LOCUS NM_001164407 5884 bp mRNA linear PRI 27-SEP-2024
DEFINITION Homo sapiens TLC domain containing 2 (TLCD2), mRNA.
ACCESSION NM_001164407 XM_001126126
VERSION NM_001164407.2
KEYWORDS RefSeq; MANE Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5884)
AUTHORS Petkevicius,K., Palmgren,H., Glover,M.S., Ahnmark,A.,
Andreasson,A.C., Madeyski-Bengtson,K., Kawana,H., Allman,E.L.,
Kaper,D., Uhrbom,M., Andersson,L., Aasehaug,L., Forsstrom,J.,
Wallin,S., Ahlstedt,I., Leke,R., Karlsson,D., Gonzalez-King,H.,
Lofgren,L., Nilsson,R., Pellegrini,G., Kono,N., Aoki,J., Hess,S.,
Sienski,G., Pilon,M., Bohlooly-Y,M., Maresca,M. and Peng,X.R.
TITLE TLCD1 and TLCD2 regulate cellular phosphatidylethanolamine
composition and promote the progression of non-alcoholic
steatohepatitis
JOURNAL Nat Commun 13 (1), 6020 (2022)
PUBMED 36241646
REMARK GeneRIF: TLCD1 and TLCD2 regulate cellular phosphatidylethanolamine
composition and promote the progression of non-alcoholic
steatohepatitis.
Publication Status: Online-Only
REFERENCE 2 (bases 1 to 5884)
AUTHORS Ruiz,M., Bodhicharla,R., Svensk,E., Devkota,R., Busayavalasa,K.,
Palmgren,H., Stahlman,M., Boren,J. and Pilon,M.
TITLE Membrane fluidity is regulated by the C. elegans transmembrane
protein FLD-1 and its human homologs TLCD1/2
JOURNAL Elife 7, e40686 (2018)
PUBMED 30509349
REMARK GeneRIF: inhibition of FLD-1 or TLCD1/2 prevents lipotoxicity by
allowing increased levels of membrane phospholipids that contain
fluidizing long-chain polyunsaturated fatty acids.
Publication Status: Online-Only
REFERENCE 3 (bases 1 to 5884)
AUTHORS Pewzner-Jung,Y., Ben-Dor,S. and Futerman,A.H.
TITLE When do Lasses (longevity assurance genes) become CerS (ceramide
synthases)?: Insights into the regulation of ceramide synthesis
JOURNAL J Biol Chem 281 (35), 25001-25005 (2006)
PUBMED 16793762
REMARK Review article
REFERENCE 4 (bases 1 to 5884)
AUTHORS Zody,M.C., Garber,M., Adams,D.J., Sharpe,T., Harrow,J.,
Lupski,J.R., Nicholson,C., Searle,S.M., Wilming,L., Young,S.K.,
Abouelleil,A., Allen,N.R., Bi,W., Bloom,T., Borowsky,M.L.,
Bugalter,B.E., Butler,J., Chang,J.L., Chen,C.K., Cook,A., Corum,B.,
Cuomo,C.A., de Jong,P.J., DeCaprio,D., Dewar,K., FitzGerald,M.,
Gilbert,J., Gibson,R., Gnerre,S., Goldstein,S., Grafham,D.V.,
Grocock,R., Hafez,N., Hagopian,D.S., Hart,E., Norman,C.H.,
Humphray,S., Jaffe,D.B., Jones,M., Kamal,M., Khodiyar,V.K.,
LaButti,K., Laird,G., Lehoczky,J., Liu,X., Lokyitsang,T.,
Loveland,J., Lui,A., Macdonald,P., Major,J.E., Matthews,L.,
Mauceli,E., McCarroll,S.A., Mihalev,A.H., Mudge,J., Nguyen,C.,
Nicol,R., O'Leary,S.B., Osoegawa,K., Schwartz,D.C., Shaw-Smith,C.,
Stankiewicz,P., Steward,C., Swarbreck,D., Venkataraman,V.,
Whittaker,C.A., Yang,X., Zimmer,A.R., Bradley,A., Hubbard,T.,
Birren,B.W., Rogers,J., Lander,E.S. and Nusbaum,C.
TITLE DNA sequence of human chromosome 17 and analysis of rearrangement
in the human lineage
JOURNAL Nature 440 (7087), 1045-1049 (2006)
PUBMED 16625196
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC130343.7.
On Nov 23, 2018 this sequence version replaced NM_001164407.1.
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments.
