LOCUS NM_012024 6260 bp mRNA linear ROD 18-JUN-2024
DEFINITION Mus musculus protein phosphatase 2, regulatory subunit B', epsilon
(Ppp2r5e), mRNA.
ACCESSION NM_012024
VERSION NM_012024.3
KEYWORDS RefSeq; RefSeq Select.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (bases 1 to 6260)
AUTHORS Dyson,J.J., Abbasi,F., Varadkar,P. and McCright,B.
TITLE Growth arrest of PPP2R5C and PPP2R5D double knockout mice indicates
a genetic interaction and conserved function for these PP2A B
subunits
JOURNAL FASEB Bioadv 4 (4), 273-282 (2021)
PUBMED 35415460
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 6260)
AUTHORS Brandt,N., Franke,K., Johannes,S., Buck,F., Harder,S., Hassel,B.,
Nitsch,R. and Schumacher,S.
TITLE B56beta, a regulatory subunit of protein phosphatase 2A, interacts
with CALEB/NGC and inhibits CALEB/NGC-mediated dendritic branching
JOURNAL FASEB J 22 (7), 2521-2533 (2008)
PUBMED 18385213
REFERENCE 3 (bases 1 to 6260)
AUTHORS Lin,Q., Donahue,S.L., Moore-Jarrett,T., Cao,S., Osipovich,A.B. and
Ruley,H.E.
TITLE Mutagenesis of diploid mammalian genes by gene entrapment
JOURNAL Nucleic Acids Res 34 (20), e139 (2006)
PUBMED 17062627
REFERENCE 4 (bases 1 to 6260)
AUTHORS Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
Ballabio,A. and Cortese,R.
TITLE Tagging genes with cassette-exchange sites
JOURNAL Nucleic Acids Res 33 (4), e44 (2005)
PUBMED 15741177
REMARK Publication Status: Online-Only
REFERENCE 5 (bases 1 to 6260)
AUTHORS Martens,E., Stevens,I., Janssens,V., Vermeesch,J., Gotz,J.,
Goris,J. and Van Hoof,C.
TITLE Genomic organisation, chromosomal localisation tissue distribution
and developmental regulation of the PR61/B' regulatory subunits of
protein phosphatase 2A in mice
JOURNAL J Mol Biol 336 (4), 971-986 (2004)
PUBMED 15095873
REFERENCE 6 (bases 1 to 6260)
AUTHORS Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
TITLE BayGenomics: a resource of insertional mutations in mouse embryonic
stem cells
JOURNAL Nucleic Acids Res 31 (1), 278-281 (2003)
PUBMED 12520002
REFERENCE 7 (bases 1 to 6260)
AUTHORS Witherden,A.S., Hafezparast,M., Nicholson,S.J., Ahmad-Annuar,A.,
Bermingham,N., Arac,D., Rankin,J., Iravani,M., Ball,S., Peters,J.,
Martin,J.E., Huntley,D., Hummerich,H., Sergot,M. and Fisher,E.M.
TITLE An integrated genetic, radiation hybrid, physical and transcription
map of a region of distal mouse chromosome 12, including an
imprinted locus and the 'Legs at odd angles' (Loa) mutation
JOURNAL Gene 283 (1-2), 71-82 (2002)
PUBMED 11867214
REFERENCE 8 (bases 1 to 6260)
AUTHORS Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
TITLE Construction of long-transcript enriched cDNA libraries from
submicrogram amounts of total RNAs by a universal PCR amplification
method
JOURNAL Genome Res 11 (9), 1553-1558 (2001)
PUBMED 11544199
REFERENCE 9 (bases 1 to 6260)
AUTHORS Gotz,J., Probst,A., Mistl,C., Nitsch,R.M. and Ehler,E.
