LOCUS NM_001394935 2089 bp mRNA linear PRI 20-AUG-2024
DEFINITION Homo sapiens leukocyte immunoglobulin like receptor B4 (LILRB4),
transcript variant 8, mRNA.
ACCESSION NM_001394935 XM_017026217
VERSION NM_001394935.1
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2089)
AUTHORS Xie,L., Chen,C., Zhang,T., Yang,W., Zheng,D., Cao,L., Yuan,J.,
Xu,Y., Zhang,Y., Liu,L., Liang,A., Yu,Z. and Zheng,J.
TITLE LILRB4 regulates multiple myeloma development through STAT3-PFKFB1
pathway
JOURNAL Cell Death Dis 15 (7), 515 (2024)
PUBMED 39025844
REMARK GeneRIF: LILRB4 regulates multiple myeloma development through
STAT3-PFKFB1 pathway.
Publication Status: Online-Only
REFERENCE 2 (bases 1 to 2089)
AUTHORS Wang,H., Wang,L., Luan,H., Xiao,J., Zhao,Z., Yu,P., Deng,M.,
Liu,Y., Ji,S., Ma,J., Zhou,Y., Zhang,J., Meng,X., Zhang,J.,
Zhao,X., Li,C., Li,F., Wang,D., Wei,S., Hui,L., Nie,S., Jin,C.,
An,Z., Zhang,N., Wang,Y., Zhang,C.C. and Li,Z.
TITLE LILRB4 on multiple myeloma cells promotes bone lesion by
p-SHP2/NF-kappaB/RELT signal pathway
JOURNAL J Exp Clin Cancer Res 43 (1), 183 (2024)
PUBMED 38951916
REMARK GeneRIF: LILRB4 on multiple myeloma cells promotes bone lesion by
p-SHP2/NF-kappaB/RELT signal pathway.
Publication Status: Online-Only
REFERENCE 3 (bases 1 to 2089)
AUTHORS Xiong,J., Wang,L., Xiong,X. and Deng,Y.
TITLE Downregulation of LILRB4 Promotes Human Aortic Smooth Muscle Cell
Contractile Phenotypic Switch and Apoptosis in Aortic Dissection
JOURNAL Cardiovasc Toxicol 24 (3), 225-239 (2024)
PUBMED 38324114
REMARK GeneRIF: Downregulation of LILRB4 Promotes Human Aortic Smooth
Muscle Cell Contractile Phenotypic Switch and Apoptosis in Aortic
Dissection.
REFERENCE 4 (bases 1 to 2089)
AUTHORS Xiang,Z., Yin,X., Wei,L., Peng,M., Zhu,Q., Lu,X., Guo,J., Zhang,J.,
Li,X. and Zou,Y.
TITLE LILRB4 Checkpoint for Immunotherapy: Structure, Mechanism and
Disease Targets
JOURNAL Biomolecules 14 (2), 187 (2024)
PUBMED 38397424
REMARK GeneRIF: LILRB4 Checkpoint for Immunotherapy: Structure, Mechanism
and Disease Targets.
Review article
Publication Status: Online-Only
REFERENCE 5 (bases 1 to 2089)
AUTHORS Li,Y., Guo,J., Zhang,H., Li,Z., Ren,Y., Jiang,Y., Liu,X. and Hu,X.
TITLE LILRB4 regulates the function of decidual MDSCs via the SHP-2/STAT6
pathway during Toxoplasma gondii infection
JOURNAL Parasit Vectors 16 (1), 237 (2023)
PUBMED 37461040
REMARK GeneRIF: LILRB4 regulates the function of decidual MDSCs via the
SHP-2/STAT6 pathway during Toxoplasma gondii infection.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 2089)
AUTHORS Jones,D.C., Roghanian,A., Brown,D.P., Chang,C., Allen,R.L.,
Trowsdale,J. and Young,N.T.
TITLE Alternative mRNA splicing creates transcripts encoding soluble
proteins from most LILR genes
JOURNAL Eur J Immunol 39 (11), 3195-3206 (2009)
PUBMED 19658091
REFERENCE 7 (bases 1 to 2089)
AUTHORS Borges,L., Hsu,M.L., Fanger,N., Kubin,M. and Cosman,D.