##Evidence-Data-START##
Transcript exon combination :: SRR1803612.448205.1,
ERR279844.3714.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN04284274 [ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000330676.8/ ENSP00000331965.6
RefSeq Select criteria :: based on single protein-coding transcript
##RefSeq-Attributes-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-311 AC130343.7 159581-159891 c
312-394 AC130343.7 159318-159400 c
395-477 AC130343.7 159013-159095 c
478-5884 AC130343.7 152330-157736 c
FEATURES Location/Qualifiers
source 1..5884
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="17"
/map="17p13.3"
gene 1..5884
/gene="TLCD2"
/note="TLC domain containing 2"
/db_xref="GeneID:727910"
/db_xref="HGNC:HGNC:33522"
/db_xref="MIM:620967"
exon 1..311
/gene="TLCD2"
/inference="alignment:Splign:2.1.0"
CDS 136..930
/gene="TLCD2"
/codon_start=1
/product="TLC domain-containing protein 2"
/protein_id="NP_001157879.1"
/db_xref="CCDS:CCDS45567.1"
/db_xref="GeneID:727910"
/db_xref="HGNC:HGNC:33522"
/db_xref="MIM:620967"
/translation="MAPTGLLVAGASFLAFRGLHWGLRRLPTPESAARDRWQWWNLCV
SLAHSLLSGTGALLGLSLYPQMAADPIHGHPRWALVLVAVSVGYFLADGADLLWNQTL
GKTWDLLCHHLVVVSCLSTAVLSGHYVGFSMVSLLLELNSACLHLRKLLLLSRQAPSL
AFSVTSWASLATLALFRLVPLGWMSLWLFRQHHQVPLALVTLGGIGLVTVGIMSIILG
IRILVNDVLQSRPHPPSPGHEKTRGTRTRRDNGPVTSNSSTLSLKD"
misc_feature 142..204
/gene="TLCD2"
/note="propagated from UniProtKB/Swiss-Prot (A6NGC4.3);
transmembrane region"
misc_feature 259..321
/gene="TLCD2"
/note="propagated from UniProtKB/Swiss-Prot (A6NGC4.3);
transmembrane region"
misc_feature 364..426
/gene="TLCD2"
/note="propagated from UniProtKB/Swiss-Prot (A6NGC4.3);
transmembrane region"
misc_feature 475..537
/gene="TLCD2"
/note="propagated from UniProtKB/Swiss-Prot (A6NGC4.3);
transmembrane region"
misc_feature 640..702
/gene="TLCD2"
/note="propagated from UniProtKB/Swiss-Prot (A6NGC4.3);
transmembrane region"
misc_feature 730..792
/gene="TLCD2"
/note="propagated from UniProtKB/Swiss-Prot (A6NGC4.3);
transmembrane region"
misc_feature 823..927
/gene="TLCD2"
/note="propagated from UniProtKB/Swiss-Prot (A6NGC4.3);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
exon 312..394
/gene="TLCD2"
/inference="alignment:Splign:2.1.0"
exon 395..477
/gene="TLCD2"
/inference="alignment:Splign:2.1.0"
exon 478..5884
/gene="TLCD2"
/inference="alignment:Splign:2.1.0"
regulatory 5864..5869
/regulatory_class="polyA_signal_sequence"
/gene="TLCD2"
/note="hexamer: AATAAA"
polyA_site 5884
/gene="TLCD2"
/note="major polyA site"
ORIGIN
1 gctgatccca aaggcgcggc ggggagggga gccggggccc cagccctgcc gggaaacggg
61 ttcccagtcc cggccgagag cgcgggcgcc gaggggaccg acccggactc cccgcaaccc
121 cccaaccgcc aggccatggc gcccacgggg ctcctggtgg ccggcgcctc cttcctcgcg
181 ttccgggggc tgcactgggg gttgcggcgg ctgcccacgc cggaatcggc cgctcgggac
241 cgctggcagt ggtggaacct ctgcgtctcc ctggcgcaca gcctgctctc ggggaccggg
301 gcgctgctcg gcctgtcact gtaccctcag atggccgccg accccatcca tggccacccg
361 cgctgggctc tggtgctggt ggctgtgtct gtgggttact tcctggcaga cggagctgac
421 ctgctgtgga accagacctt gggcaagacc tgggatcttc tctgtcatca tttggtggtg
481 gtgagctgcc tcagcaccgc tgttctgtct ggccactacg tgggcttctc catggtgtct