TITLE Distinct role of protein phosphatase 2A subunit Calpha in the
regulation of E-cadherin and beta-catenin during development
JOURNAL Mech Dev 93 (1-2), 83-93 (2000)
PUBMED 10781942
REFERENCE 10 (bases 1 to 6260)
AUTHORS Okamoto,K., Kamibayashi,C., Serrano,M., Prives,C., Mumby,M.C. and
Beach,D.
TITLE p53-dependent association between cyclin G and the B' subunit of
protein phosphatase 2A
JOURNAL Mol Cell Biol 16 (11), 6593-6602 (1996)
PUBMED 8887688
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AK132432.1 and AC124414.3.
On Feb 8, 2019 this sequence version replaced NM_012024.2.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK132432.1, BC085149.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN01164141 [ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression,
longest protein
##RefSeq-Attributes-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-2202 AK132432.1 2-2203
2203-2203 AC124414.3 88555-88555
2204-4587 AK132432.1 2205-4588
4588-6260 AC124414.3 90940-92612
FEATURES Location/Qualifiers
source 1..6260
/organism="Mus musculus"
/mol_type="mRNA"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="12"
/map="12 32.75 cM"
gene 1..6260
/gene="Ppp2r5e"
/gene_synonym="4633401M22Rik; B56beta"
/note="protein phosphatase 2, regulatory subunit B',
epsilon"
/db_xref="GeneID:26932"
/db_xref="MGI:MGI:1349473"
exon 1..598
/gene="Ppp2r5e"
/gene_synonym="4633401M22Rik; B56beta"
/inference="alignment:Splign:2.1.0"
misc_feature 405..407
/gene="Ppp2r5e"
/gene_synonym="4633401M22Rik; B56beta"
/note="upstream in-frame stop codon"
exon 599..762
/gene="Ppp2r5e"
/gene_synonym="4633401M22Rik; B56beta"
/inference="alignment:Splign:2.1.0"
CDS 606..2009
/gene="Ppp2r5e"
/gene_synonym="4633401M22Rik; B56beta"
/note="protein phosphatase 2A subunit beta"
/codon_start=1
/product="serine/threonine-protein phosphatase 2A 56 kDa
regulatory subunit epsilon isoform"
/protein_id="NP_036154.1"
/db_xref="CCDS:CCDS25983.1"
/db_xref="GeneID:26932"
/db_xref="MGI:MGI:1349473"
/translation="MSSAPTTPPSVDKVDGFSRKSVRKARQKRSQSSSQFRSQGKPIE
LTPLPLLKDVPTSEQPELFLKKLQQCCVIFDFMDTLSDLKMKEYKRSTLNELVDYITI
SRGCLTEQTYPEVVRMVSCNIFRTLPPSDSNEFDPEEDEPTLEASWPHLQLVYEFFIR
FLESQEFQPSIAKKYIDQKFVLQLLELFDSEDPRERDYLKTVLHRIYGKFLGLRAFIR
KQINNIFLRFVYETEHFNGVAELLEILGSIINGFALPLKAEHKQFLVKVLIPLHTVRS
LSLFHAQLAYCIVQFLEKDPSLTEPVIRGLMKFWPKTCSQKEVMFLGELEEILDVIEP
SQFVKIQEPLFKQIAKCVSSPHFQVAERALYYWNNEYIMSLIEENSNVILPIMFSSLY
RISKEHWNPAIVALVYNVLKAFMEMNSTMFDELTATYKSDRQREKKKEKEREELWKKL
EDLELKRGLRRDGIIPT"
misc_feature 606..722
/gene="Ppp2r5e"
/gene_synonym="4633401M22Rik; B56beta"
/note="propagated from UniProtKB/Swiss-Prot (Q61151.3);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 609..611
/gene="Ppp2r5e"
/gene_synonym="4633401M22Rik; B56beta"
/note="N-acetylserine.
/evidence=ECO:0000250|UniProtKB:Q16537; propagated from
UniProtKB/Swiss-Prot (Q61151.3); acetylation site"
misc_feature 624..626
/gene="Ppp2r5e"
/gene_synonym="4633401M22Rik; B56beta"
/note="Phosphothreonine.
