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Mus musculus complement C4A (Rodgers blood group) (C4a), transcript variant 1, mRNA

NCBI Reference Sequence: NM_011413.2

FASTA Graphics 

LOCUS       NM_011413               5369 bp    mRNA    linear   ROD 27-JUN-2023
DEFINITION  Mus musculus complement C4A (Rodgers blood group) (C4a), transcript
            variant 1, mRNA.
ACCESSION   NM_011413 XM_484625
VERSION     NM_011413.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5369)
  AUTHORS   Druart M, Nosten-Bertrand M, Poll S, Crux S, Nebeling F, Delhaye C,
            Dubois Y, Mittag M, Leboyer M, Tamouza R, Fuhrmann M and Le
            Magueresse C.
  TITLE     Elevated expression of complement C4 in the mouse prefrontal cortex
            causes schizophrenia-associated phenotypes
  JOURNAL   Mol Psychiatry 26 (7), 3489-3501 (2021)
   PUBMED   33837272
  REMARK    GeneRIF: Elevated expression of complement C4 in the mouse
            prefrontal cortex causes schizophrenia-associated phenotypes.
REFERENCE   2  (bases 1 to 5369)
  AUTHORS   Yilmaz M, Yalcin E, Presumey J, Aw E, Ma M, Whelan CW, Stevens B,
            McCarroll SA and Carroll MC.
  TITLE     Overexpression of schizophrenia susceptibility factor human
            complement C4A promotes excessive synaptic loss and behavioral
            changes in mice
  JOURNAL   Nat Neurosci 24 (2), 214-224 (2021)
   PUBMED   33353966
  REMARK    GeneRIF: Overexpression of schizophrenia susceptibility factor
            human complement C4A promotes excessive synaptic loss and
            behavioral changes in mice.
REFERENCE   3  (bases 1 to 5369)
  AUTHORS   Simoni L, Presumey J, van der Poel CE, Castrillon C, Chang SE, Utz
            PJ and Carroll MC.
  TITLE     Complement C4A Regulates Autoreactive B Cells in Murine Lupus
  JOURNAL   Cell Rep 33 (5), 108330 (2020)
   PUBMED   33147456
  REMARK    GeneRIF: Complement C4A Regulates Autoreactive B Cells in Murine
            Lupus.
REFERENCE   4  (bases 1 to 5369)
  AUTHORS   Comer AL, Jinadasa T, Sriram B, Phadke RA, Kretsge LN, Nguyen TPH,
            Antognetti G, Gilbert JP, Lee J, Newmark ER, Hausmann FS, Rosenthal
            S, Liu Kot K, Liu Y, Yen WW, Dejanovic B and Cruz-Martin A.
  TITLE     Increased expression of schizophrenia-associated gene C4 leads to
            hypoconnectivity of prefrontal cortex and reduced social
            interaction
  JOURNAL   PLoS Biol 18 (1), e3000604 (2020)
   PUBMED   31935214
  REMARK    GeneRIF: Increased expression of the schizophrenia-associated gene
            C4 causes aberrant circuit wiring in the developing prefrontal
            cortex and leads to deficits in juvenile and adult social behavior,
            suggesting that altered C4 expression contributes directly to
            schizophrenia pathogenesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5369)
  AUTHORS   Sekar A, Bialas AR, de Rivera H, Davis A, Hammond TR, Kamitaki N,
            Tooley K, Presumey J, Baum M, Van Doren V, Genovese G, Rose SA,
            Handsaker RE, Daly MJ, Carroll MC, Stevens B and McCarroll SA.
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Schizophrenia risk from complex variation of complement component 4
  JOURNAL   Nature 530 (7589), 177-183 (2016)
   PUBMED   26814963
  REMARK    GeneRIF: C4 mediated synapse elimination during postnatal
            development
            Erratum:[Nature. 2022 Jan;601(7892):E4-E5. PMID: 34912127]
REFERENCE   6  (bases 1 to 5369)
  AUTHORS   van den Berg CW, Demant P, Aerts PC and Van Dijk H.
