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Saccharomyces cerevisiae S288C AAA family ATPase SEC18 (SEC18), partial mRNA

NCBI Reference Sequence: NM_001178428.3

FASTA Graphics 

LOCUS       NM_001178428            2277 bp    mRNA    linear   PLN 17-DEC-2024
DEFINITION  Saccharomyces cerevisiae S288C AAA family ATPase SEC18 (SEC18),
            partial mRNA.
ACCESSION   NM_001178428
VERSION     NM_001178428.3
DBLINK      BioProject: PRJNA128
KEYWORDS    RefSeq.
SOURCE      Saccharomyces cerevisiae S288C
  ORGANISM  Saccharomyces cerevisiae S288C
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
            Saccharomyces.
REFERENCE   1  (bases 1 to 2277)
  AUTHORS   Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
            Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
            Weng,S. and Cherry,J.M.
  TITLE     New data and collaborations at the Saccharomyces Genome Database:
            updated reference genome, alleles, and the Alliance of Genome
            Resources
  JOURNAL   Genetics 220 (4) (2022)
   PUBMED   34897464
REFERENCE   2  (bases 1 to 2277)
  AUTHORS   Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
            Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
            Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
            Oliver,S.G.
  TITLE     Life with 6000 genes
  JOURNAL   Science 274 (5287), 546 (1996)
   PUBMED   8849441
REFERENCE   3  (bases 1 to 2277)
  AUTHORS   Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C.,
            Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al.
  TITLE     Complete DNA sequence of yeast chromosome II
  JOURNAL   EMBO J. 13 (24), 5795-5809 (1994)
   PUBMED   7813418
REFERENCE   4  (bases 1 to 2277)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (17-DEC-2024) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (bases 1 to 2277)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (04-MAY-2012) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   6  (bases 1 to 2277)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (31-MAR-2011) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Sequence update by submitter
REFERENCE   7  (bases 1 to 2277)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (11-DEC-2009) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by SGD. This record
            is derived from an annotated genomic sequence (NC_001134).
            