/evidence=ECO:0000250|UniProtKB:Q16537; propagated from
UniProtKB/Swiss-Prot (Q61151.3); phosphorylation site"
misc_feature 693..695
/gene="Ppp2r5e"
/gene_synonym="4633401M22Rik; B56beta"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q16537; propagated from
UniProtKB/Swiss-Prot (Q61151.3); phosphorylation site"
misc_feature 699..701
/gene="Ppp2r5e"
/gene_synonym="4633401M22Rik; B56beta"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q16537; propagated from
UniProtKB/Swiss-Prot (Q61151.3); phosphorylation site"
misc_feature 705..707
/gene="Ppp2r5e"
/gene_synonym="4633401M22Rik; B56beta"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q16537; propagated from
UniProtKB/Swiss-Prot (Q61151.3); phosphorylation site"
exon 763..959
/gene="Ppp2r5e"
/gene_synonym="4633401M22Rik; B56beta"
/inference="alignment:Splign:2.1.0"
exon 960..1061
/gene="Ppp2r5e"
/gene_synonym="4633401M22Rik; B56beta"
/inference="alignment:Splign:2.1.0"
exon 1062..1154
/gene="Ppp2r5e"
/gene_synonym="4633401M22Rik; B56beta"
/inference="alignment:Splign:2.1.0"
exon 1155..1285
/gene="Ppp2r5e"
/gene_synonym="4633401M22Rik; B56beta"
/inference="alignment:Splign:2.1.0"
exon 1286..1345
/gene="Ppp2r5e"
/gene_synonym="4633401M22Rik; B56beta"
/inference="alignment:Splign:2.1.0"
exon 1346..1454
/gene="Ppp2r5e"
/gene_synonym="4633401M22Rik; B56beta"
/inference="alignment:Splign:2.1.0"
exon 1455..1508
/gene="Ppp2r5e"
/gene_synonym="4633401M22Rik; B56beta"
/inference="alignment:Splign:2.1.0"
exon 1509..1559
/gene="Ppp2r5e"
/gene_synonym="4633401M22Rik; B56beta"
/inference="alignment:Splign:2.1.0"
exon 1560..1679
/gene="Ppp2r5e"
/gene_synonym="4633401M22Rik; B56beta"
/inference="alignment:Splign:2.1.0"
exon 1680..1807
/gene="Ppp2r5e"
/gene_synonym="4633401M22Rik; B56beta"
/inference="alignment:Splign:2.1.0"
exon 1808..1909
/gene="Ppp2r5e"
/gene_synonym="4633401M22Rik; B56beta"
/inference="alignment:Splign:2.1.0"
exon 1910..6260
/gene="Ppp2r5e"
/gene_synonym="4633401M22Rik; B56beta"
/inference="alignment:Splign:2.1.0"
regulatory 3206..3211
/regulatory_class="polyA_signal_sequence"
/gene="Ppp2r5e"
/gene_synonym="4633401M22Rik; B56beta"
/note="hexamer: AATAAA"
polyA_site 3236
/gene="Ppp2r5e"
/gene_synonym="4633401M22Rik; B56beta"
/note="major polyA site"
regulatory 5690..5695
/regulatory_class="polyA_signal_sequence"
/gene="Ppp2r5e"
/gene_synonym="4633401M22Rik; B56beta"
/note="hexamer: TATAAA"
polyA_site 5706
/gene="Ppp2r5e"
/gene_synonym="4633401M22Rik; B56beta"
regulatory 6239..6244
/regulatory_class="polyA_signal_sequence"
