U.S. flag

An official website of the United States government

Homo sapiens LAMB2 gene for laminin beta 2 chain (exons 1-16) and joined CDS

GenBank: Z68155.2

FASTA Graphics 

LOCUS       Z68155                  6500 bp    DNA     linear   PRI 14-NOV-2006
DEFINITION  Homo sapiens LAMB2 gene for laminin beta 2 chain (exons 1-16) and
            joined CDS.
ACCESSION   Z68155
VERSION     Z68155.2
KEYWORDS    beta 2 chain; LAMB2 gene; laminin.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5872)
  AUTHORS   Wewer,U.M., Gerecke,D.R., Durkin,M.E., Kurtz,K.S., Mattei,M.G.,
            Champliaud,M.F., Burgeson,R.E. and Albrechtsen,R.
  TITLE     Human beta 2 chain of laminin (formerly S chain): cDNA cloning,
            chromosomal localization, and expression in carcinomas
  JOURNAL   Genomics 24 (2), 243-252 (1994)
   PUBMED   7698745
REFERENCE   2  (bases 1 to 5872)
  AUTHORS   Durkin,M.E., Gautam,M., Loechel,F., Sanes,J.R., Merlie,J.P.,
            Albrechtsen,R. and Wewer,U.M.
  TITLE     Structural organization of the human and mouse laminin beta2 chain
            genes, and alternative splicing at the 5' end of the human
            transcript
  JOURNAL   J. Biol. Chem. 271 (23), 13407-13416 (1996)
   PUBMED   8662701
REFERENCE   3
  AUTHORS   Durkin,M.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-DEC-1995) Durkin M. E., University of Copenhagen,
            Institute of Pathological Anatomy, Frederik V's vej 11, Copenhagen,
            Denmark, DK-2100
  REMARK    Revised by [5]
REFERENCE   4  (bases 1 to 6500)
  AUTHORS   Durkin,M.E.
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-1999) Durkin M. E., National Cancer Institute,
            NIH, Bldg 37 Room 3C28, 9000 Rockville Pike, Bethesda, MD 20892,
            U.S.A
COMMENT     On Oct 21, 1999 this sequence version replaced Z68155.1.
FEATURES             Location/Qualifiers
     source          1..6500
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /clone="lambda2, lambda1"
                     /clone_lib="lambda FIX"
     gene            order(1..>6500,Z68156.1:45..5316)
                     /gene="LAMB2"
     regulatory      1..1724
                     /regulatory_class="promoter"
                     /gene="LAMB2"
     repeat_region   392..678
                     /gene="LAMB2"
                     /rpt_family="Alu repeat"
     regulatory      874..879
                     /regulatory_class="GC_signal"
                     /gene="LAMB2"
     5'UTR           join(1725..1936,2023)
                     /gene="LAMB2"
     exon            1725..1936
                     /gene="LAMB2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /number=1
     regulatory      1773..1778
                     /regulatory_class="GC_signal"
                     /gene="LAMB2"
     intron          1937..2022
                     /gene="LAMB2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /number=1
     exon            2023..2099
                     /gene="LAMB2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /number=2
