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Homo sapiens MINDY lysine 48 deubiquitinase 1 (MINDY1), transcript variant 12, mRNA

NCBI Reference Sequence: NM_001376669.1

FASTA Graphics 

LOCUS       NM_001376669            2645 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens MINDY lysine 48 deubiquitinase 1 (MINDY1), transcript
            variant 12, mRNA.
ACCESSION   NM_001376669 XM_017001775
VERSION     NM_001376669.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2645)
  AUTHORS   Abdul Rehman,S.A., Armstrong,L.A., Lange,S.M., Kristariyanto,Y.A.,
            Grawert,T.W., Knebel,A., Svergun,D.I. and Kulathu,Y.
  TITLE     Mechanism of activation and regulation of deubiquitinase activity
            in MINDY1 and MINDY2
  JOURNAL   Mol Cell 81 (20), 4176-4190 (2021)
   PUBMED   34529927
  REMARK    GeneRIF: Mechanism of activation and regulation of deubiquitinase
            activity in MINDY1 and MINDY2.
REFERENCE   2  (bases 1 to 2645)
  AUTHORS   Tang,J., Luo,Y., Long,G. and Zhou,L.
  TITLE     MINDY1 promotes breast cancer cell proliferation by stabilizing
            estrogen receptor alpha
  JOURNAL   Cell Death Dis 12 (10), 937 (2021)
   PUBMED   34645792
  REMARK    GeneRIF: MINDY1 promotes breast cancer cell proliferation by
            stabilizing estrogen receptor alpha.
            Erratum:[Cell Death Dis. 2022 Jan 27;13(1):88. doi:
            10.1038/s41419-022-04549-7. PMID: 35087032]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2645)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 2645)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2645)
  AUTHORS   Kristariyanto,Y.A., Abdul Rehman,S.A., Weidlich,S., Knebel,A. and
            Kulathu,Y.
  TITLE     A single MIU motif of MINDY-1 recognizes K48-linked polyubiquitin
            chains
  JOURNAL   EMBO Rep 18 (3), 392-402 (2017)
   PUBMED   28082312
REFERENCE   6  (bases 1 to 2645)
  AUTHORS   Abdul Rehman,S.A., Kristariyanto,Y.A., Choi,S.Y., Nkosi,P.J.,
            Weidlich,S., Labib,K., Hofmann,K. and Kulathu,Y.
  TITLE     MINDY-1 Is a Member of an Evolutionarily Conserved and Structurally
            Distinct New Family of Deubiquitinating Enzymes
  JOURNAL   Mol Cell 63 (1), 146-155 (2016)
   PUBMED   27292798
  REMARK    GeneRIF: MINDY-1 prefers cleaving long polyubiquitin chains and
            works by trimming chains from the distal end.
REFERENCE   7  (bases 1 to 2645)
  AUTHORS   Kirin,M., Chandra,A., Charteris,D.G., Hayward,C., Campbell,S.,
            Celap,I., Bencic,G., Vatavuk,Z., Kirac,I., Richards,A.J.,
            Tenesa,A., Snead,M.P., Fleck,B.W., Singh,J., Harsum,S.,
            Maclaren,R.E., den Hollander,A.I., Dunlop,M.G., Hoyng,C.B.,
            Wright,A.F., Campbell,H., Vitart,V. and Mitry,D.
