LOCUS NM_001376669 2645 bp mRNA linear PRI 21-SEP-2024
DEFINITION Homo sapiens MINDY lysine 48 deubiquitinase 1 (MINDY1), transcript
variant 12, mRNA.
ACCESSION NM_001376669 XM_017001775
VERSION NM_001376669.1
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2645)
AUTHORS Abdul Rehman,S.A., Armstrong,L.A., Lange,S.M., Kristariyanto,Y.A.,
Grawert,T.W., Knebel,A., Svergun,D.I. and Kulathu,Y.
TITLE Mechanism of activation and regulation of deubiquitinase activity
in MINDY1 and MINDY2
JOURNAL Mol Cell 81 (20), 4176-4190 (2021)
PUBMED 34529927
REMARK GeneRIF: Mechanism of activation and regulation of deubiquitinase
activity in MINDY1 and MINDY2.
REFERENCE 2 (bases 1 to 2645)
AUTHORS Tang,J., Luo,Y., Long,G. and Zhou,L.
TITLE MINDY1 promotes breast cancer cell proliferation by stabilizing
estrogen receptor alpha
JOURNAL Cell Death Dis 12 (10), 937 (2021)
PUBMED 34645792
REMARK GeneRIF: MINDY1 promotes breast cancer cell proliferation by
stabilizing estrogen receptor alpha.
Erratum:[Cell Death Dis. 2022 Jan 27;13(1):88. doi:
10.1038/s41419-022-04549-7. PMID: 35087032]
Publication Status: Online-Only
REFERENCE 3 (bases 1 to 2645)
AUTHORS Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
TITLE Interactome Mapping Provides a Network of Neurodegenerative Disease
Proteins and Uncovers Widespread Protein Aggregation in Affected
Brains
JOURNAL Cell Rep 32 (7), 108050 (2020)
PUBMED 32814053
REFERENCE 4 (bases 1 to 2645)
AUTHORS Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
TITLE A reference map of the human binary protein interactome
JOURNAL Nature 580 (7803), 402-408 (2020)
PUBMED 32296183
REFERENCE 5 (bases 1 to 2645)
AUTHORS Kristariyanto,Y.A., Abdul Rehman,S.A., Weidlich,S., Knebel,A. and
Kulathu,Y.
TITLE A single MIU motif of MINDY-1 recognizes K48-linked polyubiquitin
chains
JOURNAL EMBO Rep 18 (3), 392-402 (2017)
PUBMED 28082312
REFERENCE 6 (bases 1 to 2645)
AUTHORS Abdul Rehman,S.A., Kristariyanto,Y.A., Choi,S.Y., Nkosi,P.J.,
Weidlich,S., Labib,K., Hofmann,K. and Kulathu,Y.
TITLE MINDY-1 Is a Member of an Evolutionarily Conserved and Structurally
Distinct New Family of Deubiquitinating Enzymes
JOURNAL Mol Cell 63 (1), 146-155 (2016)
PUBMED 27292798
REMARK GeneRIF: MINDY-1 prefers cleaving long polyubiquitin chains and
works by trimming chains from the distal end.
REFERENCE 7 (bases 1 to 2645)
AUTHORS Kirin,M., Chandra,A., Charteris,D.G., Hayward,C., Campbell,S.,
Celap,I., Bencic,G., Vatavuk,Z., Kirac,I., Richards,A.J.,
Tenesa,A., Snead,M.P., Fleck,B.W., Singh,J., Harsum,S.,
Maclaren,R.E., den Hollander,A.I., Dunlop,M.G., Hoyng,C.B.,
Wright,A.F., Campbell,H., Vitart,V. and Mitry,D.
