LOCUS NM_001409721 3860 bp mRNA linear ROD 24-DEC-2024
DEFINITION Mus musculus ect2 oncogene (Ect2), transcript variant 22, mRNA.
ACCESSION NM_001409721
VERSION NM_001409721.1
KEYWORDS RefSeq.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (bases 1 to 3860)
AUTHORS Despin-Guitard,E., Rosa,V.S., Plunder,S., Mathiah,N., Van
Schoor,K., Nehme,E., Merino-Aceituno,S., Egea,J., Shahbazi,M.N.,
Theveneau,E. and Migeotte,I.
TITLE Non-apical mitoses contribute to cell delamination during mouse
gastrulation
JOURNAL Nat Commun 15 (1), 7364 (2024)
PUBMED 39198421
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 3860)
AUTHORS Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
Jackson,S.P. and Balmus,G.
CONSRTM Sanger Mouse Genetics Project
TITLE Genetic determinants of micronucleus formation in vivo
JOURNAL Nature 627 (8002), 130-136 (2024)
PUBMED 38355793
REFERENCE 3 (bases 1 to 3860)
AUTHORS Bedogni,F. and Hevner,R.F.
TITLE Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
Intermediate Progenitors Implicated in Axon Development
JOURNAL Front Mol Neurosci 14, 686034 (2021)
PUBMED 34321999
REMARK Publication Status: Online-Only
REFERENCE 4 (bases 1 to 3860)
AUTHORS Liberti,D.C., Kremp,M.M., Liberti,W.A. 3rd, Penkala,I.J., Li,S.,
Zhou,S. and Morrisey,E.E.
TITLE Alveolar epithelial cell fate is maintained in a spatially
restricted manner to promote lung regeneration after acute injury
JOURNAL Cell Rep 35 (6), 109092 (2021)
PUBMED 33979629
REFERENCE 5 (bases 1 to 3860)
AUTHORS Grundl,M., Walz,S., Hauf,L., Schwab,M., Werner,K.M., Spahr,S.,
Schulte,C., Maric,H.M., Ade,C.P. and Gaubatz,S.
TITLE Interaction of YAP with the Myb-MuvB (MMB) complex defines a
transcriptional program to promote the proliferation of
cardiomyocytes
JOURNAL PLoS Genet 16 (5), e1008818 (2020)
PUBMED 32469866
REMARK Publication Status: Online-Only
REFERENCE 6 (bases 1 to 3860)
AUTHORS Saito,S., Liu,X.F., Kamijo,K., Raziuddin,R., Tatsumoto,T.,
Okamoto,I., Chen,X., Lee,C.C., Lorenzi,M.V., Ohara,N. and Miki,T.
TITLE Deregulation and mislocalization of the cytokinesis regulator ECT2
activate the Rho signaling pathways leading to malignant
transformation
JOURNAL J Biol Chem 279 (8), 7169-7179 (2004)
PUBMED 14645260
REMARK GeneRIF: ECT2 has a role in activating the Rho signaling pathways
leading to malignant transformation
REFERENCE 7 (bases 1 to 3860)
AUTHORS Seibler,J., Zevnik,B., Kuter-Luks,B., Andreas,S., Kern,H.,
Hennek,T., Rode,A., Heimann,C., Faust,N., Kauselmann,G., Schoor,M.,
Jaenisch,R., Rajewsky,K., Kuhn,R. and Schwenk,F.
TITLE Rapid generation of inducible mouse mutants
JOURNAL Nucleic Acids Res 31 (4), e12 (2003)
PUBMED 12582257
REFERENCE 8 (bases 1 to 3860)
AUTHORS Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
TITLE BayGenomics: a resource of insertional mutations in mouse embryonic
stem cells
JOURNAL Nucleic Acids Res 31 (1), 278-281 (2003)
PUBMED 12520002
REFERENCE 9 (bases 1 to 3860)
AUTHORS Takai,S., Lorenzi,M.V., Long,J.E., Yamada,K. and Miki,T.
TITLE Assignment of the ect2 protooncogene to mouse chromosome band 3B by
in situ hybridization
JOURNAL Cytogenet Cell Genet 81 (1), 83-84 (1998)
PUBMED 9691182
REFERENCE 10 (bases 1 to 3860)
AUTHORS Miki,T., Smith,C.L., Long,J.E., Eva,A. and Fleming,T.P.