  TITLE     Genome-wide association study identifies genetic risk underlying
            primary rhegmatogenous retinal detachment
  JOURNAL   Hum Mol Genet 22 (15), 3174-3185 (2013)
   PUBMED   23585552
REFERENCE   8  (bases 1 to 2645)
  AUTHORS   Kottgen,A., Pattaro,C., Boger,C.A., Fuchsberger,C., Olden,M.,
            Glazer,N.L., Parsa,A., Gao,X., Yang,Q., Smith,A.V., O'Connell,J.R.,
            Li,M., Schmidt,H., Tanaka,T., Isaacs,A., Ketkar,S., Hwang,S.J.,
            Johnson,A.D., Dehghan,A., Teumer,A., Pare,G., Atkinson,E.J.,
            Zeller,T., Lohman,K., Cornelis,M.C., Probst-Hensch,N.M.,
            Kronenberg,F., Tonjes,A., Hayward,C., Aspelund,T., Eiriksdottir,G.,
            Launer,L.J., Harris,T.B., Rampersaud,E., Mitchell,B.D.,
            Arking,D.E., Boerwinkle,E., Struchalin,M., Cavalieri,M.,
            Singleton,A., Giallauria,F., Metter,J., de Boer,I.H.,
            Haritunians,T., Lumley,T., Siscovick,D., Psaty,B.M.,
            Zillikens,M.C., Oostra,B.A., Feitosa,M., Province,M., de
            Andrade,M., Turner,S.T., Schillert,A., Ziegler,A., Wild,P.S.,
            Schnabel,R.B., Wilde,S., Munzel,T.F., Leak,T.S., Illig,T.,
            Klopp,N., Meisinger,C., Wichmann,H.E., Koenig,W., Zgaga,L.,
            Zemunik,T., Kolcic,I., Minelli,C., Hu,F.B., Johansson,A., Igl,W.,
            Zaboli,G., Wild,S.H., Wright,A.F., Campbell,H., Ellinghaus,D.,
            Schreiber,S., Aulchenko,Y.S., Felix,J.F., Rivadeneira,F.,
            Uitterlinden,A.G., Hofman,A., Imboden,M., Nitsch,D.,
            Brandstatter,A., Kollerits,B., Kedenko,L., Magi,R., Stumvoll,M.,
            Kovacs,P., Boban,M., Campbell,S., Endlich,K., Volzke,H.,
            Kroemer,H.K., Nauck,M., Volker,U., Polasek,O., Vitart,V.,
            Badola,S., Parker,A.N., Ridker,P.M., Kardia,S.L., Blankenberg,S.,
            Liu,Y., Curhan,G.C., Franke,A., Rochat,T., Paulweber,B.,
            Prokopenko,I., Wang,W., Gudnason,V., Shuldiner,A.R., Coresh,J.,
            Schmidt,R., Ferrucci,L., Shlipak,M.G., van Duijn,C.M., Borecki,I.,
            Kramer,B.K., Rudan,I., Gyllensten,U., Wilson,J.F., Witteman,J.C.,
            Pramstaller,P.P., Rettig,R., Hastie,N., Chasman,D.I., Kao,W.H.,
            Heid,I.M. and Fox,C.S.
  TITLE     New loci associated with kidney function and chronic kidney disease
  JOURNAL   Nat Genet 42 (5), 376-384 (2010)
   PUBMED   20383146
REFERENCE   9  (bases 1 to 2645)
  AUTHORS   Lehner,B. and Sanderson,C.M.
  TITLE     A protein interaction framework for human mRNA degradation
  JOURNAL   Genome Res 14 (7), 1315-1323 (2004)
   PUBMED   15231747
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590133.32.
