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Saccharomyces cerevisiae S288C palmitoyltransferase AKR1 (AKR1), partial mRNA

NCBI Reference Sequence: NM_001180572.1

FASTA Graphics 

LOCUS       NM_001180572            2295 bp    mRNA    linear   PLN 17-DEC-2024
DEFINITION  Saccharomyces cerevisiae S288C palmitoyltransferase AKR1 (AKR1),
            partial mRNA.
ACCESSION   NM_001180572
VERSION     NM_001180572.1
DBLINK      BioProject: PRJNA128
KEYWORDS    RefSeq.
SOURCE      Saccharomyces cerevisiae S288C
  ORGANISM  Saccharomyces cerevisiae S288C
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
            Saccharomyces.
REFERENCE   1  (bases 1 to 2295)
  AUTHORS   Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
            Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
            Weng,S. and Cherry,J.M.
  TITLE     New data and collaborations at the Saccharomyces Genome Database:
            updated reference genome, alleles, and the Alliance of Genome
            Resources
  JOURNAL   Genetics 220 (4) (2022)
   PUBMED   34897464
REFERENCE   2  (bases 1 to 2295)
  AUTHORS   Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P.,
            Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C.,
            Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F.,
            Delaveau,T., del Rey,F., Dujon,B., Eide,L.G.,
            Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et
            al.
  TITLE     The nucleotide sequence of Saccharomyces cerevisiae chromosome IV
  JOURNAL   Nature 387 (6632 SUPPL), 75-78 (1997)
   PUBMED   9169867
REFERENCE   3  (bases 1 to 2295)
  AUTHORS   Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
            Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
            Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
            Oliver,S.G.
  TITLE     Life with 6000 genes
  JOURNAL   Science 274 (5287), 546 (1996)
   PUBMED   8849441
REFERENCE   4  (bases 1 to 2295)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (17-DEC-2024) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (bases 1 to 2295)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (16-JAN-2015) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   6  (bases 1 to 2295)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (06-FEB-2013) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   7  (bases 1 to 2295)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (04-MAY-2012) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   8  (bases 1 to 2295)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (31-MAR-2011) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Sequence update by submitter
REFERENCE   9  (bases 1 to 2295)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (11-DEC-2009) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by SGD. This record
            is derived from an annotated genomic sequence (NC_001136).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: SGD
            Annotation Status   :: Full Annotation
            Annotation Version  :: R64-4-1
            URL                 :: http://www.yeastgenome.org/
            ##Genome-Annotation-Data-END##
            COMPLETENESS: incomplete on both ends.
FEATURES             Location/Qualifiers
     source          1..2295
                     /organism="Saccharomyces cerevisiae S288C"
                     /mol_type="mRNA"
                     /strain="S288C"
                     /db_xref="taxon:559292"
                     /chromosome="IV"
     gene            <1..>2295
                     /gene="AKR1"
                     /locus_tag="YDR264C"
                     /db_xref="GeneID:851857"
     CDS             1..2295
                     /gene="AKR1"
                     /locus_tag="YDR264C"
                     /EC_number="2.3.1.225"
                     /experiment="EXISTENCE:direct assay:GO:0005794 Golgi
                     apparatus [PMID:16647879]"
                     /experiment="EXISTENCE:direct assay:GO:0016409
                     palmitoyltransferase activity [PMID:12370247]"
                     /experiment="EXISTENCE:direct assay:GO:0018345 protein
                     palmitoylation [PMID:12370247|PMID:16227572]"
                     /experiment="EXISTENCE:genetic interaction:GO:0090029
                     negative regulation of pheromone-dependent signal
                     transduction involved in conjugation with cellular fusion
                     [PMID:8524293]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0006612 protein
                     targeting to membrane [PMID:16227572]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0018345 protein
                     palmitoylation [PMID:16751107|PMID:16227572]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0030100
                     regulation of endocytosis [PMID:10866691]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0090029
                     negative regulation of pheromone-dependent signal
                     transduction involved in conjugation with cellular fusion
                     [PMID:8649369]"