TITLE Oncogene ect2 is related to regulators of small GTP-binding
proteins
JOURNAL Nature 362 (6419), 462-465 (1993)
PUBMED 8464478
REMARK Erratum:[Nature 1993 Aug 19;364(6439):737]
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC121099.8 and AC165280.3.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR17253012.1014664.1,
SRR17253011.8660551.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN01164143 [ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-120 AC121099.8 62301-62420
121-272 AC121099.8 65943-66094
273-352 AC121099.8 67051-67130
353-535 AC121099.8 69104-69286
536-625 AC121099.8 70078-70167
626-699 AC121099.8 74424-74497
700-830 AC121099.8 76461-76591
831-946 AC121099.8 76994-77109
947-1009 AC121099.8 77213-77275
1010-1232 AC121099.8 77399-77621
1233-1369 AC121099.8 78962-79098
1370-1489 AC121099.8 84219-84338
1490-1558 AC121099.8 86001-86069
1559-1669 AC165280.3 200466-200576 c
1670-1766 AC165280.3 199611-199707 c
1767-1848 AC165280.3 196635-196716 c
1849-1927 AC165280.3 195129-195207 c
1928-2047 AC165280.3 194693-194812 c
2048-2186 AC165280.3 190510-190648 c
2187-2341 AC165280.3 188128-188282 c
2342-2449 AC165280.3 175127-175234 c
2450-2593 AC165280.3 173560-173703 c
2594-3860 AC165280.3 169954-171220 c
FEATURES Location/Qualifiers
source 1..3860
/organism="Mus musculus"
/mol_type="mRNA"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="3"
/map="3 10.82 cM"
gene 1..3860
/gene="Ect2"
/note="ect2 oncogene"
/db_xref="GeneID:13605"
/db_xref="MGI:MGI:95281"
exon 1..120
/gene="Ect2"
/inference="alignment:Splign:2.1.0"
misc_feature 29..31
/gene="Ect2"
/note="upstream in-frame stop codon"
exon 121..272
/gene="Ect2"
/inference="alignment:Splign:2.1.0"
CDS 143..2683
/gene="Ect2"
/note="isoform 9 is encoded by transcript variant 22;
epithelial cell-transforming sequence 2 oncogene"
/codon_start=1
/product="protein ECT2 isoform 9"
/protein_id="NP_001396650.1"
/db_xref="GeneID:13605"
/db_xref="MGI:MGI:95281"
/translation="MADDSVLPSPSEITSLADSSVFDSKVAEMSKENLCLASTSNVDE
EMPQVEARVIMVQDAGKQEELLKALKEMKVPCVKMDSMEEFESLDSPEFENIFVVTDF
QNSVFNDLYKADCRIVGPPVILNCAQRGEPLPFSCRPLYCTSMLNLVLCFTGFRKKEE
LVAVSLGTPIMKPEWIYKAWERRNEQCFCAAVDDFRNEFKVPPFQDCILSFLGFSDEE
KHSMEEMTEMQGGSYLPVGDERCTHLIVEENTVKDLPFEPSKKLFVVKQEWFWGSIQM
DARAGETMYLYEKANTPELKKSVSLLSLSTPNSNRKRRRLKETLAQLSRETDLSPFPP
RKRPSAEHSLSIGSLLDISNTPESSIHYGETPKSCAKSSRSSTPVPPKQSARWQVAKE
LYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPDIFDVHMKIKD
DLEDLIANWDESRSIGDIFLKYAKDLVKTYPPFVNFFEMSKEMIIKCEKQKPRFHAFL
KINQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPDKSTLEKAIGSLKE
VMTHINEDKRKTEAQKQIFDVVYEVDGCPANLLSSHRSLVQRVETVSLGEHPCDRGEQ
VTLFLFNDCLEIARKRHKVIGTFRSPHDRTRPPASLKHIHLMPLSQIKKVLDIRETED
CHNAFALLVRPPTEQANVLLSFQMTSEELPKESWLKMLCRHVANTICKADAENLMYVA
DPESFEVNTKDMDSTLSRASRAIKKTSKKVTRAFSFSKTPKRALRMALSSSHSSEGRS
PPSSGKLAVSRLSSTSSLAGIPSPSLVSLPSFFERRSHTLSRSTTHLI"
exon 273..352
/gene="Ect2"
/inference="alignment:Splign:2.1.0"
exon 353..535
/gene="Ect2"
/inference="alignment:Splign:2.1.0"
