LOCUS Z68155 6500 bp DNA linear PRI 14-NOV-2006
DEFINITION Homo sapiens LAMB2 gene for laminin beta 2 chain (exons 1-16) and
joined CDS.
ACCESSION Z68155
VERSION Z68155.2
KEYWORDS beta 2 chain; LAMB2 gene; laminin.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5872)
AUTHORS Wewer,U.M., Gerecke,D.R., Durkin,M.E., Kurtz,K.S., Mattei,M.G.,
Champliaud,M.F., Burgeson,R.E. and Albrechtsen,R.
TITLE Human beta 2 chain of laminin (formerly S chain): cDNA cloning,
chromosomal localization, and expression in carcinomas
JOURNAL Genomics 24 (2), 243-252 (1994)
PUBMED 7698745
REFERENCE 2 (bases 1 to 5872)
AUTHORS Durkin,M.E., Gautam,M., Loechel,F., Sanes,J.R., Merlie,J.P.,
Albrechtsen,R. and Wewer,U.M.
TITLE Structural organization of the human and mouse laminin beta2 chain
genes, and alternative splicing at the 5' end of the human
transcript
JOURNAL J. Biol. Chem. 271 (23), 13407-13416 (1996)
PUBMED 8662701
REFERENCE 3
AUTHORS Durkin,M.E.
TITLE Direct Submission
JOURNAL Submitted (05-DEC-1995) Durkin M. E., University of Copenhagen,
Institute of Pathological Anatomy, Frederik V's vej 11, Copenhagen,
Denmark, DK-2100
REMARK Revised by [5]
REFERENCE 4 (bases 1 to 6500)
AUTHORS Durkin,M.E.
TITLE Direct Submission
JOURNAL Submitted (19-OCT-1999) Durkin M. E., National Cancer Institute,
NIH, Bldg 37 Room 3C28, 9000 Rockville Pike, Bethesda, MD 20892,
U.S.A
COMMENT On Oct 21, 1999 this sequence version replaced Z68155.1.
FEATURES Location/Qualifiers
source 1..6500
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/chromosome="3"
/clone="lambda2, lambda1"
/clone_lib="lambda FIX"
gene order(1..>6500,Z68156.1:45..5316)
/gene="LAMB2"
regulatory 1..1724
/regulatory_class="promoter"
/gene="LAMB2"
repeat_region 392..678
/gene="LAMB2"
/rpt_family="Alu repeat"
regulatory 874..879
/regulatory_class="GC_signal"
/gene="LAMB2"
5'UTR join(1725..1936,2023)
/gene="LAMB2"
exon 1725..1936
/gene="LAMB2"
/experiment="experimental evidence, no additional details
recorded"
/number=1
regulatory 1773..1778
/regulatory_class="GC_signal"
/gene="LAMB2"
intron 1937..2022
/gene="LAMB2"
/experiment="experimental evidence, no additional details
recorded"
/number=1
exon 2023..2099
/gene="LAMB2"
/experiment="experimental evidence, no additional details
recorded"
/number=2
CDS join(2024..2099,2228..2400,2486..2621,2702..2775,
3168..3356,3449..3512,3739..3941,4031..4151,4472..4660,
4873..5052,5175..5287,5567..5646,5739..5871,6072..6230,
6306..6433,Z68156.1:45..177,Z68156.1:383..575,
Z68156.1:652..795,Z68156.1:1058..1289,Z68156.1:1373..1536,
Z68156.1:1617..1841,Z68156.1:1930..2147,
Z68156.1:2256..2352,Z68156.1:2442..2814,
Z68156.1:2911..3095,Z68156.1:3169..3410,
Z68156.1:3490..3838,Z68156.1:4172..4379,
Z68156.1:4457..4598,Z68156.1:4682..4858,
Z68156.1:4950..5109,Z68156.1:5180..5316)
