LOCUS NM_011413 5369 bp mRNA linear ROD 27-JUN-2023
DEFINITION Mus musculus complement C4A (Rodgers blood group) (C4a), transcript
variant 1, mRNA.
ACCESSION NM_011413 XM_484625
VERSION NM_011413.2
KEYWORDS RefSeq; RefSeq Select.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (bases 1 to 5369)
AUTHORS Druart M, Nosten-Bertrand M, Poll S, Crux S, Nebeling F, Delhaye C,
Dubois Y, Mittag M, Leboyer M, Tamouza R, Fuhrmann M and Le
Magueresse C.
TITLE Elevated expression of complement C4 in the mouse prefrontal cortex
causes schizophrenia-associated phenotypes
JOURNAL Mol Psychiatry 26 (7), 3489-3501 (2021)
PUBMED 33837272
REMARK GeneRIF: Elevated expression of complement C4 in the mouse
prefrontal cortex causes schizophrenia-associated phenotypes.
REFERENCE 2 (bases 1 to 5369)
AUTHORS Yilmaz M, Yalcin E, Presumey J, Aw E, Ma M, Whelan CW, Stevens B,
McCarroll SA and Carroll MC.
TITLE Overexpression of schizophrenia susceptibility factor human
complement C4A promotes excessive synaptic loss and behavioral
changes in mice
JOURNAL Nat Neurosci 24 (2), 214-224 (2021)
PUBMED 33353966
REMARK GeneRIF: Overexpression of schizophrenia susceptibility factor
human complement C4A promotes excessive synaptic loss and
behavioral changes in mice.
REFERENCE 3 (bases 1 to 5369)
AUTHORS Simoni L, Presumey J, van der Poel CE, Castrillon C, Chang SE, Utz
PJ and Carroll MC.
TITLE Complement C4A Regulates Autoreactive B Cells in Murine Lupus
JOURNAL Cell Rep 33 (5), 108330 (2020)
PUBMED 33147456
REMARK GeneRIF: Complement C4A Regulates Autoreactive B Cells in Murine
Lupus.
REFERENCE 4 (bases 1 to 5369)
AUTHORS Comer AL, Jinadasa T, Sriram B, Phadke RA, Kretsge LN, Nguyen TPH,
Antognetti G, Gilbert JP, Lee J, Newmark ER, Hausmann FS, Rosenthal
S, Liu Kot K, Liu Y, Yen WW, Dejanovic B and Cruz-Martin A.
TITLE Increased expression of schizophrenia-associated gene C4 leads to
hypoconnectivity of prefrontal cortex and reduced social
interaction
JOURNAL PLoS Biol 18 (1), e3000604 (2020)
PUBMED 31935214
REMARK GeneRIF: Increased expression of the schizophrenia-associated gene
C4 causes aberrant circuit wiring in the developing prefrontal
cortex and leads to deficits in juvenile and adult social behavior,
suggesting that altered C4 expression contributes directly to
schizophrenia pathogenesis.
Publication Status: Online-Only
REFERENCE 5 (bases 1 to 5369)
AUTHORS Sekar A, Bialas AR, de Rivera H, Davis A, Hammond TR, Kamitaki N,
Tooley K, Presumey J, Baum M, Van Doren V, Genovese G, Rose SA,
Handsaker RE, Daly MJ, Carroll MC, Stevens B and McCarroll SA.
CONSRTM Schizophrenia Working Group of the Psychiatric Genomics Consortium
TITLE Schizophrenia risk from complex variation of complement component 4
JOURNAL Nature 530 (7589), 177-183 (2016)
PUBMED 26814963
REMARK GeneRIF: C4 mediated synapse elimination during postnatal
development
Erratum:[Nature. 2022 Jan;601(7892):E4-E5. PMID: 34912127]
REFERENCE 6 (bases 1 to 5369)
AUTHORS van den Berg CW, Demant P, Aerts PC and Van Dijk H.
TITLE Slp is an essential component of an EDTA-resistant activation
pathway of mouse complement
JOURNAL Proc Natl Acad Sci U S A 89 (22), 10711-10715 (1992)
PUBMED 1438267
REFERENCE 7 (bases 1 to 5369)
AUTHORS Miller RD, Aizawa Y and Shreffler DC.