exon 536..625
/gene="Ect2"
/inference="alignment:Splign:2.1.0"
exon 626..699
/gene="Ect2"
/inference="alignment:Splign:2.1.0"
exon 700..830
/gene="Ect2"
/inference="alignment:Splign:2.1.0"
exon 831..946
/gene="Ect2"
/inference="alignment:Splign:2.1.0"
exon 947..1009
/gene="Ect2"
/inference="alignment:Splign:2.1.0"
exon 1010..1232
/gene="Ect2"
/inference="alignment:Splign:2.1.0"
exon 1233..1369
/gene="Ect2"
/inference="alignment:Splign:2.1.0"
exon 1370..1489
/gene="Ect2"
/inference="alignment:Splign:2.1.0"
exon 1490..1558
/gene="Ect2"
/inference="alignment:Splign:2.1.0"
exon 1559..1669
/gene="Ect2"
/inference="alignment:Splign:2.1.0"
exon 1670..1766
/gene="Ect2"
/inference="alignment:Splign:2.1.0"
exon 1767..1848
/gene="Ect2"
/inference="alignment:Splign:2.1.0"
exon 1849..1927
/gene="Ect2"
/inference="alignment:Splign:2.1.0"
exon 1928..2047
/gene="Ect2"
/inference="alignment:Splign:2.1.0"
exon 2048..2186
/gene="Ect2"
/inference="alignment:Splign:2.1.0"
exon 2187..2341
/gene="Ect2"
/inference="alignment:Splign:2.1.0"
exon 2342..2449
/gene="Ect2"
/inference="alignment:Splign:2.1.0"
exon 2450..2593
/gene="Ect2"
/inference="alignment:Splign:2.1.0"
exon 2594..3860
/gene="Ect2"
/inference="alignment:Splign:2.1.0"
regulatory 3836..3841
/regulatory_class="polyA_signal_sequence"
/gene="Ect2"
/note="hexamer: AATAAA"
polyA_site 3860
/gene="Ect2"
/note="major polyA site"
ORIGIN
1 agcctctctc gagccatggc ggcgcctgtg agggggagac ttagtgtttg agaaggataa
61 gcgaggactg cgccgtcgtg gttccttttt aaaatctctg agcgtggtga ggactgcggg
121 ccttcatcaa gtagtgcaaa caatggctga cgacagcgtg ttaccatctc cttctgagat
181 aactagcttg gcagactctt cagtgtttga ttctaaagtt gctgaaatgt ccaaggaaaa
241 cttgtgcttg gcgtctactt caaatgttga tgaagaaatg ccgcaggttg aagcaagagt
301 gataatggtc caggatgctg ggaaacaaga agaacttcta aaggccttaa aggaaatgaa
361 agtgccctgt gtaaagatgg actcaatgga agaatttgaa agtttggatt ccccagaatt
421 tgagaatata tttgtagtta ctgacttcca gaattctgtc ttcaatgact tatacaaggc
481 tgattgtagg attgttgggc caccagttat actcaactgt gcacaaaggg gagagccctt
541 gccgttttcc tgccggccgc tgtattgtac gagtatgctg aacctggtgc tctgcttcac
601 tggattcagg aagaaggagg agcttgttgc tgtgagcctg ggcactccaa ttatgaagcc
661 agaatggatt tataaagcgt gggaaagacg caatgaacag tgtttctgtg cagcagttga
721 tgactttaga aatgaattta aagttcctcc attccaagat tgcattttaa gtttcctggg
781 attttcagat gaagagaaac atagtatgga agaaatgact gaaatgcaag gaggtagcta
841 tttaccagtt ggggatgaaa ggtgcactca ccttattgtt gaagagaata cagtaaagga
901 ccttccattc gaaccttcaa agaaactttt tgttgtcaag caagagtggt tctggggaag
961 cattcagatg gacgctcgtg caggagagac tatgtatttg tatgaaaagg ctaatactcc
1021 tgagctcaag aaatcggtgt ctctgctttc tctaagtact ccaaacagca accgcaagag
1081 acggagattg aaagagaccc tggctcagct ctccagggag actgacctct ctcctttccc
1141 tccccggaag cggccctcag ctgagcactc tctttctatt ggctcactcc tggatatctc
1201 caacacaccc gagtccagca tccactatgg agaaacaccg aagtcctgtg ctaagtcttc
1261 tagaagttct actccagttc ctccaaagca gtcagccagg tggcaggtgg cgaaagagct
1321 ctaccagact gagagcaatt atgtcaatat actggccaca atcattcaat tatttcaggt
