LOCUS NM_001386041 7785 bp mRNA linear PRI 07-APR-2024
DEFINITION Homo sapiens DENN domain containing 4C (DENND4C), transcript
variant 19, mRNA.
ACCESSION NM_001386041
VERSION NM_001386041.1
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7785)
AUTHORS Yang,B., Wang,J., Qiao,J., Zhang,Q., Liu,Q., Tan,Y., Wang,Q.,
Sun,W., Feng,W., Li,Z., Wang,C., Yang,S. and Cui,L.
TITLE Circ DENND4C inhibits pyroptosis and alleviates
ischemia-reperfusion acute kidney injury by exosomes secreted from
human urine-derived stem cells
JOURNAL Chem Biol Interact 391, 110922 (2024)
PUBMED 38412628
REMARK GeneRIF: Circ DENND4C inhibits pyroptosis and alleviates
ischemia-reperfusion acute kidney injury by exosomes secreted from
human urine-derived stem cells.
REFERENCE 2 (bases 1 to 7785)
AUTHORS Liu,S., Yuan,L., Li,J., Liu,Y., Wang,H. and Ren,X.
TITLE circDENND4C, a novel serum marker for epithelial ovarian cancer,
acts as a tumor suppressor by downregulating miR-200b/c
JOURNAL Ann Med 55 (1), 908-919 (2023)
PUBMED 36896567
REMARK GeneRIF: circDENND4C, a novel serum marker for epithelial ovarian
cancer, acts as a tumor suppressor by downregulating miR-200b/c.
REFERENCE 3 (bases 1 to 7785)
AUTHORS Zhang,Z.J., Zhang,Y.H., Qin,X.J., Wang,Y.X. and Fu,J.
TITLE Circular RNA circDENND4C facilitates proliferation, migration and
glycolysis of colorectal cancer cells through miR-760/GLUT1 axis
JOURNAL Eur Rev Med Pharmacol Sci 24 (5), 2387-2400 (2020)
PUBMED 32196590
REMARK GeneRIF: Circular RNA circDENND4C facilitates proliferation,
migration and glycolysis of colorectal cancer cells through
miR-760/GLUT1 axis.
REFERENCE 4 (bases 1 to 7785)
AUTHORS Ren,S., Liu,J., Feng,Y., Li,Z., He,L., Li,L., Cao,X., Wang,Z. and
Zhang,Y.
TITLE Knockdown of circDENND4C inhibits glycolysis, migration and
invasion by up-regulating miR-200b/c in breast cancer under hypoxia
JOURNAL J Exp Clin Cancer Res 38 (1), 388 (2019)
PUBMED 31488193
REMARK GeneRIF: circDENND4C silence suppresses glycolysis, migration and
invasion in breast cancer cells under hypoxia by increasing
miR-200b and miR-200c.
Publication Status: Online-Only
REFERENCE 5 (bases 1 to 7785)
AUTHORS Sano,H., Peck,G.R., Kettenbach,A.N., Gerber,S.A. and Lienhard,G.E.
TITLE Insulin-stimulated GLUT4 protein translocation in adipocytes
requires the Rab10 guanine nucleotide exchange factor Dennd4C
JOURNAL J Biol Chem 286 (19), 16541-16545 (2011)
PUBMED 21454697
REMARK GeneRIF: Insulin-stimulated GLUT4 protein translocation in
adipocytes requires the Rab10 guanine nucleotide exchange factor
Dennd4C
REFERENCE 6 (bases 1 to 7785)
AUTHORS Yoshimura,S., Gerondopoulos,A., Linford,A., Rigden,D.J. and
Barr,F.A.
TITLE Family-wide characterization of the DENN domain Rab GDP-GTP
exchange factors
JOURNAL J Cell Biol 191 (2), 367-381 (2010)
PUBMED 20937701
REFERENCE 7 (bases 1 to 7785)
AUTHORS Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
TITLE A probability-based approach for high-throughput protein
phosphorylation analysis and site localization
JOURNAL Nat Biotechnol 24 (10), 1285-1292 (2006)
PUBMED 16964243
REFERENCE 8 (bases 1 to 7785)
AUTHORS Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
Dunham,I.
