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Mus musculus epsin 1 (Epn1), transcript variant 38, mRNA

NCBI Reference Sequence: NM_001412371.1

FASTA Graphics 

LOCUS       NM_001412371            2570 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus epsin 1 (Epn1), transcript variant 38, mRNA.
ACCESSION   NM_001412371 XM_030242113
VERSION     NM_001412371.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2570)
  AUTHORS   Dong,Y., Wang,B., Cui,K., Cai,X., Bhattacharjee,S., Wong,S.,
            Cowan,D.B. and Chen,H.
  TITLE     Epsins Negatively Regulate Aortic Endothelial Cell Function by
            Augmenting Inflammatory Signaling
  JOURNAL   Cells 10 (8), 1918 (2021)
   PUBMED   34440686
  REMARK    GeneRIF: Epsins Negatively Regulate Aortic Endothelial Cell
            Function by Augmenting Inflammatory Signaling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2570)
  AUTHORS   Song,K., Cai,X., Dong,Y., Wu,H., Wei,Y., Shankavaram,U.T., Cui,K.,
            Lee,Y., Zhu,B., Bhattacharjee,S., Wang,B., Zhang,K., Wen,A.,
            Wong,S., Yu,L., Xia,L., Welm,A.L., Bielenberg,D.R.,
            Camphausen,K.A., Kang,Y. and Chen,H.
  TITLE     Epsins 1 and 2 promote NEMO linear ubiquitination via LUBAC to
            drive breast cancer development
  JOURNAL   J Clin Invest 131 (1) (2021)
   PUBMED   32960814
  REMARK    GeneRIF: Epsins 1 and 2 promote NEMO linear ubiquitination via
            LUBAC to drive breast cancer development.
REFERENCE   3  (bases 1 to 2570)
  AUTHORS   Dong,Y., Lee,Y., Cui,K., He,M., Wang,B., Bhattacharjee,S., Zhu,B.,
            Yago,T., Zhang,K., Deng,L., Ouyang,K., Wen,A., Cowan,D.B., Song,K.,
            Yu,L., Brophy,M.L., Liu,X., Wylie-Sears,J., Wu,H., Wong,S., Cui,G.,
            Kawashima,Y., Matsumoto,H., Kodera,Y., Wojcikiewicz,R.J.H.,
            Srivastava,S., Bischoff,J., Wang,D.Z., Ley,K. and Chen,H.
  TITLE     Epsin-mediated degradation of IP3R1 fuels atherosclerosis
  JOURNAL   Nat Commun 11 (1), 3984 (2020)
   PUBMED   32770009
  REMARK    GeneRIF: Epsin-mediated degradation of IP3R1 fuels atherosclerosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2570)
  AUTHORS   Milesi,C., Alberici,P., Pozzi,B., Oldani,A., Beznoussenko,G.V.,
            Raimondi,A., Soppo,B.E., Amodio,S., Caldieri,G., Malabarba,M.G.,
            Bertalot,G., Confalonieri,S., Parazzoli,D., Mironov,A.A.,
            Tacchetti,C., Di Fiore,P.P., Sigismund,S. and Offenhauser,N.
  TITLE     Redundant and nonredundant organismal functions of EPS15 and
            EPS15L1
  JOURNAL   Life Sci Alliance 2 (1), e201800273 (2019)
   PUBMED   30692166
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2570)
  AUTHORS   Wu,H., Rahman,H.N.A., Dong,Y., Liu,X., Lee,Y., Wen,A., To,K.H.,
            Xiao,L., Birsner,A.E., Bazinet,L., Wong,S., Song,K., Brophy,M.L.,
            Mahamud,M.R., Chang,B., Cai,X., Pasula,S., Kwak,S., Yang,W.,
            Bischoff,J., Xu,J., Bielenberg,D.R., Dixon,J.B., D'Amato,R.J.,
            Srinivasan,R.S. and Chen,H.
  TITLE     Epsin deficiency promotes lymphangiogenesis through regulation of
            VEGFR3 degradation in diabetes
  JOURNAL   J Clin Invest 128 (9), 4025-4043 (2018)
   PUBMED   30102256
  REMARK    GeneRIF: Diabetes attenuated VEGF-C-induced lymphangiogenesis in
            corneal micropocket and Matrigel plug assays in WT mice but not in
            mice with inducible lymphatic-specific deficiency of epsins 1 and 2
            (LEC-iDKO).