  TITLE     Slp is an essential component of an EDTA-resistant activation
            pathway of mouse complement
  JOURNAL   Proc Natl Acad Sci U S A 89 (22), 10711-10715 (1992)
   PUBMED   1438267
REFERENCE   7  (bases 1 to 5369)
  AUTHORS   Miller RD, Aizawa Y and Shreffler DC.
  TITLE     Restriction fragment length polymorphism of the murine C4 and Slp
            genes: two C4 groups
  JOURNAL   J Immunol 149 (9), 2926-2934 (1992)
   PUBMED   1357031
REFERENCE   8  (bases 1 to 5369)
  AUTHORS   Milstone DS, Shaw SK, Parker KL, Szyf M and Seidman JG.
  TITLE     An element regulating adrenal-specific steroid 21-hydroxylase
            expression is located within the slp gene
  JOURNAL   J Biol Chem 267 (30), 21924-21927 (1992)
   PUBMED   1400503
REFERENCE   9  (bases 1 to 5369)
  AUTHORS   Pattanakitsakul S, Zheng JH, Natsuume-Sakai S, Takahashi M and
            Nonaka M.
  TITLE     Aberrant splicing caused by the insertion of the B2 sequence into
            an intron of the complement C4 gene is the basis for low C4
            production in H-2k mice
  JOURNAL   J Biol Chem 267 (11), 7814-7820 (1992)
   PUBMED   1373139
REFERENCE   10 (bases 1 to 5369)
  AUTHORS   Robins DM and Samuelson LC.
  TITLE     Retrotransposons and the evolution of mammalian gene expression
  JOURNAL   Genetica 86 (1-3), 191-201 (1992)
   PUBMED   1281802
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK129017.1, M12384.1 and AW987669.1.
            
            On Feb 27, 2007 this sequence version replaced NM_011413.1.
            
            Transcript Variant: This variant (1) represents the functional
            non-reference strain allele and encodes the full-length protein.
            
            Sequence Note: This RefSeq record was created from transcript data
            from a non-reference strain to represent the functional allele.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M21576.1, M12384.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            polymorphic pseudogene :: based on alignments, homology
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-276               AK129017.1         11-286
            277-1166            M12384.1           171-1060
            1167-1406           AK129017.1         1177-1416
            1407-3760           M12384.1           1301-3654
            3761-5000           AK129017.1         3567-4806
            5001-5281           M12384.1           4895-5175
            5282-5356           AK129017.1         5088-5162
            5357-5369           AW987669.1         1-13                c
FEATURES             Location/Qualifiers
     source          1..5369
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.37 cM"
     gene            1..5369
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /note="complement C4A (Rodgers blood group)"
                     /db_xref="GeneID:625018"
                     /db_xref="MGI:MGI:98320"
     exon            1..114
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    26..28
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /note="upstream in-frame stop codon"
     CDS             50..5257
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /note="sex-limited protein; Complement C4-B; complement
                     component 4A (Rodgers blood group)"
                     /codon_start=1
                     /product="sex-limited protein precursor"
                     /protein_id="NP_035543.2"