     CDS             join(2024..2099,2228..2400,2486..2621,2702..2775,
                     3168..3356,3449..3512,3739..3941,4031..4151,4472..4660,
                     4873..5052,5175..5287,5567..5646,5739..5871,6072..6230,
                     6306..6433,Z68156.1:45..177,Z68156.1:383..575,
                     Z68156.1:652..795,Z68156.1:1058..1289,Z68156.1:1373..1536,
                     Z68156.1:1617..1841,Z68156.1:1930..2147,
                     Z68156.1:2256..2352,Z68156.1:2442..2814,
                     Z68156.1:2911..3095,Z68156.1:3169..3410,
                     Z68156.1:3490..3838,Z68156.1:4172..4379,
                     Z68156.1:4457..4598,Z68156.1:4682..4858,
                     Z68156.1:4950..5109,Z68156.1:5180..5316)
                     /gene="LAMB2"
                     /codon_start=1
                     /product="laminin beta 2 chain"
                     /protein_id="CAA92279.1"
                     /db_xref="GDB:132363"
                     /db_xref="GOA:P55268"
                     /db_xref="HGNC:HGNC:6487"
                     /db_xref="InterPro:IPR002049"
                     /db_xref="InterPro:IPR008211"
                     /db_xref="InterPro:IPR013015"
                     /db_xref="InterPro:IPR013032"
                     /db_xref="UniProtKB/Swiss-Prot:P55268"
                     /translation="MELTSRERGRGQPLPWELRLGLLLSVLAATLAQAPAPDVPGCSR
                     GSCYPATGDLLVGRADRLTASSTCGLNGPQPYCIVSHLQDEKKCFLCDSRRPFSARDN
                     PHSHRIQNVVTSFAPQRRAAWWQSENGIPAVTIQLDLEAEFHFTHLIMTFKTFRPAAM
                     LVERSADFGRTWHVYRYFSYDCGADFPGVPLAPPRHWDDVVCESRYSEIEPSTEGEVI
                     YRVLDPAIPIPDPYSSRIQNLLKITNLRVNLTRLHTLGDNLLDPRREIREKYYYALYE
                     LVVRGNCFCYGHASECAPAPGAPAHAEGMVHGACICKHNTRGLNCEQCQDFYRDLPWR
                     PAEDGHSHACRKCECHGHTHSCHFDMAVYLASGNVSGGVCDGCQHNTAGRHCELCRPF
                     FYRDPTKDLRDPAVCRSCDCDPMGSQDGGRCDSHDDPALGLVSGQCRCKEHVVGTRCQ
                     QCRDGFFGLSISDRLGCRRCQCNARGTVPGSTPCDPNSGSCYCKRLVTGRGCDRCLPG
                     HWGLSHDLLGCRPCDCDVGGALDPQCDEGTGQCHCRQHMVGRRCEQVQPGYFRPFLDH
                     LIWEAEDTRGQVLDVVERLVTPGETPSWTGSGFVRLQEGQTLEFLVASVPKAMDYDLL
                     LRLEPQVPEQWAELELIVQRPGPVPAHSLCGHLVPKDDRIQGTLQPHARYLIFPNPVC
                     LEPGISYKLHLKLVRTGGSAQPETPYSGPGLLIDSLVLLPRVLVLEMFSGGDAAALER
                     QATFERYQCHEEGLVPSKTSPSEACAPLLISLSTLIYNGALPCQCNPQGSLSSECNPH
                     GGQCLCKPGVVGRRCDLCAPGYYGFGPTGCQACQCSHEGALSSLCEKTSGQCLCRTGA
                     FGLRCDRCQRGQWGFPSCRPCVCNGHADECNTHTGACLGCRDHTGGEHCERCIAGFHR
                     DPRLPYGGQCRPCPCPEGPGSQRHFATSCHQDEYSQQIVCHCRAGYTGLRCEACAPGH
                     FGDPSRPGGRCQLCECSGNIDPMDPDACDPHTGQCLRCLHHTEGPHCAHCKPGFHGQA
                     ARQSCHRCTCNLLGTNPQQCPSPDQCHCDPSSGQCPCLPNVQGPSCDRCAPNFWNLTS
                     GHGCQPCACHPSRARGPTCNEFTGQCHCRAGFGGRTCSECQELHWGDPGLQCHACDCD
                     SRGIDTPQCHRFTGHCSCRPGVSGVRCDQCARGFSGIFPACHPCHACFGDWDRVVQDL
                     AARTQRLEQRAQELQQTGVLGAFESSFWHMQEKLGIVQGIVGARNTSAASTAQLVEAT
