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GenBank: DQ282155.1
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LOCUS DQ282155 6018 bp DNA linear PRI 09-APR-2007 DEFINITION Homo sapiens cytochrome P450 2D6 (CYP2D6) gene, CYP2D6*45B allele, complete cds. ACCESSION DQ282155 VERSION DQ282155.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 6018) AUTHORS Koch,W.H., Nikoloff,D.M., Lu,W., Pan,R.M., deLeon,J. and Wedlund,P.J. TITLE CYP2D6 Evolution and Allele Diversity Among Human Races JOURNAL Unpublished REFERENCE 2 (bases 1 to 6018) AUTHORS Koch,W.H., Nikoloff,D.M., Lu,W., Pan,R.M., deLeon,J. and Wedlund,P.J. TITLE Direct Submission JOURNAL Submitted (07-NOV-2005) College of Pharmacy, University of Kentucky, 420 College of Pharmacy Building, Lexington, KT 40536-0082, USA FEATURES Location/Qualifiers source 1..6018 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" variation 67 /note="compared to CYP2D6*1 allele of GenBank Accession Number AY545216" /replace="g" variation 312 /note="compared to CYP2D6*1 allele of GenBank Accession Number AY545216" /replace="g" variation 379 /note="compared to CYP2D6*1 allele of GenBank Accession Number AY545216" /replace="a" variation 874 /note="compared to CYP2D6*1 allele of GenBank Accession Number AY545216" /replace="c" variation 917^918 /note="compared to CYP2D6*1 allele of GenBank Accession Number AY545216" /replace="gtgt" gene 1522..5900 /gene="CYP2D6" /allele="CYP2D6*45B" mRNA join(1522..1789,2492..2663,3216..3368,3457..3617, 4051..4227,4418..4559,4767..4954,5409..5550,5649..5900) /gene="CYP2D6" /allele="CYP2D6*45B" CDS join(1610..1789,2492..2663,3216..3368,3457..3617, 4051..4227,4418..4559,4767..4954,5409..5550,5649..5827) /gene="CYP2D6" /allele="CYP2D6*45B" /codon_start=1 /product="cytochrome P450 2D6" /protein_id="ABB77903.1" /translation="MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLG NLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRP PVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTKEAACL CAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESG FLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFL AEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQE IDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKG TTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLAR MELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVTPSPYELCAVPR" variation 1919 /gene="CYP2D6" /note="compared to CYP2D6*1 allele of GenBank Accession Number AY545216" /replace="g" variation 2354 /gene="CYP2D6" /note="compared to CYP2D6*1 allele of GenBank Accession Number AY545216" /replace="c" variation 2451 /gene="CYP2D6" /note="compared to CYP2D6*1 allele of GenBank Accession Number AY545216" /replace="t" variation 3271 /gene="CYP2D6" /note="compared