/gene="LAMB2"
/codon_start=1
/product="laminin beta 2 chain"
/protein_id="CAA92279.1"
/db_xref="GDB:132363"
/db_xref="GOA:P55268"
/db_xref="HGNC:HGNC:6487"
/db_xref="InterPro:IPR002049"
/db_xref="InterPro:IPR008211"
/db_xref="InterPro:IPR013015"
/db_xref="InterPro:IPR013032"
/db_xref="UniProtKB/Swiss-Prot:P55268"
/translation="MELTSRERGRGQPLPWELRLGLLLSVLAATLAQAPAPDVPGCSR
GSCYPATGDLLVGRADRLTASSTCGLNGPQPYCIVSHLQDEKKCFLCDSRRPFSARDN
PHSHRIQNVVTSFAPQRRAAWWQSENGIPAVTIQLDLEAEFHFTHLIMTFKTFRPAAM
LVERSADFGRTWHVYRYFSYDCGADFPGVPLAPPRHWDDVVCESRYSEIEPSTEGEVI
YRVLDPAIPIPDPYSSRIQNLLKITNLRVNLTRLHTLGDNLLDPRREIREKYYYALYE
LVVRGNCFCYGHASECAPAPGAPAHAEGMVHGACICKHNTRGLNCEQCQDFYRDLPWR
PAEDGHSHACRKCECHGHTHSCHFDMAVYLASGNVSGGVCDGCQHNTAGRHCELCRPF
FYRDPTKDLRDPAVCRSCDCDPMGSQDGGRCDSHDDPALGLVSGQCRCKEHVVGTRCQ
QCRDGFFGLSISDRLGCRRCQCNARGTVPGSTPCDPNSGSCYCKRLVTGRGCDRCLPG
HWGLSHDLLGCRPCDCDVGGALDPQCDEGTGQCHCRQHMVGRRCEQVQPGYFRPFLDH
LIWEAEDTRGQVLDVVERLVTPGETPSWTGSGFVRLQEGQTLEFLVASVPKAMDYDLL
LRLEPQVPEQWAELELIVQRPGPVPAHSLCGHLVPKDDRIQGTLQPHARYLIFPNPVC
LEPGISYKLHLKLVRTGGSAQPETPYSGPGLLIDSLVLLPRVLVLEMFSGGDAAALER
QATFERYQCHEEGLVPSKTSPSEACAPLLISLSTLIYNGALPCQCNPQGSLSSECNPH
GGQCLCKPGVVGRRCDLCAPGYYGFGPTGCQACQCSHEGALSSLCEKTSGQCLCRTGA
FGLRCDRCQRGQWGFPSCRPCVCNGHADECNTHTGACLGCRDHTGGEHCERCIAGFHR
DPRLPYGGQCRPCPCPEGPGSQRHFATSCHQDEYSQQIVCHCRAGYTGLRCEACAPGH
FGDPSRPGGRCQLCECSGNIDPMDPDACDPHTGQCLRCLHHTEGPHCAHCKPGFHGQA
ARQSCHRCTCNLLGTNPQQCPSPDQCHCDPSSGQCPCLPNVQGPSCDRCAPNFWNLTS
GHGCQPCACHPSRARGPTCNEFTGQCHCRAGFGGRTCSECQELHWGDPGLQCHACDCD
SRGIDTPQCHRFTGHCSCRPGVSGVRCDQCARGFSGIFPACHPCHACFGDWDRVVQDL
AARTQRLEQRAQELQQTGVLGAFESSFWHMQEKLGIVQGIVGARNTSAASTAQLVEAT
EELRREIGEATEHLTQLEADLTDVQDENFNANHALSGLERDRLALNLTLRQLDQHLDL
LKHSNFLGAYDSIRHAHSQSAEAERRANTSALAVPSPVSNSASARHRTEALMDAQKED
FNSKHMANQRALGKLSAHTHTLSLTDINELVCGAPGDAPCATSPCGGAGCRDEDGQPR
CGGLSCNGAAATADLALGRARHTQAELQRALAEGGSILSRVAETRRQASEAQQRAQAA
LDKANASRGQVEQANQELQELIQSVKDFLNQEGADPDSIEMVATRVLELSIPASAEQI
QHLAGAIAERVRSLADVDAILARTVGDVRRAEQLLQDARRARSWAEDEKQKAETVQAA
LEEAQRAQGIAQGAIRGAVADTRDTEQTLYQVQERMAGAERALSSAGERARQLDALLE
ALKLKRAGNSLAASTAEETAGSAQGRAQEAEQLLRGPLGDQYQTVKALAERKAQGVLA
AQARAEQLRDEARDLLQAAQDKLQRLQELEGTYEENERALESKAAQLDGLEARMRSVL
QAINLQVQIYNTCQ"
sig_peptide join(2024..2099,2228..2247)
/gene="LAMB2"
intron 2100..2227
/gene="LAMB2"
/number=2
exon 2228..2400
/gene="LAMB2"
/number=3
intron 2401..2485
/gene="LAMB2"
/number=3
exon 2486..2621
/gene="LAMB2"
/number=4
intron 2622..2701
/gene="LAMB2"
/number=4
exon 2702..2775
/gene="LAMB2"
/number=5
intron 2776..3167
/gene="LAMB2"
/number=5
exon 3168..3356
/gene="LAMB2"
/number=6
intron 3357..3448
/gene="LAMB2"
/number=6
exon 3449..3512
/gene="LAMB2"
/number=7
intron 3513..3738
/gene="LAMB2"
/number=7
exon 3739..3941
/gene="LAMB2"
/number=8
intron 3942..4030
/gene="LAMB2"
/number=8
exon 4031..4151