                     EELRREIGEATEHLTQLEADLTDVQDENFNANHALSGLERDRLALNLTLRQLDQHLDL
                     LKHSNFLGAYDSIRHAHSQSAEAERRANTSALAVPSPVSNSASARHRTEALMDAQKED
                     FNSKHMANQRALGKLSAHTHTLSLTDINELVCGAPGDAPCATSPCGGAGCRDEDGQPR
                     CGGLSCNGAAATADLALGRARHTQAELQRALAEGGSILSRVAETRRQASEAQQRAQAA
                     LDKANASRGQVEQANQELQELIQSVKDFLNQEGADPDSIEMVATRVLELSIPASAEQI
                     QHLAGAIAERVRSLADVDAILARTVGDVRRAEQLLQDARRARSWAEDEKQKAETVQAA
                     LEEAQRAQGIAQGAIRGAVADTRDTEQTLYQVQERMAGAERALSSAGERARQLDALLE
                     ALKLKRAGNSLAASTAEETAGSAQGRAQEAEQLLRGPLGDQYQTVKALAERKAQGVLA
                     AQARAEQLRDEARDLLQAAQDKLQRLQELEGTYEENERALESKAAQLDGLEARMRSVL
                     QAINLQVQIYNTCQ"
     sig_peptide     join(2024..2099,2228..2247)
                     /gene="LAMB2"
     intron          2100..2227
                     /gene="LAMB2"
                     /number=2
     exon            2228..2400
                     /gene="LAMB2"
                     /number=3
     intron          2401..2485
                     /gene="LAMB2"
                     /number=3
     exon            2486..2621
                     /gene="LAMB2"
                     /number=4
     intron          2622..2701
                     /gene="LAMB2"
                     /number=4
     exon            2702..2775
                     /gene="LAMB2"
                     /number=5
     intron          2776..3167
                     /gene="LAMB2"
                     /number=5
     exon            3168..3356
                     /gene="LAMB2"
                     /number=6
     intron          3357..3448
                     /gene="LAMB2"
                     /number=6
     exon            3449..3512
                     /gene="LAMB2"
                     /number=7
     intron          3513..3738
                     /gene="LAMB2"
                     /number=7
     exon            3739..3941
                     /gene="LAMB2"
                     /number=8
     intron          3942..4030
                     /gene="LAMB2"
                     /number=8
     exon            4031..4151
                     /gene="LAMB2"
                     /number=9
     intron          4152..4471
                     /gene="LAMB2"
                     /number=9
     exon            4472..4660
                     /gene="LAMB2"
                     /number=10
     intron          4661..4872
                     /gene="LAMB2"
                     /number=10
     exon            4873..5052
                     /gene="LAMB2"
                     /number=11
     intron          5053..5174
                     /gene="LAMB2"
                     /number=11
     exon            5175..5287
                     /gene="LAMB2"
                     /number=12
     intron          5288..5566
                     /gene="LAMB2"
                     /number=12
     exon            5567..5646
                     /gene="LAMB2"
                     /number=13
     intron          5647..5738