TITLE A family of human lymphoid and myeloid Ig-like receptors, some of
which bind to MHC class I molecules
JOURNAL J Immunol 159 (11), 5192-5196 (1997)
PUBMED 9548455
REFERENCE 8 (bases 1 to 2089)
AUTHORS Arm,J.P., Nwankwo,C. and Austen,K.F.
TITLE Molecular identification of a novel family of human Ig superfamily
members that possess immunoreceptor tyrosine-based inhibition
motifs and homology to the mouse gp49B1 inhibitory receptor
JOURNAL J Immunol 159 (5), 2342-2349 (1997)
PUBMED 9278324
REFERENCE 9 (bases 1 to 2089)
AUTHORS Cella,M., Dohring,C., Samaridis,J., Dessing,M., Brockhaus,M.,
Lanzavecchia,A. and Colonna,M.
TITLE A novel inhibitory receptor (ILT3) expressed on monocytes,
macrophages, and dendritic cells involved in antigen processing
JOURNAL J Exp Med 185 (10), 1743-1751 (1997)
PUBMED 9151699
REFERENCE 10 (bases 1 to 2089)
AUTHORS Samaridis,J. and Colonna,M.
TITLE Cloning of novel immunoglobulin superfamily receptors expressed on
human myeloid and lymphoid cells: structural evidence for new
stimulatory and inhibitory pathways
JOURNAL Eur J Immunol 27 (3), 660-665 (1997)
PUBMED 9079806
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AC243962.3.
On May 11, 2021 this sequence version replaced XM_017026217.1.
Summary: This gene is a member of the leukocyte immunoglobulin-like
receptor (LIR) family, which is found in a gene cluster at
chromosomal region 19q13.4. The encoded protein belongs to the
subfamily B class of LIR receptors which contain two or four
extracellular immunoglobulin domains, a transmembrane domain, and
two to four cytoplasmic immunoreceptor tyrosine-based inhibitory
motifs (ITIMs). The receptor is expressed on immune cells where it
binds to MHC class I molecules on antigen-presenting cells and
transduces a negative signal that inhibits stimulation of an immune
response. The receptor can also function in antigen capture and
presentation. It is thought to control inflammatory responses and
cytotoxicity to help focus the immune response and limit
autoreactivity. Multiple transcript variants encoding different
isoforms have been found for this gene. [provided by RefSeq, Jul
2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: DRR138517.521797.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA1965299, SAMEA1966682
[ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-83 AC243962.3 41432-41514
84-119 AC243962.3 41979-42014
120-404 AC243962.3 42201-42485
405-704 AC243962.3 42633-42932
705-755 AC243962.3 43246-43296
756-803 AC243962.3 43580-43627
804-920 AC243962.3 44262-44378
921-996 AC243962.3 44687-44762
997-1034 AC243962.3 44846-44883
1035-1087 AC243962.3 45144-45196
1088-1243 AC243962.3 46085-46240
1244-2089 AC243962.3 46320-47165
FEATURES Location/Qualifiers
source 1..2089
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="19"
/map="19q13.42"
gene 1..2089
/gene="LILRB4"
/gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
/note="leukocyte immunoglobulin like receptor B4"
/db_xref="GeneID:11006"
/db_xref="HGNC:HGNC:6608"
/db_xref="MIM:604821"
exon 1..83
/gene="LILRB4"
/gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
/inference="alignment:Splign:2.1.0"
CDS 50..1390
/gene="LILRB4"
/gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
/note="isoform 8 precursor is encoded by transcript
variant 8; leukocyte immunoglobulin-like receptor 5;
monocyte inhibitory receptor HM18; immunoglobulin-like
transcript 3; CD85 antigen-like family member K; leukocyte
immunoglobulin-like receptor, subfamily B (with TM and
ITIM domains), member 4; leucocyte Ig-like receptor B4"
/codon_start=1
/product="leukocyte immunoglobulin-like receptor subfamily
B member 4 isoform 8 precursor"
/protein_id="NP_001381864.1"
/db_xref="GeneID:11006"
/db_xref="HGNC:HGNC:6608"
/db_xref="MIM:604821"
/translation="MIPTFTALLCLGLSLGPRTHMQAGPLPKPTLWAEPGSVISWGNS
VTIWCQGTLEAREYRLDKEESPAPWDRQNPLEPKNKARFSIPSMTEDYAGRYRCYYRS
PVGWSQPSDPLELVMTGAYSKPTLSALPSPLVTSGKSVTLLCQSRSPMDTFLLIKERA
AHPLLHLRSEHGAQQHQAEFPMSPVTSVHGGTYRCFSSHGFSHYLLSHPSDPLELIVS
GSLEGPRPSPTRSVSTAGPEDQPLMPTGSVPHSGLRRHWEVLIGVLVVSILLLSLLLF
LLLQHWRQGKHRTLAQRQADFQRPPGAAEPEPKDGGLQRRSSPAADVQGENFCAAVKN
TQPEDGVEMDTRSPHDEDPQAVTYAKVKHSRPRREMASPPSPLSGEFLDTKDRQAEED
RQMDTEAAASEAPQDVTYARLHSFTLRQKATEPPPSQEGASPAEPSVYATLAIH"
sig_peptide 50..112
/gene="LILRB4"
/gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
/inference="COORDINATES: ab initio prediction:SignalP:6.0"
misc_feature 152..154
/gene="LILRB4"
/gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
/note="Required for APOE-mediated activation of LILRB4.
