LOCUS NM_002148 1785 bp mRNA linear PRI 21-SEP-2024
DEFINITION Homo sapiens homeobox D10 (HOXD10), mRNA.
ACCESSION NM_002148
VERSION NM_002148.4
KEYWORDS RefSeq; MANE Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1785)
AUTHORS Lee,H., Machado,C.R.L., Hammaker,D., Choi,E., Prideaux,E.B.,
Wang,W., Boyle,D.L. and Firestein,G.S.
TITLE Joint-specific regulation of homeobox D10 expression in rheumatoid
arthritis fibroblast-like synoviocytes
JOURNAL PLoS One 19 (6), e0304530 (2024)
PUBMED 38829908
REMARK GeneRIF: Joint-specific regulation of homeobox D10 expression in
rheumatoid arthritis fibroblast-like synoviocytes.
Publication Status: Online-Only
REFERENCE 2 (bases 1 to 1785)
AUTHORS Zhang,L. and Liu,M.
TITLE Circ_0077109 sponges miR-139-5p and upregulates HOXD10 in
trophoblast cells as potential mechanism for preeclampsia
progression
JOURNAL Am J Reprod Immunol 88 (5), e13609 (2022)
PUBMED 35964231
REMARK GeneRIF: Circ_0077109 sponges miR-139-5p and upregulates HOXD10 in
trophoblast cells as potential mechanism for preeclampsia
progression.
REFERENCE 3 (bases 1 to 1785)
AUTHORS Ren,Z., Niu,Y., Fan,B. and Zhang,A.
TITLE Upregulation of homeobox D10 expression suppresses invasion and
migration of clear cell renal cell carcinoma through targeting of
E-cadherin
JOURNAL Mol Biol Rep 49 (3), 1837-1846 (2022)
PUBMED 34825321
REMARK GeneRIF: Upregulation of homeobox D10 expression suppresses
invasion and migration of clear cell renal cell carcinoma through
targeting of E-cadherin.
REFERENCE 4 (bases 1 to 1785)
AUTHORS Lai,F.J., Yu,H., Xie,Y.Y. and He,N.
TITLE Circ_0000317/microRNA-520g/HOXD10 axis affects the biological
characteristics of colorectal cancer
JOURNAL Kaohsiung J Med Sci 37 (11), 951-963 (2021)
PUBMED 34292663
REMARK GeneRIF: Circ_0000317/microRNA-520g/HOXD10 axis affects the
biological characteristics of colorectal cancer.
REFERENCE 5 (bases 1 to 1785)
AUTHORS Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
Harper,J.W. and Gygi,S.P.
TITLE Dual proteome-scale networks reveal cell-specific remodeling of the
human interactome
JOURNAL Cell 184 (11), 3022-3040 (2021)
PUBMED 33961781
REFERENCE 6 (bases 1 to 1785)
AUTHORS Tabin,C.J.
TITLE Why we have (only) five fingers per hand: hox genes and the
evolution of paired limbs
JOURNAL Development 116 (2), 289-296 (1992)
PUBMED 1363084
REMARK Review article
REFERENCE 7 (bases 1 to 1785)
AUTHORS Redline,R.W., Williams,A.J., Patterson,P. and Collins,T.
TITLE Human HOX4E: a gene strongly expressed in the adult male and female
urogenital tracts
JOURNAL Genomics 13 (2), 425-430 (1992)
PUBMED 1351871
REFERENCE 8 (bases 1 to 1785)
AUTHORS Zappavigna,V., Renucci,A., Izpisua-Belmonte,J.C., Urier,G.,
Peschle,C. and Duboule,D.
TITLE HOX4 genes encode transcription factors with potential auto- and
cross-regulatory capacities
JOURNAL EMBO J 10 (13), 4177-4187 (1991)
PUBMED 1756725
REFERENCE 9 (bases 1 to 1785)
AUTHORS Peverali,F.A., D'Esposito,M., Acampora,D., Bunone,G., Negri,M.,
Faiella,A., Stornaiuolo,A., Pannese,M., Migliaccio,E., Simeone,A.
et al.
