LOCUS NM_001357734 2636 bp mRNA linear PRI 29-OCT-2022
DEFINITION Homo sapiens eukaryotic translation initiation factor 2 subunit
gamma B (EIF2S3B), transcript variant 1, mRNA.
ACCESSION NM_001357734
VERSION NM_001357734.3
KEYWORDS RefSeq; MANE Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2636)
AUTHORS Scherer SE, Muzny DM, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha
S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson
AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ,
Metzker ML, Milosavljevic A, Miner GR, Montgomery KT, Morgan MB,
Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Lovering RC,
Wheeler DA, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA,
Ayele M, Brown MJ, Chen G, Chen Z, Clerc-Blankenburg KP, Davis C,
Delgado O, Dinh HH, Draper H, Gonzalez-Garay ML, Havlak P, Jackson
LR, Jacob LS, Kelly SH, Li L, Li Z, Liu J, Liu W, Lu J, Maheshwari
M, Nguyen BV, Okwuonu GO, Pasternak S, Perez LM, Plopper FJ,
Santibanez J, Shen H, Tabor PE, Verduzco D, Waldron L, Wang Q,
Williams GA, Zhang J, Zhou J, Allen CC, Amin AG, Anyalebechi V,
Bailey M, Barbaria JA, Bimage KE, Bryant NP, Burch PE, Burkett CE,
Burrell KL, Calderon E, Cardenas V, Carter K, Casias K, Cavazos I,
Cavazos SR, Ceasar H, Chacko J, Chan SN, Chavez D, Christopoulos C,
Chu J, Cockrell R, Cox CD, Dang M, Dathorne SR, David R, Davis CM,
Davy-Carroll L, Deshazo DR, Donlin JE, D'Souza L, Eaves KA, Egan A,
Emery-Cohen AJ, Escotto M, Flagg N, Forbes LD, Gabisi AM, Garza M,
Hamilton C, Henderson N, Hernandez O, Hines S, Hogues ME, Huang M,
Idlebird DG, Johnson R, Jolivet A, Jones S, Kagan R, King LM, Leal
B, Lebow H, Lee S, LeVan JM, Lewis LC, London P, Lorensuhewa LM,
Loulseged H, Lovett DA, Lucier A, Lucier RL, Ma J, Madu RC, Mapua
P, Martindale AD, Martinez E, Massey E, Mawhiney S, Meador MG,
Mendez S, Mercado C, Mercado IC, Merritt CE, Miner ZL, Minja E,
Mitchell T, Mohabbat F, Mohabbat K, Montgomery B, Moore N, Morris
S, Munidasa M, Ngo RN, Nguyen NB, Nickerson E, Nwaokelemeh OO,
Nwokenkwo S, Obregon M, Oguh M, Oragunye N, Oviedo RJ, Parish BJ,
Parker DN, Parrish J, Parks KL, Paul HA, Payton BA, Perez A, Perrin
W, Pickens A, Primus EL, Pu LL, Puazo M, Quiles MM, Quiroz JB,
Rabata D, Reeves K, Ruiz SJ, Shao H, Sisson I, Sonaike T, Sorelle
RP, Sutton AE, Svatek AF, Svetz LA, Tamerisa KS, Taylor TR, Teague
B, Thomas N, Thorn RD, Trejos ZY, Trevino BK, Ukegbu ON, Urban JB,
Vasquez LI, Vera VA, Villasana DM, Wang L, Ward-Moore S, Warren JT,
Wei X, White F, Williamson AL, Wleczyk R, Wooden HS, Wooden SH, Yen
J, Yoon L, Yoon V, Zorrilla SE, Nelson D, Kucherlapati R, Weinstock
G and Gibbs RA.
CONSRTM Baylor College of Medicine Human Genome Sequencing Center Sequence
Production Team
TITLE The finished DNA sequence of human chromosome 12
JOURNAL Nature 440 (7082), 346-351 (2006)
PUBMED 16541075
REFERENCE 2 (bases 1 to 2636)
AUTHORS Marques AC, Dupanloup I, Vinckenbosch N, Reymond A and Kaessmann H.
