LOCUS NM_001428421 2538 bp mRNA linear ROD 02-MAY-2024
DEFINITION Mus musculus exocyst complex component 3-like (Exoc3l), transcript
variant 3, mRNA.
ACCESSION NM_001428421 XM_006531070
VERSION NM_001428421.1
KEYWORDS RefSeq.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (bases 1 to 2538)
AUTHORS Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
Jackson,S.P. and Balmus,G.
CONSRTM Sanger Mouse Genetics Project
TITLE Genetic determinants of micronucleus formation in vivo
JOURNAL Nature 627 (8002), 130-136 (2024)
PUBMED 38355793
REFERENCE 2 (bases 1 to 2538)
AUTHORS Takashima,S., Okamura,E., Ichiyama,Y., Nishi,K., Shimizu,A.,
Watanabe,C., Muto,M., Matsumoto,S., Tsukiyama-Fujii,S.,
Tsukiyama,T., Ogita,H., Nishi,E., Ohji,M., Sugiyama,F.,
Takahashi,S., Mizuno,S., Mizutani,K.I. and Ema,M.
TITLE Null mutation of exocyst complex component 3-like does not affect
vascular development in mice
JOURNAL Exp Anim 73 (1), 93-100 (2024)
PUBMED 37661429
REMARK GeneRIF: Null mutation of exocyst complex component 3-like does not
affect vascular development in mice.
REFERENCE 3 (bases 1 to 2538)
AUTHORS Saito,T., Shibasaki,T. and Seino,S.
TITLE Involvement of Exoc3l, a protein structurally related to the
exocyst subunit Sec6, in insulin secretion
JOURNAL Biomed Res 29 (2), 85-91 (2008)
PUBMED 18480549
REFERENCE 4 (bases 1 to 2538)
AUTHORS Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
TITLE Construction of long-transcript enriched cDNA libraries from
submicrogram amounts of total RNAs by a universal PCR amplification
method
JOURNAL Genome Res 11 (9), 1553-1558 (2001)
PUBMED 11544199
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC124584.5.
On Mar 12, 2024 this sequence version replaced XM_006531070.4.
##Evidence-Data-START##
Transcript exon combination :: SRR13422589.508635.1,
SRR13422600.866833.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMN00849374,
SAMN00849375 [ECO:0006172]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-193 AC124584.5 97381-97573
194-314 AC124584.5 97733-97853
315-490 AC124584.5 98044-98219
491-710 AC124584.5 98295-98514
711-1320 AC124584.5 99618-100227
1321-1438 AC124584.5 100300-100417
1439-1564 AC124584.5 100502-100627
1565-1665 AC124584.5 100730-100830
1666-1776 AC124584.5 101034-101144
1777-1906 AC124584.5 102427-102556
1907-2029 AC124584.5 102675-102797
2030-2185 AC124584.5 102875-103030
2186-2310 AC124584.5 103123-103247
2311-2538 AC124584.5 103329-103556
FEATURES Location/Qualifiers
source 1..2538
/organism="Mus musculus"
/mol_type="mRNA"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="8"
/map="8 53.04 cM"
gene 1..2538
/gene="Exoc3l"
/gene_synonym="C730015A04Rik; Exoc3l1"
/note="exocyst complex component 3-like"
/db_xref="GeneID:277978"
/db_xref="MGI:MGI:3041195"
exon 1..193
/gene="Exoc3l"
/gene_synonym="C730015A04Rik; Exoc3l1"
/inference="alignment:Splign:2.1.0"
exon 194..314
/gene="Exoc3l"
/gene_synonym="C730015A04Rik; Exoc3l1"
/inference="alignment:Splign:2.1.0"
misc_feature 221..223
/gene="Exoc3l"
/gene_synonym="C730015A04Rik; Exoc3l1"
/note="upstream in-frame stop codon"