REFERENCE   6  (bases 1 to 2570)
  AUTHORS   Pasula,S., Cai,X., Dong,Y., Messa,M., McManus,J., Chang,B., Liu,X.,
            Zhu,H., Mansat,R.S., Yoon,S.J., Hahn,S., Keeling,J., Saunders,D.,
            Ko,G., Knight,J., Newton,G., Luscinskas,F., Sun,X., Towner,R.,
            Lupu,F., Xia,L., Cremona,O., De Camilli,P., Min,W. and Chen,H.
  TITLE     Endothelial epsin deficiency decreases tumor growth by enhancing
            VEGF signaling
  JOURNAL   J Clin Invest 122 (12), 4424-4438 (2012)
   PUBMED   23187125
  REMARK    GeneRIF: Loss of epsins 1 and 2 impaired endocytosis and
            degradation of VEGFR2, resulting in excessive VEGF signaling and
            compromised tumor vascular function.
REFERENCE   7  (bases 1 to 2570)
  AUTHORS   Chen,H., Ko,G., Zatti,A., Di Giacomo,G., Liu,L., Raiteri,E.,
            Perucco,E., Collesi,C., Min,W., Zeiss,C., De Camilli,P. and
            Cremona,O.
  TITLE     Embryonic arrest at midgestation and disruption of Notch signaling
            produced by the absence of both epsin 1 and epsin 2 in mice
  JOURNAL   Proc Natl Acad Sci U S A 106 (33), 13838-13843 (2009)
   PUBMED   19666558
  REMARK    GeneRIF: epsin has a role as a specialized endocytic adaptor, with
            a critical role in the activation of Notch signaling in mammals
REFERENCE   8  (bases 1 to 2570)
  AUTHORS   Wang,H., Traub,L.M., Weixel,K.M., Hawryluk,M.J., Shah,N.,
            Edinger,R.S., Perry,C.J., Kester,L., Butterworth,M.B., Peters,K.W.,
            Kleyman,T.R., Frizzell,R.A. and Johnson,J.P.
  TITLE     Clathrin-mediated endocytosis of the epithelial sodium channel.
            Role of epsin
  JOURNAL   J Biol Chem 281 (20), 14129-14135 (2006)
   PUBMED   16574660
  REMARK    GeneRIF: epsin is an accessory protein linking ENaC to the
            clathrin-based endocytic machinery thereby regulating the activity
            of this ion channel at the cell surface
REFERENCE   9  (bases 1 to 2570)
  AUTHORS   Chen,H., Slepnev,V.I., Di Fiore,P.P. and De Camilli,P.
  TITLE     The interaction of epsin and Eps15 with the clathrin adaptor AP-2
            is inhibited by mitotic phosphorylation and enhanced by
            stimulation-dependent dephosphorylation in nerve terminals
  JOURNAL   J Biol Chem 274 (6), 3257-3260 (1999)
   PUBMED   9920862
REFERENCE   10 (bases 1 to 2570)
  AUTHORS   Yamabhai,M., Hoffman,N.G., Hardison,N.L., McPherson,P.S.,
            Castagnoli,L., Cesareni,G. and Kay,B.K.
  TITLE     Intersectin, a novel adaptor protein with two Eps15 homology and
            five Src homology 3 domains
  JOURNAL   J Biol Chem 273 (47), 31401-31407 (1998)
   PUBMED   9813051
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162893.6.