/gene="Ppp2r5e"
/gene_synonym="4633401M22Rik; B56beta"
/note="hexamer: AATAAA"
polyA_site 6260
/gene="Ppp2r5e"
/gene_synonym="4633401M22Rik; B56beta"
ORIGIN
1 ggttgcgcct gtgccatgga ctcagccgcc cggtgatatt gacaatagga gagagaaagg
61 ggcattgacg gggaccctgc gcgggtagcg aacggcggct ctggcagcgg cggctcaggc
121 ggctccaact cttcctcccg actcccgcgc ttgctgccgc tgcaaatcca ggcttcctcc
181 ctcctccccc tccccgcgtc gccgccgccg ccgccgccgc caccaccgcc gccgggtccg
241 gtgcaacgag cagaggcgcc gcccgccggg aatgtgaacg aagagccacc ggccgcgccg
301 caaccgggtc ggtgccgatt tgatgggacg ggcccgcggg ggaggctcgt gaggccgccg
361 ctgccactgc cggagcgctg aggttagggg ccagccgaga ggcctagaaa cactgccgct
421 accgcggaac cggagggacg tcgccccgga cggccgtagt agcccggggc tctccgccgc
481 tgcctggacc tccccccgtg cgtcccgggc cgtcgcccgc ccccgccgcg gcccctagct
541 cgcagcccac tccgcgcagc cacagatcat cttccgattc tttcccagga gcttcaagta
601 gggatatgtc ctcagcacca actactcctc catcagtgga taaagtagac ggattttctc
661 ggaagtccgt cagaaaagcc agacagaaga ggtcgcaaag ctcctcccag ttcaggtctc
721 aaggcaagcc cattgagctc acgcctctgc cactgctgaa agacgttcca acctcagagc
781 agcctgaact gttcctaaag aaacttcagc agtgctgtgt catttttgac ttcatggaca
841 cgctatctga tcttaaaatg aaagaataca agcgctccac tcttaatgaa ctggtggact
901 acattacaat aagcagaggc tgtctgacag agcagactta ccctgaagta gttagaatgg
961 tatcttgcaa tatattcaga actctccctc ctagtgacag caatgaattc gacccagaag
1021 aagatgaacc taccctcgag gcatcatggc cccacttaca gcttgtatat gaatttttca
1081 taagattttt ggaaagccaa gaattccaac ccagcattgc caaaaaatac atagatcaga
1141 aatttgtatt acagcttttg gagctatttg acagtgaaga ccctcgagaa cgggactatt
1201 taaaaacagt cttgcacagg atttatggca agtttctcgg gcttagagca tttatccgaa
1261 aacaaattaa caatattttt ctaaggtttg tttatgaaac agaacacttc aatggtgtag
1321 ctgaactgct ggaaatatta ggaagtatta tcaatggctt tgctttacca ctcaaggcag
1381 aacacaaaca gttcctggtg aaagtgttga tccctctaca cactgtcagg agcttgtcac
1441 tctttcatgc acagctggcg tattgtatag tacagtttct ggagaaagac ccttccctta
1501 cagaaccagt tattaggggg ctaatgaaat tttggcctaa aacatgcagt caaaaagagg
1561 tcatgttcct cggggagctg gaagaaatct tggatgtgat tgaaccgtca caatttgtta
1621 aaatccaaga acctttgttt aaacaaattg ccaagtgtgt ttctagcccc cattttcagg
1681 tggcagaaag ggcactctat tattggaata atgaatacat catgagtttg atagaagaaa
1741 actctaacgt catccttccc atcatgttct ccagccttta taggatttca aaagagcatt
1801 ggaatccggc cattgtggca ttggtgtaca acgtgttgaa ggcatttatg gaaatgaaca
1861 gcactatgtt tgatgagctg acagccacat acaagtcaga tcgtcagcgt gagaaaaaga
1921 aagaaaagga gcgagaagaa ctgtggaaaa aattggagga tctggagtta aagagaggtc