                     /db_xref="GeneID:625018"
                     /db_xref="MGI:MGI:98320"
                     /translation="MRLLWGLAWVFSFCASSLQKPRLLLFSPSVVNLGTPLSVGVQLL
                     DAPPGQEVKGSVFLRNPKGGSCSPKKDFKLSLGDDFVLLSLEVPLEDVRSCGLFDLRR
                     APYIQLVAQSPWLRNTAFKATETQGVNLLYSSRRGHIFVQTDQPIYNPGQRVRYRVFA
                     LDQKMRPSTDFLTITVENSHGLRVLKKEIFTSTSIFQDAFTIPDISEPGTWKISARFS
                     DGLESNRSTHFEVKKYVLPNFEVKITPWKPYILMVPSNSDEIQLDIQARYIYGKPVQG
                     VAYTRFALMDEQGKRTFLQGLETQAKLVEGRTHISISKDQFQAALDKINIGVRDLEGL
                     RLYAATAVIESPGGEMEEAELTSWRFVSSAFSLDLSRTKRHLVPGAHFLLQALVREIS
                     GSEASNVIVKVSATLVSGSDSQVLNVQQSTNRIGQVSISFPIPPTVTELRLLVSAGSL
                     YPTIARLTVQSPPSRGTGFLSIEPLDPRSPRVGDTFILNLQAVGIPAPTFSHYYYMII
                     SRGQIMAMSREARRTVTSVSVLVDHQLAPSFYFVAYFYHQGHPVANSLLINIQPRDCE
                     GKLQLKVVGAKEYHNGDMMKLQIQTDSKALVALGAVDTALYAVGGWSHKPLDMSKVFE
                     VIDSYNLGCGPGGGDDAPQVFQDAGLAFSDGDRLTQTREDLSCPKEKKSRQKRNVNFL
                     KALSEKLGQYSSPDAKRCCQDGMTKLPMKRTCEQRAARVPQQACREPFLSCCKFAEDL
                     RRNQTRSQAHLARKVRDMVNLIEEDDILVRTSFPDNWLWRVEPVDSSKLLTVRLPDSM
                     TTWEIHGVSLSKSKGLCVAKPTRVRVFRKFHLHLRLPISVRRFEQLELRPVLYNYLND
                     DKNVSVHVTPVEGLCMAGGGMMAQWVIVPAGSALPVAFSVVPTASTNVPLKLVAKGTL
                     DSSDSVSKILQIEKEGAIHREEIVYNLDPLNNLGQMLEIPGSSDPNIVPEGDFSTFVK
                     VTASEPLETLGSEGALSPGGVASLLRLPRSCAEQTMIYLAPTLTASNYLDRTKQWSKL
                     SPETKDHAVHLIQKGHVRIQQFRKKDGSFGAWLHRDSSTWLTAFVLKILSLAQEQVGN
                     SPEKLQETASWLLAQQLGDGSFHDPCPVIHRAMQGGLVGSNETVALTAFVVIALHHGL
                     NVFREGHAKQLKNRVEASITKANSFLGQKASAGLLGAHAAAITAYALTLTKASEDLRN
                     VAHNSLMAMAEETGENLYWGLVLGSQDKVMLRPADPRSPTEPVPQAPALWIETTAYAL
                     LHLLLREGKGKMADKAASWLTHQGNFHGAFRSTQDTVVTLDALSAYWIASHTTEEKAL
                     NVTLSSMGRNGLKTHGLHLNNHQVKGLEEELKFSLGSTISVKVEGNSKGTLKILRTYN
                     VLDMKNTTCQDLQIEVKVTDAVEYAWSAYEDYEDDYNMPATDDPSVPLQPVTPLQLFE
                     GRRSRRRREAPKVAEERESRVHYTVCIWRNGKLGLSGMAIADITLLSGFHALRADLEK
                     LTSLSDRYVSHFETDGPHVLLYFDSVPTTRECVGFGASQEVVVGLVQPASAVLYDYYS
                     PDHKCSVFYAAPTKSQLLATLCSGDVCQCAEGKCPRLLRSLERRVEDKDGYRMRFACY
                     YHQVEYGFTVKVLREDGRAAFRLFESKITQVLHFRTDTMASIGQTRNFLSRASCRLRL
                     EPNKEYLIMGMDGETSDNKGDPQYLLDSNTWIEEMPSEQMCKSTRHRAACFQLKDFLM
                     EFSSRGCQV"
     sig_peptide     50..106
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     exon            115..307
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /inference="alignment:Splign:2.1.0"
     exon            308..509
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /inference="alignment:Splign:2.1.0"
     exon            510..580
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /inference="alignment:Splign:2.1.0"
     exon            581..669
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /inference="alignment:Splign:2.1.0"
     exon            670..752
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /inference="alignment:Splign:2.1.0"
     exon            753..849
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /inference="alignment:Splign:2.1.0"
     exon            850..955
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1088
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1204
