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Mus musculus ASH2 like histone lysine methyltransferase complex subunit (Ash2l), transcript variant 4, mRNA

NCBI Reference Sequence: NM_001359012.1

FASTA Graphics 

LOCUS       NM_001359012            3321 bp    mRNA    linear   ROD 26-OCT-2024
DEFINITION  Mus musculus ASH2 like histone lysine methyltransferase complex
            subunit (Ash2l), transcript variant 4, mRNA.
ACCESSION   NM_001359012 XM_011242135
VERSION     NM_001359012.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3321)
  AUTHORS   Wang,Q., Zeng,S., Liang,Y., Zhou,R. and Wang,D.
  TITLE     ASH2L Mediates Epidermal Differentiation and Hair Follicle
            Morphogenesis through H3K4me3 Modification
  JOURNAL   J Invest Dermatol 144 (11), 2406-2416 (2024)
   PUBMED   38582368
  REMARK    GeneRIF: ASH2L Mediates Epidermal Differentiation and Hair Follicle
            Morphogenesis through H3K4me3 Modification.
REFERENCE   2  (bases 1 to 3321)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3321)
  AUTHORS   Zhong,W., Dong,Y.J., Hong,C., Li,Y.H., Xiao,C.X., Liu,X.H. and
            Chang,J.
  TITLE     ASH2L upregulation contributes to diabetic endothelial dysfunction
            in mice through STEAP4-mediated copper uptake
  JOURNAL   Acta Pharmacol Sin 45 (3), 558-569 (2024)
   PUBMED   37903897
  REMARK    GeneRIF: ASH2L upregulation contributes to diabetic endothelial
            dysfunction in mice through STEAP4-mediated copper uptake.
REFERENCE   4  (bases 1 to 3321)
  AUTHORS   Su,Z., Wang,J., Xiao,C., Zhong,W., Liu,J., Liu,X. and Zhu,Y.Z.
  TITLE     Functional role of Ash2l in oxLDL induced endothelial dysfunction
            and atherosclerosis
  JOURNAL   Cell Mol Life Sci 81 (1), 62 (2024)
   PUBMED   38280036
  REMARK    GeneRIF: Functional role of Ash2l in oxLDL induced endothelial
            dysfunction and atherosclerosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3321)
  AUTHORS   Zhu,X., Ma,Z., Xie,F. and Wang,J.
  TITLE     ASH2L, Core Subunit of H3K4 Methylation Complex, Regulates
            Amelogenesis
  JOURNAL   J Dent Res 103 (1), 81-90 (2024)
   PUBMED   37990471
  REMARK    GeneRIF: ASH2L, Core Subunit of H3K4 Methylation Complex, Regulates
            Amelogenesis.
REFERENCE   6  (bases 1 to 3321)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3321)
  AUTHORS   Hughes,C.M., Rozenblatt-Rosen,O., Milne,T.A., Copeland,T.D.,
            Levine,S.S., Lee,J.C., Hayes,D.N., Shanmugam,K.S.,
            Bhattacharjee,A., Biondi,C.A., Kay,G.F., Hayward,N.K., Hess,J.L.
            and Meyerson,M.
  TITLE     Menin associates with a trithorax family histone methyltransferase
            complex and with the hoxc8 locus
  JOURNAL   Mol Cell 13 (4), 587-597 (2004)
   PUBMED   14992727
REFERENCE   8  (bases 1 to 3321)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 3321)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   10 (bases 1 to 3321)
  AUTHORS   Ikegawa,S., Isomura,M., Koshizuka,Y. and Nakamura,Y.
  TITLE     Cloning and characterization of ASH2L and Ash2l, human and mouse
            homologs of the Drosophila ash2 gene
  JOURNAL   Cytogenet Cell Genet 84 (3-4), 167-172 (1999)
   PUBMED   10393421
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122752.10.
            
            On Dec 16, 2017 this sequence version replaced XM_011242135.2.
            