TITLE DNA sequence and analysis of human chromosome 9
JOURNAL Nature 429 (6990), 369-374 (2004)
PUBMED 15164053
REFERENCE 9 (bases 1 to 7785)
AUTHORS Semova,N., Kapanadze,B., Corcoran,M., Kutsenko,A., Baranova,A. and
Semov,A.
TITLE Molecular cloning, structural analysis, and expression of a human
IRLB, MYC promoter-binding protein: new DENN domain-containing
protein family emerges
JOURNAL Genomics 82 (3), 343-354 (2003)
PUBMED 12906859
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AL161909.20 and AL391834.8.
##Evidence-Data-START##
Transcript exon combination :: SRR14372079.3716606.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA2144333, SAMEA2145245
[ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-141 AL161909.20 45475-45615
142-463 AL161909.20 90940-91261
464-716 AL161909.20 101551-101803
717-786 AL161909.20 103378-103447
787-959 AL161909.20 105486-105658
960-1198 AL161909.20 110790-111028
1199-1265 AL161909.20 112838-112904
1266-1324 AL161909.20 114011-114069
1325-1469 AL161909.20 114969-115113
1470-1645 AL161909.20 120134-120309
1646-1746 AL161909.20 131199-131299
1747-1965 AL161909.20 131403-131621
1966-2111 AL391834.8 3855-4000
2112-2147 AL391834.8 5432-5467
2148-2278 AL391834.8 5557-5687
2279-2411 AL391834.8 7523-7655
2412-2540 AL391834.8 14470-14598
2541-2685 AL391834.8 15763-15907
2686-2832 AL391834.8 16179-16325
2833-2955 AL391834.8 20485-20607
2956-3102 AL391834.8 22126-22272
3103-4268 AL391834.8 25414-26579
4269-4446 AL391834.8 30195-30372
4447-4556 AL391834.8 31566-31675
4557-4732 AL391834.8 31983-32158
4733-4915 AL391834.8 36465-36647
4916-5111 AL391834.8 37458-37653
5112-5357 AL391834.8 39737-39982
5358-5475 AL391834.8 41339-41456
5476-5540 AL391834.8 51249-51313
5541-7785 AL391834.8 51530-53774
FEATURES Location/Qualifiers
source 1..7785
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="9"
/map="9p22.1"
gene 1..7785
/gene="DENND4C"
/gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
/note="DENN domain containing 4C"
/db_xref="GeneID:55667"
/db_xref="HGNC:HGNC:26079"
exon 1..141
/gene="DENND4C"
/gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
/inference="alignment:Splign:2.1.0"
exon 142..463
/gene="DENND4C"
/gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
/inference="alignment:Splign:2.1.0"
CDS 159..5510
/gene="DENND4C"
/gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
/note="isoform 14 is encoded by transcript variant 19;
DENN domain-containing protein 4C; DENN/MADD domain
containing 4C; DENN/MADD domain containing 4A pseudogene"
/codon_start=1
/product="DENN domain-containing protein 4C isoform 14"
/protein_id="NP_001372970.1"
/db_xref="GeneID:55667"
/db_xref="HGNC:HGNC:26079"
/translation="MIEDKGPRVTDYFVVAGLTDTSTLLDQEINRLDTKSTGPKAPIT
DIAIIIKSAGETVPEGYTCVEATPSALQANLNYGSLKSPELFLCYKRGRDKPPLTDIG
VLYEGKERLIPGCEVILATPYGRCANVNNSSTTSQRIFITYRRAPPVRPQNSLAVTDI
CVIVTSKGETPPHTFCKVDKNLNCGMWGSSVFLCYKKSVPASNAIAYKAGLIFRYPEE
DYESFPLSESDVPLFCLPMGATIECWDPETKYPLPVFSTFVLTGSSAKKVYGAAIQFY