TITLE Restriction fragment length polymorphism of the murine C4 and Slp
genes: two C4 groups
JOURNAL J Immunol 149 (9), 2926-2934 (1992)
PUBMED 1357031
REFERENCE 8 (bases 1 to 5369)
AUTHORS Milstone DS, Shaw SK, Parker KL, Szyf M and Seidman JG.
TITLE An element regulating adrenal-specific steroid 21-hydroxylase
expression is located within the slp gene
JOURNAL J Biol Chem 267 (30), 21924-21927 (1992)
PUBMED 1400503
REFERENCE 9 (bases 1 to 5369)
AUTHORS Pattanakitsakul S, Zheng JH, Natsuume-Sakai S, Takahashi M and
Nonaka M.
TITLE Aberrant splicing caused by the insertion of the B2 sequence into
an intron of the complement C4 gene is the basis for low C4
production in H-2k mice
JOURNAL J Biol Chem 267 (11), 7814-7820 (1992)
PUBMED 1373139
REFERENCE 10 (bases 1 to 5369)
AUTHORS Robins DM and Samuelson LC.
TITLE Retrotransposons and the evolution of mammalian gene expression
JOURNAL Genetica 86 (1-3), 191-201 (1992)
PUBMED 1281802
REMARK Review article
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AK129017.1, M12384.1 and AW987669.1.
On Feb 27, 2007 this sequence version replaced NM_011413.1.
Transcript Variant: This variant (1) represents the functional
non-reference strain allele and encodes the full-length protein.
Sequence Note: This RefSeq record was created from transcript data
from a non-reference strain to represent the functional allele.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: M21576.1, M12384.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMN00849374,
SAMN00849375 [ECO:0006172]
##Evidence-Data-END##
##RefSeq-Attributes-START##
polymorphic pseudogene :: based on alignments, homology
RefSeq Select criteria :: based on single protein-coding transcript
##RefSeq-Attributes-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-276 AK129017.1 11-286
277-1166 M12384.1 171-1060
1167-1406 AK129017.1 1177-1416
1407-3760 M12384.1 1301-3654
3761-5000 AK129017.1 3567-4806
5001-5281 M12384.1 4895-5175
5282-5356 AK129017.1 5088-5162
5357-5369 AW987669.1 1-13 c
FEATURES Location/Qualifiers
source 1..5369
/organism="Mus musculus"
/mol_type="mRNA"
/db_xref="taxon:10090"
/chromosome="17"
/map="17 18.37 cM"
gene 1..5369
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/note="complement C4A (Rodgers blood group)"
/db_xref="GeneID:625018"
/db_xref="MGI:MGI:98320"
exon 1..114
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/inference="alignment:Splign:2.1.0"
misc_feature 26..28
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/note="upstream in-frame stop codon"
CDS 50..5257
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/note="sex-limited protein; Complement C4-B; complement
component 4A (Rodgers blood group)"
/codon_start=1
/product="sex-limited protein precursor"
/protein_id="NP_035543.2"
/db_xref="GeneID:625018"
/db_xref="MGI:MGI:98320"
/translation="MRLLWGLAWVFSFCASSLQKPRLLLFSPSVVNLGTPLSVGVQLL
DAPPGQEVKGSVFLRNPKGGSCSPKKDFKLSLGDDFVLLSLEVPLEDVRSCGLFDLRR
APYIQLVAQSPWLRNTAFKATETQGVNLLYSSRRGHIFVQTDQPIYNPGQRVRYRVFA
LDQKMRPSTDFLTITVENSHGLRVLKKEIFTSTSIFQDAFTIPDISEPGTWKISARFS
