LOCUS NM_014704 6431 bp mRNA linear PRI 08-OCT-2024
DEFINITION Homo sapiens centrosomal protein 104 (CEP104), mRNA.
ACCESSION NM_014704 XM_375682
VERSION NM_014704.4
KEYWORDS RefSeq; MANE Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6431)
AUTHORS Khoshbakht,S., Beheshtian,M., Fattahi,Z., Bazazzadegan,N.,
Parsimehr,E., Fadaee,M., Vazehan,R., Faraji Zonooz,M.,
Abolhassani,A., Makvand,M., Kariminejad,A., Celik,A., Kahrizi,K.
and Najmabadi,H.
TITLE CEP104 and CEP290; Genes with Ciliary Functions Cause Intellectual
Disability in Multiple Families
JOURNAL Arch Iran Med 24 (5), 364-373 (2021)
PUBMED 34196201
REMARK GeneRIF: CEP104 and CEP290; Genes with Ciliary Functions Cause
Intellectual Disability in Multiple Families.
Publication Status: Online-Only
REFERENCE 2 (bases 1 to 6431)
AUTHORS Yamazoe,T., Nagai,T., Umeda,S., Sugaya,Y. and Mizuno,K.
TITLE Roles of TOG and jelly-roll domains of centrosomal protein CEP104
in its functions in cilium elongation and Hedgehog signaling
JOURNAL J Biol Chem 295 (43), 14723-14736 (2020)
PUBMED 32820051
REMARK GeneRIF: Roles of TOG and jelly-roll domains of centrosomal protein
CEP104 in its functions in cilium elongation and Hedgehog
signaling.
REFERENCE 3 (bases 1 to 6431)
AUTHORS Latour,B.L., Van De Weghe,J.C., Rusterholz,T.D., Letteboer,S.J.,
Gomez,A., Shaheen,R., Gesemann,M., Karamzade,A., Asadollahi,M.,
Barroso-Gil,M., Chitre,M., Grout,M.E., van Reeuwijk,J., van
Beersum,S.E., Miller,C.V., Dempsey,J.C., Morsy,H., Bamshad,M.J.,
Nickerson,D.A., Neuhauss,S.C., Boldt,K., Ueffing,M.,
Keramatipour,M., Sayer,J.A., Alkuraya,F.S., Bachmann-Gagescu,R.,
Roepman,R. and Doherty,D.
CONSRTM University of Washington Center for Mendelian Genomics; Genomics
England Research Consortium
TITLE Dysfunction of the ciliary ARMC9/TOGARAM1 protein module causes
Joubert syndrome
JOURNAL J Clin Invest 130 (8), 4423-4439 (2020)
PUBMED 32453716
REFERENCE 4 (bases 1 to 6431)
AUTHORS Luo,M., Cao,L., Cao,Z., Ma,S., Shen,Y., Yang,D., Lu,C., Lin,Z.,
Liu,Z., Yu,Y., Cai,R., Chen,C., Gao,H., Wang,X., Cao,M. and Ma,X.
TITLE Whole exome sequencing reveals novel CEP104 mutations in a Chinese
patient with Joubert syndrome
JOURNAL Mol Genet Genomic Med 7 (12), e1004 (2019)
PUBMED 31625690
REMARK GeneRIF: Study identified two novel heterozygous mutations of
CEP104 in a patient with Joubert syndrome, which were c.2364+1G>A
and c.414delC (p.Asn138Lysfs*11) and consistent with the autosomal
recessive inheritance mode.
REFERENCE 5 (bases 1 to 6431)
AUTHORS Crisci,A., Raleff,F., Bagdiul,I., Raabe,M., Urlaub,H., Rain,J.C.
and Kramer,A.
TITLE Mammalian splicing factor SF1 interacts with SURP domains of U2
snRNP-associated proteins
JOURNAL Nucleic Acids Res 43 (21), 10456-10473 (2015)
PUBMED 26420826
REFERENCE 6 (bases 1 to 6431)
AUTHORS Srour,M., Hamdan,F.F., McKnight,D., Davis,E., Mandel,H.,
Schwartzentruber,J., Martin,B., Patry,L., Nassif,C.,
Dionne-Laporte,A., Ospina,L.H., Lemyre,E., Massicotte,C.,
Laframboise,R., Maranda,B., Labuda,D., Decarie,J.C., Rypens,F.,
Goldsher,D., Fallet-Bianco,C., Soucy,J.F., Laberge,A.M., Maftei,C.,
Boycott,K., Brais,B., Boucher,R.M., Rouleau,G.A., Katsanis,N.,
Majewski,J., Elpeleg,O., Kukolich,M.K., Shalev,S. and Michaud,J.L.