            
            On Nov 18, 2019 this sequence version replaced XM_017001775.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.226550.1,
                                           SRR1660809.218315.1 [ECO:0000332]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-591               AL590133.32        92505-93095         c
            592-1395            AL590133.32        88358-89161         c
            1396-1453           AL590133.32        87918-87975         c
            1454-1518           AL590133.32        87443-87507         c
            1519-1621           AL590133.32        86055-86157         c
            1622-1764           AL590133.32        85562-85704         c
            1765-1956           AL590133.32        84275-84466         c
            1957-2112           AL590133.32        83817-83972         c
            2113-2645           AL590133.32        83028-83560         c
FEATURES             Location/Qualifiers
     source          1..2645
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..2645
                     /gene="MINDY1"
                     /gene_synonym="FAM63A; MINDY-1"
                     /note="MINDY lysine 48 deubiquitinase 1"
                     /db_xref="GeneID:55793"
                     /db_xref="HGNC:HGNC:25648"
                     /db_xref="MIM:618407"
     exon            1..591
                     /gene="MINDY1"
                     /gene_synonym="FAM63A; MINDY-1"
                     /inference="alignment:Splign:2.1.0"
     exon            592..1395
                     /gene="MINDY1"
                     /gene_synonym="FAM63A; MINDY-1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    832..834
                     /gene="MINDY1"
                     /gene_synonym="FAM63A; MINDY-1"
                     /note="upstream in-frame stop codon"
     CDS             943..2193
                     /gene="MINDY1"
                     /gene_synonym="FAM63A; MINDY-1"
                     /EC_number="3.4.19.12"
                     /note="isoform 9 is encoded by transcript variant 12;
                     protein FAM63A; deubiquitinating enzyme MINDY-1; ubiquitin
                     carboxyl-terminal hydrolase MINDY-1; MIU-containing novel
                     DUB family member 1; motif interacting with Ub-containing
                     novel DUB; family with sequence similarity 63 member A;
                     MINDY deubiquitinase 1"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase MINDY-1
                     isoform 9"
                     /protein_id="NP_001363598.1"
                     /db_xref="GeneID:55793"
                     /db_xref="HGNC:HGNC:25648"
                     /db_xref="MIM:618407"
                     /translation="MEYHQPEDPAPGKAGTAEAVIPENHEVLAGPDEHPQDTDARDAD
                     GEAREREPADQALLPSQCGDNLESPLPEASSAPPGPTLGTLPEVETIRACSMPQELPQ
                     SPRTRQPEPDFYCVKWIPWKGEQTPIITQSTNGPCPLLAIMNILFLQWKVKLPPQKEV
                     ITSDELMAHLGNCLLSIKPQEKSEGLQLNFQQSPEAVRAVGKLSYNQLVERIITCKHS
                     SDTNLVTEGLIAEQFLETTAAQLTYHGLCELTAAAKEGELSVFFRNNHFSTMTKHKSH
                     LYLLVTDQGFLQEEQVVWESLHNVDGDSCFCDSDFHLSHSLGKGPGAEGGSGSPETQL
                     QVDQDYLIALSLQQQQPRGPLGLTDLELAQQLQQEEYQQQQAAQPVRMRTRVLSLQGR
                     GATSGRPAGERRQRPKHESDCILL"
     exon            1396..1453
                     /gene="MINDY1"
                     /gene_synonym="FAM63A; MINDY-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1518
                     /gene="MINDY1"
                     /gene_synonym="FAM63A; MINDY-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1621
                     /gene="MINDY1"
                     /gene_synonym="FAM63A; MINDY-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1764
                     /gene="MINDY1"
                     /gene_synonym="FAM63A; MINDY-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1956
                     /gene="MINDY1"
                     /gene_synonym="FAM63A; MINDY-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2112