EPYSRELLSEKQLMHLGLLTPVERKMVSKSINTNKCICLLSHWPFFEAFRKFLMFIYK
LSVSGPHPLPIEKHISHFMQNIPFPSPQRPRILVQLSVHDALILSQPVSTPLPLSGAN
FSTLLMNLGPENCATLLLFVLLESKILLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIP
LCPLSLAAVLSAPLPFIVGVDSRYFDLHDPPQDVVCIDLDTNMLYVSDEKKNMNWKQL
PKKPCKNLLSTLKKLYPQLSSVHQKTQEGSAIDMTPIEADFSWQKKMTQLEMEIQEAF
LRFMASILKGYRTYLRPITEAPSNKATAADSLFDRQGFLKSRDRAYAKFYTLLSKTQI
FIRFIEECSFVSDKDTGLAFFDDCIEKLFPDKGTEKTDKVDFDSAEDTRLIELDDSQK
SEHTVFIMPPEPPPDDGKDLSPKYSYKYFPRLDLKLFDRPQELKLCFSRHPTGNSITK
SPPLMAKRTKQVCYRVVMQLCGLWGHPVLAVRVLFEMKTARIKPNAITYGYYNKVVLE
SPWPSSTRSGIFLWTKVRNVVRGLAQFRQPLKKTVQRSQVSSISALQNVTGGSDGDTV
SHGSVDSSNDANNGEHTVFVRDLIRLESIDNHSSTGGQSDQGYGSKDELIKDDAEIHV
PEEQAARELITKTKMQTEEVCDASAIVAKHSQPSPEPHSPTEPPAWGSSIVKVPSGIF
DVNSRKSSTGSISNVLFSTQDPVEDAVFGEATNLKKNGDRGEKRQKHFPERSCSFSSE
SRAGMLLKKSSLDSNSSEMAIMMGADAKILTAALTCPKTSLLHIARTHSFENVSCHLP
DSRTCMSESTWNPEHRSSPVPEMLEESQELLEPVVDDVPKTTATVDTYESLLSDSNSN
QSRDLKTVSKDLRNKRSSLYGIAKVVQREDVETGLDPLSLLATECTGGKTPDSEDKLF
SPVIARNLADEIESYMNLKSPLGSKSSSMELHREENRESGMTTAFIHALERRSSLPLD
HGSPAQENPESEKSSPAVSRSKTFTGRFKQQTPSRTHKERSTSLSALVRSSPHGSLGS
VVNSLSGLKLDNILSGPKIDVLKSGMKQAATVASKMWVAVASAYSYSDDEEETNRDYS
FPAGLEDHILGENISPNTSISGLVPSELTQSNTSLGSSSSSGDVGKLHYPTGEVPFPR
GMKGQDFEKSDHGSSQNTSMSSIYQNCAMEVLMSSCSQCRACGALVYDEEIMAGWTAD
DSNLNTACPFCKSNFLPLLNIEFKDLRGSASFFLKPSTSGDSLQSGSIPLANESLEHK
PVSSLAEPDLINFMDFPKHNQIITEETGSAVEPSDEIKRASGDVQTMKISSVPNSLSK
RNVSLTRSHSVGGPLQNIDFTQRPFHGISTVSLPNSLQEVVDPLGKRPNPPPVSVPYL
SPLVLRKELESLLENEGDQVIHTSSFINQHPIIFWNLVWYFRRLDLPSNLPGLILTSE
HCNEGVQLPLSSLSQDSKLVYIQLLWDNINLHQEPREPLYVSWRNFRVYTEKSSSYH"
exon 464..716
/gene="DENND4C"
/gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
/inference="alignment:Splign:2.1.0"
exon 717..786
/gene="DENND4C"
/gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
/inference="alignment:Splign:2.1.0"
exon 787..959
/gene="DENND4C"
/gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
/inference="alignment:Splign:2.1.0"
exon 960..1198
/gene="DENND4C"
/gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
/inference="alignment:Splign:2.1.0"
exon 1199..1265
/gene="DENND4C"
/gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
/inference="alignment:Splign:2.1.0"
exon 1266..1324
/gene="DENND4C"
/gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
/inference="alignment:Splign:2.1.0"
exon 1325..1469
/gene="DENND4C"
/gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
/inference="alignment:Splign:2.1.0"
exon 1470..1645
/gene="DENND4C"
/gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
/inference="alignment:Splign:2.1.0"
exon 1646..1746
/gene="DENND4C"
/gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
/inference="alignment:Splign:2.1.0"
exon 1747..1965
/gene="DENND4C"
/gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
/inference="alignment:Splign:2.1.0"
exon 1966..2111
/gene="DENND4C"
/gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
/inference="alignment:Splign:2.1.0"
exon 2112..2147
/gene="DENND4C"
/gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
/inference="alignment:Splign:2.1.0"
exon 2148..2278
/gene="DENND4C"
/gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
/inference="alignment:Splign:2.1.0"
exon 2279..2411
/gene="DENND4C"
/gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
/inference="alignment:Splign:2.1.0"
exon 2412..2540
/gene="DENND4C"
/gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
/inference="alignment:Splign:2.1.0"
exon 2541..2685
/gene="DENND4C"
/gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
/inference="alignment:Splign:2.1.0"
exon 2686..2832
/gene="DENND4C"
/gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
/inference="alignment:Splign:2.1.0"
exon 2833..2955
/gene="DENND4C"
/gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
/inference="alignment:Splign:2.1.0"
exon 2956..3102
/gene="DENND4C"
/gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
/inference="alignment:Splign:2.1.0"
exon 3103..4268
/gene="DENND4C"
/gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
/inference="alignment:Splign:2.1.0"
exon 4269..4446
/gene="DENND4C"
/gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
/inference="alignment:Splign:2.1.0"
exon 4447..4556
/gene="DENND4C"
/gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
/inference="alignment:Splign:2.1.0"
exon 4557..4732
/gene="DENND4C"
/gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
/inference="alignment:Splign:2.1.0"
exon 4733..4915
/gene="DENND4C"
/gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
/inference="alignment:Splign:2.1.0"
exon 4916..5111
/gene="DENND4C"
/gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
/inference="alignment:Splign:2.1.0"
exon 5112..5357
/gene="DENND4C"
/gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
/inference="alignment:Splign:2.1.0"
exon 5358..5475
/gene="DENND4C"
/gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
/inference="alignment:Splign:2.1.0"
exon 5476..5540
/gene="DENND4C"
/gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
/inference="alignment:Splign:2.1.0"
exon 5541..7785
/gene="DENND4C"
/gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
/inference="alignment:Splign:2.1.0"
regulatory 7619..7624
/regulatory_class="polyA_signal_sequence"
/gene="DENND4C"
/gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
/note="hexamer: AATGAA"
polyA_site 7643
/gene="DENND4C"
/gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
/note="major polyA site"
regulatory 7750..7755
/regulatory_class="polyA_signal_sequence"
/gene="DENND4C"
/gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
/note="hexamer: ATTAAA"
polyA_site 7785
/gene="DENND4C"
/gene_synonym="bA513M16.3; C9orf55; C9orf55B; RAB10GEF"
ORIGIN
1 agaccggact gaggcggcgg cggccgctgg agctagtccc ccgccctgcc ctgccgagcg
61 cgcccagtcc gcgaatccgg tgctttcttg ccccaggaag aagccgtgtc ggggctgcgc
121 tgacagagga gcaggcagca gaaaatacag tagcagccat gatagaagac aaaggaccaa
181 gagtgacaga ctactttgtc gtagctggtc tcactgacac atctactctt ttggatcaag
