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Mus musculus abl interactor 1 (Abi1), transcript variant 26, mRNA

NCBI Reference Sequence: NM_001416864.1

FASTA Graphics 

LOCUS       NM_001416864            3015 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus abl interactor 1 (Abi1), transcript variant 26, mRNA.
ACCESSION   NM_001416864
VERSION     NM_001416864.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3015)
  AUTHORS   Verdile,V., Svetoni,F., La Rosa,P., Ferrante,G., Cesari,E.,
            Sette,C. and Paronetto,M.P.
  TITLE     EWS splicing regulation contributes to balancing Foxp1 isoforms
            required for neuronal differentiation
  JOURNAL   Nucleic Acids Res 50 (6), 3362-3378 (2022)
   PUBMED   35253879
REFERENCE   2  (bases 1 to 3015)
  AUTHORS   Aviles,E.C., Krol,A., Henle,S.J., Burroughs-Garcia,J., Deans,M.R.
            and Goodrich,L.V.
  TITLE     Fat3 acts through independent cytoskeletal effectors to coordinate
            asymmetric cell behaviors during polarized circuit assembly
  JOURNAL   Cell Rep 38 (5), 110307 (2022)
   PUBMED   35108541
REFERENCE   3  (bases 1 to 3015)
  AUTHORS   Wang,R., Wang,Y., Liao,G., Chen,B., Panettieri,R.A. Jr., Penn,R.B.
            and Tang,D.D.
  TITLE     Abi1 mediates airway smooth muscle cell proliferation and airway
            remodeling via Jak2/STAT3 signaling
  JOURNAL   iScience 25 (2), 103833 (2022)
   PUBMED   35198891
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3015)
  AUTHORS   Qi,Y., Liu,J., Chao,J., Greer,P.A. and Li,S.
  TITLE     PTEN dephosphorylates Abi1 to promote epithelial morphogenesis
  JOURNAL   J Cell Biol 219 (9) (2020)
   PUBMED   32673396
REFERENCE   5  (bases 1 to 3015)
  AUTHORS   Faulkner,J., Jiang,P., Farris,D., Walker,R. and Dai,Z.
  TITLE     CRISPR/CAS9-mediated knockout of Abi1 inhibits p185Bcr-Abl-induced
            leukemogenesis and signal transduction to ERK and PI3K/Akt pathways
  JOURNAL   J Hematol Oncol 13 (1), 34 (2020)
   PUBMED   32276588
  REMARK    GeneRIF: CRISPR/CAS9-mediated knockout of Abi1 inhibits
            p185(Bcr-Abl)-induced leukemogenesis and signal transduction to ERK
            and PI3K/Akt pathways.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3015)
  AUTHORS   Scita,G., Nordstrom,J., Carbone,R., Tenca,P., Giardina,G.,
            Gutkind,S., Bjarnegard,M., Betsholtz,C. and Di Fiore,P.P.
  TITLE     EPS8 and E3B1 transduce signals from Ras to Rac
  JOURNAL   Nature 401 (6750), 290-293 (1999)
   PUBMED   10499589
REFERENCE   7  (bases 1 to 3015)
  AUTHORS   Xiong,J.W., Leahy,A., Lee,H.H. and Stuhlmann,H.
  TITLE     Vezf1: A Zn finger transcription factor restricted to endothelial
            cells and their precursors
  JOURNAL   Dev Biol 206 (2), 123-141 (1999)
   PUBMED   9986727
REFERENCE   8  (bases 1 to 3015)
  AUTHORS   Zechner,U., Scheel,S., Hemberger,M., Hopp,M., Haaf,T., Fundele,R.,
            Wanker,E.E., Lehrach,H., Wedemeyer,N. and Himmelbauer,H.
  TITLE     Characterization of the mouse Src homology 3 domain gene Sh3d2c on
            Chr 7 demonstrates coexpression with huntingtin in the brain and
            identifies the processed pseudogene Sh3d2c-ps1 on Chr 2
  JOURNAL   Genomics 54 (3), 505-510 (1998)
   PUBMED   9878254
REFERENCE   9  (bases 1 to 3015)
  AUTHORS   Biesova,Z., Piccoli,C. and Wong,W.T.
  TITLE     Isolation and characterization of e3B1, an eps8 binding protein
            that regulates cell growth
  JOURNAL   Oncogene 14 (2), 233-241 (1997)
   PUBMED   9010225
REFERENCE   10 (bases 1 to 3015)
  AUTHORS   Shi,Y., Alin,K. and Goff,S.P.
