LOCUS NM_001180572 2295 bp mRNA linear PLN 17-DEC-2024
DEFINITION Saccharomyces cerevisiae S288C palmitoyltransferase AKR1 (AKR1),
partial mRNA.
ACCESSION NM_001180572
VERSION NM_001180572.1
DBLINK BioProject: PRJNA128
KEYWORDS RefSeq.
SOURCE Saccharomyces cerevisiae S288C
ORGANISM Saccharomyces cerevisiae S288C
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
Saccharomyces.
REFERENCE 1 (bases 1 to 2295)
AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
Weng,S. and Cherry,J.M.
TITLE New data and collaborations at the Saccharomyces Genome Database:
updated reference genome, alleles, and the Alliance of Genome
Resources
JOURNAL Genetics 220 (4) (2022)
PUBMED 34897464
REFERENCE 2 (bases 1 to 2295)
AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P.,
Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C.,
Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F.,
Delaveau,T., del Rey,F., Dujon,B., Eide,L.G.,
Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et
al.
TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV
JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997)
PUBMED 9169867
REFERENCE 3 (bases 1 to 2295)
AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
Oliver,S.G.
TITLE Life with 6000 genes
JOURNAL Science 274 (5287), 546 (1996)
PUBMED 8849441
REFERENCE 4 (bases 1 to 2295)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (17-DEC-2024) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
REFERENCE 5 (bases 1 to 2295)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Protein update by submitter
REFERENCE 6 (bases 1 to 2295)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Protein update by submitter
REFERENCE 7 (bases 1 to 2295)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Protein update by submitter
REFERENCE 8 (bases 1 to 2295)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Sequence update by submitter
REFERENCE 9 (bases 1 to 2295)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
COMMENT REVIEWED REFSEQ: This record has been curated by SGD. This record
is derived from an annotated genomic sequence (NC_001136).
##Genome-Annotation-Data-START##
Annotation Provider :: SGD
Annotation Status :: Full Annotation
Annotation Version :: R64-4-1
URL :: http://www.yeastgenome.org/
##Genome-Annotation-Data-END##
COMPLETENESS: incomplete on both ends.
FEATURES Location/Qualifiers
source 1..2295
/organism="Saccharomyces cerevisiae S288C"
/mol_type="mRNA"
/strain="S288C"
/db_xref="taxon:559292"
/chromosome="IV"
gene <1..>2295
/gene="AKR1"
/locus_tag="YDR264C"
/db_xref="GeneID:851857"
CDS 1..2295
/gene="AKR1"
/locus_tag="YDR264C"
/EC_number="2.3.1.225"
/experiment="EXISTENCE:direct assay:GO:0005794 Golgi
apparatus [PMID:16647879]"
/experiment="EXISTENCE:direct assay:GO:0016409
palmitoyltransferase activity [PMID:12370247]"
/experiment="EXISTENCE:direct assay:GO:0018345 protein
palmitoylation [PMID:12370247|PMID:16227572]"
/experiment="EXISTENCE:genetic interaction:GO:0090029
negative regulation of pheromone-dependent signal
transduction involved in conjugation with cellular fusion
[PMID:8524293]"
/experiment="EXISTENCE:mutant phenotype:GO:0006612 protein
targeting to membrane [PMID:16227572]"
/experiment="EXISTENCE:mutant phenotype:GO:0018345 protein
palmitoylation [PMID:16751107|PMID:16227572]"
/experiment="EXISTENCE:mutant phenotype:GO:0030100
regulation of endocytosis [PMID:10866691]"
/experiment="EXISTENCE:mutant phenotype:GO:0090029
negative regulation of pheromone-dependent signal
transduction involved in conjugation with cellular fusion
[PMID:8649369]"
/experiment="EXISTENCE:physical interaction:GO:0031683
G-protein beta/gamma-subunit complex binding
[PMID:8649369]"
/note="Palmitoyl transferase involved in protein
palmitoylation; acts as a negative regulator of pheromone
response pathway; required for endocytosis of pheromone
receptors; involved in cell shape control; contains