CONSRTM Care4Rare Canada Consortium
TITLE Joubert Syndrome in French Canadians and Identification of
Mutations in CEP104
JOURNAL Am J Hum Genet 97 (5), 744-753 (2015)
PUBMED 26477546
REMARK GeneRIF: Mutations in CEP104 is associated with Joubert Syndrome.
REFERENCE 7 (bases 1 to 6431)
AUTHORS Satish Tammana,T.V., Tammana,D., Diener,D.R. and Rosenbaum,J.
TITLE Centrosomal protein CEP104 (Chlamydomonas FAP256) moves to the
ciliary tip during ciliary assembly
JOURNAL J Cell Sci 126 (Pt 21), 5018-5029 (2013)
PUBMED 23970417
REFERENCE 8 (bases 1 to 6431)
AUTHORS Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
Uhlen,M., Hyman,A.A. and Andersen,J.S.
TITLE Novel asymmetrically localizing components of human centrosomes
identified by complementary proteomics methods
JOURNAL EMBO J 30 (8), 1520-1535 (2011)
PUBMED 21399614
REFERENCE 9 (bases 1 to 6431)
AUTHORS Kumar,K.N., Babcock,K.K., Johnson,P.S., Chen,X., Ahmad,M. and
Michaelis,E.K.
TITLE Cloning of the cDNA for a brain glycine-, glutamate- and
thienylcyclohexylpiperidine-binding protein
JOURNAL Biochem Biophys Res Commun 216 (1), 390-398 (1995)
PUBMED 7488117
REFERENCE 10 (bases 1 to 6431)
AUTHORS Parisi,M. and Glass,I.
TITLE Joubert Syndrome
JOURNAL (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
Amemiya A (Eds.);
GENEREVIEWS(R);
(1993)
PUBMED 20301500
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AL691523.6 and AL365330.16.
This sequence is a reference standard in the RefSeqGene project.
On Nov 23, 2018 this sequence version replaced NM_014704.3.
Summary: This gene encodes a centrosomal protein required for
ciliogenesis and for ciliary tip structural integrity. The
mammalian protein contains three amino-terminal hydrophobic
domains, two glycosylation sites, four cysteine-rich motifs, and
two regions with homology to the glutamate receptor ionotropic,
NMDA 1 protein. During ciliogenesis, the encoded protein
translocates from the distal tips of the centrioles to the tip of
the elongating cilium. Knockdown of the protein in human retinal
pigment cells results in severe defects in ciliogenesis with
structural deformities at the ciliary tips. Allelic variants of
this gene are associated with the autosomal-recessive disorder
Joubert syndrome, which is characterized by a distinctive
mid-hindbrain and cerebellar malformation, oculomotor apraxia,
irregular breathing, developmental delay, and ataxia. [provided by
RefSeq, Feb 2016].