                     /gene="LAMB2"
                     /number=13
     exon            5739..5871
                     /gene="LAMB2"
                     /number=14
     intron          5872..6071
                     /gene="LAMB2"
                     /number=14
     exon            6072..6230
                     /gene="LAMB2"
                     /number=15
     intron          6231..6305
                     /gene="LAMB2"
                     /number=15
     exon            6306..6433
                     /gene="LAMB2"
                     /number=16
     intron          6434..>6500
                     /gene="LAMB2"
                     /number=16
ORIGIN      
        1 ctgcaggccc tggagcagca ggcagctgag ctgcttgggc acatgatgtg ctttgccacc
       61 aataagtatg ccacctgcta attactgtct atggaagcca ttaagaagga ctgtgggatc
      121 acctgggtaa ctcaaagtgg ccctagagtg atccaggaat ctcctggcct tgggagacca
      181 aagatcctac tgagtgccca ctgaccctga gtgacccccc catgtggccc cacgatgtcc
      241 cccagtggcc ctctgacctt gagaaagcag acagatcatg taactccctg aggccatcta
      301 gtgtcccaga ccttgataca cctttatctc tgagtgatct aaaactgtga gactacagtg
      361 ctggcattct ccactcaaaa taaatagatg gggcctggca ctatttactg gctcatgcct
      421 gtaatcccag cgctttcgga ggcagaggcg ggaggatcac ctgagatcag gagttcaaga
      481 ccagccaagc caacatggtg aaaccccatg tctactaaaa atagaaacat tagctgggcg
      541 tggtggtggg cgcctgtaat cctagctact tgggaagctg aggcaggaga atcgcttgaa
      601 cctgggaggc agaggttgca gtaagcggag atctcgccac tgcactccag cctgggtgac
      661 agagcgacac tctgtctcaa aaaaaaaaaa aaaaaaaaaa aaaaaattaa aattctcagt
      721 aatttctagt atccctgatc ccccaggttg actacatgat cctcagggtg actggagacc
      781 tctactccgg atatccagaa taactcccag cgatgcctaa agtccaacgg attgactgac
      841 ccccacccaa ccctcaccca acccccaccc ccgccgcccc catgctcctt tgtgaagtgg
      901 ggtgattccc ctgaggaact atcatcagct ttcttccctg gatggcagct cagggcactc
      961 cctgccggga ctgtggaggc ggcaggccag acccagccct aaagaccgga ggaccccatg
     1021 tttcccccag cttcccgttc ccagggccct gggtggggcg cgccccatat cccccaccca
     1081 ctttcctcct tctctccccc tccacgccgc cgcgcacatt ccaaccccag gctcctgcga
     1141 tcccggcagg ccaaaaagtc tggagcggat aaatagccac aagatccgga gtcgctcgcc
     1201 gtagctctgg tccaccaccc agagcctatt tccatacagg gaaacccgca gcacttctcg
     1261 tgcctactta ccgtagtgac tagtggggga ggcagtgacc cccctggagc tgtgcttcgg
     1321 gctgggtgtg cactttcccc atctctcccc cagccccatt ctgtccagtc cctaggacta
     1381 cccgagagcc ccccacagcc ctgaataggg gcatgtgttg ctcctgcttg tgccctccag
     1441 cctctctgtt gatgctggag ccctgggatc aaacggctga gttgatggta atttccacgg
     1501 cgcccatgac gctgagggga aaaggctacg gtctccttgg tccagagttg gagatcccga
     1561 agatctctca tttgctcctg ccatgccccc aacttcgtga gccctcttcc aaggatagtt
     1621 taaagcacca aaccccttac cttcccctgg ccctcgtata ggtgtgggct tgggggcaca
     1681 ataaagattt gtgggtgaag tggtctgtct ctggttcctg gggcgaaggc agtttccgga
     1741 gggaaggggt agggttgggg tgggggcgct ctccgcccgg tgttgcgctc cttcccagaa
     1801 tccgctccgg cctttccttc ctgccgcgat tcccaacttt gctcaaagtc gctggactct