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1381
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1567
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1753
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1912
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..2039
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2114
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /inference="alignment:Splign:2.1.0"
     exon            2115..2309
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /inference="alignment:Splign:2.1.0"
     exon            2310..2415
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /inference="alignment:Splign:2.1.0"
     exon            2416..2486
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /inference="alignment:Splign:2.1.0"
     exon            2487..2626
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /inference="alignment:Splign:2.1.0"
     exon            2627..2830
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /inference="alignment:Splign:2.1.0"
     exon            2831..2882
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /inference="alignment:Splign:2.1.0"
     exon            2883..2972
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /inference="alignment:Splign:2.1.0"
     exon            2973..3182
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /inference="alignment:Splign:2.1.0"
     exon            3183..3258
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /inference="alignment:Splign:2.1.0"
     exon            3259..3415
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /inference="alignment:Splign:2.1.0"
     exon            3416..3532
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /inference="alignment:Splign:2.1.0"
     exon            3533..3704
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /inference="alignment:Splign:2.1.0"
     exon            3705..3937
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /inference="alignment:Splign:2.1.0"
     exon            3938..4105
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /inference="alignment:Splign:2.1.0"
     exon            4106..4165
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /inference="alignment:Splign:2.1.0"
     exon            4166..4259
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /inference="alignment:Splign:2.1.0"
     exon            4260..4440
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /inference="alignment:Splign:2.1.0"
     exon            4441..4531
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /inference="alignment:Splign:2.1.0"
     exon            4532..4606
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /inference="alignment:Splign:2.1.0"
     exon            4607..4709
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /inference="alignment:Splign:2.1.0"
     exon            4710..4799
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /inference="alignment:Splign:2.1.0"
     exon            4800..4898
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /inference="alignment:Splign:2.1.0"
     exon            4899..4982
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /inference="alignment:Splign:2.1.0"
     exon            4983..5115
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /inference="alignment:Splign:2.1.0"
     exon            5116..5362
                     /gene="C4a"
