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Mus musculus tight junction associated protein 1 (Tjap1), transcript variant 2, mRNA

NCBI Reference Sequence: NM_001252473.1

FASTA Graphics 

LOCUS       NM_001252473            2465 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus tight junction associated protein 1 (Tjap1),
            transcript variant 2, mRNA.
ACCESSION   NM_001252473
VERSION     NM_001252473.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2465)
  AUTHORS   Tamaki,H., Sanda,M., Katsumata,O., Hara,Y., Fukaya,M. and
            Sakagami,H.
  TITLE     Pilt is a coiled-coil domain-containing protein that localizes at
            the trans-Golgi complex and regulates its structure
  JOURNAL   FEBS Lett 586 (19), 3064-3070 (2012)
   PUBMED   22841714
REFERENCE   2  (bases 1 to 2465)
  AUTHORS   Kawabe,H., Nakanishi,H., Asada,M., Fukuhara,A., Morimoto,K.,
            Takeuchi,M. and Takai,Y.
  TITLE     Pilt, a novel peripheral membrane protein at tight junctions in
            epithelial cells
  JOURNAL   J Biol Chem 276 (51), 48350-48355 (2001)
   PUBMED   11602598
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116739.13.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK169889.1, SRR13948564.534880.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AC116739.13        10675-10741
            68-161              AC116739.13        11262-11355
            162-257             AC116739.13        28723-28818
            258-382             AC116739.13        29888-30012
            383-411             AC116739.13        31271-31299
            412-573             AC116739.13        32121-32282
            574-640             AC116739.13        32499-32565
            641-748             AC116739.13        33499-33606
            749-832             AC116739.13        33681-33764
            833-2465            AC116739.13        34218-35850
FEATURES             Location/Qualifiers
     source          1..2465
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 22.9 cM"
     gene            1..2465
                     /gene="Tjap1"
                     /gene_synonym="0610041D19Rik; Pilt; Tjp4"
                     /note="tight junction associated protein 1"
                     /db_xref="GeneID:74094"
                     /db_xref="MGI:MGI:1921344"
     exon            1..67
                     /gene="Tjap1"
                     /gene_synonym="0610041D19Rik; Pilt; Tjp4"
                     /inference="alignment:Splign:2.1.0"
     exon            68..161
                     /gene="Tjap1"
                     /gene_synonym="0610041D19Rik; Pilt; Tjp4"
                     /inference="alignment:Splign:2.1.0"
     exon            162..257
                     /gene="Tjap1"
                     /gene_synonym="0610041D19Rik; Pilt; Tjp4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    215..217
                     /gene="Tjap1"
                     /gene_synonym="0610041D19Rik; Pilt; Tjp4"
                     /note="upstream in-frame stop codon"
     exon            258..382
                     /gene="Tjap1"
                     /gene_synonym="0610041D19Rik; Pilt; Tjp4"
                     /inference="alignment:Splign:2.1.0"
     CDS             284..1903
                     /gene="Tjap1"
                     /gene_synonym="0610041D19Rik; Pilt; Tjp4"
                     /note="tight junction protein 4 (peripheral); hdlg-binding
                     protein Pilt; protein incorporated later into tight
                     junctions"
                     /codon_start=1
                     /product="tight junction-associated protein 1"
                     /protein_id="NP_001239402.1"
                     /db_xref="CCDS:CCDS28824.1"
                     /db_xref="GeneID:74094"
                     /db_xref="MGI:MGI:1921344"
                     /translation="MSSAAPAKKPYRKAPPEHRELRLEIPVSRLEQEESLTDAERMKL
                     LQQENEELRKRLASATRRTEALERELEIGQDCLELELGQSREELDKFKDKFRRLQNSY
                     TASQRTNQELEDKLHALIKKAEMDRKTLDWEIVELTNKLLDARNTINKLEELNERYRL
                     DCNLAVQLLKCNKSHFRNHKLADLPCELQDMVRKHLRSGQEVASPSPSPSSSLSPGAV