241 aaataaatcg tttagatact aagtcaactg gacctaaagc tccaattaca gacattgcca
301 ttattatcaa atcagctgga gaaacagtac ctgaaggtta cacctgtgta gaagccactc
361 catcagctct ccaagcaaac ttgaactatg gaagtctgaa aagcccagaa cttttcctct
421 gttataagag agggagagat aaaccaccgc ttacagatat tggagttcta tatgaaggga
481 aagaacggct tattccagga tgtgaagtga tcctagccac accctatggt cgctgtgcca
541 atgtcaacaa tagttcaact acttcacaaa gaatctttat cacttatcga agggctcctc
601 cagttcgacc ccagaattcc ttggctgtaa ctgatatctg tgttattgta accagtaaag
661 gagaaactcc tcctcatacc ttctgcaaag ttgacaaaaa cttaaattgt ggaatgtggg
721 gttccagcgt gtttctgtgt tataagaagt ctgtacctgc ttcaaatgca atagcatata
781 aggctggttt aatttttaga tatccagaag aggactatga gtcatttcca ctctcagaat
841 cagatgtacc tcttttctgc cttcctatgg gagctactat tgagtgctgg gatcctgaaa
901 ccaaatatcc acttccagtt ttttcaactt ttgtcttgac aggttcttca gccaaaaagg
961 tatatggagc tgccattcag ttttatgaac cttactctcg ggaacttcta tcagagaaac
1021 agcttatgca cctgggcttg ttgacgcctg tggagagaaa aatggtctcc aaatccatca
1081 atacaaacaa atgcatttgt ttactctcac actggccttt ttttgaagct tttaggaaat
1141 ttcttatgtt tatctacaaa ctttctgtgt ctggaccaca tcctcttccc attgaaaagc
1201 acatttcaca ttttatgcaa aacatccctt ttccttcacc acaaagaccg agaatccttg
1261 tccagctgtc agtccatgat gcattaatat tatcacagcc agtttctaca cctttaccac
1321 taagtggagc caactttagc accttgctaa tgaatctggg tcctgagaat tgtgcaacac
1381 tgctgctctt tgttttactt gagagtaaaa ttctgctgca ttctcttagg ccagctgtct
1441 tgactggggt agctgaagct gttgtagcta tgatctttcc atttcagtgg caatgcccat
1501 atattcccct ttgtcctctt tcactggctg cagtgcttag tgcaccttta ccatttatag
1561 ttggagttga ctcaaggtat tttgatcttc atgacccacc acaagatgtt gtttgcattg
1621 acttggatac gaacatgtta tatgtatcag atgaaaagaa gaacatgaac tggaagcaac
1681 ttcccaaaaa gccgtgcaaa aatctactta gcaccttaaa gaaattgtat ccccagctgt
1741 cttcagttca ccaaaaaact caagaaggct cagcgattga catgactcca attgaagcag
1801 atttctcctg gcaaaagaag atgacacagc ttgagatgga aattcaagag gcatttttgc
1861 gctttatggc gtctatttta aaaggatata gaacatatct cagaccaatc acagaggctc
1921 cttcaaataa agccacagct gctgattcat tgtttgaccg acagggattt ttaaaaagtc
1981 gagatcgtgc ctatgcaaaa ttctataccc ttttatccaa aacacagatt tttattcgtt
2041 tcattgaaga atgcagtttt gtaagtgata aagatactgg attagcattt tttgatgact
2101 gcatagaaaa gttgtttcct gataaaggca cagagaaaac agataaggtt gattttgatt
2161 cagcagaaga taccagattg atagaactag atgattcaca gaaaagtgag catactgtat
2221 ttataatgcc gccagagcca cctcctgatg atggaaagga cctgtcacca aagtacagtt
2281 acaaatactt tccaagactg gaccttaagc tttttgacag accgcaggag ttgaaacttt
2341 gttttagtag acaccctact gggaatagca ttacaaagag tccacctctc atggctaaga
2401 gaactaaaca ggtgtgctat cgagtagtga tgcagctttg tggactttgg ggtcatcctg
2461 ttttagcagt gagagtctta tttgaaatga aaactgctag gataaagcct aatgctatta
2521 cttatggtta ttataataag gtagtcttgg agagcccgtg gcctagcagt acccgcagtg
2581 gtattttctt atggacgaag gtacggaatg tggtacgtgg cttggcacag tttaggcagc
2641 cgcttaaaaa gactgtgcaa aggtcacagg tctcctcaat atcagctctt caaaatgtca
2701 caggtggaag tgatggggac acggtgagcc acggtagtgt ggatagttct aatgatgcta