/gene="LAMB2"
/number=9
intron 4152..4471
/gene="LAMB2"
/number=9
exon 4472..4660
/gene="LAMB2"
/number=10
intron 4661..4872
/gene="LAMB2"
/number=10
exon 4873..5052
/gene="LAMB2"
/number=11
intron 5053..5174
/gene="LAMB2"
/number=11
exon 5175..5287
/gene="LAMB2"
/number=12
intron 5288..5566
/gene="LAMB2"
/number=12
exon 5567..5646
/gene="LAMB2"
/number=13
intron 5647..5738
/gene="LAMB2"
/number=13
exon 5739..5871
/gene="LAMB2"
/number=14
intron 5872..6071
/gene="LAMB2"
/number=14
exon 6072..6230
/gene="LAMB2"
/number=15
intron 6231..6305
/gene="LAMB2"
/number=15
exon 6306..6433
/gene="LAMB2"
/number=16
intron 6434..>6500
/gene="LAMB2"
/number=16
ORIGIN
1 ctgcaggccc tggagcagca ggcagctgag ctgcttgggc acatgatgtg ctttgccacc
61 aataagtatg ccacctgcta attactgtct atggaagcca ttaagaagga ctgtgggatc
121 acctgggtaa ctcaaagtgg ccctagagtg atccaggaat ctcctggcct tgggagacca
181 aagatcctac tgagtgccca ctgaccctga gtgacccccc catgtggccc cacgatgtcc
241 cccagtggcc ctctgacctt gagaaagcag acagatcatg taactccctg aggccatcta
301 gtgtcccaga ccttgataca cctttatctc tgagtgatct aaaactgtga gactacagtg
361 ctggcattct ccactcaaaa taaatagatg gggcctggca ctatttactg gctcatgcct
421 gtaatcccag cgctttcgga ggcagaggcg ggaggatcac ctgagatcag gagttcaaga
481 ccagccaagc caacatggtg aaaccccatg tctactaaaa atagaaacat tagctgggcg
541 tggtggtggg cgcctgtaat cctagctact tgggaagctg aggcaggaga atcgcttgaa
601 cctgggaggc agaggttgca gtaagcggag atctcgccac tgcactccag cctgggtgac
661 agagcgacac tctgtctcaa aaaaaaaaaa aaaaaaaaaa aaaaaattaa aattctcagt
721 aatttctagt atccctgatc ccccaggttg actacatgat cctcagggtg actggagacc
781 tctactccgg atatccagaa taactcccag cgatgcctaa agtccaacgg attgactgac
841 ccccacccaa ccctcaccca acccccaccc ccgccgcccc catgctcctt tgtgaagtgg
901 ggtgattccc ctgaggaact atcatcagct ttcttccctg gatggcagct cagggcactc
961 cctgccggga ctgtggaggc ggcaggccag acccagccct aaagaccgga ggaccccatg
1021 tttcccccag cttcccgttc ccagggccct gggtggggcg cgccccatat cccccaccca
1081 ctttcctcct tctctccccc tccacgccgc cgcgcacatt ccaaccccag gctcctgcga
1141 tcccggcagg ccaaaaagtc tggagcggat aaatagccac aagatccgga gtcgctcgcc
1201 gtagctctgg tccaccaccc agagcctatt tccatacagg gaaacccgca gcacttctcg
1261 tgcctactta ccgtagtgac tagtggggga ggcagtgacc cccctggagc tgtgcttcgg
1321 gctgggtgtg cactttcccc atctctcccc cagccccatt ctgtccagtc cctaggacta
1381 cccgagagcc ccccacagcc ctgaataggg gcatgtgttg ctcctgcttg tgccctccag
1441 cctctctgtt gatgctggag ccctgggatc aaacggctga gttgatggta atttccacgg
1501 cgcccatgac gctgagggga aaaggctacg gtctccttgg tccagagttg gagatcccga
1561 agatctctca tttgctcctg ccatgccccc aacttcgtga gccctcttcc aaggatagtt
1621 taaagcacca aaccccttac cttcccctgg ccctcgtata ggtgtgggct tgggggcaca
1681 ataaagattt gtgggtgaag tggtctgtct ctggttcctg gggcgaaggc agtttccgga
1741 gggaaggggt agggttgggg tgggggcgct ctccgcccgg tgttgcgctc cttcccagaa