to CYP2D6*1 allele of GenBank Accession Number AY545216" /replace="g" variation 3326 /gene="CYP2D6" /note="compared to CYP2D6*1 allele of GenBank Accession Number AY545216" /replace="g" variation 4185 /gene="CYP2D6" /note="compared to CYP2D6*1 allele of GenBank Accession Number AY545216" /replace="c" variation 4271 /gene="CYP2D6" /note="compared to CYP2D6*1 allele of GenBank Accession Number AY545216" /replace="g" variation 4460 /gene="CYP2D6" /note="compared to CYP2D6*1 allele of GenBank Accession Number AY545216" /replace="c" variation 4864 /gene="CYP2D6" /note="compared to CYP2D6*1 allele of GenBank Accession Number AY545216" /replace="t" variation 4994 /gene="CYP2D6" /note="compared to CYP2D6*1 allele of GenBank Accession Number AY545216" /replace="a" variation 5194 /gene="CYP2D6" /note="compared to CYP2D6*1 allele of GenBank Accession Number AY545216" /replace="g" variation 5400 /gene="CYP2D6" /note="compared to CYP2D6*1 allele of GenBank Accession Number AY545216" /replace="c" variation 5790 /gene="CYP2D6" /note="compared to CYP2D6*1 allele of GenBank Accession Number AY545216" /replace="g" ORIGIN 1 ccagcctgga caacttggaa gaacccggtc tctacaaaaa atacaaaatt agctgggatt 61 gggtgcagtg gctcatgcct ataatcccag cactttggga gcctgaggtg ggtggatcac 121 ctgaagtcag gagttcaaga ctagcctggc caacatggtg aaaccctatc tctactgaaa 181 atacaaaaag ctagacgtgg tggcacacac ctgtaatccc agctacttag gaggctgagg 241 caggagaatt gcttgaagcc tagaggtgaa ggttgtagtg agccgagatt gcatcattgc 301 acaatggagg gaagccacca gcctgggcaa caagaggaaa tctccgtctc caaaaaaaaa 361 aaaaaaaaaa aaaaaaagga ttaggctggg tggtgcctgt agtcccagct acttgggagg 421 cagggggtcc acttgatgtc gagactgcag tgagccatga tcctgccact gcactccggc 481 ctgggcaaca gagtgagacc ctgtctaaag aaaaaaaaaa taaagcaaca tatcctgaac 541 aaaggatcct ccataacgtt cccaccagat ttctaatcag aaacatggag gccagaaagc 601 agtggaggag gacgaccctc aggcagcccg ggaggatgtt gtcacaggct ggggcaaggg 661 ccttccggct accaactggg agctctggga acagccctgt tgcaaacaag aagccatagc 721 ccggccagag cccaggaatg tgggctgggc tgggagcagc ctctggacag gagtggtccc 781 atccaggaaa cctccggcat ggctgggaag tggggtactt ggtgccgggt ctgtatgtgt 841 gtgtgactgg tgtgtgtgag agagaatgtg tgctctaagt gtcagtgtga gtctgtgtat 901 gtgtgaatat tgtctttggg tgattttctg cgtgtgtaat cgtgtccctg caagtgtgaa 961 caagtggaca agtgtctggg agtggacaag agatctgtgc accatcaggt gtgtgcatag 1021 cgtctgtgca tgtcaagagt gcaaggtgaa gtgaagggac caggcccatg atgccactca 1081 tcatcaggag ctctaaggcc ccaggtaagt gccagtgaca gataagggtg ctgaaggtca 1141 ctctggagtg ggcaggtggg ggtagggaaa gggcaaggcc atgttctgga ggaggggttg 1201 tgactacatt agggtgtatg agcctagctg ggaggtggat ggccgggtcc actgaaaccc 1261 tggttatccc agaaggcttt gcaggcttca ggagcttgga gtggggagag ggggtgactt 1321 ctccgaccag gcccctccac cggcctaccc tgggtaaggg cctggagcag gaagcagggg 1381 caagaacctc tggagcagcc