541 ctgctcctgg aactgaactc tgcctgcttg cacctgcgga agctgctgtt gctttctcgc
601 caggccccat ccctggcctt cagcgtgacc agctgggcct ccttggccac cttggccctc
661 ttccgcctgg tcccgctggg gtggatgagt ctgtggctgt tccggcagca ccaccaggtt
721 cctcttgctc tggtcaccct gggtggaatt gggctggtca ctgtgggcat catgagcatc
781 atattgggga tccgtattct ggtcaatgat gtcctacagt ctcgacccca tccacccagc
841 cctggccatg agaaaaccag ggggaccagg acacgtcgtg acaatggacc tgtcaccagc
901 aacagttcga ctctcagcct gaaagactag agagaagcca tgggcccctc gctgggggag
961 gtggggccag gacaaggaga tgagggtctt ccatgcacag tcccccatca gggtgagggc
1021 cagacttgct catcagaatc tcagtttctc ttccagctaa ctcacatccc ttccccttcc
1081 tcggatctaa gaagaaatgc tgatgttgga tgggtgggaa cctgggtttc tgttcactga
1141 aatccgtcat cagatgagca tcctttccag caaataaact caagaggtac agctagagct
1201 atcagtaaag ggtggcagga ggcatgcagc tggaagaaac tgccagtgga gacagaagct
1261 ctttgcttta acccagggac agatggggga aggtgaagtc ccactaggat cagagagatc
1321 tggtatgggg cgggtgggga cagagagaaa agagatctca cctataacca aattctggca
1381 gtgggaggaa ggtagaggag gtgctatctg tagcagcaga gatggacgtg atagttgcca
1441 agagacagaa cctgggccac agcaattgct gctgatgttt ctggttctca aagccacact
1501 cctgtttttc tttttctttt tctttttttt tatgagacgg aatcttactc tgtcacccag
1561 gctggagtgt agtggcacga tttcggctca ctgcaacctc agcctcctgg gttcaagtga
1621 ttgtcctgcc ttagcctccc gagtagctgt gacttcaggc atgcaccacc aagcccagct
1681 aatttttgta ttttttggtg gagaggaggt ttcaccatgt tgcccaggct ggtctcgaac
1741 tcctgacctc aagtaatcca cctgcctcgg cctcccagag tgctgggatt acagacgtga
1801 gaacaggcgc acactcctgt ttttctcctt aaccctggtc ctgctgtgtc tagcctttta
1861 tttttatttt tatttttagt atcttttgac ttttcttttt tcttttcttt tttttttttt
1921 ttttttgaga caagttcttg ctctgttgcc caggatggag tgcagtggct tgatcttggc
1981 tcactgcaat ctctgcctcc caggctcaag caattctcct gcctcccacc tcagcctccc
2041 aagtagctgg gactacaggt gcacgccact gcaccaggct aatttttgta tttttttgta
2101 gagaccaggt tttgccatgt tgcccaggct ggtctcaaac ttttgcactc aagtgatcca
2161 cccacctcag cctcccaaag tgctgggatt acagacgtga gccaccgtac ccgacccctt
2221 ttgacttttc aaagacaatt cggattctta gaggaatgaa cacagggctg gtttgtcttc
2281 ttaggacggc actgaagtct agaattacag aaggaaaggt gcccagtaca gagttttccc
2341 aggcccaggc tttcatggaa gaacaagggc agaggtagac tgtgtgagag aaggctgcag
2401 gaggataaag gaatagctgg ccctctggct gggcgcagca gctcacgcct gtaatcccag
2461 cactttggga ggccgaggcg ggaggatcac ctgaggtcag gagttcaaga ccagcctggt
2521 caacatggtg aaaccctgtc tctactaaaa atacaaaatt agccgggcat ggtggtgcat
2581 gcctgtaatc ccagctactc aggaggctga ggcaggagaa tcgcttgaac ccaggaggca
2641 gaggttgcag tgagccgagg tcgtgccact gcactccagc ctgggcaaac agagtgagac
2701 tcttgtctct aaagaaaaaa aaaaaaggaa gagctgggac ttttctgaga tacattcata
2761 aagtcttctt cctccctgct gcttctgctg cgtttttttc tgttgaacaa gaccccttcc
2821 ttcccagaac atcgaggtga cgggaagtgc ccagcagatt aagtctgctg ttccactaaa
2881 caatggactg agagaggcaa cccttagcca tccacagaaa agctacatga gcaaaagcaa
2941 gagacaggaa gattgtcttc aaaaaaaaac aaaacaaaac aaaaaccttg ctaagaagcg
3001 gaggtacaga aagatacgaa gaatgacaga gacagacata catagattga gtgatagata
3061 gaaagagaga aggattattc acatagaggt gacagaggca aagaaggatg gagggcaaaa
3121 gagacaggcc ctagcagaaa tatggagaaa ggctgtcata gatcctgaga gacaccaaag
3181 tcacagaact gataaaaggg ttataaacaa aaaggaccag aaaaatagaa atgaaggccg