            Transcript Variant: This variant (4) represents the longest
            transcript and encodes the longest protein (isoform d).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164134,
                              SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-206               AC122752.10        53152-53357         c
            207-270             AC122752.10        52582-52645         c
            271-416             AC122752.10        52313-52458         c
            417-505             AC122752.10        48570-48658         c
            506-600             AC122752.10        47530-47624         c
            601-696             AC122752.10        46321-46416         c
            697-792             AC122752.10        45210-45305         c
            793-868             AC122752.10        43843-43918         c
            869-886             AC122752.10        42945-42962         c
            887-980             AC122752.10        41336-41429         c
            981-1198            AC122752.10        39744-39961         c
            1199-1366           AC122752.10        35709-35876         c
            1367-1560           AC122752.10        35265-35458         c
            1561-1653           AC122752.10        32196-32288         c
            1654-1752           AC122752.10        31116-31214         c
            1753-1812           AC122752.10        30174-30233         c
            1813-3321           AC122752.10        28570-30078         c
FEATURES             Location/Qualifiers
     source          1..3321
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 14.17 cM"
     gene            1..3321
                     /gene="Ash2l"
                     /note="ASH2 like histone lysine methyltransferase complex
                     subunit"
                     /db_xref="GeneID:23808"
                     /db_xref="MGI:MGI:1344416"
     exon            1..206
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..1920
                     /gene="Ash2l"
                     /note="isoform d is encoded by transcript variant 4;
                     set1/Ash2 histone methyltransferase complex subunit ASH2;
                     ASH2-like protein; ash2 (absent, small, or homeotic)-like"
                     /codon_start=1
                     /product="set1/Ash2 histone methyltransferase complex
                     subunit ASH2 isoform d"
                     /protein_id="NP_001345941.1"
                     /db_xref="GeneID:23808"
                     /db_xref="MGI:MGI:1344416"
                     /translation="MAAAGAGPGPGVSAGPGPGAAASATTAEDRETEPVAAGAGEGPS
                     AAPGAEPSSGEAESGDANLVDVSGLETESSNGKDTLEGTGDTSEVMDTQAGSVDEENG
                     RQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANL
                     KEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNI
                     VKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSASG
                     NLNGGATLGGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLE
                     HPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQ
                     LKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQA
                     PLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYK
                     DKALIKFKSYLYFEEKDFVDKAEKSLKQTPHSEIIFYKNGVNQGVAYRDIFEGVYFPA
                     ISLYKSCTVSINFGPSFKYPPKDLTYHPMSDMGWGAVVEHTLADVLYHVETEVDGRRS
                     PPWEP"
     misc_feature    31..327
                     /gene="Ash2l"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91X20.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    217..546
                     /gene="Ash2l"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91X20.1);
                     Region: DNA-binding. /evidence=ECO:0000250"
     misc_feature    316..318
                     /gene="Ash2l"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q91X20.1); phosphorylation site"
     misc_feature    919..921
                     /gene="Ash2l"
                     /note="Asymmetric dimethylarginine, by PRMT1 and PRMT5.
                     /evidence=ECO:0000250|UniProtKB:Q9UBL3; propagated from
                     UniProtKB/Swiss-Prot (Q91X20.1); methylation site"
     misc_feature    979..1917
                     /gene="Ash2l"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91X20.1);
                     Region: Interaction with RBBP5.
                     /evidence=ECO:0000250|UniProtKB:Q9UBL3"
     misc_feature    979..981
                     /gene="Ash2l"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UBL3; propagated from
                     UniProtKB/Swiss-Prot (Q91X20.1); phosphorylation site"
     exon            207..270
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            271..416
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            417..505
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            506..600
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            601..696
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            697..792
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            793..868
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            869..886
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            887..980
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1198
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1366