                     VPTSVIARVLEKPESLLLNSAQSGSAGRPLAEDVFVHVDMSGGDPASPPAPGSPNGEC
                     CSVSTAGGSPEEELPLPAFDKLSPYPTPSPPHPLYPGRKVIEFSEDKIRIPRNSPLPN
                     CTYATRQAISLSLVEDGSERAHRSSVPSSPASAQGSPHHQPSPAPSALSAPASSASSE
                     EDLLASWQRAFVDRTPPPAAVVQRTAFGRDSLPELQLHFSPGHSTAPPPSPHRERGLV
                     LPAEPDSGFPQDEEEEMLNLPVSPEEERQSLLPDKEGTEEASGPSHVDGRAWPLPSPS
                     RPQRSPKRMGVHHLHRKDSLTQAQEQGTVLS"
     misc_feature    284..385
                     /gene="Tjap1"
                     /gene_synonym="0610041D19Rik; Pilt; Tjp4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9DCD5.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    872..931
                     /gene="Tjap1"
                     /gene_synonym="0610041D19Rik; Pilt; Tjp4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9DCD5.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1049..1219
                     /gene="Tjap1"
                     /gene_synonym="0610041D19Rik; Pilt; Tjp4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9DCD5.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1136..1138
                     /gene="Tjap1"
                     /gene_synonym="0610041D19Rik; Pilt; Tjp4"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5JTD0; propagated from
                     UniProtKB/Swiss-Prot (Q9DCD5.2); phosphorylation site"
     misc_feature    1190..1192
                     /gene="Tjap1"
                     /gene_synonym="0610041D19Rik; Pilt; Tjp4"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q5JTD0; propagated from
                     UniProtKB/Swiss-Prot (Q9DCD5.2); phosphorylation site"
     misc_feature    1196..1198
                     /gene="Tjap1"
                     /gene_synonym="0610041D19Rik; Pilt; Tjp4"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5JTD0; propagated from
                     UniProtKB/Swiss-Prot (Q9DCD5.2); phosphorylation site"
     misc_feature    1271..1273
                     /gene="Tjap1"
                     /gene_synonym="0610041D19Rik; Pilt; Tjp4"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5JTD0; propagated from
                     UniProtKB/Swiss-Prot (Q9DCD5.2); phosphorylation site"
     misc_feature    1328..1465
                     /gene="Tjap1"
                     /gene_synonym="0610041D19Rik; Pilt; Tjp4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9DCD5.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1481..1540
                     /gene="Tjap1"
                     /gene_synonym="0610041D19Rik; Pilt; Tjp4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9DCD5.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1502..1504
                     /gene="Tjap1"
                     /gene_synonym="0610041D19Rik; Pilt; Tjp4"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:19131326,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9DCD5.2); phosphorylation site"
     misc_feature    1553..1900
                     /gene="Tjap1"
                     /gene_synonym="0610041D19Rik; Pilt; Tjp4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9DCD5.2);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1700..1702
                     /gene="Tjap1"
                     /gene_synonym="0610041D19Rik; Pilt; Tjp4"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5JTD0; propagated from
                     UniProtKB/Swiss-Prot (Q9DCD5.2); phosphorylation site"
     misc_feature    1862..1864
                     /gene="Tjap1"
                     /gene_synonym="0610041D19Rik; Pilt; Tjp4"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9DCD5.2); phosphorylation site"
     exon            383..411
                     /gene="Tjap1"
                     /gene_synonym="0610041D19Rik; Pilt; Tjp4"
                     /inference="alignment:Splign:2.1.0"
     exon            412..573
                     /gene="Tjap1"
                     /gene_synonym="0610041D19Rik; Pilt; Tjp4"
                     /inference="alignment:Splign:2.1.0"
     exon            574..640
                     /gene="Tjap1"
                     /gene_synonym="0610041D19Rik; Pilt; Tjp4"