                     /gene_synonym="C4; C4b; Slp; SlpA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcagacag tcagaccaga caggttgacc tctcctggat cctccagcca tgcggctcct
       61 ctgggggctg gcttgggtgt tcagcttctg tgcctcatcc ctgcagaagc ccaggttgct
      121 cctgttttcc ccttctgtgg ttaatttggg gactcccctg tcagtggggg tacagctcct
      181 ggatgcccct ccaggacagg aggtaaaagg atcagtgttc ctcagaaacc caaagggtgg
      241 ttcctgctcc ccaaagaagg actttaagct gagcttggga gatgactttg tgctgctcag
      301 ccttgaggtc ccactggaag atgtgaggag ctgtggcctc tttgacctgc gcagagcccc
      361 ctacatccag ctggtagctc agtctccgtg gctaaggaac acagctttca aagccacaga
      421 gactcagggt gtcaacttgc tctactcttc ccgacgaggc cacatctttg tgcagaccga
      481 tcagcctatc tataatccgg ggcagcgggt tcgttatcgg gtctttgcac tggatcaaaa
      541 gatgcgccca tccactgatt tcctcaccat cacagtggag aactcccatg gcctccgtgt
      601 actcaagaag gagatattta cttccacatc catcttccaa gatgccttca ccattccaga
      661 catctcagag cctgggacct ggaagatctc agctaggttc tcagatggac tggagtccaa
      721 taggagcacc cactttgaag tgaagaagta tgtccttccc aacttcgagg tgaagattac
      781 tccttggaag ccatatatcc tgatggtgcc cagcaacagt gatgaaatcc aattagacat
      841 ccaggccagg tacatctatg ggaagcccgt gcagggcgtg gcatacacac ggtttgcgct
      901 catggatgag caagggaaga ggactttcct tcagggccta gagacccagg ccaagttggt
      961 ggaaggccgg acccacattt ccatctcaaa ggaccagttc caggctgccc tggataaaat
     1021 caatattggg gtcagagacc tggaggggct gcgtctctat gctgctacag ctgtcattga
     1081 gtctccagga ggagagatgg aggaggcaga actcacgtcc tggcgctttg tatcatctgc
     1141 cttttccttg gatctcagcc gcactaagcg gcatctcgtg cctggagccc acttcctgct
     1201 gcaggccttg gtcagagaaa tatcaggctc tgaagcctct aacgttattg tcaaagtttc
     1261 tgccacattg gtgtcaggct ctgattccca agtcctcaac gttcaacaga gcaccaatag
     1321 aattggccaa gtcagcattt ccttccccat cccaccaacc gtcacagaac ttcggctctt
     1381 ggtgtctgcg ggctccctct acccaacgat agccaggctc accgtgcaat ccccaccttc
     1441 aagaggcact ggctttcttt ctattgagcc actagaccct cggtcccctc gtgtggggga
     1501 cacctttatc ctaaacttac aagctgtggg catccctgca cctaccttct ctcattacta
     1561 ctacatgatc atctccagag gccagatcat ggctatgagt cgggaggccc ggaggaccgt
     1621 gacctctgtc tccgtgttgg tggaccatca gctggctcct tcattctact tcgtggctta
     1681 cttctatcac caaggacacc cggtggccaa ctctctgctc atcaacatcc agcccaggga
     1741 ctgtgagggc aagctgcaat tgaaggtagt tggtgccaag gagtatcata atggggacat
     1801 gatgaagctc caaattcaaa ctgactccaa agccctggtg gcactgggag ctgtggacac
     1861 cgctctgtat gctgtgggcg gttggtctca caaacccctc gacatgagca aggtctttga
     1921 agtaatcgac agctacaacc ttggctgtgg tcctggaggt ggggatgatg cccctcaggt
     1981 gttccaggat gctggtctgg ccttttctga tggtgatcga ctaactcaaa ccagagagga
     2041 cctgagctgt cccaaggaga agaaaagtcg gcaaaagaga aatgttaact tcctgaaggc
     2101 tcttagtgag aagttgggcc agtattcttc tccagatgcc aagcgctgct gccaagacgg
     2161 gatgacgaag ctgcccatga agcgtacctg tgagcagcgg gctgcccgtg tgcctcagca
     2221 ggcctgccgt gagcccttct tgtcctgttg caagtttgct gaggaccttc gcaggaacca
     2281 gaccaggagc caggcacacc ttgcccgaaa ggtccgggac atggtgaatt tgatagagga
     2341 agatgacatt cttgtgcgca cctccttccc agacaactgg ctctggagag tggaacctgt
     2401 agacagctcc aaactgttga cagtgcggct tcctgattct atgaccacat gggagattca
     2461 tggtgtgagc ctgtccaaaa gcaaaggtct gtgtgtagcc aagccaactc gtgttcgagt
     2521 gttcagaaaa ttccaccttc acctgcgcct gcccatctcc gtccgccgct ttgagcagct
     2581 tgaattacgg cctgttctct acaactatct gaatgatgac aagaacgtga gtgtccatgt
     2641 gaccccagtg gagggcctgt gcatggctgg tggtggaatg atggcccagt gggtgatagt