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR1660803.131782.1,
SRR1803616.70953.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMEA1965299,
SAMEA1966682 [ECO:0006172]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000378230.8/ ENSP00000367476.3
RefSeq Select criteria :: based on conservation, expression
##RefSeq-Attributes-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-323 AL691523.6 27520-27842 c
324-450 AL691523.6 22926-23052 c
451-624 AL691523.6 19239-19412 c
625-763 AL691523.6 18106-18244 c
764-826 AL691523.6 15920-15982 c
827-903 AL691523.6 15538-15614 c
904-1072 AL691523.6 10239-10407 c
1073-1228 AL691523.6 9595-9750 c
1229-1456 AL691523.6 7923-8150 c
1457-1654 AL691523.6 7126-7323 c
1655-1822 AL691523.6 5556-5723 c
1823-1996 AL691523.6 4493-4666 c
1997-2173 AL691523.6 1677-1853 c
2174-2380 AL691523.6 422-628 c
2381-2384 AL691523.6 1-4 c
2385-2488 AL365330.16 60136-60239 c
2489-2525 AL365330.16 57578-57614 c
2526-2592 AL365330.16 57240-57306 c
2593-2701 AL365330.16 56628-56736 c
2702-2840 AL365330.16 54294-54432 c
2841-2908 AL365330.16 54044-54111 c
2909-2999 AL365330.16 47150-47240 c
3000-6431 AL365330.16 42956-46387 c
FEATURES Location/Qualifiers
source 1..6431
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="1"
/map="1p36.32"
gene 1..6431
/gene="CEP104"
/gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
ROC22"
/note="centrosomal protein 104"
/db_xref="GeneID:9731"
/db_xref="HGNC:HGNC:24866"
/db_xref="MIM:616690"
exon 1..323
/gene="CEP104"
/gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
ROC22"
/inference="alignment:Splign:2.1.0"
misc_feature 317..319
/gene="CEP104"
/gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
ROC22"
/note="upstream in-frame stop codon"
exon 324..450
/gene="CEP104"
/gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
ROC22"
/inference="alignment:Splign:2.1.0"
CDS 338..3115
/gene="CEP104"
/gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
ROC22"
/note="centrosomal protein 104kDa"
/codon_start=1
/product="centrosomal protein of 104 kDa"
/protein_id="NP_055519.1"
/db_xref="CCDS:CCDS30571.1"
/db_xref="GeneID:9731"
/db_xref="HGNC:HGNC:24866"
/db_xref="MIM:616690"
/translation="MPHKIGFVVVSSSGHEDGFSARELMIHAPTVSGWRSPRFCQFPQ
EIVLQMVERCRIRKLQLLAHQYMISSKIEFYISESLPEYFAPYQAERFRRLGYVSLCD
NEKTGCKARELKSVYVDAVGQFLKLIFHQNHVNKYNIYNQVALVAINIIGDPADFSDE
SNTASREKLIDHYLGHNSEDPALEGTYARKSDYISPLDDLAFDMYQDPEVAQIIRKLD
ERKREAVQKERYDYAKKLKQAIADLQKVGERLGRYEVEKRCAVEKEDYDLAKEKKQQM
EQYRAEVYEQLELHSLLDAELMRRPFDLPLQPLARSGSPCHQKPMPSLPQLEERGTEN
QFAEPFLQEKPSSYSLTISPQHSAVDPLLPATDPHPKINAESLPYDERPLPAIRKHYG
EAVVEPEMSNADISDARRGGMLGEPEPLTEKALREASSAIDVLGETLVAEAYCKTWSY
REDALLALSKKLMEMPVGTPKEDLKNTLRASVFLVRRAIKDIVTSVFQASLKLLKMII
TQYIPKHKLSKLETAHCVERTIPVLLTRTGDSSARLRVTAANFIQEMALFKEVKSLQI
IPSYLVQPLKANSSVHLAMSQMGLLARLLKDLGTGSSGFTIDNVMKFSVSALEHRVYE
VRETAVRIILDMYRQHQASILEYLPPDDSNTRRNILYKTIFEGFAKIDGRATDAEMRA
RRKAATEEAEKQKKEEIKALQGQLAALKEIQAEVQEKESDAVKPKNQDIQGGKAAPAE
ALGIPDEHYLDNLCIFCGERSESFTEEGLDLHYWKHCLMLTRCDHCKQVVEISSLTEH
LLTECDKKDGFGKCYRCSEAVFKEELPRHIKHKDCNPAKPEKLANRCPLCHENFSPGE
EAWKAHLMGPAGCTMNLRKTHILQKAPALQPGKSSAVAASGPLGSKAGSKIPTPKGGL
SKSSSRTYAKR"
misc_feature 1922..2038
/gene="CEP104"
/gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
ROC22"
/note="propagated from UniProtKB/Swiss-Prot (O60308.1);
Region: HEAT 1"
misc_feature 2147..2257
/gene="CEP104"
/gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
ROC22"
/note="propagated from UniProtKB/Swiss-Prot (O60308.1);
Region: HEAT 2"
misc_feature 2984..3112
/gene="CEP104"
/gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
ROC22"
/note="propagated from UniProtKB/Swiss-Prot (O60308.1);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
exon 451..624
/gene="CEP104"
/gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
ROC22"