TITLE Genome-wide association study identifies genetic risk underlying
primary rhegmatogenous retinal detachment
JOURNAL Hum Mol Genet 22 (15), 3174-3185 (2013)
PUBMED 23585552
REFERENCE 8 (bases 1 to 2645)
AUTHORS Kottgen,A., Pattaro,C., Boger,C.A., Fuchsberger,C., Olden,M.,
Glazer,N.L., Parsa,A., Gao,X., Yang,Q., Smith,A.V., O'Connell,J.R.,
Li,M., Schmidt,H., Tanaka,T., Isaacs,A., Ketkar,S., Hwang,S.J.,
Johnson,A.D., Dehghan,A., Teumer,A., Pare,G., Atkinson,E.J.,
Zeller,T., Lohman,K., Cornelis,M.C., Probst-Hensch,N.M.,
Kronenberg,F., Tonjes,A., Hayward,C., Aspelund,T., Eiriksdottir,G.,
Launer,L.J., Harris,T.B., Rampersaud,E., Mitchell,B.D.,
Arking,D.E., Boerwinkle,E., Struchalin,M., Cavalieri,M.,
Singleton,A., Giallauria,F., Metter,J., de Boer,I.H.,
Haritunians,T., Lumley,T., Siscovick,D., Psaty,B.M.,
Zillikens,M.C., Oostra,B.A., Feitosa,M., Province,M., de
Andrade,M., Turner,S.T., Schillert,A., Ziegler,A., Wild,P.S.,
Schnabel,R.B., Wilde,S., Munzel,T.F., Leak,T.S., Illig,T.,
Klopp,N., Meisinger,C., Wichmann,H.E., Koenig,W., Zgaga,L.,
Zemunik,T., Kolcic,I., Minelli,C., Hu,F.B., Johansson,A., Igl,W.,
Zaboli,G., Wild,S.H., Wright,A.F., Campbell,H., Ellinghaus,D.,
Schreiber,S., Aulchenko,Y.S., Felix,J.F., Rivadeneira,F.,
Uitterlinden,A.G., Hofman,A., Imboden,M., Nitsch,D.,
Brandstatter,A., Kollerits,B., Kedenko,L., Magi,R., Stumvoll,M.,
Kovacs,P., Boban,M., Campbell,S., Endlich,K., Volzke,H.,
Kroemer,H.K., Nauck,M., Volker,U., Polasek,O., Vitart,V.,
Badola,S., Parker,A.N., Ridker,P.M., Kardia,S.L., Blankenberg,S.,
Liu,Y., Curhan,G.C., Franke,A., Rochat,T., Paulweber,B.,
Prokopenko,I., Wang,W., Gudnason,V., Shuldiner,A.R., Coresh,J.,
Schmidt,R., Ferrucci,L., Shlipak,M.G., van Duijn,C.M., Borecki,I.,
Kramer,B.K., Rudan,I., Gyllensten,U., Wilson,J.F., Witteman,J.C.,
Pramstaller,P.P., Rettig,R., Hastie,N., Chasman,D.I., Kao,W.H.,
Heid,I.M. and Fox,C.S.
TITLE New loci associated with kidney function and chronic kidney disease
JOURNAL Nat Genet 42 (5), 376-384 (2010)
PUBMED 20383146
REFERENCE 9 (bases 1 to 2645)
AUTHORS Lehner,B. and Sanderson,C.M.
TITLE A protein interaction framework for human mRNA degradation
JOURNAL Genome Res 14 (7), 1315-1323 (2004)
PUBMED 15231747
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AL590133.32.
On Nov 18, 2019 this sequence version replaced XM_017001775.2.
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments.
