LOCUS NM_001416864 3015 bp mRNA linear ROD 14-JUN-2024
DEFINITION Mus musculus abl interactor 1 (Abi1), transcript variant 26, mRNA.
ACCESSION NM_001416864
VERSION NM_001416864.1
KEYWORDS RefSeq.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (bases 1 to 3015)
AUTHORS Verdile,V., Svetoni,F., La Rosa,P., Ferrante,G., Cesari,E.,
Sette,C. and Paronetto,M.P.
TITLE EWS splicing regulation contributes to balancing Foxp1 isoforms
required for neuronal differentiation
JOURNAL Nucleic Acids Res 50 (6), 3362-3378 (2022)
PUBMED 35253879
REFERENCE 2 (bases 1 to 3015)
AUTHORS Aviles,E.C., Krol,A., Henle,S.J., Burroughs-Garcia,J., Deans,M.R.
and Goodrich,L.V.
TITLE Fat3 acts through independent cytoskeletal effectors to coordinate
asymmetric cell behaviors during polarized circuit assembly
JOURNAL Cell Rep 38 (5), 110307 (2022)
PUBMED 35108541
REFERENCE 3 (bases 1 to 3015)
AUTHORS Wang,R., Wang,Y., Liao,G., Chen,B., Panettieri,R.A. Jr., Penn,R.B.
and Tang,D.D.
TITLE Abi1 mediates airway smooth muscle cell proliferation and airway
remodeling via Jak2/STAT3 signaling
JOURNAL iScience 25 (2), 103833 (2022)
PUBMED 35198891
REMARK Publication Status: Online-Only
REFERENCE 4 (bases 1 to 3015)
AUTHORS Qi,Y., Liu,J., Chao,J., Greer,P.A. and Li,S.
TITLE PTEN dephosphorylates Abi1 to promote epithelial morphogenesis
JOURNAL J Cell Biol 219 (9) (2020)
PUBMED 32673396
REFERENCE 5 (bases 1 to 3015)
AUTHORS Faulkner,J., Jiang,P., Farris,D., Walker,R. and Dai,Z.
TITLE CRISPR/CAS9-mediated knockout of Abi1 inhibits p185Bcr-Abl-induced
leukemogenesis and signal transduction to ERK and PI3K/Akt pathways
JOURNAL J Hematol Oncol 13 (1), 34 (2020)
PUBMED 32276588
REMARK GeneRIF: CRISPR/CAS9-mediated knockout of Abi1 inhibits
p185(Bcr-Abl)-induced leukemogenesis and signal transduction to ERK
and PI3K/Akt pathways.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 3015)
AUTHORS Scita,G., Nordstrom,J., Carbone,R., Tenca,P., Giardina,G.,
Gutkind,S., Bjarnegard,M., Betsholtz,C. and Di Fiore,P.P.
TITLE EPS8 and E3B1 transduce signals from Ras to Rac
JOURNAL Nature 401 (6750), 290-293 (1999)
PUBMED 10499589
REFERENCE 7 (bases 1 to 3015)
AUTHORS Xiong,J.W., Leahy,A., Lee,H.H. and Stuhlmann,H.
TITLE Vezf1: A Zn finger transcription factor restricted to endothelial
cells and their precursors
JOURNAL Dev Biol 206 (2), 123-141 (1999)
PUBMED 9986727
REFERENCE 8 (bases 1 to 3015)
AUTHORS Zechner,U., Scheel,S., Hemberger,M., Hopp,M., Haaf,T., Fundele,R.,
Wanker,E.E., Lehrach,H., Wedemeyer,N. and Himmelbauer,H.
TITLE Characterization of the mouse Src homology 3 domain gene Sh3d2c on
Chr 7 demonstrates coexpression with huntingtin in the brain and
identifies the processed pseudogene Sh3d2c-ps1 on Chr 2
JOURNAL Genomics 54 (3), 505-510 (1998)
PUBMED 9878254
REFERENCE 9 (bases 1 to 3015)
AUTHORS Biesova,Z., Piccoli,C. and Wong,W.T.
TITLE Isolation and characterization of e3B1, an eps8 binding protein
that regulates cell growth
JOURNAL Oncogene 14 (2), 233-241 (1997)
PUBMED 9010225
REFERENCE 10 (bases 1 to 3015)
AUTHORS Shi,Y., Alin,K. and Goff,S.P.