                     /gene="MINDY1"
                     /gene_synonym="FAM63A; MINDY-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2645
                     /gene="MINDY1"
                     /gene_synonym="FAM63A; MINDY-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2625..2630
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MINDY1"
                     /gene_synonym="FAM63A; MINDY-1"
                     /note="hexamer: AATAAA"
     polyA_site      2645
                     /gene="MINDY1"
                     /gene_synonym="FAM63A; MINDY-1"
                     /note="major polyA site"
ORIGIN      
        1 agagaggcac aagcgctccg tcccttctag aggcaggcag agggaagaga aagggtctgt
       61 tgtttttctc tcctgtttct cgctccctct ctgctgatca caaagctgct gaccgggtca
      121 gaaagtcctg atggaaatcc accagcgctg ggcaggcccc tcctcctcca gggagcttgt
      181 ccttgcctaa tttttcttcg tcctgatgag aacaaaaaag agagagagaa gaaaagaaaa
      241 accacaaact tcctttgaaa accagcttgt agtcagggcc cggagcgcat gccatagact
      301 cggcgactca ggaatcctga agactctctg agcgacctgg agcaccttgg ctgtgtccct
      361 gcctgccttc accctcctcc agtgccccca gtactgggcg tgagtccgga agtggccaca
      421 acccagcctg gaccgtcgct tataaagctg tgtaaacctg tataagctca ggcgttgaca
      481 gctggaaggc agctggcact ggcagccccc ttcattgcac ctatctcccc catctcattg
      541 ccacggctga accctccttc tcaatcttgg aacagcaccc ccttctttaa gggaagctga
      601 ctccacccat gtgttcaatc ccaccagtct tccctcccaa gtctggaagc cccacgacct
      661 cttggtctca tctggtcaca gcaagttaga ggtggaaaga gctcagcacg gggcccttct
      721 gtttacacat atactgccca tagccaggag ttactgcaca aacactagcc agccttctac
      781 actacattcc ttttccaaga cttttctggg ttagtttgct ttccagccca ctgatttcct
      841 tcttattgga caggtcactc ttttgcatcc caagcctggc ttaggcaagt ccctgaggtt
      901 agtaaacacc ttcagtgccc ctcagccaag tcccttttga ccatggaata ccatcagcct
      961 gaggatccag cccctggtaa ggccgggact gcagaagcag tcatccctga aaaccatgag
     1021 gttctggcag gcccagatga gcaccctcag gacacagatg caagagatgc tgatggggag
     1081 gctagagaac gggagccagc agaccaagct ttgctgccta gccagtgtgg ggacaacctt
     1141 gagtcccctc tgcctgaagc tagctcagct ccaccggggc caacccttgg gacactgcct
     1201 gaagtagaga caataagggc atgctccatg ccccaggagc ttcctcagtc ccccaggacc
     1261 cgacagcctg agccagattt ctactgtgtc aagtggatcc cttggaaagg agaacagaca
     1321 cccatcatca cccagagcac taacggccct tgccctctcc ttgccatcat gaacatcctc
     1381 tttcttcagt ggaaggtgaa gctccccccg cagaaggaag tgatcacatc ggatgagctc
     1441 atggcccatc ttggaaactg cctcctgtcc atcaagcccc aggagaagtc agagggactt
     1501 cagcttaatt ttcagcagag tcctgaggct gtgcgtgcag ttgggaaact gagttacaac
     1561 cagctggtgg agaggatcat cacctgcaaa cactccagtg acaccaacct cgtgacagaa
     1621 ggcctgattg cagagcagtt cctggagacc accgcggccc agctgaccta ccacggactg
     1681 tgtgagctga cagcagctgc taaggagggt gaacttagcg tctttttccg aaacaaccac
     1741 tttagcacca tgactaagca taagagtcac ttatacctac tggtcactga ccagggcttt
     1801 ctacaggagg agcaagtcgt atgggagagc ctgcacaatg tggatggaga cagctgcttt
     1861 tgtgactctg actttcacct gagtcattcc ctgggcaagg ggcctggagc agaaggtggg
     1921 agtggctccc cagaaacgca gctgcaggta gaccaggact acctgattgc tctgtccctg
     1981 cagcagcaac agccacgagg cccgctgggg cttaccgact tggagctggc ccagcagctt
     2041 cagcaagagg agtatcaaca gcagcaggca gcgcagccag tgcggatgcg gacgcgggtc
     2101 ctgtcactgc aggggagagg agccacatct ggacgcccag ccggggagcg tcggcagagg
     2161 ccgaagcacg agtcagactg cattctgctg tagctctgcc ccagtgccag gctggcctgc
     2221 cccttcttcc agaggctatg gctagttggc ttgctccccc gcctccaccc ctgagatgtg
     2281 ctggataact tatttatgga ctgttgggga tgagagcagg caacaaatgc caaggtcaga
     2341 cttggtaatg tccttgacct cacgtgctgc tgccttctct gcctcccatc cagggcaaca
     2401 ctaggattgg tgggtttctg gttctcaact cccggtccct gaatagtcac acgtatgtac
     2461 agactgaggc tctggggtga ggtccctatc cagaatgcat ctcttctgct tcccatccct
     2521 gctgcctgga tgctcctgat cacctaggca ggcctgtctc cagttgtttc agagcttaat
     2581 ttgggtttct atctcttatt tgtaatgcct tcctggggtt tggaaataaa acttctggcc
     2641 gggca
//
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