LOCUS NM_001004312 1346 bp mRNA linear PRI 30-JUL-2024
DEFINITION Homo sapiens receptor transporter protein 2 (RTP2), mRNA.
ACCESSION NM_001004312 XM_293633
VERSION NM_001004312.2
KEYWORDS RefSeq; MANE Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1346)
AUTHORS Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
TITLE A reference map of the human binary protein interactome
JOURNAL Nature 580 (7803), 402-408 (2020)
PUBMED 32296183
REFERENCE 2 (bases 1 to 1346)
AUTHORS Yu,T., Su,X., Pan,Y. and Zhuang,H.
TITLE Receptor-transporting protein (RTP) family members play divergent
roles in the functional expression of odorant receptors
JOURNAL PLoS One 12 (6), e0179067 (2017)
PUBMED 28586385
REMARK GeneRIF: further cell-surface and permeabilized immunocytochemical
studies revealed that odorant receptors (ORs) and the co-expressed
RTP1S proteins were retained in the Golgi when co-transfected with
RTP2, indicating that RTP1S and RTP2 could play different roles in
the OR trafficking process.
Publication Status: Online-Only
REFERENCE 3 (bases 1 to 1346)
AUTHORS Hancock,D.B., Soler Artigas,M., Gharib,S.A., Henry,A.,
Manichaikul,A., Ramasamy,A., Loth,D.W., Imboden,M., Koch,B.,
McArdle,W.L., Smith,A.V., Smolonska,J., Sood,A., Tang,W.,
Wilk,J.B., Zhai,G., Zhao,J.H., Aschard,H., Burkart,K.M.,
Curjuric,I., Eijgelsheim,M., Elliott,P., Gu,X., Harris,T.B.,
Janson,C., Homuth,G., Hysi,P.G., Liu,J.Z., Loehr,L.R., Lohman,K.,
Loos,R.J., Manning,A.K., Marciante,K.D., Obeidat,M., Postma,D.S.,
Aldrich,M.C., Brusselle,G.G., Chen,T.H., Eiriksdottir,G.,
Franceschini,N., Heinrich,J., Rotter,J.I., Wijmenga,C.,
Williams,O.D., Bentley,A.R., Hofman,A., Laurie,C.C., Lumley,T.,
Morrison,A.C., Joubert,B.R., Rivadeneira,F., Couper,D.J.,
Kritchevsky,S.B., Liu,Y., Wjst,M., Wain,L.V., Vonk,J.M.,
Uitterlinden,A.G., Rochat,T., Rich,S.S., Psaty,B.M., O'Connor,G.T.,
North,K.E., Mirel,D.B., Meibohm,B., Launer,L.J., Khaw,K.T.,
Hartikainen,A.L., Hammond,C.J., Glaser,S., Marchini,J., Kraft,P.,
Wareham,N.J., Volzke,H., Stricker,B.H., Spector,T.D.,
Probst-Hensch,N.M., Jarvis,D., Jarvelin,M.R., Heckbert,S.R.,
Gudnason,V., Boezen,H.M., Barr,R.G., Cassano,P.A., Strachan,D.P.,
Fornage,M., Hall,I.P., Dupuis,J., Tobin,M.D. and London,S.J.
TITLE Genome-wide joint meta-analysis of SNP and SNP-by-smoking
interaction identifies novel loci for pulmonary function
JOURNAL PLoS Genet 8 (12), e1003098 (2012)
PUBMED 23284291
REFERENCE 4 (bases 1 to 1346)
AUTHORS Behrens,M., Bartelt,J., Reichling,C., Winnig,M., Kuhn,C. and
Meyerhof,W.
TITLE Members of RTP and REEP gene families influence functional bitter
taste receptor expression
JOURNAL J Biol Chem 281 (29), 20650-20659 (2006)
PUBMED 16720576
REFERENCE 5 (bases 1 to 1346)
AUTHORS Clark,A.J., Metherell,L.A., Cheetham,M.E. and Huebner,A.
TITLE Inherited ACTH insensitivity illuminates the mechanisms of ACTH
action
JOURNAL Trends Endocrinol Metab 16 (10), 451-457 (2005)
PUBMED 16271481
REMARK Review article
REFERENCE 6 (bases 1 to 1346)
AUTHORS Saito,H., Kubota,M., Roberts,R.W., Chi,Q. and Matsunami,H.
TITLE RTP family members induce functional expression of mammalian
odorant receptors
JOURNAL Cell 119 (5), 679-691 (2004)
PUBMED 15550249
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BC068081.1, AY562236.1 and AC072022.19.
