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NCBI Reference Sequence: NM_001037774.1
FASTA Graphics
LOCUS NM_001037774 2285 bp mRNA linear ROD 21-MAR-2023 DEFINITION Rattus norvegicus claudin 8 (Cldn8), mRNA. ACCESSION NM_001037774 XM_221709 VERSION NM_001037774.1 KEYWORDS RefSeq; RefSeq Select. SOURCE Rattus norvegicus (Norway rat) ORGANISM Rattus norvegicus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. REFERENCE 1 (bases 1 to 2285) AUTHORS Molina-Jijon E, Rodriguez-Munoz R, Gonzalez-Ramirez R, Namorado-Tonix C, Pedraza-Chaverri J and Reyes JL. TITLE Aldosterone signaling regulates the over-expression of claudin-4 and -8 at the distal nephron from type 1 diabetic rats JOURNAL PLoS One 12 (5), e0177362 (2017) PUBMED 28493961 REMARK GeneRIF: the participation of aldosterone (ALD), and the effect of spironolactone (SPL), a mineralocorticoid receptor antagonist, on the expressions of claudin-2, -4, -5 and -8, and occludin in glomeruli, proximal and distal tubules isolated from diabetic rats, was evaluated. Publication Status: Online-Only REFERENCE 2 (bases 1 to 2285) AUTHORS Krause G, Winkler L, Mueller SL, Haseloff RF, Piontek J and Blasig IE. TITLE Structure and function of claudins JOURNAL Biochim Biophys Acta 1778 (3), 631-645 (2008) PUBMED 18036336 REMARK Review article REFERENCE 3 (bases 1 to 2285) AUTHORS Fujita H, Chiba H, Yokozaki H, Sakai N, Sugimoto K, Wada T, Kojima T, Yamashita T and Sawada N. TITLE Differential expression and subcellular localization of claudin-7, -8, -12, -13, and -15 along the mouse intestine JOURNAL J Histochem Cytochem 54 (8), 933-944 (2006) PUBMED 16651389 REFERENCE 4 (bases 1 to 2285) AUTHORS Hu YH, Warnatz HJ, Vanhecke D, Wagner F, Fiebitz A, Thamm S, Kahlem P, Lehrach H, Yaspo ML and Janitz M. TITLE Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins JOURNAL BMC Genomics 7, 155 (2006) PUBMED 16780588 REMARK Publication Status: Online-Only REFERENCE 5 (bases 1 to 2285) AUTHORS Ohta H, Adachi H and Inaba M. TITLE Developmental changes in the expression of tight junction protein claudins in murine metanephroi and embryonic kidneys JOURNAL J Vet Med Sci 68 (2), 149-155 (2006) PUBMED 16520537 REFERENCE 6 (bases 1 to 2285) AUTHORS Morita K, Furuse M, Fujimoto K and Tsukita S. TITLE Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands JOURNAL Proc Natl Acad Sci U S A 96 (2), 511-516 (1999) PUBMED 9892664 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC099804.1. On Dec 16, 2005 this sequence version replaced XM_221709.3. ##Evidence-Data-START## Transcript is intronless :: BC099804.1, DN932765.