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Mus musculus ect2 oncogene (Ect2), transcript variant 22, mRNA

NCBI Reference Sequence: NM_001409721.1

FASTA Graphics 

LOCUS       NM_001409721            3860 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus ect2 oncogene (Ect2), transcript variant 22, mRNA.
ACCESSION   NM_001409721
VERSION     NM_001409721.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3860)
  AUTHORS   Despin-Guitard,E., Rosa,V.S., Plunder,S., Mathiah,N., Van
            Schoor,K., Nehme,E., Merino-Aceituno,S., Egea,J., Shahbazi,M.N.,
            Theveneau,E. and Migeotte,I.
  TITLE     Non-apical mitoses contribute to cell delamination during mouse
            gastrulation
  JOURNAL   Nat Commun 15 (1), 7364 (2024)
   PUBMED   39198421
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3860)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3860)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3860)
  AUTHORS   Liberti,D.C., Kremp,M.M., Liberti,W.A. 3rd, Penkala,I.J., Li,S.,
            Zhou,S. and Morrisey,E.E.
  TITLE     Alveolar epithelial cell fate is maintained in a spatially
            restricted manner to promote lung regeneration after acute injury
  JOURNAL   Cell Rep 35 (6), 109092 (2021)
   PUBMED   33979629
REFERENCE   5  (bases 1 to 3860)
  AUTHORS   Grundl,M., Walz,S., Hauf,L., Schwab,M., Werner,K.M., Spahr,S.,
            Schulte,C., Maric,H.M., Ade,C.P. and Gaubatz,S.
  TITLE     Interaction of YAP with the Myb-MuvB (MMB) complex defines a
            transcriptional program to promote the proliferation of
            cardiomyocytes
  JOURNAL   PLoS Genet 16 (5), e1008818 (2020)
   PUBMED   32469866
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3860)
  AUTHORS   Saito,S., Liu,X.F., Kamijo,K., Raziuddin,R., Tatsumoto,T.,
            Okamoto,I., Chen,X., Lee,C.C., Lorenzi,M.V., Ohara,N. and Miki,T.
  TITLE     Deregulation and mislocalization of the cytokinesis regulator ECT2
            activate the Rho signaling pathways leading to malignant
            transformation
  JOURNAL   J Biol Chem 279 (8), 7169-7179 (2004)
   PUBMED   14645260
  REMARK    GeneRIF: ECT2 has a role in activating the Rho signaling pathways
            leading to malignant transformation
REFERENCE   7  (bases 1 to 3860)
  AUTHORS   Seibler,J., Zevnik,B., Kuter-Luks,B., Andreas,S., Kern,H.,
            Hennek,T., Rode,A., Heimann,C., Faust,N., Kauselmann,G., Schoor,M.,
            Jaenisch,R., Rajewsky,K., Kuhn,R. and Schwenk,F.
  TITLE     Rapid generation of inducible mouse mutants
  JOURNAL   Nucleic Acids Res 31 (4), e12 (2003)
   PUBMED   12582257
REFERENCE   8  (bases 1 to 3860)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 3860)
  AUTHORS   Takai,S., Lorenzi,M.V., Long,J.E., Yamada,K. and Miki,T.
  TITLE     Assignment of the ect2 protooncogene to mouse chromosome band 3B by
            in situ hybridization
  JOURNAL   Cytogenet Cell Genet 81 (1), 83-84 (1998)
   PUBMED   9691182
REFERENCE   10 (bases 1 to 3860)
  AUTHORS   Miki,T., Smith,C.L., Long,J.E., Eva,A. and Fleming,T.P.