  TITLE     Abl-interactor-1, a novel SH3 protein binding to the
            carboxy-terminal portion of the Abl protein, suppresses v-abl
            transforming activity
  JOURNAL   Genes Dev 9 (21), 2583-2597 (1995)
   PUBMED   7590237
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845257.2 and CT030013.7.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13948564.1951341.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-247               AL845257.2         23338-23584         c
            248-424             CT030013.7         150317-150493       c
            425-525             CT030013.7         141635-141735       c
            526-666             CT030013.7         139941-140081       c
            667-767             CT030013.7         136252-136352       c
            768-854             CT030013.7         129418-129504       c
            855-1040            CT030013.7         125810-125995       c
            1041-3015           CT030013.7         119307-121281       c
FEATURES             Location/Qualifiers
     source          1..3015
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 15.18 cM"
     gene            1..3015
                     /gene="Abi1"
                     /gene_synonym="abi-1; E3B1; NAP1; Ssh3bp1"
                     /note="abl interactor 1"
                     /db_xref="GeneID:11308"
                     /db_xref="MGI:MGI:104913"
     exon            1..247
                     /gene="Abi1"
                     /gene_synonym="abi-1; E3B1; NAP1; Ssh3bp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..1216
                     /gene="Abi1"
                     /gene_synonym="abi-1; E3B1; NAP1; Ssh3bp1"
                     /note="isoform 26 is encoded by transcript variant 26;
                     spectrin SH3 domain binding protein 1; abelson interactor
                     1; ablphilin-1; eps8 binding protein; eps8 SH3
                     domain-binding protein"
                     /codon_start=1
                     /product="abl interactor 1 isoform 26"
                     /protein_id="NP_001403793.1"
                     /db_xref="GeneID:11308"
                     /db_xref="MGI:MGI:104913"
                     /translation="MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQTVDIH
                     KEKVARREIGILTTNKNTSRTHKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKHGNN
                     QPARTGTLSRTNPPTQKPPSPPVSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLG
                     SQHSPGRTASLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTAGPVSVAPP
                     PPPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYED
                     EEAAVVQYSDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFKEGAIIYVIKKNDD
                     GWFEGVCNRVTGLFPGNYVESIMHYTD"
     exon            248..424
                     /gene="Abi1"
                     /gene_synonym="abi-1; E3B1; NAP1; Ssh3bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            425..525
                     /gene="Abi1"
                     /gene_synonym="abi-1; E3B1; NAP1; Ssh3bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            526..666
                     /gene="Abi1"
                     /gene_synonym="abi-1; E3B1; NAP1; Ssh3bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            667..767
                     /gene="Abi1"
                     /gene_synonym="abi-1; E3B1; NAP1; Ssh3bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            768..854
                     /gene="Abi1"
                     /gene_synonym="abi-1; E3B1; NAP1; Ssh3bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1040
                     /gene="Abi1"
                     /gene_synonym="abi-1; E3B1; NAP1; Ssh3bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..3015
                     /gene="Abi1"
                     /gene_synonym="abi-1; E3B1; NAP1; Ssh3bp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1840..1845
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abi1"
                     /gene_synonym="abi-1; E3B1; NAP1; Ssh3bp1"
                     /note="hexamer: AATACA"
     polyA_site      1858
                     /gene="Abi1"
                     /gene_synonym="abi-1; E3B1; NAP1; Ssh3bp1"
                     /note="major polyA site"
     regulatory      2521..2526
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abi1"
                     /gene_synonym="abi-1; E3B1; NAP1; Ssh3bp1"
                     /note="hexamer: ATTAAA"
     polyA_site      2545
                     /gene="Abi1"
                     /gene_synonym="abi-1; E3B1; NAP1; Ssh3bp1"
                     /note="major polyA site"
     regulatory      2699..2704
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abi1"
