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GenBank: AF209479.1
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LOCUS AF209479 4424 bp DNA linear PRI 17-SEP-2000 DEFINITION Homo sapiens probable mannose-binding C-type lectin DC-SIGN gene, complete cds. ACCESSION AF209479 VERSION AF209479.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 4424) AUTHORS Soilleux,E.J., Barten,R. and Trowsdale,J. TITLE DC-SIGN; a related gene, DC-SIGNR; and CD23 form a cluster on 19p13 JOURNAL J. Immunol. 165 (6), 2937-2942 (2000) PUBMED 10975799 REFERENCE 2 (bases 1 to 4424) AUTHORS Soilleux,E.J. TITLE Direct Submission JOURNAL Submitted (26-NOV-1999) Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, Cambs CB2 1QP, UK FEATURES Location/Qualifiers source 1..4424 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /chromosome="19" /map="19p13; adjacent to CD23" mRNA join(<42..87,188..247,874..945,1318..1887,2312..2463, 3185..3297,4167..>4368) /product="probable mannose-binding C-type lectin DC-SIGN" CDS join(42..87,188..247,874..945,1318..1887,2312..2463, 3185..3297,4167..4368) /note="type II integral membrane protein" /codon_start=1 /product="probable mannose-binding C-type lectin DC-SIGN" /protein_id="AAG13814.1" /translation="MSDSKEPRLQQLGLLEEEQLRGLGFRQTRGYKSLAGCLGHGPLV LQLLSFTLLAGLLVQVSKVPSSISQEQSRQDAIYQNLTQLKAAVGELSEKSKLQEIYQ ELTQLKAAVGELPEKSKLQEIYQELTRLKAAVGELPEKSKLQEIYQELTWLKAAVGEL PEKSKMQEIYQELTRLKAAVGELPEKSKQQEIYQELTRLKAAVGELPEKSKQQEIYQE LTRLKAAVGELPEKSKQQEIYQELTQLKAAVERLCHPCPWEWTFFQGNCYFMSNSQRN WHDSITACKEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNQEGTWQWVDGSP LLPSFKQYWNRGEPNNVGEEDCAEFSGNGWNDDKCNLAKFWICKKSAASCSRDEEQFL SPAPATPNPPPA" exon <42..87 /note="encodes cytoplasmic domain" /number=1 exon 188..247 /note="encodes cytoplasmic domain" /number=2 exon 874..945 /note="encodes transmembrane region" /number=3 exon 1318..1887 /number=4 repeat_region 1392..1874 /note="encodes likely alpha helical coiled-coil region that forms the neck of the protein" /rpt_type=tandem /rpt_unit_range=1392..1460 exon 2312..2463 /note="encodes C-type lectin domain CRD1 involved in the formation of the carbohydrate recognition domain" /number=5 exon 3185..3297 /note="encodes C-type lectin domain CRD2 involved in the formation of the carbohydrate recognition domain" /number=6 exon 4167..>4368 /note="encodes C-type lectin domain CRD3 involved in the formation of the carbohydrate recognition domain" /number=7 ORIGIN 1 ctaaagcagg agttctggac actgggggag agtggggtga catgagtgac tccaaggaac 61 caagactgca gcagctgggc ctcctgggtg aggctgggtt gggacgctgg gattctggga 121 agggggaagg gatggccagc catggcctca gcctgcccag gctctgattt cacgtctatc 181 cattcagagg aggaacagct gagaggcctt ggattccgac agactcgagg atacaagagc 241 ttagcaggta gagaggactt agcagtttgg gaggagagac gagagactcc tggactcctg 301 ggtcctgagg agctggacgc tggggcctgg actcttgggt cctggggatg tggggctagg 361 ggcctggact cctgggacct gaggaggttg agtttggggc ctgaattcct ggttcctggg 421 aaggtggagg ctggggccaa gactcctggg ttctggggag gtagaagttg aagcctgggt 481 tcctgggtcc tggggaggtg gggtcagggg cctagactcc tgggtcctgg agaggtgggg 541 gcctgggcct ggactcctgg gtcatgggga ggtggggact tgggcctggg ttcctgggac 601 ctggggatgt aggggctggg acccagattc ttgggtcttg gggaggtggg agcaggtacc 661 tgggttactg ggacctgggg aaggggaggc tgggtcctgg gcccctgggt cctggggagg 721 tgggagctgg gggcctgggt tccagggacc tgggaatgta gaggctgggg ctggggttcc 781 tgggtcctgg ggtgctgagg gatttagacc aggctctccc tgggccaggc tccggtggga 841 cactggcagg ctgacgcatg tatcttctct cagggtgtct tggccatggt cccctggtgc 901 tgcaactcct ctccttcacg ctcttggctg ggctccttgt ccaaggtcag gggcaggttc 961 tgagggtgtg gggtccccac gcctggcttt tggctgtgga cacagcctgg ggctgccaga 1021 tctgggaggg aggtggggtt gagagccaag atgttgtccc tgggggtctg taggggcctc 1081 tcccacagcc catccccact ttagggcagg acaggagagg gaggaggagg aggacaggaa 1141 gaatctggct ctccttggcc ttctgtgctg ccttctccag gtgtcagtgt tcttcatctt 1201 caaaggggat