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GenBank: DQ282154.1
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LOCUS DQ282154 6019 bp DNA linear PRI 09-APR-2007 DEFINITION Homo sapiens cytochrome P450 2D6 (CYP2D6) gene, CYP2D6*43 allele, complete cds. ACCESSION DQ282154 VERSION DQ282154.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 6019) AUTHORS Koch,W.H., Nikoloff,D.M., Lu,W., Pan,R.M., deLeon,J. and Wedlund,P.J. TITLE CYP2D6 Evolution and Allele Diversity Among Human Races JOURNAL Unpublished REFERENCE 2 (bases 1 to 6019) AUTHORS Koch,W.H., Nikoloff,D.M., Lu,W., Pan,R.M., deLeon,J. and Wedlund,P.J. TITLE Direct Submission JOURNAL Submitted (07-NOV-2005) College of Pharmacy, University of Kentucky, 420 College of Pharmacy Building, Lexington, KT 40536-0082, USA FEATURES Location/Qualifiers source 1..6019 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" gene 1519..5897 /gene="CYP2D6" /allele="CYP2D6*43" mRNA join(1519..1786,2489..2660,3213..3365,3454..3614, 4048..4224,4415..4556,4764..4951,5406..5547,5646..5897) /gene="CYP2D6" /allele="CYP2D6*43" CDS join(1607..1786,2489..2660,3213..3365,3454..3614, 4048..4224,4415..4556,4764..4951,5406..5547,5646..5824) /gene="CYP2D6" /allele="CYP2D6*43" /codon_start=1 /product="cytochrome P450 2D6" /protein_id="ABB77902.1" /translation="MGLEALVPLAVIVAIFLLLVDLMHRHQRWAARYPPGPLPLPGLG NLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRP PVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACL CAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESG FLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFL AEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQE IDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKG TTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLAR MELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR" variation 1683 /gene="CYP2D6" /note="compared to CYP2D6*1 allele of GenBank Accession Number AY545216" /replace="g" variation 1916 /gene="CYP2D6" /note="compared to CYP2D6*1 allele of GenBank Accession Number AY545216" /replace="g" ORIGIN 1 gcctggacaa cttggaagaa cccggtctct acaaaaaata caaaattagc tgggattggg 61 tgcggtggct catgcctata atcccagcac tttgggagcc tgaggtgggt ggatcacctg 121 aagtcaggag ttcaagacta gcctggccaa catggtgaaa ccctatctct actgaaaata 181 caaaaagcta gacgtggtgg cacacacctg taatcccagc tacttaggag gctgaggcag 241 gagaattgct tgaagcctag aggtgaaggt tgtagtgagc cgagattgca tcattgcaca 301 atggagggga gccaccagcc tgggcaacaa gaggaaatct ccgtctccaa aaaaaaaaaa 361 aaaaaaaaaa gaattaggct gggtggtgcc tgtagtccca gctacttggg aggcaggggg 421 tccacttgat gtcgagactg cagtgagcca tgatcctgcc actgcactcc ggcctgggca 481 acagagtgag accctgtcta aagaaaaaaa aaataaagca acatatcctg aacaaaggat 541 cctccataac gttcccacca gatttctaat cagaaacatg gaggccagaa agcagtggag 601 gaggacgacc ctcaggcagc ccgggaggat gttgtcacag gctggggcaa gggccttccg 661 gctaccaact gggagctctg ggaacagccc tgttgcaaac aagaagccat agcccggcca 721 gagcccagga atgtgggctg ggctgggagc agcctctgga caggagtggt cccatccagg 781 aaacctccgg catggctggg aagtggggta cttggtgccg ggtctgtatg tgtgtgtgac 841 tggtgtgtgt gagagagaat