1981 ttagacgcga tgggataatt ccaacttaac aacagcctga cagcgacaca ctaacccgtg
2041 ggtcacacgc ttatgtagta gaaggatgga gcaacagttt tctgtattgt gcaactttac
2101 agtagatttc acatttgtct cattattaca gcagcactgt atatacctgt ctctaagtaa
2161 aggaaaacat aaggacttca aagtgtggac agtagatgga ctctcagaac tttgcaaaca
2221 taatcattgt tctaaccctc tttaaaaaca aacaaacaaa caaaaggtct acagagatct
2281 gtcggggaaa ttgctatgtt aaaattccat tatcaggagt tccttattta tcactagcag
2341 agagtatgat acaattttca aatgtgaaca atcttaaatt tagcttgtct ttctgctaag
2401 ctgttaaatg tatttatagt aaaggaagaa aagattgtca tttctttata agtttgtata
2461 gcgccctcct ctggacatga ctgtaacgtg atatcctttc cttttgcaca tcttcatgag
2521 tcaagtgtcc acatggaccg gggctgtgag tcagaggtct ctgaggaaag gttgtctgct
2581 ggatgaacat cttcccagct gccaggtcct ggtactcctt tagttttcag attaggagta
2641 aaaagaagag gtgataagca tggtagcgaa gggaatgttg gacttcatat cagatatggt
2701 gagtccaaat cagtgtcttg aatcctttga aaacaggcag tgggacgcgc aggcttcagc
2761 acctgcagca ttagctgcag acataagtgt gcatccagac cagagacaac ttagaaatgt
2821 cagagaacat cctttcggat cctgtggagt aagagagaga gcactaagcg atagaaccgt
2881 gaagccgagc accaggaccg cgcatccact tgggaaccga gttgagcaaa cagcatgaac
2941 tgtttgcagt tgatgcctta cttcctaatg tgtacttaca aagtatttca gcagaagagg
3001 atgcagggtg cagcctctgg gaggaacatc ctccttctct agctcaccac agcgccagcc
3061 ctgtttttag ccagaaagga ttcaggatca acattatgcg ttctgaattg gatgcatatt
3121 cctaactact gtatttgtta ccaaaagtgg ttctacaaat gctactgaaa aaaatctgga
3181 aattcctaat gtcctgagta ttaataataa agtttaaaaa atgcttttat atcaaaggtg
3241 catcgtgacc aaattgttta agttaaaaac aaaacaaaac caaaccaacc cgagggctgt
3301 gctctagctg ggcttactgt ctctgtactg ggtccccctg ggtaggtaag ttgctgatgt
3361 acaggtgtgc agtatgtatt cacccgatgt gttgcatcgc tgtgtattgg caagtgtgtg
3421 ttgtggggtt tgtttccagg aagctttttc ttgttagaga caggacagtg gtgagcccat
3481 aaccccgagc catcacatcc agcagtgttc atggcataga gccgactctg tgttcatatg
3541 ttgagttgtg attatagcta acatgaacac acatgagcta ttgttgctct tagtagaaat
3601 acagtataaa tatgggcttg tatattttct tccttccttt taaatgtaaa gtagaatata
3661 tagagctttg ttgtttccaa ggaaaaggag gggaaaagcc actgacctat ttcacttatg
3721 aagtatttcc agattgtcag tcacaatgtg tacataaatg taagctaatt atggatattt
3781 tcatttaggt acctttgttc tcttgttttt taaaggtatg cgtaccacca agtccaagat
3841 ggttcagtgg aataaatagg actcttaaag agcgttaagg agggttccat ctgaggacct
3901 ggaaagtgtg agcagagctg catgttcaca tattgatgct aagaagcaaa ccatagcaca
3961 tctcccttag ctgtcttagc cgtttccatc ttcattacac atatctttga tagtgtagac
4021 cttgcttgct gtggtccctc tggggatgac atgtgctcat ttgacatgag gaaggtcagg
4081 acctctttct gcaccgtgtc ctgtcctcag agctaagggt cagtgttgtc tgttggtcat