  TITLE     Oncogene ect2 is related to regulators of small GTP-binding
            proteins
  JOURNAL   Nature 362 (6419), 462-465 (1993)
   PUBMED   8464478
  REMARK    Erratum:[Nature 1993 Aug 19;364(6439):737]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121099.8 and AC165280.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253012.1014664.1,
                                           SRR17253011.8660551.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               AC121099.8         62301-62420
            121-272             AC121099.8         65943-66094
            273-352             AC121099.8         67051-67130
            353-535             AC121099.8         69104-69286
            536-625             AC121099.8         70078-70167
            626-699             AC121099.8         74424-74497
            700-830             AC121099.8         76461-76591
            831-946             AC121099.8         76994-77109
            947-1009            AC121099.8         77213-77275
            1010-1232           AC121099.8         77399-77621
            1233-1369           AC121099.8         78962-79098
            1370-1489           AC121099.8         84219-84338
            1490-1558           AC121099.8         86001-86069
            1559-1669           AC165280.3         200466-200576       c
            1670-1766           AC165280.3         199611-199707       c
            1767-1848           AC165280.3         196635-196716       c
            1849-1927           AC165280.3         195129-195207       c
            1928-2047           AC165280.3         194693-194812       c
            2048-2186           AC165280.3         190510-190648       c
            2187-2341           AC165280.3         188128-188282       c
            2342-2449           AC165280.3         175127-175234       c
            2450-2593           AC165280.3         173560-173703       c
            2594-3860           AC165280.3         169954-171220       c
FEATURES             Location/Qualifiers
     source          1..3860
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 10.82 cM"
     gene            1..3860
                     /gene="Ect2"
                     /note="ect2 oncogene"
                     /db_xref="GeneID:13605"
                     /db_xref="MGI:MGI:95281"
     exon            1..120
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    29..31
                     /gene="Ect2"
                     /note="upstream in-frame stop codon"
     exon            121..272
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..2683
                     /gene="Ect2"
                     /note="isoform 9 is encoded by transcript variant 22;
                     epithelial cell-transforming sequence 2 oncogene"
                     /codon_start=1
                     /product="protein ECT2 isoform 9"
                     /protein_id="NP_001396650.1"
                     /db_xref="GeneID:13605"
                     /db_xref="MGI:MGI:95281"
                     /translation="MADDSVLPSPSEITSLADSSVFDSKVAEMSKENLCLASTSNVDE
                     EMPQVEARVIMVQDAGKQEELLKALKEMKVPCVKMDSMEEFESLDSPEFENIFVVTDF
                     QNSVFNDLYKADCRIVGPPVILNCAQRGEPLPFSCRPLYCTSMLNLVLCFTGFRKKEE
                     LVAVSLGTPIMKPEWIYKAWERRNEQCFCAAVDDFRNEFKVPPFQDCILSFLGFSDEE
                     KHSMEEMTEMQGGSYLPVGDERCTHLIVEENTVKDLPFEPSKKLFVVKQEWFWGSIQM
                     DARAGETMYLYEKANTPELKKSVSLLSLSTPNSNRKRRRLKETLAQLSRETDLSPFPP
                     RKRPSAEHSLSIGSLLDISNTPESSIHYGETPKSCAKSSRSSTPVPPKQSARWQVAKE