2761 acaatgggga gcacacagtc ttcgtcagag atttaatcag gcttgagtcc attgataatc
2821 actctagcac aggtggtcag tctgaccaag gatacgggtc taaggatgaa cttataaagg
2881 atgatgcaga aattcatgtg cctgaagaac aggcagcaag agaattgata actaaaacaa
2941 aaatgcaaac agaagaggtg tgtgatgcct ctgctattgt ggcaaaacat tcacaaccta
3001 gtccagagcc tcacagtcct actgaacctc ctgcatgggg cagcagtatt gtgaaagttc
3061 cgtctggtat atttgatgtc aacagcagga aaagtagcac tggtagtata tcaaatgtgc
3121 tgttttctac tcaagatcca gttgaagatg cagtctttgg cgaagctact aatctcaaga
3181 agaatggtga tagaggagaa aaaagacaaa agcattttcc tgagaggagt tgtagtttta
3241 gttctgaaag tcgagcagga atgttgctta agaagagtag tttggattcg aattcaagtg
3301 aaatggctat catgatggga gcagatgcca agattctcac agcagcattg acatgtccta
3361 agacttctct acttcatatt gcaagaaccc atagctttga gaatgttagc tgtcacctac
3421 ctgatagtag gacttgtatg tctgaaagca cttggaatcc tgagcacaga tcatctccgg
3481 tgccagagat gcttgaggaa agccaagaac tccttgagcc tgtggttgat gacgtaccta
3541 aaactactgc aacagtagat acatatgaga gtctactaag tgatagtaac agtaatcagt
3601 ccagagactt gaaaacagta tccaaagatc tgaggaataa gagaagtagt ttatatggta
3661 ttgctaaggt ggttcagagg gaagatgttg aaactggact agatcctttg tctcttttag
3721 ccactgaatg tacaggagga aaaactcctg attctgaaga taagttgttt tctccagtta
3781 ttgcacgtaa tctggctgat gaaatagaaa gctatatgaa cctaaaaagt cccctaggta
3841 gtaaatcttc tagtatggaa ttacacagag aggaaaacag agagtctggc atgactactg
3901 catttattca tgctctagag aggagatcaa gcctaccttt agatcatggt tcaccagcac
3961 aggaaaatcc tgaaagtgaa aagagctcac ctgcagtgtc caggtctaaa acttttactg
4021 ggcgtttcaa gcagcaaacc ccctctcgaa ctcataaaga acgttcaact tctttgtcag
4081 cactggtgcg ttcttcgcca catggctcgt tgggttctgt agtaaattct ttgtcagggc
4141 taaagctgga taatatactc tcagggccca agatagatgt cctgaaatct ggtatgaaac
4201 aagcagcgac agtagccagt aagatgtggg tagctgttgc gtctgcctac agctactcag
4261 atgatgagga agaaactaat agagactaca gcttcccagc tggcctagaa gaccatattt
4321 tgggggagaa tatatcgcct aacacaagta tctcagggtt ggtccccagt gaacttaccc
4381 agagcaacac aagtcttggc agtagcagca gtagtggaga tgtaggaaaa ctgcattatc
4441 caacaggtga agttccattt ccaagaggca tgaaagggca agactttgaa aaatcagatc
4501 atggttcttc tcaaaatacc agcatgtcta gcatctatca gaattgtgca atggaggttt
4561 tgatgtccag ttgttcacag tgtagagctt gtggagcttt agtttatgat gaagaaatta
4621 tggctggatg gacagcagat gactcaaatt tgaatacagc ttgtccattc tgtaaaagca
4681 acttcttgcc tcttctcaat atagaattca aagatttgag aggttctgca agctttttcc
4741 tgaaaccaag tacctctggt gacagtttac aaagtggaag cattccattg gcaaatgaat
4801 ccttggagca caaacctgta tccagtttag cagaacctga cttgatcaac tttatggact
4861 tcccaaaaca taaccagatc ataactgaag aaacaggctc tgcagttgaa ccaagtgatg
4921 aaataaagag agccagtgga gatgtccaaa ctatgaaaat ttcatctgtg cctaatagtt
4981 tatcaaagcg aaatgtgtct ttgactcgaa gtcacagtgt tggaggccca ttgcagaata
5041 ttgactttac ccagcgaccg tttcatggca tctcaacagt tagtcttcca aatagtctgc
5101 aggaagttgt ggatccttta ggaaaaagac ccaatcctcc ccctgtttct gtgccctact
5161 tgagtcctct agtactccgt aaagaacttg aatctttgct agaaaatgaa ggtgatcagg
5221 tgattcatac atcttctttc atcaatcaac atccaatcat tttctggaac ctcgtttggt