/evidence=ECO:0000269|PubMed:30333625; propagated from
UniProtKB/Swiss-Prot (Q8NHJ6.3); other site"
misc_feature 365..367
/gene="LILRB4"
/gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
/note="Required for APOE-mediated activation of LILRB4.
/evidence=ECO:0000269|PubMed:30333625; propagated from
UniProtKB/Swiss-Prot (Q8NHJ6.3); other site"
misc_feature 410..412
/gene="LILRB4"
/gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
/note="Required for APOE-mediated activation of LILRB4.
/evidence=ECO:0000269|PubMed:30333625; propagated from
UniProtKB/Swiss-Prot (Q8NHJ6.3); other site"
misc_feature 824..886
/gene="LILRB4"
/gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
/note="propagated from UniProtKB/Swiss-Prot (Q8NHJ6.3);
transmembrane region"
misc_feature 1001..1003
/gene="LILRB4"
/gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:24275569; propagated from
UniProtKB/Swiss-Prot (Q8NHJ6.3); phosphorylation site"
misc_feature 1115..1132
/gene="LILRB4"
/gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
/note="propagated from UniProtKB/Swiss-Prot (Q8NHJ6.3);
Region: ITIM motif 1"
misc_feature 1361..1378
/gene="LILRB4"
/gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
/note="propagated from UniProtKB/Swiss-Prot (Q8NHJ6.3);
Region: ITIM motif 3"
exon 84..119
/gene="LILRB4"
/gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
/inference="alignment:Splign:2.1.0"
exon 120..404
/gene="LILRB4"
/gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
/inference="alignment:Splign:2.1.0"
exon 405..704
/gene="LILRB4"
/gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
/inference="alignment:Splign:2.1.0"
exon 705..755
/gene="LILRB4"
/gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
/inference="alignment:Splign:2.1.0"
exon 756..803
/gene="LILRB4"
/gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
/inference="alignment:Splign:2.1.0"
exon 804..920
/gene="LILRB4"
/gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
/inference="alignment:Splign:2.1.0"
exon 921..996
/gene="LILRB4"
/gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
/inference="alignment:Splign:2.1.0"
exon 997..1034
/gene="LILRB4"
/gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
/inference="alignment:Splign:2.1.0"
exon 1035..1087
/gene="LILRB4"
/gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
/inference="alignment:Splign:2.1.0"
exon 1088..1243
/gene="LILRB4"
/gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
/inference="alignment:Splign:2.1.0"
exon 1244..2089
/gene="LILRB4"
/gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
/inference="alignment:Splign:2.1.0"
regulatory 1576..1581
/regulatory_class="polyA_signal_sequence"
/gene="LILRB4"
/gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
/note="hexamer: AATAAA"
polyA_site 1601
/gene="LILRB4"
/gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
/note="major polyA site"
polyA_site 1626
/gene="LILRB4"
/gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
regulatory 1740..1745
/regulatory_class="polyA_signal_sequence"
/gene="LILRB4"
/gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
/note="hexamer: AATAAA"
polyA_site 1768
/gene="LILRB4"
/gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
regulatory 1805..1810
/regulatory_class="polyA_signal_sequence"
/gene="LILRB4"
/gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
/note="hexamer: AATAAA"
polyA_site 1822
/gene="LILRB4"
/gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
regulatory 2070..2075
/regulatory_class="polyA_signal_sequence"
/gene="LILRB4"
/gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
/note="hexamer: AGTAAA"
polyA_site 2089
/gene="LILRB4"
/gene_synonym="B4; CD85K; ILT-3; ILT3; LIR-5; LIR5"
ORIGIN
1 actgaggact catccatctg cacagctggg gcccctggga ggagacgcca tgatccccac
61 cttcacggct ctgctctgcc tcgggctgag tctgggcccc aggacccaca tgcaggcagg
121 gcccctcccc aaacccaccc tctgggctga gccaggctct gtgatcagct gggggaactc
181 tgtgaccatc tggtgtcagg ggaccctgga ggctcgggag taccgtctgg ataaagagga
241 aagcccagca ccctgggaca gacagaaccc actggagccc aagaacaagg ccagattctc
301 catcccatcc atgacagagg actatgcagg gagataccgc tgttactatc gcagccctgt
361 aggctggtca cagcccagtg accccctgga gctggtgatg acaggagcct acagtaaacc
421 caccctttca gccctgccga gtcctcttgt gacctcagga aagagcgtga ccctgctgtg
481 tcagtcacgg agcccaatgg acacttttct tctgatcaag gagcgggcag cccatcccct
541 actgcatctg agatcagagc acggagctca gcagcaccag gctgaattcc ccatgagtcc
601 tgtgacctca gtgcacgggg ggacctacag gtgcttcagc tcacacggct tctcccacta
661 cctgctgtca caccccagtg accccctgga gctcatagtc tcaggatcct tggagggtcc
721 caggccctca cccacaaggt ccgtctcaac agctggccct gaggaccagc ccctcatgcc
781 tacagggtca gtcccccaca gtggtctgag aaggcactgg gaggtactga tcggggtctt
841 ggtggtctcc atcctgcttc tctccctcct cctcttcctc ctcctccaac actggcgtca
901 gggaaaacac aggacattgg cccagagaca ggctgatttc caacgtcctc caggggctgc
961 cgagccagag cccaaggacg ggggcctaca gaggaggtcc agcccagctg ctgacgtcca
1021 gggagaaaac ttctgtgctg ccgtgaagaa cacacagcct gaggacgggg tggaaatgga
1081 cactcggagc ccacacgatg aagaccccca ggcagtgacg tatgccaagg tgaaacactc
1141 cagacctagg agagaaatgg cctctcctcc ctccccactg tctggggaat tcctggacac
1201 aaaggacaga caggcagaag aggacagaca gatggacact gaggctgctg catctgaagc
1261 cccccaggat gtgacctacg cccggctgca cagctttacc ctcagacaga aggcaactga
1321 gcctcctcca tcccaggaag gggcctctcc agctgagccc agtgtctatg ccactctggc
1381 catccactaa tccagggggg acccagaccc cacaagccat ggagactcag gaccccagaa
1441 ggcatggaag ctgcctccag tagacatcac tgaaccccag ccagcccaga cccctgacac
1501 agaccactag aagattccgg gaacgttggg agtcacctga ttctgcaaag ataaataata
1561 tccctgcatt atcaaaataa agtagcagac ctctcaattc acaatgagtt aactgataaa
1621 acaaaacaga agtcagacaa tgttttaaat tgaatgatca tgtaaatatt acacatcaaa
1681 ccaatgacat gggaaaatgg gagcttctaa tgaggacaaa caaaaaatag agaaaaatta
1741 ataaagtcaa aatgtttatt cttgaaaaca ttaatgatac atgaatcttg gccacaatga
1801 gaaaaataaa aatgaaaaaa gagcaggcat ccatttccat acaggaacaa aataggaggc
1861 agcactacag accctacaca cagctttaca gaggtgaaag aaaactgtca gcaattctat
1921 gctgacataa cagaaaatgt agatgagata gatgaaatac gaaaaattac agtttactta
1981 atgaacataa ggataaatag aaaaactgaa tcatcataca taaacatata taaaatgcat
2041 tgatcctgta atcaaaaatg ttcccacaaa gtaaatgcca cttcagcaa
//