            
            On Sep 29, 2022 this sequence version replaced XM_030242113.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1959776.1,
                                           SRR7652917.1056212.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-390               AC162893.6         47117-47506
            391-494             AC162893.6         48886-48989
            495-747             AC162893.6         50598-50850
            748-997             AC162893.6         56787-57036
            998-1122            AC162893.6         59709-59833
            1123-1206           AC162893.6         60767-60850
            1207-1510           AC162893.6         61822-62125
            1511-1621           AC162893.6         62511-62621
            1622-1705           AC162893.6         62759-62842
            1706-1963           AC162893.6         64022-64279
            1964-2570           AC162893.6         64440-65046
FEATURES             Location/Qualifiers
     source          1..2570
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 2.94 cM"
     gene            1..2570
                     /gene="Epn1"
                     /gene_synonym="Ibp1"
                     /note="epsin 1"
                     /db_xref="GeneID:13854"
                     /db_xref="MGI:MGI:1333763"
     exon            1..390
                     /gene="Epn1"
                     /gene_synonym="Ibp1"
                     /inference="alignment:Splign:2.1.0"
     exon            391..494
                     /gene="Epn1"
                     /gene_synonym="Ibp1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    403..405
                     /gene="Epn1"
                     /gene_synonym="Ibp1"
                     /note="upstream in-frame stop codon"
     exon            495..747
                     /gene="Epn1"
                     /gene_synonym="Ibp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             520..2172
                     /gene="Epn1"
                     /gene_synonym="Ibp1"
                     /note="isoform 7 is encoded by transcript variant 38;
                     EPS-15-interacting protein 1; intersectin-EH-binding
                     protein 1"
                     /codon_start=1
                     /product="epsin-1 isoform 7"
                     /protein_id="NP_001399300.1"
                     /db_xref="GeneID:13854"
                     /db_xref="MGI:MGI:1333763"
                     /translation="MSTSSLRRQMKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIA
                     DLTYNVVAFSEIMSMIWKRLNDHGKNWRHVYKAMTLMEYLIKTGSERVSQQCKENMYA
                     VQTLKDFQYVDRDGKDQGVNVREKAKQLVALLRDEDRLREERAHALKTKEKLAQTATA
                     SSAAVGSGPPPEAEQAWPQSSGEEELQLQLALAMSKEEADQEERIRRGDDLRLQMAIE
                     ESKRETGGKEESSLMDLADVFTTPAPPQASDPWGGPASVPTAVPVAAAASDPWGGPAV
                     PPAADPWGGAAPTPASGDPWRPAAPTGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGAP
                     VSGPPSSDPWAPAPAFSDPWGGSPAKPSSNGTAVGGFDTEPDEFSDFDRLRTALPTSG
                     SSTGELELLAGEVPARSPGAFDMSGVGGSLAESVGSPPPAATPTPTPPTRKTPESFLG
                     PNAALVDLDSLVSRPGPTPPGSKASNPFLPSGAPPTGPSVTNPFQPAPPATLTLNQLR
                     LSPVPPVPGAPPTYISPLGGGPGLPPMMPPGPPAPNTNPFLL"
     exon            748..997
                     /gene="Epn1"
                     /gene_synonym="Ibp1"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1122
                     /gene="Epn1"
                     /gene_synonym="Ibp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1206
                     /gene="Epn1"
                     /gene_synonym="Ibp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1510
                     /gene="Epn1"
                     /gene_synonym="Ibp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1621
                     /gene="Epn1"
                     /gene_synonym="Ibp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1705
                     /gene="Epn1"