DGLESNRSTHFEVKKYVLPNFEVKITPWKPYILMVPSNSDEIQLDIQARYIYGKPVQG
VAYTRFALMDEQGKRTFLQGLETQAKLVEGRTHISISKDQFQAALDKINIGVRDLEGL
RLYAATAVIESPGGEMEEAELTSWRFVSSAFSLDLSRTKRHLVPGAHFLLQALVREIS
GSEASNVIVKVSATLVSGSDSQVLNVQQSTNRIGQVSISFPIPPTVTELRLLVSAGSL
YPTIARLTVQSPPSRGTGFLSIEPLDPRSPRVGDTFILNLQAVGIPAPTFSHYYYMII
SRGQIMAMSREARRTVTSVSVLVDHQLAPSFYFVAYFYHQGHPVANSLLINIQPRDCE
GKLQLKVVGAKEYHNGDMMKLQIQTDSKALVALGAVDTALYAVGGWSHKPLDMSKVFE
VIDSYNLGCGPGGGDDAPQVFQDAGLAFSDGDRLTQTREDLSCPKEKKSRQKRNVNFL
KALSEKLGQYSSPDAKRCCQDGMTKLPMKRTCEQRAARVPQQACREPFLSCCKFAEDL
RRNQTRSQAHLARKVRDMVNLIEEDDILVRTSFPDNWLWRVEPVDSSKLLTVRLPDSM
TTWEIHGVSLSKSKGLCVAKPTRVRVFRKFHLHLRLPISVRRFEQLELRPVLYNYLND
DKNVSVHVTPVEGLCMAGGGMMAQWVIVPAGSALPVAFSVVPTASTNVPLKLVAKGTL
DSSDSVSKILQIEKEGAIHREEIVYNLDPLNNLGQMLEIPGSSDPNIVPEGDFSTFVK
VTASEPLETLGSEGALSPGGVASLLRLPRSCAEQTMIYLAPTLTASNYLDRTKQWSKL
SPETKDHAVHLIQKGHVRIQQFRKKDGSFGAWLHRDSSTWLTAFVLKILSLAQEQVGN
SPEKLQETASWLLAQQLGDGSFHDPCPVIHRAMQGGLVGSNETVALTAFVVIALHHGL
NVFREGHAKQLKNRVEASITKANSFLGQKASAGLLGAHAAAITAYALTLTKASEDLRN
VAHNSLMAMAEETGENLYWGLVLGSQDKVMLRPADPRSPTEPVPQAPALWIETTAYAL
LHLLLREGKGKMADKAASWLTHQGNFHGAFRSTQDTVVTLDALSAYWIASHTTEEKAL
NVTLSSMGRNGLKTHGLHLNNHQVKGLEEELKFSLGSTISVKVEGNSKGTLKILRTYN
VLDMKNTTCQDLQIEVKVTDAVEYAWSAYEDYEDDYNMPATDDPSVPLQPVTPLQLFE
GRRSRRRREAPKVAEERESRVHYTVCIWRNGKLGLSGMAIADITLLSGFHALRADLEK
LTSLSDRYVSHFETDGPHVLLYFDSVPTTRECVGFGASQEVVVGLVQPASAVLYDYYS
PDHKCSVFYAAPTKSQLLATLCSGDVCQCAEGKCPRLLRSLERRVEDKDGYRMRFACY
YHQVEYGFTVKVLREDGRAAFRLFESKITQVLHFRTDTMASIGQTRNFLSRASCRLRL
EPNKEYLIMGMDGETSDNKGDPQYLLDSNTWIEEMPSEQMCKSTRHRAACFQLKDFLM
EFSSRGCQV"
sig_peptide 50..106
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
exon 115..307
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/inference="alignment:Splign:2.1.0"
exon 308..509
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/inference="alignment:Splign:2.1.0"
exon 510..580
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/inference="alignment:Splign:2.1.0"
exon 581..669
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/inference="alignment:Splign:2.1.0"
exon 670..752
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/inference="alignment:Splign:2.1.0"
exon 753..849
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/inference="alignment:Splign:2.1.0"
exon 850..955
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/inference="alignment:Splign:2.1.0"
exon 956..1088
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/inference="alignment:Splign:2.1.0"
exon 1089..1204
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/inference="alignment:Splign:2.1.0"
exon 1205..1381
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/inference="alignment:Splign:2.1.0"
exon 1382..1567
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/inference="alignment:Splign:2.1.0"
exon 1568..1753
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/inference="alignment:Splign:2.1.0"
exon 1754..1912
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/inference="alignment:Splign:2.1.0"
exon 1913..2039