                     /experiment="EXISTENCE:physical interaction:GO:0031683
                     G-protein beta/gamma-subunit complex binding
                     [PMID:8649369]"
                     /note="Palmitoyl transferase involved in protein
                     palmitoylation; acts as a negative regulator of pheromone
                     response pathway; required for endocytosis of pheromone
                     receptors; involved in cell shape control; contains
                     ankyrin repeats; AKR1 has a paralog, AKR2, that arose from
                     the whole genome duplication; any of several human
                     homologs encoding DHHC-type zinc fingers (ZDHHC) can
                     complement temperature sensitivity of yeast akr1 null
                     mutant"
                     /codon_start=1
                     /product="palmitoyltransferase AKR1"
                     /protein_id="NP_010550.1"
                     /db_xref="GeneID:851857"
                     /db_xref="SGD:S000002672"
                     /translation="MVNELENVPRASTLTNEEQTVDPSNNDSQEDISLGDSNEITSLA
                     SLKAIRSGNEEESGNEQVNHNDEAEEDPLLTRYHTACQRGDLATVKEMIHGKLLEVNN
                     DGDSTEHITGLHWASINNRLSVVDFLVSQGADVNARAGALHATPLHWAARYGYVYIVD
                     FLLKHGADPTMTDDQGFNLLHLSVNSSNIMLVLYVLFNVVSKGLLDIDCRDPKGRTSL
                     LWAAYQGDSLTVAELLKFGASIKIADTEGFTPLHWGTVKGQPHVLKYLIQDGADFFQK
                     TDTGKDCFAIAQEMNTVYSLREALTHSGFDYHGYPIKKWFKKSQHAKLVTFITPFLFL
                     GIAFALFSHINPLFVIIVLFLLAIATNKGLNKFVLPSYGRMGVHNVTLLRSPLLSGVF
                     FGTLLWVTIVWFFKVMPRTFSDEQYTNILMLVILVSVFYLFGQLVIMDPGCLPEETDH
                     ENVRQTISNLLEIGKFDTKNFCIETWIRKPLRSKFSPLNNAVVARFDHYCPWIFNDVG
                     LKNHKAFIFFITLMESGIFTFLALCLEYFDELEDAHEDTSQKNGKCFILGASDLCSGL
                     IYDRFVFLILLWALLQSIWVASLIFVQAFQICKGMTNTEFNVLMKESKSIGPDGLSFN
                     ENFNTTPEGFAPSIDPGEESNDTVLAPVPGSTIRKPRTCFGVCYAVTGMDQWLAVIKE
                     TIGIKDSTGHNVYSITSRIPTNYGWKRNVKDFWLTSDINAPLWRRILYPPSGSKALLN
                     GIEVDYFKLYKLPNKDVEQGNDMV"
ORIGIN      
        1 atggtgaacg aattagagaa tgtgccacgg gcgtcgacct tgacgaatga agagcaaacg
       61 gttgatccta gcaataacga ctcacaggaa gatattagtc tgggtgattc taacgaaatt
      121 acttcgttgg catcattaaa ggctatccga tcaggaaatg aagaggaaag cgggaacgag
      181 caggtgaatc ataatgatga ggccgaagaa gatcctctgt taactcgcta ccataccgct
      241 tgccaaagag gtgatctagc gactgtcaaa gaaatgatac atggaaagtt gctcgaagtt
      301 aataacgacg gtgactctac ggaacatatc actggtttgc attgggcaag tattaataac
      361 agactttctg tagtggattt tctagtttca caaggcgctg atgtcaatgc aagggctggt
      421 gctttgcatg ccacaccatt acattgggct gcaaggtatg ggtacgtgta cattgtcgat
      481 tttttgctta agcatggagc tgatcccacc atgaccgatg accaaggttt caatctacta
      541 cacttatctg tgaacagctc aaatataatg ctagttctat acgttttatt caacgttgtc
      601 agcaaaggtc ttttagatat agattgccga gacccaaagg gcagaacttc actactatgg
      661 gctgcttacc agggagattc cctaactgta gcagaattgt tgaaatttgg tgccagcata
      721 aagatcgcag atacagaagg attcacccca ctgcactggg gcactgtaaa agggcaacca
      781 catgtactaa aatacttgat tcaagatggt gcagattttt tccaaaaaac ggataccgga
      841 aaagattgct ttgctattgc tcaagaaatg aacactgtgt actcacttag agaggctcta
      901 acacattctg gattcgacta ccatggttat cccattaaaa aatggttcaa aaaaagtcaa
      961 catgctaagc tcgttacatt cataacgcca tttctatttc taggaatcgc atttgctctt
     1021 ttctctcata ttaacccttt gtttgtaatc attgtccttt ttttattggc cattgccact
     1081 aacaaaggct tgaacaaatt cgttctgccg tcatatggac gaatgggtgt ccacaacgtt
     1141 accttgttaa ggtcaccttt gttatccggt gttttttttg gcactttact ttgggtgact
     1201 atcgtttggt ttttcaaagt tatgcctcga acattttctg atgaacaata tactaacatc
     1261 ctaatgctgg taatacttgt ttctgtattt tacctttttg ggcagcttgt tattatggac
     1321 ccaggatgtt tgccagaaga aactgatcat gagaacgtgc gacaaacaat ctcgaacttg
     1381 ctcgaaatcg gtaaatttga tacgaagaac ttttgtatcg aaacttggat tagaaaacct
     1441 ctaagaagca aattttcgcc cttaaacaat gctgtggttg caagatttga tcattactgc
     1501 ccttggatct ttaatgatgt cggactcaaa aatcacaaag catttatatt ttttattaca
     1561 ttaatggaaa gtggtatttt cacatttctt gcactttgcc tggaatattt tgatgaactt
     1621 gaagatgcac acgaagatac atcccagaaa aatggcaaat gtttcatcct aggcgcttca
     1681 gatctctgtt cgggattaat atatgataga tttgtctttc tgatattatt atgggcttta
     1741 ctccaatcta tttgggttgc aagtttgatc ttcgtccaag cctttcaaat atgtaaagga
     1801 atgaccaata cagaattcaa tgttttgatg aaagagagta agtccattgg ccccgatggg
     1861 ttatctttca atgaaaactt caatactact ccagaaggat ttgcgccgtc gattgatccg
     1921 ggtgaggaga gtaatgatac tgtactagca ccagtcccag gctcaacgat aaggaaacca
     1981 cgcacttgtt ttggcgtttg ttacgcggtg actggtatgg atcagtggtt agcggttata
     2041 aaagaaacca ttggcatcaa ggatagcacc ggacataatg tgtattcgat tacatcaaga
     2101 ataccaacaa attacggttg gaaaagaaat gttaaagact tttggcttac aagcgatata
     2161 aatgcgcctt tgtggaggcg aattttgtat cctccttcgg gctctaaagc tttgctcaac
     2221 gggatagaag ttgactattt taagctttac aaattgccaa ataaggatgt tgaacaagga
     2281 aatgatatgg tatga
//
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