                     /gene_synonym="Ibp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1963
                     /gene="Epn1"
                     /gene_synonym="Ibp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2570
                     /gene="Epn1"
                     /gene_synonym="Ibp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2551..2556
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Epn1"
                     /gene_synonym="Ibp1"
                     /note="hexamer: AATAAA"
     polyA_site      2570
                     /gene="Epn1"
                     /gene_synonym="Ibp1"
                     /note="major polyA site"
ORIGIN      
        1 ggttgcttcc cgtccgctcg gcggctcccc tcccccgccc ggctctctgc gcccctcccg
       61 ggcgccgggg cggcggggcc gtcgctgtgc ggccctccgt gcgtctgtgc gtgcgcacgt
      121 gcgcacttct gcttcccgca gctcggcgcg cgccccgcga caccgaggcc gagcgggggc
      181 agggggctga ccgtcatgac ccctggaagc ccggtataag cgggccgagg tgagcgaggg
      241 gcgcaatgct ggcctccgtc gcggcaagtc cggtgttccg gcctgggccg tggcgcgcgc
      301 gggtccagcc agcctcggag ccggtgttcc agccgctgat ggcttgtggc tgcttttgta
      361 ccgctgtgcc cgggtcgggt ttgcctgccg gttggatcat ggtagggctc agtaaatctc
      421 cctccatggc ttgttggaga ggcacagact ggtgatcgga gtctactctg gacccaggct
      481 gctccagttg tgagcccctt gacaccacta ctgggcacaa tgtcgacctc atcgctgcgg
      541 cgtcagatga agaatatcgt ccacaactac tcagaggctg agatcaaggt ccgcgaggcc
      601 acaagcaatg atccctgggg cccatccagc tccctcatgt cagagattgc tgacctcacc
      661 tacaatgttg tggccttctc cgagatcatg agcatgatct ggaagcggct caatgaccac
      721 ggcaagaact ggaggcacgt ctacaaggcc atgacgttga tggagtacct catcaagact
      781 ggctctgagc gtgtatcaca acagtgcaaa gagaacatgt atgctgtgca gacgctgaag
      841 gacttccagt atgtggaccg tgatggcaag gaccagggtg tgaatgtgcg ggagaaggcc
      901 aagcagctgg tggctttgct gcgtgatgag gatcggctcc gggaggagcg cgcccacgcg
      961 ctcaagacca aggagaagct ggcacagact gccacggcct cctcagcagc cgtgggctct
     1021 ggaccacctc ccgaggcgga gcaggcatgg ccacagagca gcggggagga ggagttgcag
     1081 ctccagctgg ccctggctat gagcaaggag gaggccgacc aggaagagcg gatccgtcgt
     1141 ggggatgacc tgaggctgca gatggcaata gaggagagca agagggagac tgggggcaag
     1201 gaggagtcat ctctcatgga tcttgctgat gtcttcacaa ccccagcgcc tccacaggcc
     1261 tcagaccctt gggggggccc ggcatctgtg cctactgctg tccctgtggc tgctgccgct
     1321 tcagaccctt gggggggacc tgctgtccct ccagctgctg atccttgggg tggtgcagcc
     1381 cccacaccag cctcagggga tccctggagg cctgcagccc ctacagggcc ctctgttgat
     1441 ccttggggtg ggaccccagc tcctgcagct ggagaggggc ccacccctga cccgtgggga
     1501 agctctgatg gtggggctcc tgtcagtggg cccccatctt ctgacccctg ggcacctgcc
     1561 ccggctttct cagacccctg gggaggctca cctgcaaagc ccagcagcaa cggcactgca
     1621 gttgggggct ttgacacaga gcctgatgag ttctcagact tcgaccgact ccgcactgcc
     1681 ctgccaacct ctgggagcag cacgggggag ttggagttgc tcgcaggaga ggtgcctgct
     1741 cgcagccctg gggcattcga catgagtggg gttgggggat ctctggctga gtctgtgggg
     1801 agtcccccac ctgctgcaac cccaactccc acccccccaa cacggaagac tccggagtca
     1861 ttcctaggcc ctaatgcagc ccttgtggat ctggactcgc tggtgagccg accaggcccc
     1921 acaccaccag gatccaaggc ttccaaccca ttccttccaa gcggagctcc gcccacaggc
     1981 ccctctgtca ccaatccttt ccagccagca ccccctgcaa cgctcaccct gaaccagctc
     2041 cgtctcagtc ctgtgccccc agttcctgga gcgccaccca cctacatctc tcctcttggt
     2101 ggaggccctg gcctgccccc catgatgccc ccaggtcccc cagcccccaa cactaacccc
     2161 ttcctcctat aatccagggt aggagggagg cctggttcag ctggcttccc caatttctgc
     2221 tccctgggag atcagtattg tgagtgcatg tgaaatgggg gggccctccc ccacagtgcc
     2281 cttccccctc ctggggccca ctcacactac accctcttcc caagtcccca ccccacctcc
     2341 ccttgagaaa aactggacat ggggatgggg aggggagccg gccagaggag gacccttttc
     2401 tgtggcatta gatgggggag ggacagctgg ggttccccca cccattccac ctccctctaa
     2461 actcatgaca acccccaaat cagtgtttga gcctcctcgt tcccttggca cccctggtga
     2521 atccttggtg atgattttgg caacttcggg aataaatggc aattctcatg
//
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