ccctggtgct tggtggtgtt ggcatggtgg
       61 gcacagtggc tgtgacgatc atgcctcagt ggagagtgtc tgccttcatc gaaagtaaca
      121 ttgtcgtgtt tgagaaccgc tgggaaggtt tgtggatgaa ctgcatgagg catgccaaca
      181 tcagaatgca gtgtaaggtc tatgactccc tgctggctct tagtccagac ctccaggcat
      241 ccagaggact gatgtgtgct gcgtccgtcc tgtccttctt ggctttcatg acagccatcc
      301 tcggaatgaa gtgcaccagg tgcaccgggg aggacgagaa cgtgaagagc cgcatcttgc
      361 tgacggctgg aatcatcttc ttcatcaccg gcttggttgt gctcatccct gtcagctggg
      421 ttgccaatgc catcatcaga gacttctaca acccgctggt ggatgtggcc caaaagcgcg
      481 agcttggtga agccctctac ataggctgga ccacggcgct ggtgctgatc gctggaggag
      541 cactgttctg ttgcgtgttt tgctgtactg aaaggagtaa cagttacaag tactcggtac
      601 catcccatcg caccactcag aggagtttcc acgccgaaaa gagatccccg agcatatact
      661 ccaaaagtca gtatgtgtag ctgtgtgtgt atattttagc tgtagctata aagcgaagct
      721 ttataaatca ctgaaccagc cactatttta tagaaatgga acccacagtg tttccattta
      781 cctttcttaa ctgcctcgta ctcattacag gaaatacgca gcgtctatga ttccataaat
      841 gattttagca gaatgaggta ttatgcacac tgcttcaatt gttccagaaa gcatagccat
      901 ttgttttcta aaatggttca cgcggttctt cttttatcag tcactctaag acgacccatc
      961 gaaagactgt tggtttaagc tgcgatttct ctgtgtcatg gcattataca agtaatgcga
     1021 gtggcagtta tagctcacac aaatagagac aggcttatgt ggttctattt aaagtgaaat
     1081 gccaatccat caggctgaat aaacagaact cagctattgc atttcagggg acctggggat
     1141 aaaaggaaag aaggctgata ttaattgcct aaaaacagct taaggattag tgcactctat
     1201 ttatagcaaa ggttaaaatg aaggctttca tcattagtgt aagggaaact gaatggcttt
     1261 ctgatcgcct gctttgcagc ctccaggagt taaaaatcct gtcaccttta tcctttatcc
     1321 acgtgccttt tttttttctg attgtgttcc ttagtatctt ttaaagttta aagcagatat
     1381 tgtaacaaaa tatttttttt cttcagacta cgtttgtaag gctgggctaa caagagagat
     1441 aaagcagtgg tcttagaaaa attaacgttt tcagaaaaat gactttacct tagcctttct
     1501 ctttagagaa gaatgtattg tttttaaaat gaagtcacat catataaaag gggccgttca
     1561 agtgctattt gtgcatacct ttttgggaat ttttctgtat aaataagaga ggaaaaagaa
     1621 tattttgtca tttacttacc ccaaagaggt acaatccctc caaatccaaa aacttgtcct
     1681 ctttcaactc ttgtcattca atcaaagttg tcatttctgt tctgttggag gtgatttcct
     1741 ctttttctat gtctttgcta agttttatta aagtgtggta tcactgtgtg tttcctccta
     1801 atttgagaca actattaagg taataccaaa tttcatatat atgactttta tattggtaaa
     1861 ttgtatcttt tataacaata tagcatttct tacatttaca ttctttttca ttactttgca
     1921 caagtgttta aaacttggca ttgacaattt atgtttgaac atagatttcg tgttcatttt
     1981 ttctggtgcg gtgtaggatt taaatcaatt tactttataa tgacctgact catgcattaa
     2041 tatttgatta atatattaat aatactaagt tctacttagg tccagtgaaa tgtgtttgct
     2101 gtaaatattg tgtatgtaat catattttta aaagttgtcc atatgtattt caacttctga
     2161 gaattcgttt gaattaaaaa caaagctgaa tgatttggga gtatgcacca tatttatgtg
     2221 aagtatatta ttaaaacttt gcaatactaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2281 aaaaa
//
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