##Evidence-Data-START##
Transcript exon combination :: SRR1803616.226550.1,
SRR1660809.218315.1 [ECO:0000332]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-591 AL590133.32 92505-93095 c
592-1395 AL590133.32 88358-89161 c
1396-1453 AL590133.32 87918-87975 c
1454-1518 AL590133.32 87443-87507 c
1519-1621 AL590133.32 86055-86157 c
1622-1764 AL590133.32 85562-85704 c
1765-1956 AL590133.32 84275-84466 c
1957-2112 AL590133.32 83817-83972 c
2113-2645 AL590133.32 83028-83560 c
FEATURES Location/Qualifiers
source 1..2645
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1q21.3"
gene 1..2645
/gene="MINDY1"
/gene_synonym="FAM63A; MINDY-1"
/note="MINDY lysine 48 deubiquitinase 1"
/db_xref="GeneID:55793"
/db_xref="HGNC:HGNC:25648"
/db_xref="MIM:618407"
exon 1..591
/gene="MINDY1"
/gene_synonym="FAM63A; MINDY-1"
/inference="alignment:Splign:2.1.0"
exon 592..1395
/gene="MINDY1"
/gene_synonym="FAM63A; MINDY-1"
/inference="alignment:Splign:2.1.0"
misc_feature 832..834
/gene="MINDY1"
/gene_synonym="FAM63A; MINDY-1"
/note="upstream in-frame stop codon"
CDS 943..2193
/gene="MINDY1"
/gene_synonym="FAM63A; MINDY-1"
/EC_number="3.4.19.12"
/note="isoform 9 is encoded by transcript variant 12;
protein FAM63A; deubiquitinating enzyme MINDY-1; ubiquitin
carboxyl-terminal hydrolase MINDY-1; MIU-containing novel
DUB family member 1; motif interacting with Ub-containing
novel DUB; family with sequence similarity 63 member A;
MINDY deubiquitinase 1"
/codon_start=1
/product="ubiquitin carboxyl-terminal hydrolase MINDY-1
isoform 9"
/protein_id="NP_001363598.1"
/db_xref="GeneID:55793"
/db_xref="HGNC:HGNC:25648"
/db_xref="MIM:618407"
/translation="MEYHQPEDPAPGKAGTAEAVIPENHEVLAGPDEHPQDTDARDAD
GEAREREPADQALLPSQCGDNLESPLPEASSAPPGPTLGTLPEVETIRACSMPQELPQ
SPRTRQPEPDFYCVKWIPWKGEQTPIITQSTNGPCPLLAIMNILFLQWKVKLPPQKEV
ITSDELMAHLGNCLLSIKPQEKSEGLQLNFQQSPEAVRAVGKLSYNQLVERIITCKHS
SDTNLVTEGLIAEQFLETTAAQLTYHGLCELTAAAKEGELSVFFRNNHFSTMTKHKSH
LYLLVTDQGFLQEEQVVWESLHNVDGDSCFCDSDFHLSHSLGKGPGAEGGSGSPETQL
QVDQDYLIALSLQQQQPRGPLGLTDLELAQQLQQEEYQQQQAAQPVRMRTRVLSLQGR
GATSGRPAGERRQRPKHESDCILL"
exon 1396..1453
/gene="MINDY1"
/gene_synonym="FAM63A; MINDY-1"
/inference="alignment:Splign:2.1.0"
exon 1454..1518
/gene="MINDY1"
/gene_synonym="FAM63A; MINDY-1"
/inference="alignment:Splign:2.1.0"
exon 1519..1621
/gene="MINDY1"
/gene_synonym="FAM63A; MINDY-1"
/inference="alignment:Splign:2.1.0"
exon 1622..1764
/gene="MINDY1"
/gene_synonym="FAM63A; MINDY-1"
/inference="alignment:Splign:2.1.0"
exon 1765..1956
/gene="MINDY1"
/gene_synonym="FAM63A; MINDY-1"
/inference="alignment:Splign:2.1.0"
exon 1957..2112
/gene="MINDY1"
/gene_synonym="FAM63A; MINDY-1"
/inference="alignment:Splign:2.1.0"
exon 2113..2645
/gene="MINDY1"
/gene_synonym="FAM63A; MINDY-1"
/inference="alignment:Splign:2.1.0"
regulatory 2625..2630
/regulatory_class="polyA_signal_sequence"
/gene="MINDY1"
/gene_synonym="FAM63A; MINDY-1"
/note="hexamer: AATAAA"
polyA_site 2645
/gene="MINDY1"
/gene_synonym="FAM63A; MINDY-1"
/note="major polyA site"
ORIGIN
1 agagaggcac aagcgctccg tcccttctag aggcaggcag agggaagaga aagggtctgt