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1560
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1653
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1752
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1812
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..3321
                     /gene="Ash2l"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1978..1983
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ash2l"
                     /note="hexamer: TATAAA"
     polyA_site      2003
                     /gene="Ash2l"
     regulatory      2422..2427
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ash2l"
                     /note="hexamer: AATAAA"
     polyA_site      2451
                     /gene="Ash2l"
                     /note="major polyA site"
     regulatory      2769..2774
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ash2l"
                     /note="hexamer: AATACA"
     polyA_site      2801
                     /gene="Ash2l"
     regulatory      3299..3304
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ash2l"
                     /note="hexamer: AATAAA"
     polyA_site      3317
                     /gene="Ash2l"
ORIGIN      
        1 attctcgcga gagcttggga aggagcagcg atggcggcgg ctggagcggg tcctggtccg
       61 ggagtcagcg ccggccctgg tcccggagcc gctgcaagtg ccacaacggc ggaggaccga
      121 gagacagagc cggtggccgc gggggctggc gaggggccgt cagccgcccc gggagcggag
      181 cccagctccg gagaggccga aagtggggat gcaaacttgg ttgatgtaag tggtctggag
      241 acagaatctt ctaatggaaa agatactttg gaaggtaccg gagacacttc agaagtgatg
      301 gatacccagg cgggctctgt ggatgaggag aatgggcggc agttgggaga agtggagttg
      361 cagtgtggga tatgtacaaa atggttcacc gctgacacct ttggaataga cacgtcgtca
      421 tgtctgcctt ttatgaccaa ctacagcttc cattgcaatg tgtgccatca cagtgggaat
      481 acctactttc tccggaagca agcaaattta aaagaaatgt gccttagtgc cttggcgaat
      541 ttgacgtggc agtctcgaac acaggatgaa catccaaaaa ccatgttctc caaagataag
      601 gatattatac catttattga taaatactgg gaatgtatga caaccagaca gagacctgga
      661 aaaatgactt ggcccaataa cattgtcaaa acaatgagta aggaaagaga tgtgttcttg
      721 gtaaaggaac accctgaccc aggaagcaaa gacccagaag aagattaccc caagtttgga
      781 cttttggatc aggatcttag taatattggt cctgcttatg acaaccagaa acaaagcagt
      841 gctgtgtctg ctagtgggaa cctaaatggt ggagccactt tgggaggggg gatcgcagcc
      901 ggaagcagtg ggaaaggaag aggagccaag cgtaagcagc aagatggagg gacaacaggg
      961 accaccaaga aggccagaag tgatccttta ttttctgctc agcgtctccc tcctcatggc
     1021 tatcctttgg aacatccatt taacaaagat ggctatcggt atattcttgc tgagcccgat
     1081 cctcatgccc ccgacccgga gaagcttgaa cttgactgct gggcgggaaa gcctattcct
     1141 ggagaccttt acagagcctg cttatatgaa cgagtcttgt tagccctaca tgatcgagct
     1201 ccccagttaa agatctctga tgaccggctg accgtggttg gagagaaggg ctactccatg
     1261 gtccgggcct ctcatggggt acgcaaaggg gcctggtact ttgaaatcac tgtggatgag
     1321 atgcccccag acactgctgc caggctgggc tggtcccagc ccttaggtaa cctccaagct
     1381 cccttaggct atgataagtt tagctattct tggcggagca agaaaggcac caagttccac
     1441 cagtccattg gcaagcacta ttcgtctggc tacggacaag gggacgtcct agggttctat
     1501 atcaaccttc ccgaagacac agagacagcc aagtcactgc cggacaccta caaagataag
     1561 gctttgataa agttcaagag ttatttgtat tttgaagaaa aagactttgt ggacaaagca
     1621 gagaagagcc taaaacagac cccccatagt gagataatat tttataaaaa tggtgtcaat
     1681 cagggtgtgg cttacagaga tatttttgaa ggagtttact tcccagccat ctcactgtac
     1741 aagagctgca cggtttccat taactttgga ccatccttca aataccctcc aaaggatctc
     1801 acgtaccacc ctatgagtga catgggctgg ggcgctgtgg tagaacacac actggctgat
     1861 gttttgtatc acgtggagac agaagtggac ggaagacgta gtccaccctg ggaaccctaa
     1921 ccagtccttg cttctggtga cactgtaaaa taatcctggg ggttttgttt ttgtttttat
     1981 aaagtgtcaa atgttttcca agagatgctg cagtacactt tgatcaaggt aaaagggtgg
     2041 gtgggactgc agcagtgcct gctcttcagc atccctgccc cacacaacta cttactctga
     2101 gtgccataaa tcagccgctc cctgtaaggc tgctgctgtg cccagacctg ccagggagga
     2161 cctgttactt tcctgtgtct gtgtgttcca aagagcgagt aatcatgctc agacagcttg
     2221 cttgaggatg ttggatcccc tggtttctgg ggaggcaagc ttgtttgagt ggctgaaatc
     2281 aatggcattc cattccagag cagtctaaag gcagtctttt tggtgtggag tttggggatc
     2341 atctgggaag ctagtgggtt ctataaacta taattgtgaa aggaatatgc ctacagggtt
     2401 taaaagatag atctttcctc caataaaact tgttttcaag cttgtatggt acttggcttc
     2461 actggaagtg aagttcctgt tgaccctgtt agcagtgtga gcagtgtgac ggggacaaca
     2521 ctggcagggt gggacaggcg cttttattgc tgtcctcccc gggtcaccag gcgctttcac
     2581 tgccctgtgt acagtggact ctcagggaga gcaagactgt agcaggcctc cagtccgtgt
     2641 cttggaactt ggtgctgata tgtgcggctt gtcctcttgc ctgcctttct agtagccagc
     2701 caggggttag gatcaaagaa tgatgaggag cctgccttac gaggatgcct taatgacctc
     2761 cgattttaaa tacataagtc tgtggcaaat gcaaaatcct acactgacct aaagacttcc
     2821 cttttttgtg tagccttttt tgtttgtttg ctttgttttg ttttaactta agtactagtg
     2881 atataaagtg actaaccagg agctaggtag gatgcagaat tatattctaa gtattttgtt
     2941 ttgctattta agaaatttcc caagccgggc gtggtggcgc acgcctttaa tcccagcact
     3001 tgggaggcag aggcagattt ctgagtttga ggccagcctg gtctacaaag tgagttccag
     3061 gacagccagg gctacacaga gaaaccctgt ctcgaaaaaa ccaaaaaaca acaacaacaa
     3121 aaaaaagaaa tttcccgggc tggcgagatg gctcagtggt taagagcacc aactgctctt
     3181 ctgaaggtcc cgagttcaaa tcccaacaac cacatgatgg ctcacaacca tccataacga
     3241 gatctgatgc cctcttctgg agtatctgag gacagctaca gtgtacttac atataataaa
     3301 taaatcttta aaagaaagaa a
//
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