4141 tcccaactga gaggaatgaa gctaagcttt agactattta aagatgtgat gagagctgaa
4201 tgtcagaact cacagggcaa tctctgagaa gaaacactca tttccctttt aaccaaaagt
4261 gacaatgtga cctctgtcat gttgtgtgtg gtgaggagaa gctagcccag gtgacttgat
4321 tgttgcacta tgtgacatat ttaaggacat acttgctgca tttgcagcag cccccctgtc
4381 tgacctccct gggcaatcct gctgtcactc aatgtgagtt aactgtgaca aactcagctc
4441 tgtgttatat tttgtttgct tcatagtttc cagaactata tataaatata ttttttcaat
4501 agcaaatatt gtagttagtg agtggtgacc acttcaacct tatccctacc atattggttt
4561 cagggatggg actaagaatg tccttggaat aaaaaaatta aaatataacc ctgtgattta
4621 gaatgatgcc gaggttgcag gttgcagcct gcagcagctg tgtgagcgaa gtgaccgtct
4681 cctctggatc aagcgtccac tcctcattgt gcccaggccc cagtgctcct tcatcactgt
4741 ttagttattg tccgctgtgg ttttgattat attttgctct tcctgacatt gactgttttt
4801 ttttaataaa agaaaataaa aagtaaatga ataacccctg aatgtgactg gatgcaggga
4861 taagcccctc cctcctcctt gggctctttc cctaagtggc aggatcgcgc tggctctgta
4921 tctcccgtgc gtgcggcagt ccaaggtgca gacctaggga gcacttgtca tcacacctcc
4981 tatactgaac acataaccct aggctcaatc actttatgga aagggaaata aagtagactt
5041 tattttaggg atggagccgg ggagtggtgt gtggatggga ggctggtatc aacatcacta
5101 agtattccga aggtcttctt gctttgtttt tccattttaa ttgatacact gacctggccc
5161 aggaaaggaa gagccgctct cctttgatgt tattagccaa cattcccaca aagtgacggt
5221 cacctgtctc agaaaggcaa caggagatat gatccgtgac attttatttg cacatgaata
5281 ttttattttt gtattctggc tcagctgctt ctcttcgtgg agttagggag gagccataaa
5341 ggacttttgt aataagtaat attggcaacg cattttatac tcctctatgt ttacttttga
5401 gaacctgaaa gaaggggtgt gcgtccgaga ggagggtgag cggagcttga gccagcggaa
5461 tgttccattt gtctgccgct tgtgcacgag agcggccagc tgtagcgtct cctggaaacc
5521 aacgccccgt gctatgacgt ctgtgagcct aggtttcctt tcctcccctc ccttccccca
5581 tcctctcctc cattttcttt ctttctcaac ccatcccttt ttttttttaa atcacttact
5641 gtaaataagt tgtaatctaa acctcatgta tcaatgggga aatttcaaat ataaatatta
5701 ccaacacgtt ttcttgttgt ctggcttttg attggagtgt aatgagaatg gcatgcccat
5761 ctcctcaggc ctgagggttt catctcagct ccagcctctc ctctccctca tttcattgtt
5821 gtggcaggag agggcagcac acgttcattt ttccccccgc taggaagcca cagtgttagc
5881 tgtggatgag tgtttttctt aagttttcaa aacatccgtt ggtgcataga tgtgaaaatg
5941 aaacaatatg aaaagttgca tatgaaaaat gacagactgg tttagccagg cagggaagcc
6001 ttctgatcca cttcaaagta aaaaattacc caagacactt ccagcccctg ttgaaccaga
6061 cttcttccgt ttcaaacagc aggatgcagg tggcagctta cacacttgga aataagcgtt
6121 catctttgaa aataatatac tctctcaaaa gtggttacag actaagcaga ggtgctcccc
6181 aaagcaatgt aatcctcccg ttgacagcta tgtgagattc tgtactgtgg gtgtccctaa
6241 taaataagca ctgaagggtg
//