gtgtgcccta agtgtcagtg tgagtctgtg tatgtgtgaa 901 tattgtcttt gtgtgggtga ttttctgcgt gtgtaatcgt gtccctgcaa gtgtgaacaa 961 gtggacaagt gtctgggagt ggacaagaga tctgtgcacc atcaggtgtg tgcatagcgt 1021 ctgtgcatgt caagagtgca aggtgaagtg aagggaccag gcccatgatg ccactcatca 1081 tcaggagctc taaggcccca ggtaagtgcc agtgacagat aagggtgctg aaggtcactc 1141 tggagtgggc aggtgggggt agggaaaggg caaggccatg ttctggagga ggggttgtga 1201 ctacattagg gtgtatgagc ctagctggga ggtggatggc cgggtccact gaaaccctgg 1261 ttatcccaga aggctttgca ggcttcagga gcttggagtg gggagagggg gtgacttctc 1321 cgaccaggcc cctccaccgg cctaccctgg gtaagggcct ggagcaggaa gcaggggcaa 1381 gaacctctgg agcagcccat acccgccctg gcctgactct gccactggca gcacagtcaa 1441 cacagcaggt tcactcacag cagagggcaa aggccatcat cagctccctt tataagggaa 1501 gggtcacgcg ctcggtgtgc tgagagtgtc ctgcctggtc ctctgtgcct ggtggggtgg 1561 gggtgccagg tgtgtccaga ggagcccatt tggtagtgag gcaggtatgg ggctagaagc 1621 actggtgccc ctggccgtga tagtggccat cttcctgctc ctggtggacc tgatgcaccg 1681 gcaccaacgc tgggctgcac gctacccacc aggccccctg ccactgcccg ggctgggcaa 1741 cctgctgcat gtggacttcc agaacacacc atactgcttc gaccaggtga gggaggaggt 1801 cctggagggc ggcagaggtg ctgaggctcc cctaccagaa gcaaacatgg atggtgggtg 1861 aaaccacagg ctggaccaga agccaggctg agaaggggaa gcaggtttgg gggacttcct 1921 ggagaagggc atttatacat ggcatgaagg actggatttt ccaaaggcca aggaagagta 1981 gggcaagggc ctggaggtgg agctggactt ggcagtgggc atgcaagccc attgggcaac 2041 atatgttatg gagtacaaag tcccttctgc tgacaccaga aggaaaggcc ttgggaatgg 2101 aagatgagtt agtcctgagt gccgtttaaa tcacgaaatc gaggatgaag ggggtgcagt 2161 gacccggttc aaaccttttg cactgtgggt cctcgggcct cactgctcac cggcatggac 2221 catcatctgg gaatgggatg ctaactgggg cctctcggca attttggtga ctcttgcaag 2281 gtcatacctg ggtgacgcat ccaaactgag ttcctccatc acagaaggtg tgacccccac 2341 ccccgcccca cgatcaggag gctgggtctc ctccttccac ctgctcactc ctggtagccc 2401 cgggggtcgt ccaaggttca aataggacta ggacctgtag tctggggtga tcctggcttg 2461 acaagaggcc ctgaccctcc ctctgcagtt gcggcgccgc ttcggggacg tgttcagcct 2521 gcagctggcc tggacgccgg tggtcgtgct caatgggctg gcggccgtgc gcgaggcgct 2581 ggtgacccac ggcgaggaca ccgccgaccg cccgcctgtg cccatcaccc agatcctggg 2641 tttcgggccg cgttcccaag gcaagcagcg gtggggacag agacagattt ccgtgggacc 2701 cgggtgggtg atgaccgtag tccgagctgg gcagagaggg cgcggggtcg tggacatgaa 2761 acaggccagc gagtggggac agcgggccaa gaaaccacct gcactaggga ggtgtgagca 2821 tggggacgag ggcggggctt gtgacgagtg ggcggggcca ctgccgagac ctggcaggag 2881 cccaatgggt gaggctggcg catttcccag ctggaatccg gtgtcgaagt ggggggcggg 2941 gaccgcacct gtgctgtaag ctcagtgtgg gtggcgcggg gcccgcgggg tcttccctga 3001 gtgcaaaggc ggtcagggtg ggcagagacg aggtggggca aagccctgcc ccagccaagg 3061 gagcaaggtg gatgcacaaa gagtgggccc tgtgaccagc tggacagagc cagggactgc 3121 gggagaccag ggggagcata gggttggagt gggtggtgga tggtggggct aatgccttca 3181 tggccacgcg cacgtgcccg tcccaccccc aggggtgttc ctggcgcgct atgggcccgc 3241 gtggcgcgag cagaggcgct tctccgtgtc caccttgcgc aacttgggcc tgggcaagaa 3301 gtcgctggag cagtgggtga ccgaggaggc cgcctgcctt tgtgccgcct tcgccaacca 3361 ctccggtggg tgatgggcag aagggcacaa agcgggaact gggaaggcgg gggacgggga 3421 aggcgacccc ttacccgcat ctcccacccc caggacgccc ctttcgcccc