CDS 281..2500
/gene="Exoc3l"
/gene_synonym="C730015A04Rik; Exoc3l1"
/note="isoform 1 is encoded by transcript variant 3;
exocyst complex component 3-like protein"
/codon_start=1
/product="exocyst complex component 3-like protein isoform
1"
/protein_id="NP_001415350.1"
/db_xref="GeneID:277978"
/db_xref="MGI:MGI:3041195"
/translation="MDSKIQPTLRPGSSCPRPEWPEQERAEQLARGAALKWASGIFYR
PEQLTRLGQYRSREIQRNYSLEARIKSVVQSYLEGVQTGVWQLTRALEAVQGTREALS
QAHHLLKGLSRTSQTLEPLRECVVQHKQLQILTRLLPRLQAVPATVAHTQTLIDSERL
LEAYVSLRELEQLKEETLAPLGGLELPIFQGLGLLAEALGQAVEAAAGAAGRLAREDP
ALLVAAIRVAEVETERTILGQAPRDWRQRCLRALQEGLERVHFASPVLPEPGALAGWL
EALQVALPAELATAEALVAPCCPPSYRVVELWAHTLHSGLRRSVQQLLAGPELGAADT
FALLHWALHVYTGKEMMGNLELGPEADVSQLEPLLTSENIEQLEAAFVAQVQVSVAQW
LKKALDGEVAEWSGEQEPPTDPSGFYHSPMPAIVLQILAENIQVTNLISDSLHRRAHN
MAVSELGAFLRSFSDALIRFSRDHLRGDAVAPHYVPYLLSAFNHQSALRSSVSVLLPD
GEASGVLAPVEAALDDVQRRICRLVLEVLQVELQPLFSALPSRRWLLSSELLDGVCEQ
TSHFCQDFWRVRKPGVQLLLAEAERTVVLQYLRALMQGRLVCRGTDERSQAAERLRQD
AAQLKELFLGLGLEESAHCAPVLLALRELLNLHDPTLLGLEVAGLRQQFPDVSEDHVS
ALLDLRGDVSREHRQAALSSLQAGPPPSPSTGRRALFSLVPTPTPSLSSCLPSGPCS"
misc_feature 281..1390
/gene="Exoc3l"
/gene_synonym="C730015A04Rik; Exoc3l1"
/note="propagated from UniProtKB/Swiss-Prot (Q8BI71.1);
Region: Mediates interaction with EXOC2, EXOC4 and EXOC5.
/evidence=ECO:0000269|PubMed:18480549"
misc_feature 281..343
/gene="Exoc3l"
/gene_synonym="C730015A04Rik; Exoc3l1"
/note="propagated from UniProtKB/Swiss-Prot (Q8BI71.1);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 2372..2434
/gene="Exoc3l"
/gene_synonym="C730015A04Rik; Exoc3l1"
/note="propagated from UniProtKB/Swiss-Prot (Q8BI71.1);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
exon 315..490
/gene="Exoc3l"
/gene_synonym="C730015A04Rik; Exoc3l1"
/inference="alignment:Splign:2.1.0"
exon 491..710
/gene="Exoc3l"
/gene_synonym="C730015A04Rik; Exoc3l1"
/inference="alignment:Splign:2.1.0"
exon 711..1320
/gene="Exoc3l"
/gene_synonym="C730015A04Rik; Exoc3l1"
/inference="alignment:Splign:2.1.0"
exon 1321..1438
/gene="Exoc3l"
/gene_synonym="C730015A04Rik; Exoc3l1"
/inference="alignment:Splign:2.1.0"
exon 1439..1564
/gene="Exoc3l"
/gene_synonym="C730015A04Rik; Exoc3l1"
/inference="alignment:Splign:2.1.0"
exon 1565..1665
/gene="Exoc3l"
/gene_synonym="C730015A04Rik; Exoc3l1"
/inference="alignment:Splign:2.1.0"
exon 1666..1776
/gene="Exoc3l"
/gene_synonym="C730015A04Rik; Exoc3l1"
/inference="alignment:Splign:2.1.0"
exon 1777..1906
/gene="Exoc3l"
/gene_synonym="C730015A04Rik; Exoc3l1"
/inference="alignment:Splign:2.1.0"
exon 1907..2029
/gene="Exoc3l"
/gene_synonym="C730015A04Rik; Exoc3l1"
/inference="alignment:Splign:2.1.0"
exon 2030..2185
/gene="Exoc3l"
/gene_synonym="C730015A04Rik; Exoc3l1"
/inference="alignment:Splign:2.1.0"
exon 2186..2310
/gene="Exoc3l"
/gene_synonym="C730015A04Rik; Exoc3l1"
/inference="alignment:Splign:2.1.0"
exon 2311..2538
/gene="Exoc3l"
/gene_synonym="C730015A04Rik; Exoc3l1"
/inference="alignment:Splign:2.1.0"
regulatory 2518..2523
/regulatory_class="polyA_signal_sequence"
/gene="Exoc3l"
/gene_synonym="C730015A04Rik; Exoc3l1"
/note="hexamer: AATAAA"