                     LYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPDIFDVHMKIKD
                     DLEDLIANWDESRSIGDIFLKYAKDLVKTYPPFVNFFEMSKEMIIKCEKQKPRFHAFL
                     KINQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPDKSTLEKAIGSLKE
                     VMTHINEDKRKTEAQKQIFDVVYEVDGCPANLLSSHRSLVQRVETVSLGEHPCDRGEQ
                     VTLFLFNDCLEIARKRHKVIGTFRSPHDRTRPPASLKHIHLMPLSQIKKVLDIRETED
                     CHNAFALLVRPPTEQANVLLSFQMTSEELPKESWLKMLCRHVANTICKADAENLMYVA
                     DPESFEVNTKDMDSTLSRASRAIKKTSKKVTRAFSFSKTPKRALRMALSSSHSSEGRS
                     PPSSGKLAVSRLSSTSSLAGIPSPSLVSLPSFFERRSHTLSRSTTHLI"
     exon            273..352
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            353..535
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            536..625
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            626..699
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            700..830
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            831..946
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1009
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1232
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1369
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1489
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1558
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1669
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1766
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1848
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..1927
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2047
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2186
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            2187..2341
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            2342..2449
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            2450..2593
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     exon            2594..3860
                     /gene="Ect2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3836..3841
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ect2"
                     /note="hexamer: AATAAA"
     polyA_site      3860
                     /gene="Ect2"
                     /note="major polyA site"
ORIGIN      
        1 agcctctctc gagccatggc ggcgcctgtg agggggagac ttagtgtttg agaaggataa
       61 gcgaggactg cgccgtcgtg gttccttttt aaaatctctg agcgtggtga ggactgcggg
      121 ccttcatcaa gtagtgcaaa caatggctga cgacagcgtg ttaccatctc cttctgagat
      181 aactagcttg gcagactctt cagtgtttga ttctaaagtt gctgaaatgt ccaaggaaaa
      241 cttgtgcttg gcgtctactt caaatgttga tgaagaaatg ccgcaggttg aagcaagagt
      301 gataatggtc caggatgctg ggaaacaaga agaacttcta aaggccttaa aggaaatgaa
      361 agtgccctgt gtaaagatgg actcaatgga agaatttgaa agtttggatt ccccagaatt
      421 tgagaatata tttgtagtta ctgacttcca gaattctgtc ttcaatgact tatacaaggc
      481 tgattgtagg attgttgggc caccagttat actcaactgt gcacaaaggg gagagccctt
      541 gccgttttcc tgccggccgc tgtattgtac gagtatgctg aacctggtgc tctgcttcac
      601 tggattcagg aagaaggagg agcttgttgc tgtgagcctg ggcactccaa ttatgaagcc
      661 agaatggatt tataaagcgt gggaaagacg caatgaacag tgtttctgtg cagcagttga
      721 tgactttaga aatgaattta aagttcctcc attccaagat tgcattttaa gtttcctggg
      781 attttcagat gaagagaaac atagtatgga agaaatgact gaaatgcaag gaggtagcta
      841 tttaccagtt ggggatgaaa ggtgcactca ccttattgtt gaagagaata cagtaaagga
      901 ccttccattc gaaccttcaa agaaactttt tgttgtcaag caagagtggt tctggggaag
      961 cattcagatg gacgctcgtg caggagagac tatgtatttg tatgaaaagg ctaatactcc
     1021 tgagctcaag aaatcggtgt ctctgctttc tctaagtact ccaaacagca accgcaagag