                     /gene_synonym="abi-1; E3B1; NAP1; Ssh3bp1"
                     /note="hexamer: AATAAA"
     polyA_site      2724
                     /gene="Abi1"
                     /gene_synonym="abi-1; E3B1; NAP1; Ssh3bp1"
                     /note="major polyA site"
     regulatory      2806..2811
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abi1"
                     /gene_synonym="abi-1; E3B1; NAP1; Ssh3bp1"
                     /note="hexamer: AACAAA"
     polyA_site      2832
                     /gene="Abi1"
                     /gene_synonym="abi-1; E3B1; NAP1; Ssh3bp1"
     regulatory      2986..2991
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abi1"
                     /gene_synonym="abi-1; E3B1; NAP1; Ssh3bp1"
                     /note="hexamer: AATAAA"
     polyA_site      3015
                     /gene="Abi1"
                     /gene_synonym="abi-1; E3B1; NAP1; Ssh3bp1"
ORIGIN      
        1 gcagtcccac aatacccggc ggagggaggg tgggtggttg gcgtctggtc tgtgcggagc
       61 tcgggtcccc ggcggactca gcttcctctg tctctttaat gcgagaggaa gcgatgcgga
      121 ggggtggaaa atggcagagc tgcagatgtt actagaggag gagatcccgt ctggcaagag
      181 ggcgctgata gagagttacc agaacctgac ccgggtggcg gactactgtg aaaacaacta
      241 tatacagact gtggatattc ataaagaaaa agtggctcga agagagattg gtattttgac
      301 aacaaataag aatacatcaa gaactcacaa aataatcgca cccgcaaata tggagcgtcc
      361 tgtcaggtat attcggaaac ctatcgacta tacagttctg gatgatgtgg gccatggagt
      421 taagcacgga aataaccagc ctgcaagaac tggcacattg tcgagaacaa accctcccac
      481 gcagaaacca ccaagccctc ccgtgtcggg ccgagggact ttgggacgga atacccctta
      541 caaaacccta gagcctgtta agcctccaac agttcccaat gactacatga ctagtcctgc
      601 gaggcttgga agccagcata gtccaggcag gacagcttct ttaaatcaga gaccaaggac
      661 gcatagtgga agtagtggag gaagcggaag ccgagagaac agtgggagca gcagcattgg
      721 cattcctatt gctgtgccta cgccctcacc gcccactgcg ggcccagttt ctgttgcccc
      781 tcctcctccc cccatgcctc agttgactcc acagatccct ctcacaggct tcgtggccag
      841 ggtgcaggaa aacattgctg atagcccaac tccaccacca ccccctccac cagatgacat
      901 tcccatgttt gatgactctc cgcctcctcc gccacctcct cctgtggact atgaagatga
      961 ggaagctgca gtagttcagt atagtgaccc atatgcagat ggggaccctg catgggctcc
     1021 caagaactat attgagaaag ttgttgcaat atatgattat acaaaagaca aggatgatga
     1081 gctgtccttt aaagagggtg caatcatcta tgttataaag aagaatgatg atggctggtt
     1141 tgaaggagtt tgcaatcgag tgactggact cttccctggg aactatgttg aatcaatcat
     1201 gcactatact gattagtttt tcttttttct tttcatgtag gttattactc cgtcatactg
     1261 tgggattata tggttaacag aattgtttta atgtttaaaa tgtgcccata ttttcaagga
     1321 catgttttat tggtatattt ggatgtctac ctgtaagcat aaattttgga ggcagttcaa
     1381 acattgctga gcagcagttt atatgcctat aattgattat gcatatgtac tcacaccttg
     1441 ctaagtttat gaccagccta aaacttctgg ggattgggta ttatgtttaa caaatcatgg
     1501 ttcagaatgc accattacat gtttcagtgc agcatggtca ctaacattgt gtcagactaa
     1561 taggaaaaaa cagaaaacgt caatgctggt gctggtcata cttttggttt caattctcat
     1621 ttttaaaaaa atactgtgtt taaagcatgc ataaattttt atgtattgaa atatacttaa
     1681 caattcaaga tgcttccaat ttgtgtaacg attatctgga gtactcatac ttgagtctcc
     1741 taagctctcc atgtgaaatg aaagactatc tgtaatgttg taatttgtat ctaagttttt
     1801 taatgagtga aatttgcatt ataaattttt ccattcataa atacataagt gaaccaaagg
     1861 attttggcct ctcctttact ggtttgcttt aattatgtat gctagtgcat atgcatgcac
     1921 accctcccac ccctttaaga aagatttatt gcagaattat ggttctattt tctcaatgca
     1981 tcagttttga aaatattttt agcttaatct taatgtgtcc aaacagtcaa tgtgacagaa
     2041 ttttgcagat tttggagcta gactgtgtca gagtaagcac atgatattct gggggcaaca
     2101 tctgaaggag gagtgccaca ccggtccttt ggattttaat gaaactgaat ttacattgac
     2161 tcagtgaaag gaaaatcctt tacatattgt aaagatggat gcagttcatt tgtggatagg
     2221 catatttaat ccattccctg gcactagaaa cataaaattt tacaataatt ttgaaagaaa
     2281 ctaggccatg tattaatctg taaacaggta ataagcaggt ttgtattgta actttgatgc
     2341 aacacatgca ctttgtgtgt ctccttgatt caagggaggg tgtgagggat acttctcttg
     2401 tatataagac tgtactgctt aggatattaa agtagatcac acaagtgtgg gtttctatgt
     2461 actgagggtt gcagatttat gacagcatag tgatgagagc agtgcaaaat atttctgaaa
     2521 attaaagacc attgttccta ccaaatcaat gattccatat atattttaac ctttgttatt
     2581 tttgaagtac tatgtcatta gcaatcagat agctttttat tatgcatttc ctttttgaag
     2641 caaaatgttt tcttcatttg taaataacct gttgtctaaa ttttatctag tcttttataa
     2701 taaactatgc tcctatatga aaaatttgga tattgttaaa gtataactaa tgtggattta
     2761 aatagtacag acttcaaaat tctctgacct ttaatcctat ggtgaaacaa agacaaacca
     2821 cttgaatttt aacgttgatt atttatttgt gtaatggctt tacatgtggg cattaacagt
     2881 gtaaacaata ccacatataa ccatcaggat acctcgatta gaatttatag gactataatg
     2941 acactggttt aattacattt aaaaagtttt ccgaaaaact ttgccaataa aaattgccca
     3001 tcaataaggt tgaaa
//
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