TITLE Emergence of young human genes after a burst of retroposition in
primates
JOURNAL PLoS Biol 3 (11), e357 (2005)
PUBMED 16201836
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC068775.52.
On Jan 15, 2021 this sequence version replaced NM_001357734.2.
##Evidence-Data-START##
Transcript is intronless :: ERR3218371.335706.1,
ERR3218374.206948.1 [ECO:0000345]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000538173.2/ ENSP00000445077.1
RefSeq Select criteria :: based on manual assertion, conservation,
longest protein
##RefSeq-Attributes-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-2636 AC068775.52 90075-92710
FEATURES Location/Qualifiers
source 1..2636
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="12p13.2"
gene 1..2636
/gene="EIF2S3B"
/gene_synonym="eIF-2gA; eIF2gA; EIF2S3L"
/note="eukaryotic translation initiation factor 2 subunit
gamma B"
/db_xref="GeneID:255308"
/db_xref="HGNC:HGNC:43863"
exon 1..2636
/gene="EIF2S3B"
/gene_synonym="eIF-2gA; eIF2gA; EIF2S3L"
/inference="alignment:Splign:2.1.0"
CDS 14..1432
/gene="EIF2S3B"
/gene_synonym="eIF-2gA; eIF2gA; EIF2S3L"
/EC_number="3.6.5.3"
/note="isoform 1 is encoded by transcript variant 1;
putative eukaryotic translation initiation factor 2
subunit 3-like protein; eukaryotic translation initiation
factor 2, subunit 3 gamma, 52kDa; eukaryotic translation
initiation factor 2 subunit 3B; eIF-2-gamma2"
/codon_start=1
/product="eukaryotic translation initiation factor 2
subunit 3B isoform 1"
/protein_id="NP_001344663.1"
/db_xref="CCDS:CCDS91654.1"
/db_xref="GeneID:255308"
/db_xref="HGNC:HGNC:43863"
/translation="MAGGEAGVTLGQPHLSRQDLTTLDVTKLTPLSHEVISRQATINI
GTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYQLDDPSCPRPECY
RSCGSSMPDEFPTDIPGTKGNFRLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIA
GNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKERQAKEQYEQILAFVQGTVAEG
APIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKG
GVAGGSILKGVLKVGQETEVRPGIVSKDSEGKLMCKSIFSKIVSLFAEHNDLQYAAPG
GLIGVGTKIDPTLCRADRMVGQILGAVGALPEIFTELEISYFLLRRLLGVRTEGDKKA
AKVQKLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGEKIALSRRVEKH
WRLIGWGQIRRGVTIKPTVDDD"
regulatory 2078..2083
/regulatory_class="polyA_signal_sequence"
/gene="EIF2S3B"
/gene_synonym="eIF-2gA; eIF2gA; EIF2S3L"
/note="hexamer: AATAAA"
polyA_site 2102
/gene="EIF2S3B"
/gene_synonym="eIF-2gA; eIF2gA; EIF2S3L"
/note="major polyA site"
ORIGIN
1 ctcttttggc aacatggcgg gcggagaagc tggggtgact ctggggcagc cgcacctttc
61 gcgtcaggat ctcaccacct tggatgttac caagttgacg ccactttcac acgaagttat
121 cagcagacaa gccacaatta atataggtac aattggtcat gtagctcatg ggaaatccac
181 agtcgtcaaa gctatttctg gagttcacac cgtcaggttc aaaaatgaac tagaaagaaa
241 tattacaatc aagcttggat atgctaatgc taagatttat caacttgatg acccaagttg