            On Jul 30, 2012 this sequence version replaced NM_001178428.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: SGD
            Annotation Status   :: Full Annotation
            Annotation Version  :: R64-4-1
            URL                 :: http://www.yeastgenome.org/
            ##Genome-Annotation-Data-END##
            COMPLETENESS: incomplete on both ends.
FEATURES             Location/Qualifiers
     source          1..2277
                     /organism="Saccharomyces cerevisiae S288C"
                     /mol_type="mRNA"
                     /strain="S288C"
                     /db_xref="taxon:559292"
                     /chromosome="II"
     gene            <1..>2277
                     /gene="SEC18"
                     /locus_tag="YBR080C"
                     /gene_synonym="ANU4"
                     /db_xref="GeneID:852372"
     CDS             1..2277
                     /gene="SEC18"
                     /locus_tag="YBR080C"
                     /gene_synonym="ANU4"
                     /experiment="EXISTENCE:direct assay:GO:0000149 SNARE
                     binding [PMID:27364524]"
                     /experiment="EXISTENCE:direct assay:GO:0005794 Golgi
                     apparatus [PMID:23613772]"
                     /experiment="EXISTENCE:direct assay:GO:0005829 cytosol
                     [PMID:26928762]"
                     /experiment="EXISTENCE:direct assay:GO:0006888 endoplasmic
                     reticulum to Golgi vesicle-mediated transport
                     [PMID:9382859]"
                     /experiment="EXISTENCE:direct assay:GO:0016887 ATP
                     hydrolysis activity [PMID:10387016]"
                     /experiment="EXISTENCE:direct assay:GO:0035494 SNARE
                     complex disassembly [PMID:18650938|PMID:9425154]"
                     /experiment="EXISTENCE:direct assay:GO:0042144 vacuole
                     fusion, non-autophagic [PMID:9685264|PMID:8670830]"
                     /experiment="EXISTENCE:direct assay:GO:0043332 mating
                     projection tip [PMID:19053807]"
                     /experiment="EXISTENCE:direct assay:GO:0048280 vesicle
                     fusion with Golgi apparatus [PMID:9382859]"
                     /experiment="EXISTENCE:direct assay:GO:0070300
                     phosphatidic acid binding [PMID:27364524]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0000045
                     autophagosome assembly [PMID:11694599]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0016236
                     macroautophagy [PMID:11694599]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0043001 Golgi
                     to plasma membrane protein transport [PMID:2071670]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0048219
                     inter-Golgi cisterna vesicle-mediated transport
                     [PMID:2071670|PMID:10637300]"
                     /note="AAA ATPase and SNARE disassembly chaperone;
                     required for vesicular transport between ER and Golgi, the
                     'priming' step in homotypic vacuole fusion, autophagy, and
                     protein secretion; releases Sec17p from SNAP complexes;
                     has similarity to mammalian N-ethylmaleimide-sensitive
                     factor (NSF)"
                     /codon_start=1
                     /product="AAA family ATPase SEC18"
                     /protein_id="NP_009636.3"
                     /db_xref="GeneID:852372"
                     /db_xref="SGD:S000000284"
                     /translation="MFKIPGFGKAAANHTPPDMTNMDTRTRHLKVSNCPNNSYALANV
                     AAVSPNDFPNNIYIIIDNLFVFTTRHSNDIPPGTIGFNGNQRTWGGWSLNQDVQAKAF
                     DLFKYSGKQSYLGSIDIDISFRARGKAVSTVFDQDELAKQFVRCYESQIFSPTQYLIM
                     EFQGHFFDLKIRNVQAIDLGDIEPTSAVATGIETKGILTKQTQINFFKGRDGLVNLKS
                     SNSLRPRSNAVIRPDFKFEDLGVGGLDKEFTKIFRRAFASRIFPPSVIEKLGISHVKG
                     LLLYGPPGTGKTLIARKIGTMLNAKEPKIVNGPEILSKYVGSSEENIRNLFKDAEAEY
                     RAKGEESSLHIIIFDELDSVFKQRGSRGDGTGVGDNVVNQLLAKMDGVDQLNNILVIG
                     MTNRKDLIDSALLRPGRFEVQVEIHLPDEKGRLQIFDIQTKKMRENNMMSDDVNLAEL
                     AALTKNFSGAEIEGLVKSASSFAINKTVNIGKGATKLNTKDIAKLKVTREDFLNALND
                     VTPAFGISEEDLKTCVEGGMMLYSERVNSILKNGARYVRQVRESDKSRLVSLLIHGPA
                     GSGKTALAAEIALKSGFPFIRLISPNELSGMSESAKIAYIDNTFRDAYKSPLNILVID
                     SLETLVDWVPIGPRFSNNILQMLKVALKRKPPQDRRLLIMTTTSAYSVLQQMDILSCF
                     DNEIAVPNMTNLDELNNVMIESNFLDDAGRVKVINELSRSCPNFNVGIKKTLTNIETA
                     RHDEDPVNELVELMTQSA"
ORIGIN      
        1 atgttcaaga tacctggttt tggaaaagct gctgcaaatc atactccacc agatatgaca
       61 aacatggata cccgtacacg ccatttaaag gtgtcaaact gtccaaataa ctcctatgca
      121 ctcgcaaacg tagctgctgt ctcaccaaat gatttcccta ataacattta tattattatc
      181 gataatttat ttgttttcac aactagacac tccaacgaca ttccaccggg aaccattgga
      241 tttaacggta accagcgtac ctggggtggt tggtccctaa atcaagacgt gcaagcaaaa
      301 gcatttgatt tattcaagta ttccggtaag caatcgtatc ttggttcaat agatatagat
      361 atctcattca gagctagagg taaggcggta agcacggtat tcgatcaaga tgagttagcc
      421 aaacaatttg ttcgttgcta cgaatctcaa atattttctc ccacccagta ccttatcatg
      481 gagttccaag gccatttctt tgacttaaaa attagaaatg tccaagcaat cgatttgggt
      541 gatattgaac caacctccgc tgttgcaact gggatagaga caaagggaat tttgacaaaa
      601 caaacacaaa ttaatttttt caaaggaaga gatggtttag ttaatttgaa atcatcaaat
      661 tcattaagac caagatcaaa tgctgtgatc agaccggatt tcaagtttga agatttgggt
      721 gtcggtggtt tggataaaga gtttactaaa attttcagaa gagcgtttgc aagtcgaatc
      781 tttcctcctt cagttataga aaaactgggt atttctcatg ttaaaggttt gctattgtac
      841 ggtcctccag gtactggtaa gaccttaatt gcaagaaaga ttggtacaat gctgaatgcc
      901 aaagagccca aaatcgtcaa tggtccagaa attttgagta agtacgttgg ttcttcagaa
      961 gaaaacattc gtaatttatt taaggatgca gaagcagaat atagggccaa gggtgaggaa
     1021 tcttccttac atattattat tttcgatgag ctggattctg ttttcaagca gagaggttca
     1081 agaggtgatg gtaccggtgt aggggacaat gtagttaatc aattgttagc taaaatggat
     1141 ggtgttgatc aattgaataa tattttggtt attggtatga ccaatcgtaa agatttaata
     1201 gacagtgctc ttttgcgtcc aggtagattt gaagtccaag ttgaaattca tttacccgat
     1261 gaaaaaggaa gactccaaat tttcgacatt cagacgaaga aaatgaggga aaataatatg
     1321 atgagcgacg atgttaactt agctgagtta gctgcgttaa caaaaaactt ctctggtgct
     1381 gagattgagg gtttagtgaa gagtgcaagt tcttttgcaa tcaacaaaac cgtcaacatc
     1441 gggaaaggtg ccacaaaact taacactaaa gatatagcaa aacttaaagt aacaagagaa
     1501 gactttttaa atgcactcaa cgatgttact cccgcttttg ggattagtga agaagatttg
     1561 aaaacatgtg tggaaggtgg aatgatgctt tattccgaac gagttaactc aatattgaag
     1621 aacggagccc gttacgtccg ccaagttcgc gagagtgata aatccaggtt agtatctcta
     1681 ttaatccacg gccctgcagg gtccggtaaa acagctttag ccgctgaaat tgctttaaaa
     1741 tctggattcc cattcatcag gttaatttct cccaacgagt tgtcaggcat gtcagaaagc
     1801 gcaaaaattg cctatattga taacactttc agagatgcgt ataaatctcc actaaacatt
     1861 cttgttattg attcgttaga gactctagtt gattgggtac caattggtcc aagattctct
     1921 aataacattt tacaaatgct aaaggttgca ttgaagcgta aacccccaca agaccgtcgt
     1981 ttattgatca tgactactac atcagcttat tcggtacttc aacaaatgga tatcttgagt
     2041 tgcttcgaca atgagatagc agttccaaat atgaccaatt tagatgaatt gaacaacgtc
     2101 atgatagaat caaactttct tgacgatgct ggtagagtta aagttattaa tgaattatca
     2161 aggagctgtc ctaacttcaa tgtcggtatt aaaaagacct tgaccaacat tgaaaccgca
     2221 aggcacgatg aagatcccgt gaacgagctt gttgagttga tgacccaatc cgcataa
//
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