polyA_site 2538
/gene="Exoc3l"
/gene_synonym="C730015A04Rik; Exoc3l1"
/note="major polyA site"
ORIGIN
1 aggggtttct gggccgtgaa gtgggagaga ggcttccttg gggagaggaa tttggctgct
61 ggtgccaaag gagctggagt ccctccggtc ccgtgagcag tgagggtgtg cccagctctg
121 caggagcgag aaggctactc tcaaggccaa ggccacttgc agaggaggga gaactggaca
181 ccggtcagat ctgcggagcc caaggaacat ccgctctgcc tgatctcctc caggcactcg
241 ctcccactcc taccacatcg gcagcagctc taggcaaact atggacagca agatacagcc
301 cacacttcgt cctggatctt cctgcccaag gcctgagtgg ccagagcagg agagggccga
361 acagctggct cggggtgcag cactcaagtg ggcttcaggc atcttctacc ggccagagca
421 gctgaccagg ctgggccagt accgaagccg tgaaatacag cgtaactatt ccctggaagc
481 aagaattaag tcagtggtgc agtcctacct ggaaggtgtg cagactggtg tgtggcagct
541 gacccgagcc ctcgaggctg tgcagggaac tcgtgaagct ttgagccagg cccatcactt
601 actaaagggt ttgtctcgga cctcacaaac cctggaaccc ctgagggaat gtgttgtcca
661 gcacaaacaa cttcagatcc tgactcggtt gttgccaagg ctacaagcag tgccggctac
721 agtggcccac acgcagaccc tgatagactc tgagcgactc ttggaggcat atgtgagcct
781 gcgggaacta gagcagctga aagaggagac actggcaccc ctaggaggtc tggagttgcc
841 aatcttccag gggctaggcc ttctggctga ggccctaggc caagctgtgg aggcggctgc
901 aggagctgcg gggcggctgg cacgagagga cccagccctg ctggtagctg ctattcgtgt
961 ggcagaggtg gagactgagc gcacaatcct ggggcaggca ccccgagact ggcggcagcg
1021 atgtcttcgg gcgctacagg agggcctgga gcgggtccac tttgcatcgc ctgtgcttcc
1081 ggagccaggg gctctggcgg ggtggcttga ggctctgcag gtagccttgc ccgccgagtt
1141 ggcaacagcg gaggcattgg tggcaccctg ctgcccacca agctaccgtg tggttgagct
1201 atgggcccac accctgcaca gtggcctgcg ccgtagcgtg cagcaactcc tcgcggggcc
1261 cgagctagga gctgctgaca cgtttgcctt gctgcactgg gcactgcatg tgtacacggg
1321 gaaggaaatg atggggaact tggaactggg gcctgaggct gatgtgtccc agctagagcc
1381 cctcttgacc tcagagaaca ttgagcagct ggaggcagcc tttgtggctc aggttcaggt
1441 aagtgtggct cagtggctga agaaggcact ggatggagag gtagcagagt ggagcgggga
1501 acaggagccc cccacagatc catccggttt ctaccactcc ccaatgccag ccattgtcct
1561 gcagatcctg gctgaaaaca ttcaagtgac caacctgatt agtgactcat tgcatcggcg
1621 ggcgcataac atggcagtgt cagagctggg cgcattcttg agaagcttca gcgacgctct
1681 gatccgattc tctcgagacc atctcagggg agacgccgtg gcccctcact atgtgcccta
1741 cctactgtct gccttcaacc accaatcagc actgagatct tcggtctcgg tcctgctgcc
1801 ggacggggaa gcttccgggg tcttagctcc agtggaagct gcgctggacg acgtacaaag
1861 gaggatctgc cgcctggttt tggaagtact gcaggttgag ctccagcccc tgttctccgc
1921 tctgccctcg cgccggtggc tattgagttc tgagttgcta gatggtgtgt gtgagcagac
1981 gtcgcacttc tgccaggact tctggcgcgt acggaagcct ggtgttcagc tgctgctggc
2041 agaggcggaa cgaaccgtgg tgttacaata cctaagggct ctgatgcagg gccgcctagt
2101 gtgccgcggt acggacgagc ggagccaggc ggctgagcga cttcggcagg atgctgccca
2161 gctcaaagag cttttccttg gtttgggcct ggaagagagc gctcactgcg cgcccgtcct
2221 gctcgcgctg agggaactgc tcaacctcca cgaccccaca ctgcttggcc tcgaggtggc
2281 aggcttgagg cagcaatttc ccgacgtgag cgaggatcac gtctctgccc tcttggacct
2341 gcgcggagac gtgtcccgag agcatcgtca ggcagcactc agttcgctgc aggcgggtcc
2401 accgccctca ccgtccactg gccgccgggc gctcttcagc ctggtaccga cgcctacgcc
2461 ctccctgtcc tcctgcctcc cttcaggtcc ctgctcctga cacccatctg tttgcgtaat
2521 aaagccacgt ctacgaca
//