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NCBI Reference Sequence: NM_001252473.1
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LOCUS NM_001252473 2465 bp mRNA linear ROD 04-JUN-2024 DEFINITION Mus musculus tight junction associated protein 1 (Tjap1), transcript variant 2, mRNA. ACCESSION NM_001252473 VERSION NM_001252473.1 KEYWORDS RefSeq. SOURCE Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. REFERENCE 1 (bases 1 to 2465) AUTHORS Tamaki,H., Sanda,M., Katsumata,O., Hara,Y., Fukaya,M. and Sakagami,H. TITLE Pilt is a coiled-coil domain-containing protein that localizes at the trans-Golgi complex and regulates its structure JOURNAL FEBS Lett 586 (19), 3064-3070 (2012) PUBMED 22841714 REFERENCE 2 (bases 1 to 2465) AUTHORS Kawabe,H., Nakanishi,H., Asada,M., Fukuhara,A., Morimoto,K., Takeuchi,M. and Takai,Y. TITLE Pilt, a novel peripheral membrane protein at tight junctions in epithelial cells JOURNAL J Biol Chem 276 (51), 48350-48355 (2001) PUBMED 11602598 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC116739.13. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AK169889.1, SRR13948564.534880.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375 [ECO:0006172] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-67 AC116739.13 10675-10741 68-161 AC116739.13 11262-11355 162-257 AC116739.13 28723-28818 258-382 AC116739.13 29888-30012 383-411 AC116739.13 31271-31299 412-573 AC116739.13 32121-32282 574-640 AC116739.13 32499-32565 641-748 AC116739.13 33499-33606 749-832 AC116739.13 33681-33764 833-2465 AC116739.13 34218-35850 FEATURES Location/Qualifiers source 1..2465 /organism="Mus musculus" /mol_type="mRNA" /strain="C57BL/6" /db_xref="taxon:10090" /chromosome="17" /map="17 22.9 cM" gene 1..2465 /gene="Tjap1" /gene_synonym="0610041D19Rik; Pilt; Tjp4" /note="tight junction associated protein 1" /db_xref="GeneID:74094" /db_xref="MGI:MGI:1921344" exon 1..67 /gene="Tjap1" /gene_synonym="0610041D19Rik; Pilt; Tjp4" /inference="alignment:Splign:2.1.0" exon 68..161 /gene="Tjap1" /gene_synonym="0610041D19Rik; Pilt; Tjp4" /inference="alignment:Splign:2.1.0" exon 162..257 /gene="Tjap1" /gene_synonym="0610041D19Rik; Pilt; Tjp4" /inference="alignment:Splign:2.1.0" misc_feature 215..217 /gene="Tjap1" /gene_synonym="0610041D19Rik; Pilt; Tjp4" /note="upstream in-frame stop codon" exon 258..382 /gene="Tjap1" /gene_synonym="0610041D19Rik; Pilt; Tjp4" /inference="alignment:Splign:2.1.0" CDS 284..1903 /gene="Tjap1" /gene_synonym="0610041D19Rik; Pilt; Tjp4" /note="tight junction protein 4 (peripheral); hdlg-binding protein Pilt; protein incorporated later into tight junctions" /codon_start=1 /product="tight junction-associated protein 1" /protein_id="NP_001239402.1" /db_xref="CCDS:CCDS28824.1" /db_xref="GeneID:74094" /db_xref="MGI:MGI:1921344" /translation="MSSAAPAKKPYRKAPPEHRELRLEIPVSRLEQEESLTDAERMKL LQQENEELRKRLASATRRTEALERELEIGQDCLELELGQSREELDKFKDKFRRLQNSY TASQRTNQELEDKLHALIKKAEMDRKTLDWEIVELTNKLLDARNTINKLEELNERYRL DCNLAVQLLKCNKSHFRNHKLADLPCELQDMVRKHLRSGQEVASPSPSPSSSLSPGAV VPTSVIARVLEKPESLLLNSAQSGSAGRPLAEDVFVHVDMSGGDPASPPAPGSPNGEC CSVSTAGGSPEEELPLPAFDKLSPYPTPSPPHPLYPGRKVIEFSEDKIRIPRNSPLPN CTYATRQAISLSLVEDGSERAHRSSVPSSPASAQGSPHHQPSPAPSALSAPASSASSE EDLLASWQRAFVDRTPPPAAVVQRTAFGRDSLPELQLHFSPGHSTAPPPSPHRERGLV