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/inference="alignment:Splign:2.1.0"
exon 2040..2114
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/inference="alignment:Splign:2.1.0"
exon 2115..2309
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/inference="alignment:Splign:2.1.0"
exon 2310..2415
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/inference="alignment:Splign:2.1.0"
exon 2416..2486
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/inference="alignment:Splign:2.1.0"
exon 2487..2626
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/inference="alignment:Splign:2.1.0"
exon 2627..2830
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/inference="alignment:Splign:2.1.0"
exon 2831..2882
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/inference="alignment:Splign:2.1.0"
exon 2883..2972
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/inference="alignment:Splign:2.1.0"
exon 2973..3182
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/inference="alignment:Splign:2.1.0"
exon 3183..3258
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/inference="alignment:Splign:2.1.0"
exon 3259..3415
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/inference="alignment:Splign:2.1.0"
exon 3416..3532
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/inference="alignment:Splign:2.1.0"
exon 3533..3704
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/inference="alignment:Splign:2.1.0"
exon 3705..3937
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/inference="alignment:Splign:2.1.0"
exon 3938..4105
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/inference="alignment:Splign:2.1.0"
exon 4106..4165
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/inference="alignment:Splign:2.1.0"
exon 4166..4259
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/inference="alignment:Splign:2.1.0"
exon 4260..4440
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/inference="alignment:Splign:2.1.0"
exon 4441..4531
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/inference="alignment:Splign:2.1.0"
exon 4532..4606
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/inference="alignment:Splign:2.1.0"
exon 4607..4709
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/inference="alignment:Splign:2.1.0"
exon 4710..4799
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/inference="alignment:Splign:2.1.0"
exon 4800..4898
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/inference="alignment:Splign:2.1.0"
exon 4899..4982
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/inference="alignment:Splign:2.1.0"
exon 4983..5115
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/inference="alignment:Splign:2.1.0"
exon 5116..5362
/gene="C4a"
/gene_synonym="C4; C4b; Slp; SlpA"
/inference="alignment:Splign:2.1.0"
ORIGIN
1 gagcagacag tcagaccaga caggttgacc tctcctggat cctccagcca tgcggctcct
61 ctgggggctg gcttgggtgt tcagcttctg tgcctcatcc ctgcagaagc ccaggttgct
121 cctgttttcc ccttctgtgg ttaatttggg gactcccctg tcagtggggg tacagctcct
181 ggatgcccct ccaggacagg aggtaaaagg atcagtgttc ctcagaaacc caaagggtgg