301 ccctcggcca gaatgttatc gatcttgtgg gagcagtatg cctgatgagt ttcctacaga
361 cattccagga accaaaggga acttcagatt agtcagacat gtttcctttg ttgactgtcc
421 tggccacgat attttgatgg ctactatgct gaacggtgca gcagtgatgg atgcagctct
481 tctgttgata gctggtaatg aatcttgccc tcagcctcag acatctgaac acctggctgc
541 tatagagatc atgaaactga agcatatttt gattctacaa aataaaattg atttggtaaa
601 agaaaggcag gctaaagaac aatacgagca gatccttgcg tttgtccaag gtacagtagc
661 agagggagct cccattattc caatttcggc tcagctgaaa tacaatattg aagttgtttg
721 tgagtacata gtaaagaaaa ttccagtacc cccaagagac tttacttcag agccccggct
781 tattgttatt agatcttttg atgtcaacaa acctggctgt gaagttgatg accttaaggg
841 aggtgtagct ggtggtagta tcctaaaagg agtattaaag gtgggccagg agacagaagt
901 aagacctggt attgtttcca aagatagtga aggaaaactc atgtgtaaat caatcttttc
961 caaaattgtt tcactttttg cggagcataa tgatctgcaa tatgctgctc caggcggtct
1021 tattggagtt ggaacaaaaa ttgaccccac tttgtgccgg gctgacagaa tggtggggca
1081 aatacttggt gcagtcggag ctttacctga gatattcaca gaattggaaa tttcctattt
1141 cctgcttaga cggcttctag gtgtacgcac tgaaggagac aagaaagcag caaaggttca
1201 aaagctgtct aagaatgaag tgctcatggt gaacatagga tccctgtcga caggagggag
1261 agttagtgct gtcaaggccg atttgggcaa aattgttttg accaatccag tgtgcacaga
1321 ggtaggagaa aaaattgccc ttagccgaag agttgaaaaa cactggcgtt taattggttg
1381 gggtcagata agaagaggag tgacaatcaa gccaacagta gatgatgact gaagaatacc
1441 ggttaaataa tacattcgga tggagctgga agttgcaatt tctctttaac aaccaagggg
1501 tttattttca aagcgatatt ggggaattga tttcacagtt tgttacctta gtaggtaacg
1561 gtaaggttat tctctctttt tttttttggt tatgaaaact tagggactac aattagtata
1621 aaaattggca taatgttgga ttgaatctac attttggcag aagttaagca ttcccacata
1681 atgtcaaaat tatacattat gcagtttttt tgtttgtttt attttgtttt gtttttgagt
1741 ctggctttgt cacctaggct ggcatgtagt ggcatgatct gcaatctctg cctcccaggt
1801 tcaagcgatt ctcctgcctc agccccccaa gtagctgaga ttacaggtgt gtgccaccac
1861 acggggctaa tttttgtatt agtagagacg gggtttcggc atgttggcca ggccagtctc
1921 tcctgacctc agggtgatca gcccacctcg gcctcacaaa gtgccgggat tacaggcgtg
1981 agccaccttg cctagcccac atcatgcagt ttgaaatgaa actttgccac aaccagcctt
2041 tgctgtagca cacacatata tcactgaaac tgttcgaaat aaagtttttt tttgtttttc
2101 atgattcgtc tttgagtacc tccaggctga aggactgttg taccagtaaa aacttaaagg
2161 cacaaattat ccttgaagac cttctccctt ttctttggcc ccatatttta tgttgcttta
2221 tctttgaaat tttgcatgaa aaggatgcaa tgaatgggtt cgaattgcat gaaaaggatg
2281 cacgaatggg ttcgaatgaa attgtccttt agagcatgat tacttgttcc catgggcaaa
2341 taattttctc cccttgctct tcctggcctg aaatacggga aactagagtc agaagttatc
2401 tccctctccc tgtgatgcct tgagatgttt ttctgcattg ttttatgcct gaaatccaat
2461 agtcttcctc cattggaaaa tactgttata ccaaataatt ctagatgagt aacaaagatc
2521 cttctaggcc ttcattttat gttttttctt aactgttata tgattgtgac acagattata
2581 atattactaa tttttggatg tttcaaaagg tcaataagta aaagatgtta gaaagc
//