TITLE Abl-interactor-1, a novel SH3 protein binding to the
carboxy-terminal portion of the Abl protein, suppresses v-abl
transforming activity
JOURNAL Genes Dev 9 (21), 2583-2597 (1995)
PUBMED 7590237
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AL845257.2 and CT030013.7.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR13948564.1951341.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN01164142 [ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-247 AL845257.2 23338-23584 c
248-424 CT030013.7 150317-150493 c
425-525 CT030013.7 141635-141735 c
526-666 CT030013.7 139941-140081 c
667-767 CT030013.7 136252-136352 c
768-854 CT030013.7 129418-129504 c
855-1040 CT030013.7 125810-125995 c
1041-3015 CT030013.7 119307-121281 c
FEATURES Location/Qualifiers
source 1..3015
/organism="Mus musculus"
/mol_type="mRNA"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="2"
/map="2 15.18 cM"
gene 1..3015
/gene="Abi1"
/gene_synonym="abi-1; E3B1; NAP1; Ssh3bp1"
/note="abl interactor 1"
/db_xref="GeneID:11308"
/db_xref="MGI:MGI:104913"
exon 1..247
/gene="Abi1"
/gene_synonym="abi-1; E3B1; NAP1; Ssh3bp1"
/inference="alignment:Splign:2.1.0"
CDS 131..1216
/gene="Abi1"
/gene_synonym="abi-1; E3B1; NAP1; Ssh3bp1"
/note="isoform 26 is encoded by transcript variant 26;
spectrin SH3 domain binding protein 1; abelson interactor
1; ablphilin-1; eps8 binding protein; eps8 SH3
domain-binding protein"
/codon_start=1
/product="abl interactor 1 isoform 26"
/protein_id="NP_001403793.1"
/db_xref="GeneID:11308"
/db_xref="MGI:MGI:104913"
/translation="MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQTVDIH
KEKVARREIGILTTNKNTSRTHKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKHGNN
QPARTGTLSRTNPPTQKPPSPPVSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLG
SQHSPGRTASLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTAGPVSVAPP
PPPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYED
EEAAVVQYSDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFKEGAIIYVIKKNDD
GWFEGVCNRVTGLFPGNYVESIMHYTD"
exon 248..424
/gene="Abi1"
/gene_synonym="abi-1; E3B1; NAP1; Ssh3bp1"
/inference="alignment:Splign:2.1.0"
exon 425..525
/gene="Abi1"
/gene_synonym="abi-1; E3B1; NAP1; Ssh3bp1"
/inference="alignment:Splign:2.1.0"
exon 526..666
/gene="Abi1"
/gene_synonym="abi-1; E3B1; NAP1; Ssh3bp1"
/inference="alignment:Splign:2.1.0"
exon 667..767
/gene="Abi1"
/gene_synonym="abi-1; E3B1; NAP1; Ssh3bp1"
/inference="alignment:Splign:2.1.0"
exon 768..854
/gene="Abi1"
/gene_synonym="abi-1; E3B1; NAP1; Ssh3bp1"
/inference="alignment:Splign:2.1.0"
exon 855..1040
/gene="Abi1"
/gene_synonym="abi-1; E3B1; NAP1; Ssh3bp1"
/inference="alignment:Splign:2.1.0"
exon 1041..3015
/gene="Abi1"
/gene_synonym="abi-1; E3B1; NAP1; Ssh3bp1"
/inference="alignment:Splign:2.1.0"
regulatory 1840..1845
/regulatory_class="polyA_signal_sequence"
/gene="Abi1"
/gene_synonym="abi-1; E3B1; NAP1; Ssh3bp1"
/note="hexamer: AATACA"
polyA_site 1858
/gene="Abi1"
/gene_synonym="abi-1; E3B1; NAP1; Ssh3bp1"
/note="major polyA site"
regulatory 2521..2526
/regulatory_class="polyA_signal_sequence"
/gene="Abi1"
/gene_synonym="abi-1; E3B1; NAP1; Ssh3bp1"
/note="hexamer: ATTAAA"
polyA_site 2545
/gene="Abi1"
/gene_synonym="abi-1; E3B1; NAP1; Ssh3bp1"
/note="major polyA site"
regulatory 2699..2704
/regulatory_class="polyA_signal_sequence"
/gene="Abi1"
/gene_synonym="abi-1; E3B1; NAP1; Ssh3bp1"
/note="hexamer: AATAAA"
polyA_site 2724
/gene="Abi1"
/gene_synonym="abi-1; E3B1; NAP1; Ssh3bp1"
/note="major polyA site"
regulatory 2806..2811
/regulatory_class="polyA_signal_sequence"
/gene="Abi1"
/gene_synonym="abi-1; E3B1; NAP1; Ssh3bp1"
/note="hexamer: AACAAA"
polyA_site 2832
/gene="Abi1"
/gene_synonym="abi-1; E3B1; NAP1; Ssh3bp1"
regulatory 2986..2991