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## FEATURES Location/Qualifiers source 1..2285 /organism="Rattus norvegicus" /mol_type="mRNA" /db_xref="taxon:10116" /chromosome="11" /map="11q11" gene 1..2285 /gene="Cldn8" /note="claudin 8" /db_xref="GeneID:304124" /db_xref="RGD:1308575" exon 1..2250 /gene="Cldn8" /inference="alignment:Splign:2.1.0" CDS 3..680 /gene="Cldn8" /codon_start=1 /product="claudin-8" /protein_id="NP_001032863.1" /db_xref="GeneID:304124" /db_xref="RGD:1308575" /translation="MATYALQMAALVLGGVGMVGTVAVTIMPQWRVSAFIESNIVVFE NRWEGLWMNCMRHANIRMQCKVYDSLLALSPDLQASRGLMCAASVLSFLAFMTAILGM KCTRCTGEDENVKSRILLTAGIIFFITGLVVLIPVSWVANAIIRDFYNPLVDVAQKRE LGEALYIGWTTALVLIAGGALFCCVFCCTERSNSYKYSVPSHRTTQRSFHAEKRSPSI YSKSQYV" ORIGIN 1 ccatggcaac ctacgctctt caaatggctg ccctggtgct tggtggtgtt ggcatggtgg 61 gcacagtggc tgtgacgatc atgcctcagt ggagagtgtc tgccttcatc gaaagtaaca 121 ttgtcgtgtt tgagaaccgc tgggaaggtt tgtggatgaa ctgcatgagg catgccaaca 181 tcagaatgca gtgtaaggtc tatgactccc tgctggctct tagtccagac ctccaggcat 241 ccagaggact gatgtgtgct gcgtccgtcc tgtccttctt ggctttcatg acagccatcc 301 tcggaatgaa gtgcaccagg tgcaccgggg aggacgagaa cgtgaagagc cgcatcttgc 361 tgacggctgg aatcatcttc ttcatcaccg gcttggttgt gctcatccct gtcagctggg 421 ttgccaatgc catcatcaga gacttctaca acccgctggt ggatgtggcc caaaagcgcg 481 agcttggtga agccctctac ataggctgga ccacggcgct ggtgctgatc gctggaggag 541 cactgttctg ttgcgtgttt tgctgtactg aaaggagtaa cagttacaag tactcggtac 601 catcccatcg caccactcag aggagtttcc acgccgaaaa gagatccccg agcatatact 661 ccaaaagtca gtatgtgtag ctgtgtgtgt atattttagc tgtagctata aagcgaagct 721 ttataaatca ctgaaccagc cactatttta tagaaatgga acccacagtg tttccattta 781 cctttcttaa ctgcctcgta ctcattacag gaaatacgca gcgtctatga ttccataaat 841 gattttagca gaatgaggta ttatgcacac tgcttcaatt gttccagaaa gcatagccat 901 ttgttttcta aaatggttca cgcggttctt cttttatcag tcactctaag acgacccatc 961 gaaagactgt tggtttaagc tgcgatttct ctgtgtcatg gcattataca agtaatgcga 1021 gtggcagtta tagctcacac aaatagagac aggcttatgt ggttctattt aaagtgaaat 1081 gccaatccat caggctgaat aaacagaact cagctattgc atttcagggg acctggggat 1141 aaaaggaaag aaggctgata ttaattgcct aaaaacagct taaggattag tgcactctat 1201 ttatagcaaa ggttaaaatg aaggctttca tcattagtgt aagggaaact gaatggcttt 1261 ctgatcgcct gctttgcagc ctccaggagt taaaaatcct gtcaccttta tcctttatcc 1321 acgtgccttt tttttttctg attgtgttcc ttagtatctt ttaaagttta aagcagatat 1381 tgtaacaaaa tatttttttt cttcagacta cgtttgtaag gctgggctaa caagagagat 1441 aaagcagtgg tcttagaaaa attaacgttt tcagaaaaat gactttacct tagcctttct 1501 ctttagagaa gaatgtattg tttttaaaat gaagtcacat catataaaag gggccgttca 1561 agtgctattt gtgcatacct ttttgggaat ttttctgtat aaataagaga ggaaaaagaa 1621 tattttgtca tttacttacc ccaaagaggt acaatccctc caaatccaaa aacttgtcct 1681 ctttcaactc ttgtcattca atcaaagttg tcatttctgt tctgttggag gtgatttcct 1741 ctttttctat gtctttgcta agttttatta aagtgtggta tcactgtgtg tttcctccta 1801 atttgagaca actattaagg taataccaaa tttcatatat atgactttta tattggtaaa 1861 ttgtatcttt tataacaata tagcatttct tacatttaca ttctttttca ttactttgca 1921 caagtgttta aaacttggca ttgacaattt atgtttgaac atagatttcg tgttcatttt 1981 ttctggtgcg gtgtaggatt taaatcaatt tactttataa tgacctgact catgcattaa 2041 tatttgatta atatattaat aatactaagt tctacttagg tccagtgaaa tgtgtttgct 2101 gtaaatattg tgtatgtaat catattttta aaagttgtcc atatgtattt caacttctga 2161 gaattcgttt gaattaaaaa caaagctgaa tgatttggga gtatgcacca tatttatgtg 2221 aagtatatta ttaaaacttt gcaatactaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 2281 aaaaa //
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