TITLE Expression of HOX homeogenes in human neuroblastoma cell culture
lines
JOURNAL Differentiation 45 (1), 61-69 (1990)
PUBMED 1981366
REFERENCE 10 (bases 1 to 1785)
AUTHORS Acampora,D., D'Esposito,M., Faiella,A., Pannese,M., Migliaccio,E.,
Morelli,F., Stornaiuolo,A., Nigro,V., Simeone,A. and Boncinelli,E.
TITLE The human HOX gene family
JOURNAL Nucleic Acids Res 17 (24), 10385-10402 (1989)
PUBMED 2574852
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AL526269.3, BC069619.1,
BX114645.1, AW243295.1, AW299531.1 and AA653427.1.
On Oct 2, 2019 this sequence version replaced NM_002148.3.
Summary: This gene is a member of the Abd-B homeobox family and
encodes a protein with a homeobox DNA-binding domain. It is
included in a cluster of homeobox D genes located on chromosome 2.
The encoded nuclear protein functions as a sequence-specific
transcription factor that is expressed in the developing limb buds
and is involved in differentiation and limb development. Mutations
in this gene have been associated with Wilm's tumor and congenital
vertical talus (also known as 'rocker-bottom foot' deformity or
congenital convex pes valgus) and/or a foot deformity resembling
that seen in Charcot-Marie-Tooth disease. [provided by RefSeq, Jul
2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC069619.1, X59373.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA1966682, SAMEA1968189
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000249501.5/ ENSP00000249501.4
RefSeq Select criteria :: based on single protein-coding transcript
##RefSeq-Attributes-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-6 AL526269.3 15-20
7-1150 BC069619.1 1-1144
1151-1190 BX114645.1 533-572
1191-1546 AW243295.1 1-356 c
1547-1752 AW299531.1 33-238 c
1753-1785 AA653427.1 32-64 c
FEATURES Location/Qualifiers
source 1..1785
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2q31.1"
gene 1..1785
/gene="HOXD10"
/gene_synonym="Hox-4.4; HOX4; HOX4D; HOX4E"
/note="homeobox D10"
/db_xref="GeneID:3236"
/db_xref="HGNC:HGNC:5133"
/db_xref="MIM:142984"
exon 1..801
/gene="HOXD10"
/gene_synonym="Hox-4.4; HOX4; HOX4D; HOX4E"
/inference="alignment:Splign:2.1.0"
CDS 57..1079
/gene="HOXD10"
/gene_synonym="Hox-4.4; HOX4; HOX4D; HOX4E"
/note="homeo box D10; homeo box 4D; homeobox protein
Hox-4D; homeobox protein Hox-4E"
/codon_start=1
/product="homeobox protein Hox-D10"
/protein_id="NP_002139.2"
/db_xref="CCDS:CCDS2266.1"
/db_xref="GeneID:3236"
/db_xref="HGNC:HGNC:5133"
/db_xref="MIM:142984"
/translation="MSFPNSSPAANTFLVDSLISACRSDSFYSSSASMYMPPPSADMG
TYGMQTCGLLPSLAKREVNHQNMGMNVHPYIPQVDSWTDPNRSCRIEQPVTQQVPTCS
FTTNIKEESNCCMYSDKRNKLISAEVPSYQRLVPESCPVENPEVPVPGYFRLSQTYAT
GKTQEYNNSPEGSSTVMLQLNPRGAAKPQLSAAQLQMEKKMNEPVSGQEPTKVSQVES
PEAKGGLPEERSCLAEVSVSSPEVQEKESKEEIKSDTPTSNWLTAKSGRKKRCPYTKH
QTLELEKEFLFNMYLTRERRLEISKSVNLTDRQVKIWFQNRRMKLKKMSRENRIRELT
ANLTFS"
misc_feature 654..860
/gene="HOXD10"
/gene_synonym="Hox-4.4; HOX4; HOX4D; HOX4E"