1801 tccgctccgg cctttccttc ctgccgcgat tcccaacttt gctcaaagtc gctggactct
1861 aagctgtcgg agggaccgct ggacagacct gggaactgac agagggcctg gagggaaaca
1921 ggccaaagac ccacaggcag agttgacacg gaaccccaaa gcaaggagga gggctcgggc
1981 ccgagaccgt tcacctcccc ttatccctgt tcccctcttc aggatggagc tgacctcaag
2041 ggaaagaggg aggggacagc ctctgccctg ggaacttcga ctgggcctac tgctaagcgg
2101 tgagagggcc tggtgggggc tgggggttgt ggaatgtgat ggtaggtcct ggtagttgcc
2161 cttggggcac atgaggtgga gccactggat aggaactcag cggaactgac tgagctactg
2221 tccccagtgc tggctgccac actggcacag gcccctgccc cggatgtgcc tggctgttcc
2281 aggggaagct gctaccccgc cacgggcgac ctgctggtgg gccgagctga cagactgact
2341 gcctcatcca cttgtggcct gaatggcccc cagccctact gcatcgtcag tcacctgcag
2401 gtgtggctgg ggacagggtg tgacgccgag tcagggtggg gctggcactg cctgaggcac
2461 tgattctaat ccccatccaa cccaggacga aaagaagtgc ttcctttgtg actcccggcg
2521 ccccttctct gctagagaca acccacacag ccatcgcatc cagaatgtag tcaccagctt
2581 tgcaccacag cggcgggcag cctggtggca gtcagagaat ggtgaggcca tgggtggggc
2641 aaaagtgagc agggctgccc accagtagct ttgagtcctt gacttccgat tcctgtccca
2701 ggtatccctg cggtcaccat ccagctggac ctggaggctg agtttcattt cacacacctc
2761 attatgacct tcaaggtgcc tgcatatctg ggagcctgcc cgaatcaccc tgcttggctc
2821 tccattgccc ctggacagag cctcagctcc ttaacacagc ctccttgagc atggatgcag
2881 gaggctcctt catcccttca caccttccat ttgcctccag gcctttgcac atgctcttct
2941 gcctttccaa tcccaggctg ggtcaggcgc tgtctccctg agccccatga accctgagtc
3001 tccccattag aggtggctac ctttgctggt cattatctgg cttccaccag tcacccccac
3061 tctctgtgag ctatttgagg gcagtcttgg gctgagcagg gctcttgatg gctctgggtt
3121 gggcttgggt cctggtgcct gctgatcagc tatgcccccc tacccagaca tttcgccctg
3181 ctgccatgct ggtggaacgc tcagcagact ttggccgcac ctggcatgtg taccgatatt
3241 tctcctatga ctgtggggct gacttcccag gagtcccact agcaccccca cggcactggg
3301 atgatgtagt ctgtgagtcc cgctactcag agattgagcc atccactgaa ggcgaggtga
3361 gggctggcat ctgggctggg ggctggaagc tggggatgat gggcctgagg caaggtccag
3421 tgtgactatg aactccctgc ttctccaggt catctatcgt gtgctggacc ctgccatccc
3481 tatcccagac ccctacagct cacggattca gagtgagtgc tccacccttt gagtctggca
3541 cagtccgtgt ccggctaggg actatttggg gcctcagtaa ctattttggg tgcttcctag
3601 ggcaggtgcc aagcccagtt tagctcgggt ggcagtgtat aggaggtctt tcaaggtgac
3661 cttggcagct gagcccctgg gtggacatgg ggcagcaagg gcctgcctgg tcagttggcc
3721 ccccttcccc cgcctcagac ctgttgaaga tcaccaacct acgggtgaac ctgactcgtc
3781 tacacacgtt gggagacaac ctactcgacc cacggaggga gatccgagag aagtactact
3841 atgccctcta tgagctggtt gtacgtggca actgcttctg ctacggacac gcctcagagt
3901 gtgcacccgc cccaggggca ccagcccatg ctgagggcat ggtaaggggc ttcagacggt
3961 tgggataggg ctaggggcag gggcggacat ggctgagcag tgctgacaac ctacctgcca
4021 acctctatag gtgcacggag cttgcatctg caaacacaac acacgtggcc tcaactgcga
4081 gcagtgtcag gatttctatc gtgacctgcc ctggcgtccg gctgaggacg gccatagtca