     1861 aagctgtcgg agggaccgct ggacagacct gggaactgac agagggcctg gagggaaaca
     1921 ggccaaagac ccacaggcag agttgacacg gaaccccaaa gcaaggagga gggctcgggc
     1981 ccgagaccgt tcacctcccc ttatccctgt tcccctcttc aggatggagc tgacctcaag
     2041 ggaaagaggg aggggacagc ctctgccctg ggaacttcga ctgggcctac tgctaagcgg
     2101 tgagagggcc tggtgggggc tgggggttgt ggaatgtgat ggtaggtcct ggtagttgcc
     2161 cttggggcac atgaggtgga gccactggat aggaactcag cggaactgac tgagctactg
     2221 tccccagtgc tggctgccac actggcacag gcccctgccc cggatgtgcc tggctgttcc
     2281 aggggaagct gctaccccgc cacgggcgac ctgctggtgg gccgagctga cagactgact
     2341 gcctcatcca cttgtggcct gaatggcccc cagccctact gcatcgtcag tcacctgcag
     2401 gtgtggctgg ggacagggtg tgacgccgag tcagggtggg gctggcactg cctgaggcac
     2461 tgattctaat ccccatccaa cccaggacga aaagaagtgc ttcctttgtg actcccggcg
     2521 ccccttctct gctagagaca acccacacag ccatcgcatc cagaatgtag tcaccagctt
     2581 tgcaccacag cggcgggcag cctggtggca gtcagagaat ggtgaggcca tgggtggggc
     2641 aaaagtgagc agggctgccc accagtagct ttgagtcctt gacttccgat tcctgtccca
     2701 ggtatccctg cggtcaccat ccagctggac ctggaggctg agtttcattt cacacacctc
     2761 attatgacct tcaaggtgcc tgcatatctg ggagcctgcc cgaatcaccc tgcttggctc
     2821 tccattgccc ctggacagag cctcagctcc ttaacacagc ctccttgagc atggatgcag
     2881 gaggctcctt catcccttca caccttccat ttgcctccag gcctttgcac atgctcttct
     2941 gcctttccaa tcccaggctg ggtcaggcgc tgtctccctg agccccatga accctgagtc
     3001 tccccattag aggtggctac ctttgctggt cattatctgg cttccaccag tcacccccac
     3061 tctctgtgag ctatttgagg gcagtcttgg gctgagcagg gctcttgatg gctctgggtt
     3121 gggcttgggt cctggtgcct gctgatcagc tatgcccccc tacccagaca tttcgccctg
     3181 ctgccatgct ggtggaacgc tcagcagact ttggccgcac ctggcatgtg taccgatatt
     3241 tctcctatga ctgtggggct gacttcccag gagtcccact agcaccccca cggcactggg
     3301 atgatgtagt ctgtgagtcc cgctactcag agattgagcc atccactgaa ggcgaggtga
     3361 gggctggcat ctgggctggg ggctggaagc tggggatgat gggcctgagg caaggtccag
     3421 tgtgactatg aactccctgc ttctccaggt catctatcgt gtgctggacc ctgccatccc
     3481 tatcccagac ccctacagct cacggattca gagtgagtgc tccacccttt gagtctggca
     3541 cagtccgtgt ccggctaggg actatttggg gcctcagtaa ctattttggg tgcttcctag
     3601 ggcaggtgcc aagcccagtt tagctcgggt ggcagtgtat aggaggtctt tcaaggtgac
     3661 cttggcagct gagcccctgg gtggacatgg ggcagcaagg gcctgcctgg tcagttggcc
     3721 ccccttcccc cgcctcagac ctgttgaaga tcaccaacct acgggtgaac ctgactcgtc
     3781 tacacacgtt gggagacaac ctactcgacc cacggaggga gatccgagag aagtactact
     3841 atgccctcta tgagctggtt gtacgtggca actgcttctg ctacggacac gcctcagagt
     3901 gtgcacccgc cccaggggca ccagcccatg ctgagggcat ggtaaggggc ttcagacggt
     3961 tgggataggg ctaggggcag gggcggacat ggctgagcag tgctgacaac ctacctgcca
     4021 acctctatag gtgcacggag cttgcatctg caaacacaac acacgtggcc tcaactgcga
     4081 gcagtgtcag gatttctatc gtgacctgcc ctggcgtccg gctgaggacg gccatagtca
     4141 tgcctgtagg agtgagtgag atcttggcct ccatagctcc agcactctgc agcctggctg
     4201 tgccctgggt agaacctaga gctagttggt caagccccta aaacccaggc tgtatccaaa