241 ttcctgctcc ccaaagaagg actttaagct gagcttggga gatgactttg tgctgctcag
301 ccttgaggtc ccactggaag atgtgaggag ctgtggcctc tttgacctgc gcagagcccc
361 ctacatccag ctggtagctc agtctccgtg gctaaggaac acagctttca aagccacaga
421 gactcagggt gtcaacttgc tctactcttc ccgacgaggc cacatctttg tgcagaccga
481 tcagcctatc tataatccgg ggcagcgggt tcgttatcgg gtctttgcac tggatcaaaa
541 gatgcgccca tccactgatt tcctcaccat cacagtggag aactcccatg gcctccgtgt
601 actcaagaag gagatattta cttccacatc catcttccaa gatgccttca ccattccaga
661 catctcagag cctgggacct ggaagatctc agctaggttc tcagatggac tggagtccaa
721 taggagcacc cactttgaag tgaagaagta tgtccttccc aacttcgagg tgaagattac
781 tccttggaag ccatatatcc tgatggtgcc cagcaacagt gatgaaatcc aattagacat
841 ccaggccagg tacatctatg ggaagcccgt gcagggcgtg gcatacacac ggtttgcgct
901 catggatgag caagggaaga ggactttcct tcagggccta gagacccagg ccaagttggt
961 ggaaggccgg acccacattt ccatctcaaa ggaccagttc caggctgccc tggataaaat
1021 caatattggg gtcagagacc tggaggggct gcgtctctat gctgctacag ctgtcattga
1081 gtctccagga ggagagatgg aggaggcaga actcacgtcc tggcgctttg tatcatctgc
1141 cttttccttg gatctcagcc gcactaagcg gcatctcgtg cctggagccc acttcctgct
1201 gcaggccttg gtcagagaaa tatcaggctc tgaagcctct aacgttattg tcaaagtttc
1261 tgccacattg gtgtcaggct ctgattccca agtcctcaac gttcaacaga gcaccaatag
1321 aattggccaa gtcagcattt ccttccccat cccaccaacc gtcacagaac ttcggctctt
1381 ggtgtctgcg ggctccctct acccaacgat agccaggctc accgtgcaat ccccaccttc
1441 aagaggcact ggctttcttt ctattgagcc actagaccct cggtcccctc gtgtggggga
1501 cacctttatc ctaaacttac aagctgtggg catccctgca cctaccttct ctcattacta
1561 ctacatgatc atctccagag gccagatcat ggctatgagt cgggaggccc ggaggaccgt
1621 gacctctgtc tccgtgttgg tggaccatca gctggctcct tcattctact tcgtggctta
1681 cttctatcac caaggacacc cggtggccaa ctctctgctc atcaacatcc agcccaggga
1741 ctgtgagggc aagctgcaat tgaaggtagt tggtgccaag gagtatcata atggggacat
1801 gatgaagctc caaattcaaa ctgactccaa agccctggtg gcactgggag ctgtggacac
1861 cgctctgtat gctgtgggcg gttggtctca caaacccctc gacatgagca aggtctttga
1921 agtaatcgac agctacaacc ttggctgtgg tcctggaggt ggggatgatg cccctcaggt
1981 gttccaggat gctggtctgg ccttttctga tggtgatcga ctaactcaaa ccagagagga
2041 cctgagctgt cccaaggaga agaaaagtcg gcaaaagaga aatgttaact tcctgaaggc
2101 tcttagtgag aagttgggcc agtattcttc tccagatgcc aagcgctgct gccaagacgg
2161 gatgacgaag ctgcccatga agcgtacctg tgagcagcgg gctgcccgtg tgcctcagca
2221 ggcctgccgt gagcccttct tgtcctgttg caagtttgct gaggaccttc gcaggaacca
2281 gaccaggagc caggcacacc ttgcccgaaa ggtccgggac atggtgaatt tgatagagga
2341 agatgacatt cttgtgcgca cctccttccc agacaactgg ctctggagag tggaacctgt
2401 agacagctcc aaactgttga cagtgcggct tcctgattct atgaccacat gggagattca
2461 tggtgtgagc ctgtccaaaa gcaaaggtct gtgtgtagcc aagccaactc gtgttcgagt
2521 gttcagaaaa ttccaccttc acctgcgcct gcccatctcc gtccgccgct ttgagcagct
2581 tgaattacgg cctgttctct acaactatct gaatgatgac aagaacgtga gtgtccatgt
2641 gaccccagtg gagggcctgt gcatggctgg tggtggaatg atggcccagt gggtgatagt
2701 gcctgcaggc tctgccctgc ctgtggcctt ctctgtggta cccacagctt ctaccaacgt
2761 gcccctgaaa ttggtggcta aagggacttt ggattcaagc gattctgtgt ctaagattct