5281 atttcagacg tttggacctt cctagtaact tgccaggact tatcctcaca tctgaacatt
5341 gtaatgaagg tgtacagctt cctctgtcat ctctgtccca ggatagcaaa cttgtgtata
5401 ttcagctgtt atgggataat atcaaccttc atcaggaacc aagagaacct ctgtatgtct
5461 catggaggaa ttttagagtt tatacagaga aatcctcttc ttatcattag tgtctctagg
5521 aagagagaat attgatattg aggcatttga caatgaatat ggaattgcat acaatagtct
5581 gtcttcagag attcttgaaa ggttgcagaa aattgatgct ccaccaagtg ccagtgtcga
5641 gtggtgcagg aagtgttttg gagcgcctct catttaaata gagattcact agaatgttga
5701 cacacaaggc ttggggatta gatttcatct ggaaacattc aagttttttt ttccaaatcg
5761 taagaactgg tgaatacgga attgaagtaa ctcttgggga caatatataa tgaattatga
5821 ttcatattgc attaccttga aatatgaagt gccatttgaa tgtcccaggg cttattaata
5881 ttgaagattt tcaacccctg aactgctttt ctgcctctgt ggaaaactac tttgggattc
5941 ttcagtattt gtagtagttt gatagaaata atgaggaacc atattcattc taggcattgt
6001 ttatatttga agttactgag tttgaggaat ggcaaattaa atttgcctaa cccccaaaac
6061 aaatgaaata tctcaattat aaaagcaaca tggccgggca cggtggctca ggcctgtaat
6121 cccagcactt tgggaggctg agcaaggtgg gtggatcact tgaggccagg agttcgagac
6181 cagcctggcc aacacggtga gaccctgtct ttactaaaaa tacaaaaatt agccaggcgc
6241 accactgtag tcccagctac tcaggctgag gcaggagaat cgcttgaact gaggcagagg
6301 ctacagtgag tggagatcac gccactgcaa ctccagcttg ggtgacagag tgagaccgtc
6361 tcaaaaaaaa aaaaaaaaaa aaaagagagc aacatatttg tgtaagtttg tatatgtgta
6421 gggctgtgta ggtatgtgta tatacagcca tattctaagt gtatatttat taaaatagat
6481 tgcatgttgc aatacggttt tctgaaaggg gtctcattga ctattaaata aatgactact
6541 actaaacttg tctgtagtca ttaatcttaa aattacctga aaatctgatg acagctgcct
6601 tccctaactt taatgtatta ggttggcaca aaattaattg tagtttttgc cactattaat
6661 ggcaaaaacc gcaattattt ttgtaccaac ataatacacc tttcatatta tgtattatct
6721 tgcttaatgg gttttatctt gattatccag ttacttccat cctcttccca atgttaattt
6781 gcaatagttt taaaatggga acaaatgaat caatcatcag atagttaaaa tgaaattaaa
6841 tcagctgcct aataatttat ggaattcatt ggaatgtgct taaaatgcta aagtgtatgt
6901 cattgaacat gaaatctttt ttcaggcaca tacattgttg gtattgatga ctttttaaaa
6961 cctgtgggat aaacttgcac tgcacacgga agttttattc ttgtatattt agatttgtat
7021 gcttgtgagt aaaaatgtgc atttgtaaat actgtgtttt taggttgaat caattaagtc
7081 ttaaaactgt aaatttatta agcttgttgc cagtaggttt aagaaaatca tgatctcaca
7141 tgcctcactt tgacatttat catgcctttt attaaaaata tcccttagga acagtaagtt
7201 tgccttaact ctctgcatgg tttaaaaagc cattggtttt gtgtgtgttt acagtaatta
7261 tgcagatgac taaatgagtt gacacagtaa aattacttcc atatggtaca gtaacaacct
7321 aactcccttc tacctgatgt aaccatttac aaattatagt tattgtacca gtctttcaac
7381 atttcagggt taatctgacc tatgcagaat tctagtgtga atttattgtg aaaatgctaa
7441 atgaaacaat ttgtcagaaa ttatgtacaa ttttcattac cttcaaaatg gatcttttgc
7501 actgtctgag agtatatatt tttgcaactc aagacttggt actagtttta atacttaaca
7561 cttactgacc caacagaagt ttggaattac cttgcatata aaaattgagg ttgaataaaa
7621 tgaaaaattg ttgttttctg ttacattaag cctcttgaaa tctgtaatct ttagaatccc
7681 aatattttgt tttttccatt ccttcactcg taacttgaac tcaagttttc acttactgac
7741 gcgcttccca ttaaaaaaaa tctgtaaaga tctctacctt gaaaa
//