4141 tgcctgtagg agtgagtgag atcttggcct ccatagctcc agcactctgc agcctggctg
4201 tgccctgggt agaacctaga gctagttggt caagccccta aaacccaggc tgtatccaaa
4261 gagtatgcag accttgatgc cccttgggac cccctcaatc ctcctctgca gtctgctctg
4321 ggtagggaac cagtatgatg ctgaggcctt gaagtccctg agcccctacc cacaaattct
4381 ggcctgtgat agggatctaa ggtggcctac ttcttaccct tgtgacctgg ttcctcatgt
4441 ggcctttgcc ctgcccttcc tcccctgcca gagtgtgagt gccatgggca cacccacagc
4501 tgccacttcg acatggccgt atacctggca tctggcaatg tgagtggagg tgtgtgtgat
4561 ggatgtcagc ataacacagc tgggcgccac tgtgagctct gtcggccctt cttctaccgt
4621 gacccaacca aggacctgcg ggatccggct gtgtgccgct gtgaggctgg gattgggcac
4681 ggggagagaa agctgagcct ggggcaggaa ctagagagct ggactgctgt ctaaattgca
4741 ggaaattggg gttaggggct tgggatagaa cttgaccagg gatccagggt gggatccctt
4801 aggcttagga gaggactggc agtgagctag ttgagatagg gtgagtgacc ctgtatctct
4861 ttttgccgtc agcctgtgat tgtgacccca tgggttctca agacggtggt cgctgtgatt
4921 cccatgatga ccctgcactg ggactggtct ccggccagtg tcgctgcaaa gaacatgtgg
4981 tgggcactcg ctgccagcaa tgccgtgatg gcttctttgg gctcagcatc agtgaccgtc
5041 tgggctgccg gcgtatgtgt ctcctgccct aacttctatg ctgaccttta acccctgtcc
5101 tcttactcct gactcagctg aacatgagca ctgccacagt ttcccaaagt gctgatggtt
5161 ctccttccct gcaggatgtc aatgtaatgc acggggcaca gtgcctggga gcactccttg
5221 tgaccccaac agtggatcct gttactgcaa acgtctagtg actggacgtg gatgtgaccg
5281 ctgcctggtg cgactggaag gggctggagt tctaggggca tgatttgtcc ttagagcaca
5341 gggctggggt gtcacatcta tgccagtggg tgggtgctga gagcttagga tccagtcctg
5401 gctgagaagc ctcaggtctg ggaggccaag gatgtgggcc agtggtctgg ggggcatgtt
5461 ttcactgagg ggtgattgag gctaagacgt gtggttggga tttcctgctg ggtggtgatg
5521 gggtctggag gtctgtttct ggcccccagc aactcctttc gtgcagcctg gccactgggg
5581 cctgagccac gacctgctcg gctgccgccc ctgtgactgc gacgtgggtg gtgctttgga
5641 tccccagtaa gtgttgtaaa gggggcctgg gaagggatgg ggaaagatcc tgagcagaag
5701 agaaggttct tcttgagtaa ccacagagtt ccctccaggt gtgatgaggg cacaggtcaa
5761 tgccactgcc gccagcacat ggttgggcga cgctgtgagc aggtgcaacc tggctacttc
5821 cggcccttcc tggaccacct aatttgggag gctgaggaca cccgagggca ggtgtggggc
5881 ctccccctaa gcagagggct ggatgtgggt ggacacgtct atgactggag aggtggggtt
5941 atgggcagta ccttgttgag gggatagggg tgatatctag ctttggcagg agaaatgggg
6001 tttggggctg gctgtggcag aagaggcaaa gcctcacctg agcctccatc cctggctgca
6061 ttatctccca ggtgctcgat gtggtggagc gcctggtgac ccccggggaa actccatcct
6121 ggactggctc aggcttcgtg cggctacagg aaggtcagac cctggagttc ctggtggcct
6181 ctgtgccgaa ggctatggac tatgacctgc tgctgcgctt agagccccag gttagaccct
6241 gttatctaat ctggagctga acctctgggt gtgggagcat ctcctccatc atcccgtttt
6301 cccaggtccc tgagcaatgg gcagagttgg aactgattgt gcagcgtcca gggcctgtgc
6361 ctgcccacag cctgtgtggg catttggtgc ccaaggatga tcgcatccaa gggactctgc
6421 aaccacatgc caggtgaggg cactggtggt agcactcaca atggcagggg gttgtggggc
6481 cagccctaag ctccctgcag
//