     1081 acggagattg aaagagaccc tggctcagct ctccagggag actgacctct ctcctttccc
     1141 tccccggaag cggccctcag ctgagcactc tctttctatt ggctcactcc tggatatctc
     1201 caacacaccc gagtccagca tccactatgg agaaacaccg aagtcctgtg ctaagtcttc
     1261 tagaagttct actccagttc ctccaaagca gtcagccagg tggcaggtgg cgaaagagct
     1321 ctaccagact gagagcaatt atgtcaatat actggccaca atcattcaat tatttcaggt
     1381 gcccttagaa gaagaaggac agcgtggtgg gcctattctt gcacctgagg agatcaagac
     1441 tatttttggg agcatcccag atatctttga tgtgcatatg aagatcaagg atgatcttga
     1501 agaccttatt gctaactggg atgagagcag aagtattggt gacatctttc ttaaatatgc
     1561 aaaagatttg gtaaaaacct accctccgtt tgtaaacttc tttgaaatga gcaaggaaat
     1621 gatcattaaa tgtgagaaac aaaagcccag atttcatgct ttcctcaaga taaatcaagc
     1681 taaaccagaa tgtggacgac agagccttgt ggaacttctc atccggccag tgcagaggct
     1741 acccagtgtc gctttacttt taaacgatct taaaaagcat acagctgatg aaaatccaga
     1801 caaaagcact ttagaaaaag ctattggatc actaaaagaa gtaatgacac atatcaatga
     1861 ggataagaga aaaacagaag cacagaagca aatttttgat gttgtttatg aagtagatgg
     1921 atgcccagct aatctcttat cttctcatcg gagcctggtg caacgagtgg aaacggtttc
     1981 ccttggtgag cacccttgcg accgaggaga acaagtcact ctcttcctct tcaatgactg
     2041 cctcgagata gcaagaaagc ggcacaaggt tattggcact tttagaagtc ctcacgaccg
     2101 cacccggccc cccgcttctc tgaagcacat tcatctcatg cctctttctc agattaagaa
     2161 ggtgctggac atccgagaga cagaagattg tcacaatgcc tttgccttgc ttgtaaggcc
     2221 accaacagaa caggccaatg tactgctcag cttccagatg acgtcagagg agcttccaaa
     2281 ggagagctgg ctgaagatgc tgtgccgaca tgtagccaac accatttgta aggcagatgc
     2341 tgagaatctt atgtatgtgg ctgatccaga atcctttgaa gtaaatacaa aagatatgga
     2401 tagtacattg agtcgagcat ctagagcaat aaagaagact tcaaaaaagg ttacaagggc
     2461 attctctttt tccaaaactc ccaagagagc cctgcggatg gctctttcat catcccatag
     2521 ctcagaggga aggagtcctc cgagcagtgg caagcttgct gtgagccgtc tgtccagcac
     2581 atcatcctta gcaggtattc catctccctc ccttgtcagc ctcccttctt tctttgaacg
     2641 gagaagtcat acattaagtc gatctacaac tcacttgata tgaaacttaa gtcctgtggg
     2701 acctatgctt caacaagacg ctgacttaag tggtactttg aattagcact tggtaaagtt
     2761 gtagagaaga ttagtaacac taaccaacgc cgttttattt tcttgaaata caattttcaa
     2821 gatggtctat gtaaaaaaaa tatggatttt gatgtaattt atctttattt gaatctcaca
     2881 tctgaagacc agtgacttaa gttattcctg ataatcagta gctttgtaac cctgatacag
     2941 taaacagttg gtgggtgcaa aatactattg tgtatttgta tagtatcttg aatttttgga
     3001 agtacatatt tgtgtatctc aatttgtgca aagactgaac agcaatgcaa cacttgctga
     3061 ataaaaccct ctgattaaat tctagaggct tgttcagttc gattgtttga tgtacttaac
     3121 tgcgcttttg cagtttattt tcttttaaaa taagagatct aacacatgaa ttttaaagga
     3181 tacaccatta ttaaccatac aattacgatc gtttggaatt ttcttttgca aattgagata
     3241 agaagagaaa gattacaaaa cattgtatat gttgcgaaga taagatatta gtatgtactt
     3301 tataattgtt tcagagactt ttatttttat tttattttct tattctagac actagcaaat
     3361 cttgatttag ttttgactac tgtattgaat ttatttcaaa ggataagacc acgtgaaaac
     3421 tgtgttaaga attgcttctg ttctttgtac agttctgaag ttgtcttcag ttttgctaat
     3481 cgcctgtgaa aagcatagat ataatgtgtg gtgaactttt tattgtggtc atatcattaa
     3541 aataagattg gaaatttatt gtcaaaaatt ttgtgaatct gccattatct tctactgcaa
     3601 tatttctttt agtcagtaat acagaatgac tgggctacta tggccaagaa tattttattt
     3661 cttacacgtt cagaggagtg ttacaggtct ccttgttaca taattttcaa taatctgctt
     3721 taatagttta actgactgga tttttttcta taccatgtat gtaccaattc acacgttagt
     3781 aaatgacctt gttttgctat attttaaaag cagttatatt agcaagaact ttgtaaataa
     3841 atagctttaa aatacaagta
//
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