                     /inference="alignment:Splign:2.1.0"
     exon            641..748
                     /gene="Tjap1"
                     /gene_synonym="0610041D19Rik; Pilt; Tjp4"
                     /inference="alignment:Splign:2.1.0"
     exon            749..832
                     /gene="Tjap1"
                     /gene_synonym="0610041D19Rik; Pilt; Tjp4"
                     /inference="alignment:Splign:2.1.0"
     exon            833..2465
                     /gene="Tjap1"
                     /gene_synonym="0610041D19Rik; Pilt; Tjp4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2420..2425
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tjap1"
                     /gene_synonym="0610041D19Rik; Pilt; Tjp4"
                     /note="hexamer: AATAAA"
     polyA_site      2442
                     /gene="Tjap1"
                     /gene_synonym="0610041D19Rik; Pilt; Tjp4"
                     /note="major polyA site"
ORIGIN      
        1 ggtccaggcc cctacccggc ctgccccgcg gcaagatggc tgcctgaagg agaggccccg
       61 gcagaaactt gaagacccaa gggccccagg gactggaaga aatcacattg cctgcttgga
      121 aagaagaggt agcaacttgc cccagcccaa ccccagagcg ggagctcttg gctagaggaa
      181 gtagaggggc cgtgggatgt ggagagccga aggctgattc caggagagca gaacagagag
      241 ctgccagcga acagacgcag gagacgagcc cataccttcc aggatgagca gtgctgcccc
      301 tgctaagaaa ccttaccgta aggcgcctcc agagcaccga gagctacgcc tggagattcc
      361 cgtgtcccgg ctcgagcaag aggagtccct gactgacgca gagcggatga aacttttgca
      421 gcaggagaat gaagaacttc gcaaacgcct ggcctcagct accagacgca ctgaggcctt
      481 ggagcgggag ctggaaatag gacaagactg cctagaactg gagttaggac agagccgtga
      541 ggagctggac aagtttaagg acaaattccg caggctacag aacagctaca cggcatccca
      601 gcggaccaac caggaactgg aggacaagct gcacgcactg atcaagaagg ctgagatgga
      661 caggaagacg ctggactggg agattgtgga gctgaccaac aagctactgg atgccaggaa
      721 caccatcaat aaactggaag agctcaatga gcggtaccgg ctggactgca acctggcggt
      781 gcagcttctc aagtgcaaca agtcccactt ccggaaccac aagcttgctg acctaccctg
      841 tgagctccag gacatggttc gaaaacatct gcgcagtggg caggaggttg ccagccccag
      901 ccccagccct tcttccagcc tgtccccagg ggctgtggtg cctacctcag tcattgcccg
      961 ggtgttggag aaacctgagt ctctcttgct caattcagct cagtctggca gtgctgggcg
     1021 ccccttggct gaggatgtat tcgtgcatgt ggacatgagt gggggtgacc cagccagccc
     1081 ccctgccccg ggcagcccca atggggagtg ttgctcagtg agtactgcag ggggctcccc
     1141 ggaggaggag ctgcccctgc cagccttcga caagttgagt ccctacccta ccccgtctcc
     1201 accacaccca ttataccctg gtaggaaggt gatagaattc tctgaggaca agatccgaat
     1261 tcctcggaac agccccctcc ccaactgtac ctatgccacc cggcaggcca tctccttgag
     1321 cctggtggag gacggcagtg agcgggccca ccgcagctca gtgcctagca gtcctgcctc
     1381 tgcccaaggg tcgccccatc accagcctag tccagctccc tcagcactga gtgccccagc
     1441 tagttcggcc agctcggagg aggacctgct ggccagctgg cagcgtgcat ttgtggaccg
     1501 caccccgccc cctgctgccg tggtccagcg cacggccttt ggacgagact cactgcccga
     1561 gctacaattg catttctccc cgggccactc cacagcccca ccgccttccc cgcaccgtga
     1621 gcggggactt gtgctgccag cagaacctga ctctggcttt cctcaagacg aggaagagga
     1681 aatgctgaac ctgcctgtca gccccgagga agagcgtcag agcctgctgc ctgataaaga
     1741 gggcaccgag gaggcctctg gcccttctca tgttgatggc agggcctggc ctctccccag
     1801 tcccagccgc ccccagcgca gccccaagag aatgggagta caccatctcc accgcaagga
     1861 cagcctgacg caggcacagg agcagggcac tgtgctcagc tagacctgcc tgccttctgc
     1921 caccacctca gggctgcaga tggcccagac tctccctaca gacctgggca gctcagccag
     1981 tggggcccac atcaatcctt ggagctgcgt ttgcactaat gggtgccagc ttgccatcat
     2041 catttttgtt tccttttcct ttgaaatatt tattctccaa ggtaacaagt catttgggcc
     2101 ccaagctctt ccaccatcca gtccgtccgt aagggacggg cggtgggctt gtcagttttc
     2161 ctttcccagc tcctttctca ttgagagctc tggttggtag gggagggtgt cgttggtgct
     2221 gctgacctct attcctctgc ctctgcgtgg gctgctctta ggcctgctca gctggcccca
     2281 gagacaaggg tggactcact cagggctccc ccttccagag ggagggcgtg acttctgggg
     2341 cctggcccca ttcttaacct tggctctaga ctgttactcc cagatttggg aagttttcac
     2401 aatgactatt ttaaaatcaa ataaaactta ttttacaggt aaggcttaat ttctttctcc
     2461 ttccc
//
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