3241 acaagaagag accccaaggc tgaaaggcac agagagtcta gacagtgaaa tagagtgagt
3301 gacaaggaga aacacccagg ctcaggagtg atggaggaaa tactggcaga tagagagatc
3361 agaagagcaa gaggagaggt gggaacagag aagagcgggg acgagtccgg ggagctgaga
3421 agcagaaggc ggaggaggca gtcagtggga agattcactg acagaagaga ccaggagata
3481 tggggacttg gaggcaggca gaaagacaaa ggacaaacag ctgcagcgca aaccctaaag
3541 acaggctgac agtaaccggt cggcagagac tggtaggaag ataaggacaa gtcagaatca
3601 ggggtgtcaa ctgagatgca aatataggca aaggagctga caaagagaat cacagagaga
3661 aaaaaaagga ggagagcaca gaacaattta aatatccagg ctgggcatgg tgggtcacgc
3721 ctgtaatccc agcattttgg gaggccgagg caggcggatc acgaggtcag gagatgacca
3781 tcctggctaa catggtgaaa caccatctct actaaaaata caaaaaattg gccgggcgtg
3841 gtggcaggcg cccgtaatcc cggctactga ggaggctgag gcaggagaat cgtttgaacc
3901 tgggaggccg aggttgttat aatgagccga gatagtgcca ctgcagtcca gcaggggtga
3961 cagagtgaga ctccgtctca aaaaaaaaaa ttgaatatcc aaagaacaaa gaagaggcag
4021 gaacccagaa atgaaaagag gaggaaaaat acaggtgtga aaaaaaaatg agagggattg
4081 tgagaagtct ccatcataga gtcataaaaa caggcgcaaa ggatgaaaat acatcgagac
4141 tgaggaaaac acagttggaa ggagctaaac acaagcagaa aataagagca gagcatttaa
4201 atgtaattag ataaaaaccc aagaggcaaa ggtatagata gtgagctaga gaaacaatgc
4261 agaattttgt cagagtctgt acttctagaa gtcatgtttg ctggctgggc atggtggctc
4321 acgcctgtaa tcccagcact ttgggaggcc gaggtaggag gagtggttga gctcaggagt
4381 tcaagaccag tctgggcaac atattgagac ctcctctcta caaaaaaaaa aaattttctt
4441 ttttctttct tttcttcttt tttttttttt ttttttgaga cagtttcatt cttgctgccc
4501 aggctggaat gcagtggcac aatcttggct cactgcaacc tccacctcct ggactcaagt
4561 gattctcctg cctcagcctc cctagtagct gggattacag gtacccacca ccacactcgg
4621 ctaatttttg tgtttttagt agagacagga tttcaccata ttggccaggc tggtctcaaa
4681 ctcctgacct caggtgatcc gcccaccttg ggctcccaaa ctactgggat tatatgcgtg
4741 agccaacaca cccggccaaa aaaaaatttt taattaaaaa aaaaagtcat atctgcaaaa
4801 ctcaatttgc catcttaact gaatgccttg attaacaaaa atgttgtctg ccttgagttt
4861 ttaaagaaaa agaaatatga caaactcatg tgaggaatct attccttaaa tatctgttga
4921 ggttgatatg aattgattct aagtcataca ccttttcttt ggccactggt atacattcat
4981 gatggtttga gtgagtgtcc cttttggtaa tacttgatag tgtctatgag gccgggcgtg
5041 gtggctcacg cctgtaatcc cagcactttg ggggaccgag gcaggtgaaa tcccatctct
5101 actaaaaata aaaaaaatta gccgggcgtg gtggcgggcg cctgtagtcc cagctactca
5161 ggaggctgag gcaggagaat ggcatgaacc cgggaggcgg agcttgcagt gagccaagat
5221 cgtgccactg cactccagcc tgggtgacag agcaagactc cgtcttaaaa aataaataaa
5281 taaataaata gacagataga tagatagata gtgtctatga aggctgccca agaacttgac
5341 cattagggaa acatggctgt ttctgtggat taactagtca agcccataca ggaagagtga
5401 ggtcagctcc caggtggggc aggatgtagt ggacgcttgg aagaatttgg gaccacacac
5461 gaattgctac catggtgagc cagtgaaact tgaggaaggc aggactggat tgtgattaca
5521 actgagtaag taggcagaga attggagtgt gggcaacata aagatgatgt gaatcaaaga
5581 agaatggtca attaagaccc taaaaaaagg acgttcaaaa atgcagaggt taaaaaaaaa
5641 aaaagcagag attgccagat gctccatttg gtaggagtct gcttagcaca gtggtgcttc
5701 gccagacttt accgtggccc agggaaatgg tcctcaagac ggactccatg tctaccaagc
5761 tacttgctaa tgatttcttt gtcctccagg acagggaagg ggcttttctg gatgggatac
5821 attgatattt tatggccttg aaacactatc ctgattataa attaataaat tgctatgcaa
5881 ataa
//