On Sep 15, 2009 this sequence version replaced NM_001004312.1.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
##Evidence-Data-START##
Transcript exon combination :: BC068081.1, BQ671345.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA1968968, SAMEA2146411
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000358241.1/ ENSP00000350976.1
RefSeq Select criteria :: based on manual assertion, conservation,
longest protein
##RefSeq-Attributes-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-673 BC068081.1 1-673
674-1107 AY562236.1 245-678
1108-1139 BC068081.1 1108-1139
1140-1346 AC072022.19 84560-84766
FEATURES Location/Qualifiers
source 1..1346
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3q27.3"
gene 1..1346
/gene="RTP2"
/gene_synonym="Z3CXXC2"
/note="receptor transporter protein 2"
/db_xref="GeneID:344892"
/db_xref="HGNC:HGNC:32486"
/db_xref="MIM:609138"
exon 1..593
/gene="RTP2"
/gene_synonym="Z3CXXC2"
/inference="alignment:Splign:2.1.0"
misc_feature 397..399
/gene="RTP2"
/gene_synonym="Z3CXXC2"
/note="upstream in-frame stop codon"
CDS 430..1107
/gene="RTP2"
/gene_synonym="Z3CXXC2"
/note="zinc finger, 3CxxC-type 2; 3CxxC-type zinc finger
protein 2; receptor (chemosensory) transporter protein 2"
/codon_start=1
/product="receptor-transporting protein 2"
/protein_id="NP_001004312.2"
/db_xref="CCDS:CCDS33911.1"
/db_xref="GeneID:344892"
/db_xref="HGNC:HGNC:32486"
/db_xref="MIM:609138"
/translation="MCTSLTTCEWKKVFYEKMEVAKPADSWELIIDPNLKPSELAPGW
KQYLEQHASGRFHCSWCWHTWQSAHVVILFHMFLDRAQRAGSVRMRVFKQLCYECGTA
RLDESSMLEENIEGLVDNLITSLREQCYEEDGGQYRIHVASRPDSGPHRAEFCEACQE
GIVHWKPSEKLLEEEVTTYTSEASKPRAQAGSGYNFLSLRWCLFWASLCLLVVYLQFS
FLSPAFF"
misc_feature 1018..1086
/gene="RTP2"
/gene_synonym="Z3CXXC2"
/note="propagated from UniProtKB/Swiss-Prot (Q5QGT7.1);
transmembrane region"
exon 594..1346
/gene="RTP2"
/gene_synonym="Z3CXXC2"
/inference="alignment:Splign:2.1.0"
ORIGIN
1 ctagggtgtc gtacttacca tagcacatga tgtggagaat gctagaagag cagttgggtg
61 aagcagggcc accaaatagt ccttgcctcc tggagacctc tggaaatcca gatgagtgtg
121 gtctgaggtt gggcctccca ctgtgcttgc tcctctcagg cctacccagc gctgcctctg
181 aagcctaact cagggccctg aaactccccc ttggggcttc ccttctcccc agccctcact
241 cttggtgccc tgcctggcta ccatggtaac aggttccagg gtaacagagg agggagctgg
301 gtcctgttta ctcccagtcc tgccgatgag gattctgacc gtagacactg aattgtcccg
361 tacctatccg tgctctttct gtgttctcac cagggctgag ctcgaactgc cacctctgcc
421 agcaggacca tgtgtaccag cttgaccact tgtgagtgga agaaagtctt ctatgagaag
481 atggaggtgg caaagccagc ggacagctgg gagctcatca tagaccccaa cctcaagccc
541 agtgagctgg cccctggctg gaagcagtac ctggagcagc acgcctcagg caggttccac
601 tgctcctggt gctggcacac ctggcagtct gcccatgtgg tcatcctctt ccacatgttc
661 ctggaccgcg cccagcgggc gggctcggtg cgcatgcgcg tcttcaagca gctgtgctat
721 gagtgcggca cggcgcggct ggacgagtcc agcatgctgg aggagaacat cgagggcctg
781 gtggacaacc tcatcaccag cctgcgcgag cagtgctacg aggaggatgg tggccagtac
841 cgcatccacg tggccagccg cccggacagc gggccgcatc gtgcagagtt ctgtgaggcc
901 tgccaggagg gcatcgttca ctggaagccc agcgagaagc tgctggagga ggaggtgacc
961 acctacacct ctgaagcctc caagccgagg gcccaggcgg gatccggcta caacttcttg
1021 tctcttcgct ggtgcctctt ctgggcctct ctctgcctgc tcgttgttta cctgcagttc
1081 tccttcctca gtcctgcctt cttttagtgg agctggttaa gggtgggaga gggcacatgg
1141 gcttgagagt ggggaggaca cagtctggac ttgatcctgc tacagattca acatatgact
1201 ggacaatccg gtcacctctc tgggcctcag ttaatgcatc tgcggaatga gaggattgca
1261 ttagaagata ggcaatgatt ctttcactgg atgtgacaat aattggggga aggggaaaag
1321 ggtgtaataa aggttttaga gcttgc
//