ankyrin repeats; AKR1 has a paralog, AKR2, that arose from
the whole genome duplication; any of several human
homologs encoding DHHC-type zinc fingers (ZDHHC) can
complement temperature sensitivity of yeast akr1 null
mutant"
/codon_start=1
/product="palmitoyltransferase AKR1"
/protein_id="NP_010550.1"
/db_xref="GeneID:851857"
/db_xref="SGD:S000002672"
/translation="MVNELENVPRASTLTNEEQTVDPSNNDSQEDISLGDSNEITSLA
SLKAIRSGNEEESGNEQVNHNDEAEEDPLLTRYHTACQRGDLATVKEMIHGKLLEVNN
DGDSTEHITGLHWASINNRLSVVDFLVSQGADVNARAGALHATPLHWAARYGYVYIVD
FLLKHGADPTMTDDQGFNLLHLSVNSSNIMLVLYVLFNVVSKGLLDIDCRDPKGRTSL
LWAAYQGDSLTVAELLKFGASIKIADTEGFTPLHWGTVKGQPHVLKYLIQDGADFFQK
TDTGKDCFAIAQEMNTVYSLREALTHSGFDYHGYPIKKWFKKSQHAKLVTFITPFLFL
GIAFALFSHINPLFVIIVLFLLAIATNKGLNKFVLPSYGRMGVHNVTLLRSPLLSGVF
FGTLLWVTIVWFFKVMPRTFSDEQYTNILMLVILVSVFYLFGQLVIMDPGCLPEETDH
ENVRQTISNLLEIGKFDTKNFCIETWIRKPLRSKFSPLNNAVVARFDHYCPWIFNDVG
LKNHKAFIFFITLMESGIFTFLALCLEYFDELEDAHEDTSQKNGKCFILGASDLCSGL
IYDRFVFLILLWALLQSIWVASLIFVQAFQICKGMTNTEFNVLMKESKSIGPDGLSFN
ENFNTTPEGFAPSIDPGEESNDTVLAPVPGSTIRKPRTCFGVCYAVTGMDQWLAVIKE
TIGIKDSTGHNVYSITSRIPTNYGWKRNVKDFWLTSDINAPLWRRILYPPSGSKALLN
GIEVDYFKLYKLPNKDVEQGNDMV"
ORIGIN
1 atggtgaacg aattagagaa tgtgccacgg gcgtcgacct tgacgaatga agagcaaacg
61 gttgatccta gcaataacga ctcacaggaa gatattagtc tgggtgattc taacgaaatt
121 acttcgttgg catcattaaa ggctatccga tcaggaaatg aagaggaaag cgggaacgag
181 caggtgaatc ataatgatga ggccgaagaa gatcctctgt taactcgcta ccataccgct
241 tgccaaagag gtgatctagc gactgtcaaa gaaatgatac atggaaagtt gctcgaagtt
301 aataacgacg gtgactctac ggaacatatc actggtttgc attgggcaag tattaataac
361 agactttctg tagtggattt tctagtttca caaggcgctg atgtcaatgc aagggctggt
421 gctttgcatg ccacaccatt acattgggct gcaaggtatg ggtacgtgta cattgtcgat
481 tttttgctta agcatggagc tgatcccacc atgaccgatg accaaggttt caatctacta
541 cacttatctg tgaacagctc aaatataatg ctagttctat acgttttatt caacgttgtc
601 agcaaaggtc ttttagatat agattgccga gacccaaagg gcagaacttc actactatgg
661 gctgcttacc agggagattc cctaactgta gcagaattgt tgaaatttgg tgccagcata
721 aagatcgcag atacagaagg attcacccca ctgcactggg gcactgtaaa agggcaacca
781 catgtactaa aatacttgat tcaagatggt gcagattttt tccaaaaaac ggataccgga
841 aaagattgct ttgctattgc tcaagaaatg aacactgtgt actcacttag agaggctcta
901 acacattctg gattcgacta ccatggttat cccattaaaa aatggttcaa aaaaagtcaa
961 catgctaagc tcgttacatt cataacgcca tttctatttc taggaatcgc atttgctctt
1021 ttctctcata ttaacccttt gtttgtaatc attgtccttt ttttattggc cattgccact
1081 aacaaaggct tgaacaaatt cgttctgccg tcatatggac gaatgggtgt ccacaacgtt
1141 accttgttaa ggtcaccttt gttatccggt gttttttttg gcactttact ttgggtgact
1201 atcgtttggt ttttcaaagt tatgcctcga acattttctg atgaacaata tactaacatc
1261 ctaatgctgg taatacttgt ttctgtattt tacctttttg ggcagcttgt tattatggac
1321 ccaggatgtt tgccagaaga aactgatcat gagaacgtgc gacaaacaat ctcgaacttg
1381 ctcgaaatcg gtaaatttga tacgaagaac ttttgtatcg aaacttggat tagaaaacct
1441 ctaagaagca aattttcgcc cttaaacaat gctgtggttg caagatttga tcattactgc
1501 ccttggatct ttaatgatgt cggactcaaa aatcacaaag catttatatt ttttattaca
1561 ttaatggaaa gtggtatttt cacatttctt gcactttgcc tggaatattt tgatgaactt
1621 gaagatgcac acgaagatac atcccagaaa aatggcaaat gtttcatcct aggcgcttca
1681 gatctctgtt cgggattaat atatgataga tttgtctttc tgatattatt atgggcttta
1741 ctccaatcta tttgggttgc aagtttgatc ttcgtccaag cctttcaaat atgtaaagga
1801 atgaccaata cagaattcaa tgttttgatg aaagagagta agtccattgg ccccgatggg
1861 ttatctttca atgaaaactt caatactact ccagaaggat ttgcgccgtc gattgatccg
1921 ggtgaggaga gtaatgatac tgtactagca ccagtcccag gctcaacgat aaggaaacca
1981 cgcacttgtt ttggcgtttg ttacgcggtg actggtatgg atcagtggtt agcggttata
2041 aaagaaacca ttggcatcaa ggatagcacc ggacataatg tgtattcgat tacatcaaga
2101 ataccaacaa attacggttg gaaaagaaat gttaaagact tttggcttac aagcgatata
2161 aatgcgcctt tgtggaggcg aattttgtat cctccttcgg gctctaaagc tttgctcaac
2221 gggatagaag ttgactattt taagctttac aaattgccaa ataaggatgt tgaacaagga
2281 aatgatatgg tatga
//