catacccgcc ctggcctgac tctgccactg gcagcacagt 1441 caacacagca ggttcactca cagcagaggg caaaggccat catcagctcc ctttataagg 1501 gaagggtcac gcgctcggtg tgctgagagt gtcctgcctg gtcctctgtg cctggtgggg 1561 tgggggtgcc aggtgtgtcc agaggagccc atttggtagt gaggcaggta tggggctaga 1621 agcactggtg cccctggccg tgatagtggc catcttcctg ctcctggtgg acctgatgca 1681 ccggcgccaa cgctgggctg cacgctaccc accaggcccc ctgccactgc ccgggctggg 1741 caacctgctg catgtggact tccagaacac accatactgc ttcgaccagg tgagggagga 1801 ggtcctggag ggcggcagag gtgctgaggc tcccctacca gaagcaaaca tggatggtgg 1861 gtgaaaccac aggctggacc agaagccagg ctgagaaggg gaagcaggtt tgggggactt 1921 cctggagaag ggcatttata catggcatga aggactggat tttccaaagg ccaaggaaga 1981 gtagggcaag ggcctggagg tggagctgga cttggcagtg ggcatgcaag cccattgggc 2041 aacatatgtt atggagtaca aagtcccttc tgctgacacc agaaggaaag gccttgggaa 2101 tggaagatga gttagtcctg agtgccgttt aaatcacgaa atcgaggatg aagggggtgc 2161 agtgacccgg ttcaaacctt ttgcactgtg ggtcctcggg cctcactgct caccggcatg 2221 gaccatcatc tgggaatggg atgctaactg gggcctctcg gcaattttgg tgactcttgc 2281 aaggtcatac ctgggtgacg catccaaact gagttcctcc atcacagaag gtgtgacccc 2341 cacccccgcc ccaggatcag gaggctgggt ctcctccttc cacctgctca ctcctggtag 2401 ccccgggggt cgtccaaggt tcaaatagga ctaggacctg tagtctgggg ggatcctggc 2461 ttgacaagag gccctgaccc tccctctgca gttgcggcgc cgcttcgggg acgtgttcag 2521 cctgcagctg gcctggacgc cggtggtcgt gctcaatggg ctggcggccg tgcgcgaggc 2581 gctggtgacc cacggcgagg acaccgccga ccgcccgcct gtgcccatca cccagatcct 2641 gggtttcggg ccgcgttccc aaggcaagca gcggtgggga cagagacaga tttccgtggg 2701 acccgggtgg gtgatgaccg tagtccgagc tgggcagaga gggcgcgggg tcgtggacat 2761 gaaacaggcc agcgagtggg gacagcgggc caagaaacca cctgcactag ggaggtgtga 2821 gcatggggac gagggcgggg cttgtgacga gtgggcgggg ccactgccga gacctggcag 2881 gagcccaatg ggtgaggctg gcgcatttcc cagctggaat ccggtgtcga agtggggggc 2941 ggggaccgca cctgtgctgt aagctcagtg tgggtggcgc ggggcccgcg gggtcttccc 3001 tgagtgcaaa ggcggtcagg gtgggcagag acgaggtggg gcaaagccct gccccagcca 3061 agggagcaag gtggatgcac aaagagtggg ccctgtgacc agctggacag agccagggac 3121 tgcgggagac cagggggagc atagggttgg agtgggtggt ggatggtggg gctaatgcct 3181 tcatggccac gcgcacgtgc ccgtcccacc cccaggggtg ttcctggcgc gctatgggcc 3241 cgcgtggcgc gagcagaggc gcttctccgt ctccaccttg cgcaacttgg gcctgggcaa 3301 gaagtcgctg gagcagtggg tgaccaagga ggccgcctgc ctttgtgccg ccttcgccaa 3361 ccactccggt gggtgatggg cagaagggca caaagcggga actgggaagg cgggggacgg 3421 ggaaggcgac cccttacccg catctcccac ccccaggacg cccctttcgc cccaacggtc 3481 tcttggacaa agccgtgagc aacgtgatcg cctccctcac ctgcgggcgc cgcttcgagt 3541 acgacgaccc tcgcttcctc aggctgctgg acctagctca ggagggactg aaggaggagt 3601 cgggctttct gcgcgaggtg cggagcgaga gaccgaggag tctctgcagg gcgagctccc 3661 gagaggtgcc ggggctggac tggggcctcg gaagagcagg atttgcatag atgggtttgg 3721 gaaaggacat