taaccaagac cttggctctc acaaatgatg tccctatggg gctcagttca 1261 aggcttggca cacagtaggt gtctaataat tgcagttcct tttttatttt ggcccagtgt 1321 ccaaggtccc cagctccata agtcaggaac aatccaggca agacgcgatc taccagaacc 1381 tgacccagct taaagctgca gtgggtgagc tctcagagaa atccaagctg caggagatct 1441 accaggagct gacccagctg aaggctgcag tgggtgagct tccagagaaa tctaagctgc 1501 aggagatcta ccaggagctg acccggctga aggctgcagt gggtgagctt ccagagaaat 1561 ctaagctgca ggagatctac caggagctga cctggctgaa ggctgcagtg ggtgagcttc 1621 cagagaaatc taagatgcag gagatctacc aggagctgac tcggctgaag gctgcagtgg 1681 gtgagcttcc agagaaatct aagcagcagg agatctacca ggagctgacc cggctgaagg 1741 ctgcagtggg tgagcttcca gagaaatcta agcagcagga gatctaccag gagctgaccc 1801 ggctgaaggc tgcagtgggt gagcttccag agaaatctaa gcagcaggag atctaccagg 1861 agctgaccca gctgaaggct gcagtgggtg agtatctgga accaggcttc ttgggcctga 1921 gatggtcgtt gtgtggtgtg agtttgcttg agtcactgac cctgcctgag caagtttctt 1981 catctgtgaa atgagaacac agggtaactg tgatcattgc cctcagtgtt cacagtgggc 2041 caggtacaca acaggcactc agttaagcca gtctcctgcc ttctgttctg agttctaaag 2101 ccccaacttc tcctagtctg gaggagatgg ggccaggact cctgggttct catggggatg 2161 ggggagggtc tcgggaagtg gggaggggaa tggtctaccc ggcgtggaca gtcaaggaag 2221 gactctgact ctcaagacct tgaaggctgg gcaggtacag gaatatggac aacctaatct 2281 aagcccagcc ctgaccagcc tcccccaaca gaacgcctgt gccacccctg tccctgggaa 2341 tggacattct tccaaggaaa ctgttacttc atgtctaact cccagcggaa ctggcacgac 2401 tccatcaccg cctgcaaaga agtgggggcc cagctcgtcg taatcaaaag tgctgaggag 2461 caggtacacc tggtggggat ccccgtcctg gcctagggca tggcttctgg ccaactgggg 2521 aggaggtgct cagagatgac tttgcagaag aggggttttg ctccacttgg aaagaaggga 2581 ggagaaggat atgaatgagg gagtctcaag tacccttaga gcagatacaa accaaatctg 2641 aacatgtgtg aatgctccgg aaaaaaacat caaatgtaag caaacccctg cagcatgctg 2701 caagaggtta acaaccagct ctctggagga agaatcctga tgggtcgtgt ttgccagttt 2761 ccctggtgta aatattccca tggtggctga ttttcaagct gtcgttgtga tgtcactcag 2821 tgcagagctg aaaggagatg tgcatgacca gcagttagga aatggttgct tctggctcca 2881 acacattaag cccagttatg agtaaatgtg catggacatg cacagaacat gtgaaatgga 2941 taaacatgca gtattagcaa gagggtgtga ggagaggcca gctgtgcatg gatgtgtgca 3001 tgtcaggaca catgtgccgt gggatacaca tgtgagaggg actcagacac gagggggctc 3061 aggacctagt ataccagaag gctgtaggtt agcctacaag cagaacttcc taccaagaga 3121 tggggagaca gagcctggaa aatgggaagc agagctccct cctgactcct cctgtaccct 3181 ccagaacttc ctacagctgc agtcttccag aagtaaccgc ttcacctgga tgggactttc 3241 agatctaaat caggaaggca cgtggcaatg ggtggacggc tcacctctgt tgcccaggta 3301 gatctcagaa ggggcaccct atccactggg gctggaattg tgaaactctg atttgaactt 3361 tccctgggga tcctccccaa ctccctgaca ccctagaccc aagaatctgg aggttttact 3421 gagttgagga aggtggtctt catacccact tccagacagc atggcaggtg cctagaattc 3481 caccagcaga gctgcaggag gagcctgcca ccggggaggt tgttattaaa tataatgtta 3541 ttaataggaa gttctgaggt ccagtaaggc caccagctca ggagacacct gccattgtga 3601 atagcttctc atatacacag atccctagag agaggacaca tcacagctgg gggccacctg 3661 gggaagcacc agggtctgtt atgagtcaga gtggtgggga ggggggactg tgggccagag 3721 cctttattat ggtttctgtg gaaaggaaag gtcaaggcca ggtgaacagg cttaggattg 3781 ggaagtgtga agcatttttt gggctctggg gcacaggggc tgcccctcgc tgtctgacac 3841 ctggccttgg ggtgattagt acaggatagt ggcttggagt acaagagccc agtaaggcag 3901 gtcgctggag gtgtggactc cagactggtt ggcttgtatt tgaaaatcac acactcaata 3961 ggtggagtcc acccaaggac aggttgtgag aagagaggca ggaactcaag gcatcgtgag 4021 tcaggcatat tatcaggtat gcagagggat tcaagtccag catacacacg cagggcagat 4081 gttaaggcat caagatgaca gaaggtagaa acacagctca tgtagctggc ggggacagag 4141 gctcacattc cgcatgggct ttgcagcttc aagcagtatt ggaacagagg agagcccaac 4201 aacgttgggg aggaagactg cgcggaattt agtggcaatg gctggaacga cgacaaatgt 4261 aatcttgcca aattctggat ctgcaaaaag tccgcagcct cctgctccag ggatgaagaa 4321 cagtttcttt ctccagcccc tgccacccca aacccccctc ctgcgtagca gaacttcacc 4381 cccttttaag ctacagttcc ttctctccat ccttcgacct ttag //
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