61 tgtttttctc tcctgtttct cgctccctct ctgctgatca caaagctgct gaccgggtca
121 gaaagtcctg atggaaatcc accagcgctg ggcaggcccc tcctcctcca gggagcttgt
181 ccttgcctaa tttttcttcg tcctgatgag aacaaaaaag agagagagaa gaaaagaaaa
241 accacaaact tcctttgaaa accagcttgt agtcagggcc cggagcgcat gccatagact
301 cggcgactca ggaatcctga agactctctg agcgacctgg agcaccttgg ctgtgtccct
361 gcctgccttc accctcctcc agtgccccca gtactgggcg tgagtccgga agtggccaca
421 acccagcctg gaccgtcgct tataaagctg tgtaaacctg tataagctca ggcgttgaca
481 gctggaaggc agctggcact ggcagccccc ttcattgcac ctatctcccc catctcattg
541 ccacggctga accctccttc tcaatcttgg aacagcaccc ccttctttaa gggaagctga
601 ctccacccat gtgttcaatc ccaccagtct tccctcccaa gtctggaagc cccacgacct
661 cttggtctca tctggtcaca gcaagttaga ggtggaaaga gctcagcacg gggcccttct
721 gtttacacat atactgccca tagccaggag ttactgcaca aacactagcc agccttctac
781 actacattcc ttttccaaga cttttctggg ttagtttgct ttccagccca ctgatttcct
841 tcttattgga caggtcactc ttttgcatcc caagcctggc ttaggcaagt ccctgaggtt
901 agtaaacacc ttcagtgccc ctcagccaag tcccttttga ccatggaata ccatcagcct
961 gaggatccag cccctggtaa ggccgggact gcagaagcag tcatccctga aaaccatgag
1021 gttctggcag gcccagatga gcaccctcag gacacagatg caagagatgc tgatggggag
1081 gctagagaac gggagccagc agaccaagct ttgctgccta gccagtgtgg ggacaacctt
1141 gagtcccctc tgcctgaagc tagctcagct ccaccggggc caacccttgg gacactgcct
1201 gaagtagaga caataagggc atgctccatg ccccaggagc ttcctcagtc ccccaggacc
1261 cgacagcctg agccagattt ctactgtgtc aagtggatcc cttggaaagg agaacagaca
1321 cccatcatca cccagagcac taacggccct tgccctctcc ttgccatcat gaacatcctc
1381 tttcttcagt ggaaggtgaa gctccccccg cagaaggaag tgatcacatc ggatgagctc
1441 atggcccatc ttggaaactg cctcctgtcc atcaagcccc aggagaagtc agagggactt
1501 cagcttaatt ttcagcagag tcctgaggct gtgcgtgcag ttgggaaact gagttacaac
1561 cagctggtgg agaggatcat cacctgcaaa cactccagtg acaccaacct cgtgacagaa
1621 ggcctgattg cagagcagtt cctggagacc accgcggccc agctgaccta ccacggactg
1681 tgtgagctga cagcagctgc taaggagggt gaacttagcg tctttttccg aaacaaccac
1741 tttagcacca tgactaagca taagagtcac ttatacctac tggtcactga ccagggcttt
1801 ctacaggagg agcaagtcgt atgggagagc ctgcacaatg tggatggaga cagctgcttt
1861 tgtgactctg actttcacct gagtcattcc ctgggcaagg ggcctggagc agaaggtggg
1921 agtggctccc cagaaacgca gctgcaggta gaccaggact acctgattgc tctgtccctg
1981 cagcagcaac agccacgagg cccgctgggg cttaccgact tggagctggc ccagcagctt
2041 cagcaagagg agtatcaaca gcagcaggca gcgcagccag tgcggatgcg gacgcgggtc
2101 ctgtcactgc aggggagagg agccacatct ggacgcccag ccggggagcg tcggcagagg
2161 ccgaagcacg agtcagactg cattctgctg tagctctgcc ccagtgccag gctggcctgc
2221 cccttcttcc agaggctatg gctagttggc ttgctccccc gcctccaccc ctgagatgtg
2281 ctggataact tatttatgga ctgttgggga tgagagcagg caacaaatgc caaggtcaga
2341 cttggtaatg tccttgacct cacgtgctgc tgccttctct gcctcccatc cagggcaaca
2401 ctaggattgg tgggtttctg gttctcaact cccggtccct gaatagtcac acgtatgtac
2461 agactgaggc tctggggtga ggtccctatc cagaatgcat ctcttctgct tcccatccct
2521 gctgcctgga tgctcctgat cacctaggca ggcctgtctc cagttgtttc agagcttaat
2581 ttgggtttct atctcttatt tgtaatgcct tcctggggtt tggaaataaa acttctggcc
2641 gggca
//