aacggtctct 3481 tggacaaagc cgtgagcaac gtgatcgcct ccctcacctg cgggcgccgc ttcgagtacg 3541 acgaccctcg cttcctcagg ctgctggacc tagctcagga gggactgaag gaggagtcgg 3601 gctttctgcg cgaggtgcgg agcgagagac cgaggagtct ctgcagggcg agctcccgag 3661 aggtgccggg gctggactgg ggcctcggaa gagcaggatt tgcatagatg ggtttgggaa 3721 aggacattcc aggagacccc actgtaagaa gggcctggag gaggagggga catctcagac 3781 atggtcgtgg gagaggtgtg cccgggtcag ggggcaccag gagaggccaa ggactctgta 3841 cctcctatcc acgtcagaga tttcgatttt aggtttctcc tctgggcaag gagagagggt 3901 ggaggctggc acttggggag ggacttggtg aggtcagtgg taaggacagg caggccctgg 3961 gtctacctgg agatggctgg ggcctgagac ttgtccaggt gaacgcagag cacaggaggg 4021 attgagaccc cgttctgtct ggtgtaggtg ctgaatgctg tccccgtcct cctgcatatc 4081 ccagcgctgg ctggcaaggt cctacgcttc caaaaggctt tcctgaccca gctggatgag 4141 ctgctaactg agcacaggat gacctgggac ccagcccagc ccccccgaga cctgactgag 4201 gccttcctgg cagagatgga gaaggtgaga gtggctgcca cggtgggggg caagggtggt 4261 gggttgagcg tcccaggagg aatgagggga ggctgggcaa aaggttggac cagtgcatca 4321 cccggcgagc cgcatctggg ctgacaggtg cagaattgga ggtcatttgg gggctacccc 4381 gttctgtccc gagtatgctc tcggccctgc tcaggccaag gggaaccctg agagcagctt 4441 caatgatgag aacctgcgca tagtggtggc tgacctgttc tctgccggga tggtgaccac 4501 ctcgaccacg ctggcctggg gcctcctgct catgatccta catccggatg tgcagcgtga 4561 gcccatctgg gaaacagtgc aggggccgag ggaggaaggg tacaggcggg ggcccatgaa 4621 ctttgctggg acacccgggg ctccaagcac aggcttgacc aggatcctgt aagcctgacc 4681 tcctccaaca taggaggcaa gaaggagtgt cagggccgga ccccctgggt gctgacccat 4741 tgtggggacg catgtctgtc caggccgtgt ccaacaggag atcgacgacg tgatagggca 4801 ggtgcggcga ccagagatgg gtgaccaggc tcacatgccc tacaccactg ccgtgattca 4861 tgaggtgcag cgctttgggg acatcgtccc cctgggtgtg acccatatga catcccgtga 4921 catcgaagta cagggcttcc gcatccctaa ggtaggcctg gcgccctcct caccccagct 4981 cagcaccagc acctggtgat agccccagca tggctactgc caggtgggcc cactctagga 5041 accctggcca cctagtcctc aatgccacca cactgactgt ccccacttgg gtggggggtc 5101 cagagtatag gcagggctgg cctgtccatc cagagccccc gtctagtggg gagacaaacc 5161 aggacctgcc agaatgttgg aggacccaac gcctgcaggg agagggggca gtgtgggtgc 5221 ctctgagagg tgtgactgcg ccctgctgtg gggtcggaga gggtactgtg gagcttctcg 5281 ggcgcaggac tagttgacag agtccagctg tgtgccaggc agtgtgtgtc ccccgtgtgt 5341 ttggtggcag gggtcccagc atcctagagt ccagtcccca ctctcaccct gcatctcctg 5401 cccagggaac gacactcatc accaacctgt catcggtgct gaaggatgag gccgtctggg 5461 agaagccctt ccgcttccac cccgaacact tcctggatgc ccagggccac tttgtgaagc 5521 cggaggcctt cctgcctttc tcagcaggtg cctgtgggga gcccggctcc ctgtcccctt 5581 ccgtggagtc ttgcaggggt atcacccagg agccaggctc actgacgccc ctcccctccc 5641 cacaggccgc cgtgcatgcc tcggggagcc cctggcccgc atggagctct tcctcttctt 5701 cacctccctg ctgcagcact tcagcttctc ggtgcccact ggacagcccc ggcccagcca 5761 ccatggtgtc tttgctttcc tggtgagccc atccccctat gagctttgtg ctgtgccccg 5821 ctagaatggg gtacctagtc cccagcctgc tccctagcca gaggctctaa tgtacaataa 5881 agcaatgtgg tagttccaac tcgggtcccc tgctcacgcc ctcgttggga tcatcctcct 5941 cagggcaacc ccacccctgc ctcattcctg cttaccccac cgcctggccg catttgagac 6001 aggggtacgt tgaggctga //
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