1381 gcccttagaa gaagaaggac agcgtggtgg gcctattctt gcacctgagg agatcaagac
1441 tatttttggg agcatcccag atatctttga tgtgcatatg aagatcaagg atgatcttga
1501 agaccttatt gctaactggg atgagagcag aagtattggt gacatctttc ttaaatatgc
1561 aaaagatttg gtaaaaacct accctccgtt tgtaaacttc tttgaaatga gcaaggaaat
1621 gatcattaaa tgtgagaaac aaaagcccag atttcatgct ttcctcaaga taaatcaagc
1681 taaaccagaa tgtggacgac agagccttgt ggaacttctc atccggccag tgcagaggct
1741 acccagtgtc gctttacttt taaacgatct taaaaagcat acagctgatg aaaatccaga
1801 caaaagcact ttagaaaaag ctattggatc actaaaagaa gtaatgacac atatcaatga
1861 ggataagaga aaaacagaag cacagaagca aatttttgat gttgtttatg aagtagatgg
1921 atgcccagct aatctcttat cttctcatcg gagcctggtg caacgagtgg aaacggtttc
1981 ccttggtgag cacccttgcg accgaggaga acaagtcact ctcttcctct tcaatgactg
2041 cctcgagata gcaagaaagc ggcacaaggt tattggcact tttagaagtc ctcacgaccg
2101 cacccggccc cccgcttctc tgaagcacat tcatctcatg cctctttctc agattaagaa
2161 ggtgctggac atccgagaga cagaagattg tcacaatgcc tttgccttgc ttgtaaggcc
2221 accaacagaa caggccaatg tactgctcag cttccagatg acgtcagagg agcttccaaa
2281 ggagagctgg ctgaagatgc tgtgccgaca tgtagccaac accatttgta aggcagatgc
2341 tgagaatctt atgtatgtgg ctgatccaga atcctttgaa gtaaatacaa aagatatgga
2401 tagtacattg agtcgagcat ctagagcaat aaagaagact tcaaaaaagg ttacaagggc
2461 attctctttt tccaaaactc ccaagagagc cctgcggatg gctctttcat catcccatag
2521 ctcagaggga aggagtcctc cgagcagtgg caagcttgct gtgagccgtc tgtccagcac
2581 atcatcctta gcaggtattc catctccctc ccttgtcagc ctcccttctt tctttgaacg
2641 gagaagtcat acattaagtc gatctacaac tcacttgata tgaaacttaa gtcctgtggg
2701 acctatgctt caacaagacg ctgacttaag tggtactttg aattagcact tggtaaagtt
2761 gtagagaaga ttagtaacac taaccaacgc cgttttattt tcttgaaata caattttcaa
2821 gatggtctat gtaaaaaaaa tatggatttt gatgtaattt atctttattt gaatctcaca
2881 tctgaagacc agtgacttaa gttattcctg ataatcagta gctttgtaac cctgatacag
2941 taaacagttg gtgggtgcaa aatactattg tgtatttgta tagtatcttg aatttttgga
3001 agtacatatt tgtgtatctc aatttgtgca aagactgaac agcaatgcaa cacttgctga
3061 ataaaaccct ctgattaaat tctagaggct tgttcagttc gattgtttga tgtacttaac
3121 tgcgcttttg cagtttattt tcttttaaaa taagagatct aacacatgaa ttttaaagga
3181 tacaccatta ttaaccatac aattacgatc gtttggaatt ttcttttgca aattgagata
3241 agaagagaaa gattacaaaa cattgtatat gttgcgaaga taagatatta gtatgtactt
3301 tataattgtt tcagagactt ttatttttat tttattttct tattctagac actagcaaat
3361 cttgatttag ttttgactac tgtattgaat ttatttcaaa ggataagacc acgtgaaaac
3421 tgtgttaaga attgcttctg ttctttgtac agttctgaag ttgtcttcag ttttgctaat
3481 cgcctgtgaa aagcatagat ataatgtgtg gtgaactttt tattgtggtc atatcattaa
3541 aataagattg gaaatttatt gtcaaaaatt ttgtgaatct gccattatct tctactgcaa
3601 tatttctttt agtcagtaat acagaatgac tgggctacta tggccaagaa tattttattt
3661 cttacacgtt cagaggagtg ttacaggtct ccttgttaca taattttcaa taatctgctt
3721 taatagttta actgactgga tttttttcta taccatgtat gtaccaattc acacgttagt
3781 aaatgacctt gttttgctat attttaaaag cagttatatt agcaagaact ttgtaaataa
3841 atagctttaa aatacaagta
//