LOCUS NM_001182894 852 bp mRNA linear PLN 17-DEC-2024
DEFINITION Saccharomyces cerevisiae S288C porin POR1 (POR1), partial mRNA.
ACCESSION NM_001182894
VERSION NM_001182894.1
DBLINK BioProject: PRJNA128
KEYWORDS RefSeq.
SOURCE Saccharomyces cerevisiae S288C
ORGANISM Saccharomyces cerevisiae S288C
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
Saccharomyces.
REFERENCE 1 (bases 1 to 852)
AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
Weng,S. and Cherry,J.M.
TITLE New data and collaborations at the Saccharomyces Genome Database:
updated reference genome, alleles, and the Alliance of Genome
Resources
JOURNAL Genetics 220 (4) (2022)
PUBMED 34897464
REFERENCE 2 (bases 1 to 852)
AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K.,
Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R.,
Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P.,
Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F.,
Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A.,
Hani,J. et al.
TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV
and its evolutionary implications
JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997)
PUBMED 9169873
REFERENCE 3 (bases 1 to 852)
AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
Oliver,S.G.
TITLE Life with 6000 genes
JOURNAL Science 274 (5287), 546 (1996)
PUBMED 8849441
REFERENCE 4 (bases 1 to 852)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (17-DEC-2024) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
REFERENCE 5 (bases 1 to 852)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Protein update by submitter
REFERENCE 6 (bases 1 to 852)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Sequence update by submitter
REFERENCE 7 (bases 1 to 852)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Sequence update by submitter
REFERENCE 8 (bases 1 to 852)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
COMMENT REVIEWED REFSEQ: This record has been curated by SGD. This record
is derived from an annotated genomic sequence (NC_001146).
##Genome-Annotation-Data-START##
Annotation Provider :: SGD
Annotation Status :: Full Annotation
Annotation Version :: R64-4-1
URL :: http://www.yeastgenome.org/
##Genome-Annotation-Data-END##
COMPLETENESS: incomplete on both ends.
FEATURES Location/Qualifiers
source 1..852
/organism="Saccharomyces cerevisiae S288C"
/mol_type="mRNA"
/strain="S288C"
/db_xref="taxon:559292"
/chromosome="XIV"
gene <1..>852
/gene="POR1"
/locus_tag="YNL055C"
/gene_synonym="OMP2"
/db_xref="GeneID:855669"
CDS 1..852
/gene="POR1"
/locus_tag="YNL055C"
/gene_synonym="OMP2"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:22842922]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005741
mitochondrial outer membrane
[PMID:7499333|PMID:16689936|PMID:16407407]"
/experiment="EXISTENCE:direct assay:GO:0006811 monoatomic
ion transport [PMID:9593723]"
/experiment="EXISTENCE:direct assay:GO:0008308
voltage-gated monoatomic anion channel activity
[PMID:9593723]"
/experiment="EXISTENCE:direct assay:GO:0017128
phospholipid scramblase activity [PMID:38065946]"
/experiment="EXISTENCE:direct assay:GO:0048039 ubiquinone
binding [PMID:38906315|PMID:28051849]"
/experiment="EXISTENCE:mutant phenotype:GO:0005741
mitochondrial outer membrane [PMID:38065946]"
/experiment="EXISTENCE:mutant phenotype:GO:0006915
apoptotic process [PMID:17822411]"
/experiment="EXISTENCE:mutant phenotype:GO:0007005
mitochondrion organization [PMID:11488609]"
/experiment="EXISTENCE:mutant phenotype:GO:0042307
positive regulation of protein import into nucleus
[PMID:29359182]"
/experiment="EXISTENCE:mutant phenotype:GO:0045332
phospholipid translocation [PMID:38065946]"
/experiment="EXISTENCE:mutant phenotype:GO:0045454 cell
redox homeostasis [PMID:18768136]"
/experiment="EXISTENCE:mutant phenotype:GO:0051027 DNA
transport [PMID:19056337]"
/experiment="EXISTENCE:physical interaction:GO:0005739
mitochondrion [PMID:16962558]"
/experiment="EXISTENCE:physical interaction:GO:0044289
mitochondrial inner-outer membrane contact site
[PMID:37073556]"
/note="Mitochondrial porin and phospholipid scramblase;
voltage-dependent anion channel in the outer mitochondrial
membrane required for maintenance of mitochondrial osmotic
stability and membrane permeability; scramblase involved
in mitochondrial transbilayer translocation of
phospholipids; ubiquinone binding protein; couples
glutathione pools of the intermembrane space and the
cytosol; phosphorylated; protein abundance increases in
response to DNA replication stress; orthologous to human
VDAC1 and 2"
/codon_start=1
/product="porin POR1"
/protein_id="NP_014343.1"
/db_xref="GeneID:855669"
/db_xref="SGD:S000005000"
/translation="MSPPVYSDISRNINDLLNKDFYHATPAAFDVQTTTANGIKFSLK
AKQPVKDGPLSTNVEAKLNDKQTGLGLTQGWSNTNNLQTKLEFANLTPGLKNELITSL
TPGVAKSAVLNTTFTQPFFTARGAFDLCLKSPTFVGDLTMAHEGIVGGAEFGYDISAG
SISRYAMALSYFAKDYSLGATLNNEQITTVDFFQNVNAFLQVGAKATMNCKLPNSNVN
IEFATRYLPDASSQVKAKVSDSGIVTLAYKQLLRPGVTLGVGSSFDALKLSEPVHKLG
WSLSFDA"
ORIGIN
1 atgtctcctc cagtttacag cgatatctcc agaaatatca atgacctatt gaacaaggat
61 ttctatcatg ctaccccagc tgcctttgat gtgcaaacaa caaccgccaa tggcattaag
121 ttctcattga aggctaaaca gcctgtcaaa gacggtccac tgtctactaa cgtggaagca
181 aagttgaatg acaagcaaac cggcttgggt ctaactcaag gctggtctaa cacaaacaac
241 ttgcaaacca aattagagtt tgccaacttg acccctggtc taaagaacga attgatcact
301 tctttgactc caggcgtcgc caagtccgcc gtcttaaaca ctacgttcac acaacctttc
361 ttcaccgcaa gaggtgcctt tgacttgtgt ttgaagtcac caacatttgt tggtgactta
421 actatggccc acgaaggtat tgttggtggc gcagagtttg gttacgatat cagcgccggt
481 tccatttctc gttatgccat ggctttaagt tatttcgcca aagactactc cttgggcgct
541 acattgaaca acgagcaaat aactaccgtt gacttcttcc aaaacgtcaa cgccttttta
601 caggtcggtg ctaaggctac aatgaactgc aaactaccta actccaatgt caacatcgaa
661 ttcgccacta gatatttgcc tgatgcatct tcccaagtta aggctaaggt gtccgattcc
721 ggtattgtca ctttggctta caagcaattg ttaagacctg gcgtcactct gggtgtcggt
781 tcctctttcg atgctttgaa gttgtctgaa cctgttcaca agctaggttg gtctttgtcc
841 ttcgacgctt ga
//