LPAEPDSGFPQDEEEEMLNLPVSPEEERQSLLPDKEGTEEASGPSHVDGRAWPLPSPS RPQRSPKRMGVHHLHRKDSLTQAQEQGTVLS" misc_feature 284..385 /gene="Tjap1" /gene_synonym="0610041D19Rik; Pilt; Tjp4" /note="propagated from UniProtKB/Swiss-Prot (Q9DCD5.2); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 872..931 /gene="Tjap1" /gene_synonym="0610041D19Rik; Pilt; Tjp4" /note="propagated from UniProtKB/Swiss-Prot (Q9DCD5.2); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 1049..1219 /gene="Tjap1" /gene_synonym="0610041D19Rik; Pilt; Tjp4" /note="propagated from UniProtKB/Swiss-Prot (Q9DCD5.2); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 1136..1138 /gene="Tjap1" /gene_synonym="0610041D19Rik; Pilt; Tjp4" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:Q5JTD0; propagated from UniProtKB/Swiss-Prot (Q9DCD5.2); phosphorylation site" misc_feature 1190..1192 /gene="Tjap1" /gene_synonym="0610041D19Rik; Pilt; Tjp4" /note="Phosphothreonine. /evidence=ECO:0000250|UniProtKB:Q5JTD0; propagated from UniProtKB/Swiss-Prot (Q9DCD5.2); phosphorylation site" misc_feature 1196..1198 /gene="Tjap1" /gene_synonym="0610041D19Rik; Pilt; Tjp4" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:Q5JTD0; propagated from UniProtKB/Swiss-Prot (Q9DCD5.2); phosphorylation site" misc_feature 1271..1273 /gene="Tjap1" /gene_synonym="0610041D19Rik; Pilt; Tjp4" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:Q5JTD0; propagated from UniProtKB/Swiss-Prot (Q9DCD5.2); phosphorylation site" misc_feature 1328..1465 /gene="Tjap1" /gene_synonym="0610041D19Rik; Pilt; Tjp4" /note="propagated from UniProtKB/Swiss-Prot (Q9DCD5.2); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 1481..1540 /gene="Tjap1" /gene_synonym="0610041D19Rik; Pilt; Tjp4" /note="propagated from UniProtKB/Swiss-Prot (Q9DCD5.2); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 1502..1504 /gene="Tjap1" /gene_synonym="0610041D19Rik; Pilt; Tjp4" /note="Phosphothreonine. /evidence=ECO:0007744|PubMed:19131326, ECO:0007744|PubMed:21183079; propagated from UniProtKB/Swiss-Prot (Q9DCD5.2); phosphorylation site" misc_feature 1553..1900 /gene="Tjap1" /gene_synonym="0610041D19Rik; Pilt; Tjp4" /note="propagated from UniProtKB/Swiss-Prot (Q9DCD5.2); Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite" misc_feature 1700..1702 /gene="Tjap1" /gene_synonym="0610041D19Rik; Pilt; Tjp4" /note="Phosphoserine. /evidence=ECO:0000250|UniProtKB:Q5JTD0; propagated from UniProtKB/Swiss-Prot (Q9DCD5.2); phosphorylation site" misc_feature 1862..1864 /gene="Tjap1" /gene_synonym="0610041D19Rik; Pilt; Tjp4" /note="Phosphoserine. /evidence=ECO:0007744|PubMed:21183079; propagated from UniProtKB/Swiss-Prot (Q9DCD5.2); phosphorylation site" exon 383..411 /gene="Tjap1" /gene_synonym="0610041D19Rik; Pilt; Tjp4" /inference="alignment:Splign:2.1.0" exon 412..573 /gene="Tjap1" /gene_synonym="0610041D19Rik; Pilt; Tjp4" /inference="alignment:Splign:2.1.0" exon 574..640 /gene="Tjap1" /gene_synonym="0610041D19Rik; Pilt; Tjp4" /inference="alignment:Splign:2.1.0" exon 641..748 /gene="Tjap1" /gene_synonym="0610041D19Rik; Pilt; Tjp4" /inference="alignment:Splign:2.1.0" exon 749..832 /gene="Tjap1" /gene_synonym="0610041D19Rik; Pilt; Tjp4" /inference="alignment:Splign:2.1.0" exon 833..2465 /gene="Tjap1" /gene_synonym="0610041D19Rik; Pilt; Tjp4" /inference="alignment:Splign:2.1.0" regulatory 2420..2425 /regulatory_class="polyA_signal_sequence" /gene="Tjap1" /gene_synonym="0610041D19Rik; Pilt; Tjp4" /note="hexamer: AATAAA" polyA_site 2442 /gene="Tjap1" /gene_synonym="0610041D19Rik; Pilt; Tjp4" /note="major polyA site" ORIGIN 1 ggtccaggcc cctacccggc ctgccccgcg gcaagatggc tgcctgaagg agaggccccg 61 gcagaaactt gaagacccaa gggccccagg gactggaaga aatcacattg cctgcttgga 121 aagaagaggt agcaacttgc cccagcccaa ccccagagcg ggagctcttg gctagaggaa 181 gtagaggggc cgtgggatgt ggagagccga aggctgattc caggagagca gaacagagag 241 ctgccagcga acagacgcag gagacgagcc cataccttcc aggatgagca gtgctgcccc 301 tgctaagaaa ccttaccgta aggcgcctcc agagcaccga gagctacgcc tggagattcc 361 cgtgtcccgg ctcgagcaag aggagtccct gactgacgca gagcggatga aacttttgca 421 gcaggagaat gaagaacttc gcaaacgcct ggcctcagct accagacgca ctgaggcctt 481 ggagcgggag ctggaaatag gacaagactg cctagaactg gagttaggac agagccgtga 541 ggagctggac aagtttaagg acaaattccg caggctacag aacagctaca cggcatccca 601 gcggaccaac caggaactgg aggacaagct gcacgcactg atcaagaagg ctgagatgga 661 caggaagacg ctggactggg agattgtgga gctgaccaac aagctactgg atgccaggaa 721 caccatcaat aaactggaag agctcaatga gcggtaccgg ctggactgca acctggcggt 781 gcagcttctc aagtgcaaca agtcccactt ccggaaccac aagcttgctg acctaccctg 841 tgagctccag gacatggttc gaaaacatct gcgcagtggg caggaggttg ccagccccag 901 ccccagccct tcttccagcc tgtccccagg ggctgtggtg cctacctcag tcattgcccg 961 ggtgttggag aaacctgagt ctctcttgct caattcagct cagtctggca gtgctgggcg 1021 ccccttggct gaggatgtat tcgtgcatgt ggacatgagt gggggtgacc cagccagccc 1081 ccctgccccg ggcagcccca atggggagtg ttgctcagtg agtactgcag ggggctcccc 1141 ggaggaggag ctgcccctgc cagccttcga caagttgagt ccctacccta ccccgtctcc 1201 accacaccca ttataccctg gtaggaaggt gatagaattc tctgaggaca agatccgaat 1261 tcctcggaac agccccctcc ccaactgtac ctatgccacc cggcaggcca tctccttgag 1321 cctggtggag gacggcagtg agcgggccca ccgcagctca gtgcctagca gtcctgcctc 1381 tgcccaaggg tcgccccatc accagcctag tccagctccc tcagcactga gtgccccagc 1441 tagttcggcc agctcggagg aggacctgct ggccagctgg cagcgtgcat ttgtggaccg 1501 caccccgccc cctgctgccg tggtccagcg cacggccttt ggacgagact cactgcccga 1561 gctacaattg catttctccc cgggccactc cacagcccca ccgccttccc cgcaccgtga 1621 gcggggactt gtgctgccag cagaacctga ctctggcttt cctcaagacg aggaagagga 1681 aatgctgaac ctgcctgtca gccccgagga agagcgtcag agcctgctgc ctgataaaga 1741 gggcaccgag gaggcctctg gcccttctca tgttgatggc agggcctggc ctctccccag 1801 tcccagccgc ccccagcgca gccccaagag aatgggagta caccatctcc accgcaagga 1861 cagcctgacg caggcacagg agcagggcac tgtgctcagc tagacctgcc tgccttctgc 1921 caccacctca gggctgcaga tggcccagac tctccctaca gacctgggca gctcagccag 1981 tggggcccac atcaatcctt ggagctgcgt ttgcactaat gggtgccagc ttgccatcat 2041 catttttgtt tccttttcct ttgaaatatt tattctccaa ggtaacaagt catttgggcc 2101 ccaagctctt ccaccatcca gtccgtccgt aagggacggg cggtgggctt gtcagttttc 2161 ctttcccagc tcctttctca ttgagagctc tggttggtag gggagggtgt cgttggtgct 2221 gctgacctct attcctctgc ctctgcgtgg gctgctctta ggcctgctca gctggcccca 2281 gagacaaggg tggactcact cagggctccc ccttccagag ggagggcgtg acttctgggg 2341 cctggcccca ttcttaacct tggctctaga ctgttactcc cagatttggg aagttttcac 2401 aatgactatt ttaaaatcaa ataaaactta ttttacaggt aaggcttaat ttctttctcc 2461 ttccc //
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