     4261 gagtatgcag accttgatgc cccttgggac cccctcaatc ctcctctgca gtctgctctg
     4321 ggtagggaac cagtatgatg ctgaggcctt gaagtccctg agcccctacc cacaaattct
     4381 ggcctgtgat agggatctaa ggtggcctac ttcttaccct tgtgacctgg ttcctcatgt
     4441 ggcctttgcc ctgcccttcc tcccctgcca gagtgtgagt gccatgggca cacccacagc
     4501 tgccacttcg acatggccgt atacctggca tctggcaatg tgagtggagg tgtgtgtgat
     4561 ggatgtcagc ataacacagc tgggcgccac tgtgagctct gtcggccctt cttctaccgt
     4621 gacccaacca aggacctgcg ggatccggct gtgtgccgct gtgaggctgg gattgggcac
     4681 ggggagagaa agctgagcct ggggcaggaa ctagagagct ggactgctgt ctaaattgca
     4741 ggaaattggg gttaggggct tgggatagaa cttgaccagg gatccagggt gggatccctt
     4801 aggcttagga gaggactggc agtgagctag ttgagatagg gtgagtgacc ctgtatctct
     4861 ttttgccgtc agcctgtgat tgtgacccca tgggttctca agacggtggt cgctgtgatt
     4921 cccatgatga ccctgcactg ggactggtct ccggccagtg tcgctgcaaa gaacatgtgg
     4981 tgggcactcg ctgccagcaa tgccgtgatg gcttctttgg gctcagcatc agtgaccgtc
     5041 tgggctgccg gcgtatgtgt ctcctgccct aacttctatg ctgaccttta acccctgtcc
     5101 tcttactcct gactcagctg aacatgagca ctgccacagt ttcccaaagt gctgatggtt
     5161 ctccttccct gcaggatgtc aatgtaatgc acggggcaca gtgcctggga gcactccttg
     5221 tgaccccaac agtggatcct gttactgcaa acgtctagtg actggacgtg gatgtgaccg
     5281 ctgcctggtg cgactggaag gggctggagt tctaggggca tgatttgtcc ttagagcaca
     5341 gggctggggt gtcacatcta tgccagtggg tgggtgctga gagcttagga tccagtcctg
     5401 gctgagaagc ctcaggtctg ggaggccaag gatgtgggcc agtggtctgg ggggcatgtt
     5461 ttcactgagg ggtgattgag gctaagacgt gtggttggga tttcctgctg ggtggtgatg
     5521 gggtctggag gtctgtttct ggcccccagc aactcctttc gtgcagcctg gccactgggg
     5581 cctgagccac gacctgctcg gctgccgccc ctgtgactgc gacgtgggtg gtgctttgga
     5641 tccccagtaa gtgttgtaaa gggggcctgg gaagggatgg ggaaagatcc tgagcagaag
     5701 agaaggttct tcttgagtaa ccacagagtt ccctccaggt gtgatgaggg cacaggtcaa
     5761 tgccactgcc gccagcacat ggttgggcga cgctgtgagc aggtgcaacc tggctacttc
     5821 cggcccttcc tggaccacct aatttgggag gctgaggaca cccgagggca ggtgtggggc
     5881 ctccccctaa gcagagggct ggatgtgggt ggacacgtct atgactggag aggtggggtt
     5941 atgggcagta ccttgttgag gggatagggg tgatatctag ctttggcagg agaaatgggg
     6001 tttggggctg gctgtggcag aagaggcaaa gcctcacctg agcctccatc cctggctgca
     6061 ttatctccca ggtgctcgat gtggtggagc gcctggtgac ccccggggaa actccatcct
     6121 ggactggctc aggcttcgtg cggctacagg aaggtcagac cctggagttc ctggtggcct
     6181 ctgtgccgaa ggctatggac tatgacctgc tgctgcgctt agagccccag gttagaccct
     6241 gttatctaat ctggagctga acctctgggt gtgggagcat ctcctccatc atcccgtttt
     6301 cccaggtccc tgagcaatgg gcagagttgg aactgattgt gcagcgtcca gggcctgtgc
     6361 ctgcccacag cctgtgtggg catttggtgc ccaaggatga tcgcatccaa gggactctgc
     6421 aaccacatgc caggtgaggg cactggtggt agcactcaca atggcagggg gttgtggggc
     6481 cagccctaag ctccctgcag
//
Feature
Display: FASTA GenBank Help
Details

Supplemental Content

Change region shown

Customize view

Reference sequence information

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
External link. Please review our privacy policy.