tccaggagac cccactgtaa gaagggcctg gaggaggagg ggacatctca 3781 gacatggtcg tgggagaggt gtgcccgggt cagggggcac caggagaggc caaggactct 3841 gtacctccta tccacgtcag agatttcgat tttaggtttc tcctctgggc aaggagagag 3901 ggtggaggct ggcacttggg gagggacttg gtgaggtcag tggtaaggac aggcaggccc 3961 tgggtctacc tggagatggc tggggcctga gacttgtcca ggtgaacgca gagcacagga 4021 gggattgaga ccccgttctg tctggtgtag gtgctgaatg ctgtccccgt cctcctgcat 4081 atcccagcgc tggctggcaa ggtcctacgc ttccaaaagg ctttcctgac ccagctggat 4141 gagctgctaa ctgagcacag gatgacctgg gacccagccc agccaccccg agacctgact 4201 gaggccttcc tggcagagat ggagaaggtg agagtggctg ccacggtggg gggcaagggt 4261 ggtgggttga acgtcccagg aggaatgagg ggaggctggg caaaaggttg gaccagtgca 4321 tcacccggcg agccgcatct gggctgacag gtgcagaatt ggaggtcatt tgggggctac 4381 cccgttctgt cccgagtatg ctctcggccc tgctcaggcc aaggggaacc ctgagagcag 4441 cttcaatgat gagaacctgt gcatagtggt ggctgacctg ttctctgccg ggatggtgac 4501 cacctcgacc acgctggcct ggggcctcct gctcatgatc ctacatccgg atgtgcagcg 4561 tgagcccatc tgggaaacag tgcaggggcc gagggaggaa gggtacaggc gggggcccat 4621 gaactttgct gggacacccg gggctccaag cacaggcttg accaggatcc tgtaagcctg 4681 acctcctcca acataggagg caagaaggag tgtcagggcc ggaccccctg ggtgctgacc 4741 cattgtgggg acgcatgtct gtccaggccg tgtccaacag gagatcgacg acgtgatagg 4801 gcaggtgcgg cgaccagaga tgggtgacca ggctcacatg ccctacacca ctgccgtgat 4861 tcacgaggtg cagcgctttg gggacatcgt ccccctgggt gtgacccata tgacatcccg 4921 tgacatcgaa gtacagggct tccgcatccc taaggtaggc ctggcgccct cctcacccca 4981 gctcagcacc agcccctggt gatagcccca gcatggctac tgccaggtgg gcccactcta 5041 ggaaccctgg ccacctagtc ctcaatgcca ccacactgac tgtccccact tgggtggggg 5101 gtccagagta taggcagggc tggcctgtcc atccagagcc cccgtctagt ggggagacaa 5161 accaggacct gccagaatgt tggaggaccc aacacctgca gggagagggg gcagtgtggg 5221 tgcctctgag aggtgtgact gcgccctgct gtggggtcgg agagggtact gtggagcttc 5281 tcgggcgcag gactagttga cagagtccag ctgtgtgcca ggcagtgtgt gtcccccgtg 5341 tgtttggtgg caggggtccc agcatcctag agtccagtcc ccactctcac cctgcatctt 5401 ctgcccaggg aacgacactc atcaccaacc tgtcatcggt gctgaaggat gaggccgtct 5461 gggagaagcc cttccgcttc caccccgaac acttcctgga tgcccagggc cactttgtga 5521 agccggaggc cttcctgcct ttctcagcag gtgcctgtgg ggagcccggc tccctgtccc 5581 cttccgtgga gtcttgcagg ggtatcaccc aggagccagg ctcactgacg cccctcccct 5641 ccccacaggc cgccgtgcat gcctcgggga gcccctggcc cgcatggagc tcttcctctt 5701 cttcacctcc ctgctgcagc acttcagctt ctcggtgccc actggacagc cccggcccag 5761 ccaccatggt gtctttgctt tcctggtgac cccatccccc tatgagcttt gtgctgtgcc 5821 ccgctagaat ggggtaccta gtccccagcc tgctccctag ccagaggctc taatgtacaa 5881 taaagcaatg tggtagttcc aactcgggtc ccctgctcac gccctcgttg ggatcatcct 5941 cctcagggca accccacccc tgcctcattc ctgcttaccc caccgcctgg ccgcatttga 6001 gacaggggta cgttgagg //
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