/regulatory_class="polyA_signal_sequence"
/gene="Abi1"
/gene_synonym="abi-1; E3B1; NAP1; Ssh3bp1"
/note="hexamer: AATAAA"
polyA_site 3015
/gene="Abi1"
/gene_synonym="abi-1; E3B1; NAP1; Ssh3bp1"
ORIGIN
1 gcagtcccac aatacccggc ggagggaggg tgggtggttg gcgtctggtc tgtgcggagc
61 tcgggtcccc ggcggactca gcttcctctg tctctttaat gcgagaggaa gcgatgcgga
121 ggggtggaaa atggcagagc tgcagatgtt actagaggag gagatcccgt ctggcaagag
181 ggcgctgata gagagttacc agaacctgac ccgggtggcg gactactgtg aaaacaacta
241 tatacagact gtggatattc ataaagaaaa agtggctcga agagagattg gtattttgac
301 aacaaataag aatacatcaa gaactcacaa aataatcgca cccgcaaata tggagcgtcc
361 tgtcaggtat attcggaaac ctatcgacta tacagttctg gatgatgtgg gccatggagt
421 taagcacgga aataaccagc ctgcaagaac tggcacattg tcgagaacaa accctcccac
481 gcagaaacca ccaagccctc ccgtgtcggg ccgagggact ttgggacgga atacccctta
541 caaaacccta gagcctgtta agcctccaac agttcccaat gactacatga ctagtcctgc
601 gaggcttgga agccagcata gtccaggcag gacagcttct ttaaatcaga gaccaaggac
661 gcatagtgga agtagtggag gaagcggaag ccgagagaac agtgggagca gcagcattgg
721 cattcctatt gctgtgccta cgccctcacc gcccactgcg ggcccagttt ctgttgcccc
781 tcctcctccc cccatgcctc agttgactcc acagatccct ctcacaggct tcgtggccag
841 ggtgcaggaa aacattgctg atagcccaac tccaccacca ccccctccac cagatgacat
901 tcccatgttt gatgactctc cgcctcctcc gccacctcct cctgtggact atgaagatga
961 ggaagctgca gtagttcagt atagtgaccc atatgcagat ggggaccctg catgggctcc
1021 caagaactat attgagaaag ttgttgcaat atatgattat acaaaagaca aggatgatga
1081 gctgtccttt aaagagggtg caatcatcta tgttataaag aagaatgatg atggctggtt
1141 tgaaggagtt tgcaatcgag tgactggact cttccctggg aactatgttg aatcaatcat
1201 gcactatact gattagtttt tcttttttct tttcatgtag gttattactc cgtcatactg
1261 tgggattata tggttaacag aattgtttta atgtttaaaa tgtgcccata ttttcaagga
1321 catgttttat tggtatattt ggatgtctac ctgtaagcat aaattttgga ggcagttcaa
1381 acattgctga gcagcagttt atatgcctat aattgattat gcatatgtac tcacaccttg
1441 ctaagtttat gaccagccta aaacttctgg ggattgggta ttatgtttaa caaatcatgg
1501 ttcagaatgc accattacat gtttcagtgc agcatggtca ctaacattgt gtcagactaa
1561 taggaaaaaa cagaaaacgt caatgctggt gctggtcata cttttggttt caattctcat
1621 ttttaaaaaa atactgtgtt taaagcatgc ataaattttt atgtattgaa atatacttaa
1681 caattcaaga tgcttccaat ttgtgtaacg attatctgga gtactcatac ttgagtctcc
1741 taagctctcc atgtgaaatg aaagactatc tgtaatgttg taatttgtat ctaagttttt
1801 taatgagtga aatttgcatt ataaattttt ccattcataa atacataagt gaaccaaagg
1861 attttggcct ctcctttact ggtttgcttt aattatgtat gctagtgcat atgcatgcac
1921 accctcccac ccctttaaga aagatttatt gcagaattat ggttctattt tctcaatgca
1981 tcagttttga aaatattttt agcttaatct taatgtgtcc aaacagtcaa tgtgacagaa
2041 ttttgcagat tttggagcta gactgtgtca gagtaagcac atgatattct gggggcaaca
2101 tctgaaggag gagtgccaca ccggtccttt ggattttaat gaaactgaat ttacattgac
2161 tcagtgaaag gaaaatcctt tacatattgt aaagatggat gcagttcatt tgtggatagg
2221 catatttaat ccattccctg gcactagaaa cataaaattt tacaataatt ttgaaagaaa
2281 ctaggccatg tattaatctg taaacaggta ataagcaggt ttgtattgta actttgatgc
2341 aacacatgca ctttgtgtgt ctccttgatt caagggaggg tgtgagggat acttctcttg
2401 tatataagac tgtactgctt aggatattaa agtagatcac acaagtgtgg gtttctatgt
2461 actgagggtt gcagatttat gacagcatag tgatgagagc agtgcaaaat atttctgaaa
2521 attaaagacc attgttccta ccaaatcaat gattccatat atattttaac ctttgttatt
2581 tttgaagtac tatgtcatta gcaatcagat agctttttat tatgcatttc ctttttgaag
2641 caaaatgttt tcttcatttg taaataacct gttgtctaaa ttttatctag tcttttataa
2701 taaactatgc tcctatatga aaaatttgga tattgttaaa gtataactaa tgtggattta
2761 aatagtacag acttcaaaat tctctgacct ttaatcctat ggtgaaacaa agacaaacca
2821 cttgaatttt aacgttgatt atttatttgt gtaatggctt tacatgtggg cattaacagt
2881 gtaaacaata ccacatataa ccatcaggat acctcgatta gaatttatag gactataatg
2941 acactggttt aattacattt aaaaagtttt ccgaaaaact ttgccaataa aaattgccca
3001 tcaataaggt tgaaa
//