/note="propagated from UniProtKB/Swiss-Prot (P28358.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 768..770
/gene="HOXD10"
/gene_synonym="Hox-4.4; HOX4; HOX4D; HOX4E"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:P28359; propagated from
UniProtKB/Swiss-Prot (P28358.2); phosphorylation site"
misc_feature 771..773
/gene="HOXD10"
/gene_synonym="Hox-4.4; HOX4; HOX4D; HOX4E"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:P28359; propagated from
UniProtKB/Swiss-Prot (P28358.2); phosphorylation site"
exon 802..1785
/gene="HOXD10"
/gene_synonym="Hox-4.4; HOX4; HOX4D; HOX4E"
/inference="alignment:Splign:2.1.0"
regulatory 1768..1773
/regulatory_class="polyA_signal_sequence"
/gene="HOXD10"
/gene_synonym="Hox-4.4; HOX4; HOX4D; HOX4E"
/note="hexamer: AATAAA"
polyA_site 1785
/gene="HOXD10"
/gene_synonym="Hox-4.4; HOX4; HOX4D; HOX4E"
/note="major polyA site"
ORIGIN
1 ctagagatgt cagcctacaa aggacacaat ctctcttctt caaattcttc cccaaaatgt
61 cctttcccaa cagctctcct gctgctaata cttttttagt agattccttg atcagtgcct
121 gcaggagtga cagtttttat tccagcagcg ccagcatgta catgccacca cctagcgcag
181 acatggggac ctatggaatg caaacctgtg gactgctccc gtctctggcc aaaagagaag
241 tgaaccacca aaatatgggt atgaatgtgc atccttatat acctcaagta gacagttgga
301 cagatccgaa cagatcttgt cgaatagagc aacctgttac acagcaagtc cccacttgct
361 ccttcaccac caacattaag gaagaatcca attgctgcat gtattctgat aagcgcaaca
421 aactcatttc ggccgaggtc ccttcgtacc agaggctggt ccctgagtct tgtcccgttg
481 agaaccctga ggttcccgtc cctggatatt ttagactgag tcagacctac gccaccggga
541 aaacccaaga gtacaataat agccccgaag gcagctccac tgtcatgctc cagctcaacc
601 ctcgtggcgc ggccaagccg cagctctccg ctgcccagct gcagatggaa aagaagatga
661 acgagcccgt gagcggccag gagcccacca aagtctccca ggtggagagc cccgaggcca
721 aaggcggcct tcccgaagag aggagctgcc tggctgaggt ctccgtgtcc agtcccgaag
781 tgcaggagaa ggaaagcaaa gaggaaatca agtctgatac accaaccagc aattggctca
841 ctgcaaagag tggcagaaag aagaggtgcc cttacactaa gcaccaaacg ctggaattag
901 aaaaagagtt cttgttcaat atgtacctca cccgcgagcg ccgcctagag atcagtaaga
961 gcgttaacct caccgacagg caggtcaaga tttggtttca aaaccgccga atgaaactca
1021 agaagatgag ccgagagaac cggatccgag aactgaccgc caacctcacg ttttcttagg
1081 tctgaggccg gtctgaggcc ggtcagaggc caggattgga gagggggcac cgcgttccag
1141 ggcccagtgc tggaggactg ggaaagcgga aacaaaacct tcaccgctct ttgtttgttg
1201 ttttgttgta ttttgttttc ctgctagaat gtgactttgg ggtcattatg ttcgtgctgc
1261 aagtgatctg taatccctat gagtatatat atatatatat atatatatat ataaaaactt
1321 agcacgtgta atttattatt ttttcatcgt aatgcagggt aactattatt gcgcattttc
1381 atttgggtct taacttattg gaactgtaga gcatccatcc atccatccat ccagcaatgt
1441 gactttttca tgtctttcct aacacaaaag gtctatgtgt gtggttagtc catgaactca
1501 tggcattttg aatacatcca gtactttaaa aatgacatat atatttaaaa aaaaaagatt
1561 aagaaaaccc acaagttgga gggaggggga cttaaaaagc acattacaat gtatcttttc
1621 acaaatgaat ttagcagttg tccttggtga gatgggatat tggcgattta tgccttgtag
1681 cctttccctt gtggtgcatc tgtggtttgg tagaagtaca acagcaacct gtcctttctg
1741 tgcatgttct ggtcgcatgt ataatgcaat aaactctgga aatga
//