     2701 gcctgcaggc tctgccctgc ctgtggcctt ctctgtggta cccacagctt ctaccaacgt
     2761 gcccctgaaa ttggtggcta aagggacttt ggattcaagc gattctgtgt ctaagattct
     2821 ccaaattgag aaggaaggag ccatccacag agaagagata gtctacaacc tcgaccccct
     2881 aaataaccta ggtcagatgt tggagatacc tggcagctcg gatcccaaca tagtccctga
     2941 aggagacttc agcacctttg tcaaggttac agcctctgaa cccttggaga ctctgggctc
     3001 tgaaggagct ttgtccccag gaggcgtggc ctccctcctg aggcttcccc ggagctgcgc
     3061 agagcaaacc atgatctatt tggctcctac cctgactgct tccaactacc tggacaggac
     3121 aaaacagtgg agcaaactgt cccctgagac caaggaccat gctgtgcatc tgatccagaa
     3181 aggccacgtt cggatccagc agtttcggaa gaaagatggc tcttttgggg cttggttaca
     3241 ccgggacagc agcacctggc tgactgcctt tgtgctgaag attctgagtt tggcccagga
     3301 acaggtgggc aactccccgg agaagctgca ggagacggct agctggctgc tggcccagca
     3361 gctgggtgat ggctccttcc acgacccatg tccagtcatc cacagagcaa tgcagggggg
     3421 cttggtgggg tccaatgaga cggtggcact gaccgccttt gtggtcattg cccttcacca
     3481 cgggctgaac gtcttccggg aggggcatgc gaagcagctg aagaacagag tggaagcctc
     3541 catcaccaag gcaaactctt tcttggggca gaaggcaagt gctgggctcc tgggtgccca
     3601 tgccgccgcc atcacagcct atgcccttac gctgaccaag gcctcggagg acctgcggaa
     3661 tgttgcccac aacagcctga tggccatggc tgaggaaacg ggggaaaacc tctactgggg
     3721 cttagtcctt ggctctcagg acaaagttat gttgcgcccc gcagaccccc gtagcccaac
     3781 agaacctgtg ccccaggccc cagccttgtg gatcgaaacc acagcctatg ccctgctcca
     3841 cctgcttctg cgggagggaa agggaaaaat ggctgacaag gctgcatcct ggctcaccca
     3901 ccagggaaac ttccacgggg cattccgcag tacccaggac actgtggtca ccctggatgc
     3961 cctgtctgcc tactggatcg cttcacacac cactgaggag aaagcactga acgtgacgct
     4021 cagctccatg ggccgcaatg ggcttaagac ccacgggcta cacttgaaca accaccaagt
     4081 caagggcctg gaggaggagc taaagttctc cctgggcagc acaatcagtg tcaaggtgga
     4141 aggaaacagc aaaggcacct tgaagatcct tcgtacctac aacgtcctgg acatgaagaa
     4201 caccacatgc caggaccttc agatagaagt gaaggtcaca gacgctgtgg aatatgcatg
     4261 gagcgcctac gaagactatg aagacgacta taacatgcca gccacagatg atcccagcgt
     4321 tcccttgcag cctgtcacgc ccctgcagct atttgagggt cgtcggagcc gccgcaggag
     4381 ggaggccccc aaggtggctg aagagcggga gtccagagtt cactacactg tgtgtatctg
     4441 gcgcaatggc aagctggggc tgtctggcat ggccatcgca gacatcaccc tcctgagtgg
     4501 attccacgcc ctgagggctg acctggagaa gctgacctct ctctctgacc gttatgtgag
     4561 tcactttgag actgacgggc cccatgtcct gttgtacttt gactcggtcc ctaccacccg
     4621 ggagtgtgtg ggctttggag cctcacagga ggtggttgtg ggactggtgc agccagccag
     4681 cgctgtcctg tatgactact acagccctga tcacaagtgc tctgtgtttt atgctgcacc
     4741 caccaagagc cagctcctgg ccacactgtg ctctggagat gtatgccagt gtgccgaggg
     4801 gaagtgccct cgactgctaa ggtcactgga gcgaagggtg gaggacaagg acggctaccg
     4861 gatgaggttc gcctgctatt atcaccaagt ggagtatggc ttcacggtta aggttcttcg
     4921 agaagatggc agagctgcct tccgtctctt tgagtccaag atcacccaag tcctgcattt
     4981 cagaacggac accatggcct ccataggtca gacccgcaac ttcctgagcc gggcctcttg
     5041 ccgccttcgt ttggagccta acaaagagta cttgatcatg gggatggacg gggaaaccag
     5101 tgacaacaag ggagaccccc agtacttgct ggactcaaat acctggattg aggagatgcc
     5161 ttcagaacaa atgtgcaaga gcacccgcca tcgggcagcc tgtttccagc tcaaagactt
     5221 cctgatggag ttcagcagcc gggggtgcca ggtgtgaggc cttaggactc tggctctctg
     5281 agctcagctc agggtcaggg cctcgctgga tgaggggctc tgctctacag ggtaaataaa
     5341 agaaaagctt tttgacagcc aaaaaaaaa
//
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