2821 ccaaattgag aaggaaggag ccatccacag agaagagata gtctacaacc tcgaccccct
2881 aaataaccta ggtcagatgt tggagatacc tggcagctcg gatcccaaca tagtccctga
2941 aggagacttc agcacctttg tcaaggttac agcctctgaa cccttggaga ctctgggctc
3001 tgaaggagct ttgtccccag gaggcgtggc ctccctcctg aggcttcccc ggagctgcgc
3061 agagcaaacc atgatctatt tggctcctac cctgactgct tccaactacc tggacaggac
3121 aaaacagtgg agcaaactgt cccctgagac caaggaccat gctgtgcatc tgatccagaa
3181 aggccacgtt cggatccagc agtttcggaa gaaagatggc tcttttgggg cttggttaca
3241 ccgggacagc agcacctggc tgactgcctt tgtgctgaag attctgagtt tggcccagga
3301 acaggtgggc aactccccgg agaagctgca ggagacggct agctggctgc tggcccagca
3361 gctgggtgat ggctccttcc acgacccatg tccagtcatc cacagagcaa tgcagggggg
3421 cttggtgggg tccaatgaga cggtggcact gaccgccttt gtggtcattg cccttcacca
3481 cgggctgaac gtcttccggg aggggcatgc gaagcagctg aagaacagag tggaagcctc
3541 catcaccaag gcaaactctt tcttggggca gaaggcaagt gctgggctcc tgggtgccca
3601 tgccgccgcc atcacagcct atgcccttac gctgaccaag gcctcggagg acctgcggaa
3661 tgttgcccac aacagcctga tggccatggc tgaggaaacg ggggaaaacc tctactgggg
3721 cttagtcctt ggctctcagg acaaagttat gttgcgcccc gcagaccccc gtagcccaac
3781 agaacctgtg ccccaggccc cagccttgtg gatcgaaacc acagcctatg ccctgctcca
3841 cctgcttctg cgggagggaa agggaaaaat ggctgacaag gctgcatcct ggctcaccca
3901 ccagggaaac ttccacgggg cattccgcag tacccaggac actgtggtca ccctggatgc
3961 cctgtctgcc tactggatcg cttcacacac cactgaggag aaagcactga acgtgacgct
4021 cagctccatg ggccgcaatg ggcttaagac ccacgggcta cacttgaaca accaccaagt
4081 caagggcctg gaggaggagc taaagttctc cctgggcagc acaatcagtg tcaaggtgga
4141 aggaaacagc aaaggcacct tgaagatcct tcgtacctac aacgtcctgg acatgaagaa
4201 caccacatgc caggaccttc agatagaagt gaaggtcaca gacgctgtgg aatatgcatg
4261 gagcgcctac gaagactatg aagacgacta taacatgcca gccacagatg atcccagcgt
4321 tcccttgcag cctgtcacgc ccctgcagct atttgagggt cgtcggagcc gccgcaggag
4381 ggaggccccc aaggtggctg aagagcggga gtccagagtt cactacactg tgtgtatctg
4441 gcgcaatggc aagctggggc tgtctggcat ggccatcgca gacatcaccc tcctgagtgg
4501 attccacgcc ctgagggctg acctggagaa gctgacctct ctctctgacc gttatgtgag
4561 tcactttgag actgacgggc cccatgtcct gttgtacttt gactcggtcc ctaccacccg
4621 ggagtgtgtg ggctttggag cctcacagga ggtggttgtg ggactggtgc agccagccag
4681 cgctgtcctg tatgactact acagccctga tcacaagtgc tctgtgtttt atgctgcacc
4741 caccaagagc cagctcctgg ccacactgtg ctctggagat gtatgccagt gtgccgaggg
4801 gaagtgccct cgactgctaa ggtcactgga gcgaagggtg gaggacaagg acggctaccg
4861 gatgaggttc gcctgctatt atcaccaagt ggagtatggc ttcacggtta aggttcttcg
4921 agaagatggc agagctgcct tccgtctctt tgagtccaag atcacccaag tcctgcattt
4981 cagaacggac accatggcct ccataggtca gacccgcaac ttcctgagcc gggcctcttg
5041 ccgccttcgt ttggagccta acaaagagta cttgatcatg gggatggacg gggaaaccag
5101 tgacaacaag ggagaccccc agtacttgct ggactcaaat acctggattg aggagatgcc
5161 ttcagaacaa atgtgcaaga gcacccgcca tcgggcagcc tgtttccagc tcaaagactt
5221 cctgatggag ttcagcagcc gggggtgcca ggtgtgaggc cttaggactc tggctctctg
5281 agctcagctc agggtcaggg cctcgctgga tgaggggctc tgctctacag ggtaaataaa
5341 agaaaagctt tttgacagcc aaaaaaaaa
//