/inference="alignment:Splign:2.1.0"
exon 625..763
/gene="CEP104"
/gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
ROC22"
/inference="alignment:Splign:2.1.0"
exon 764..826
/gene="CEP104"
/gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
ROC22"
/inference="alignment:Splign:2.1.0"
exon 827..903
/gene="CEP104"
/gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
ROC22"
/inference="alignment:Splign:2.1.0"
exon 904..1072
/gene="CEP104"
/gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
ROC22"
/inference="alignment:Splign:2.1.0"
exon 1073..1228
/gene="CEP104"
/gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
ROC22"
/inference="alignment:Splign:2.1.0"
exon 1229..1456
/gene="CEP104"
/gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
ROC22"
/inference="alignment:Splign:2.1.0"
exon 1457..1654
/gene="CEP104"
/gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
ROC22"
/inference="alignment:Splign:2.1.0"
exon 1655..1822
/gene="CEP104"
/gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
ROC22"
/inference="alignment:Splign:2.1.0"
exon 1823..1996
/gene="CEP104"
/gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
ROC22"
/inference="alignment:Splign:2.1.0"
exon 1997..2173
/gene="CEP104"
/gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
ROC22"
/inference="alignment:Splign:2.1.0"
exon 2174..2380
/gene="CEP104"
/gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
ROC22"
/inference="alignment:Splign:2.1.0"
exon 2381..2488
/gene="CEP104"
/gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
ROC22"
/inference="alignment:Splign:2.1.0"
exon 2489..2525
/gene="CEP104"
/gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
ROC22"
/inference="alignment:Splign:2.1.0"
exon 2526..2592
/gene="CEP104"
/gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
ROC22"
/inference="alignment:Splign:2.1.0"
exon 2593..2701
/gene="CEP104"
/gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
ROC22"
/inference="alignment:Splign:2.1.0"
exon 2702..2840
/gene="CEP104"
/gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
ROC22"
/inference="alignment:Splign:2.1.0"
exon 2841..2908
/gene="CEP104"
/gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
ROC22"
/inference="alignment:Splign:2.1.0"
exon 2909..2999
/gene="CEP104"
/gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
ROC22"
/inference="alignment:Splign:2.1.0"
exon 3000..6431
/gene="CEP104"
/gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
ROC22"
/inference="alignment:Splign:2.1.0"
regulatory 3713..3718
/regulatory_class="polyA_signal_sequence"
/gene="CEP104"
/gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
ROC22"
/note="hexamer: AATAAA"
polyA_site 3732
/gene="CEP104"
/gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
ROC22"
/note="major polyA site"
regulatory 6414..6419
/regulatory_class="polyA_signal_sequence"
/gene="CEP104"
/gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
ROC22"
/note="hexamer: AATAAA"
polyA_site 6431
/gene="CEP104"
/gene_synonym="CFAP256; GlyBP; JBTS25; KIAA0562; MRT77;
ROC22"
/note="major polyA site"
ORIGIN
1 agggctgggc ttggttgtca tgagagtgga ggctgcggcc ggggctatgg gcagaggtgg
61 ccgggtctgc ttcttccctg tcactgccgc agcagcttgg ggtgcaaggc ggcctggggc
121 ggcggaaggg gcgccccccg agttccgtct gaggaagcgg cggctgccga ggaagtccac
181 gagagccggg tcccgcacgc ccctggggtc cgggtgctga ggcgccgcct ggccgcctcc
241 ccgggccgcg gcaccgctcc gacccagccg ccctctccac cggggccgcg gcagcgccag
301 tcggggccct tccctctaag cagcccaaac gtgcagaatg ccccacaaga ttggatttgt
361 agtcgtcagc tcatctggac acgaagacgg cttcagtgcc cgggagctca tgatccacgc
421 gccaactgtc agtgggtggc ggtcacctag attttgccag tttccacaag aaattgtcct
481 tcaaatggtg gagagatgtc gaataaggaa actgcagtta cttgctcacc agtatatgat
541 ttcaagtaaa attgagttct acattagtga aagcttgcct gaatattttg caccctatca
601 agcagagcgg tttcgaagac ttggctacgt gtctctctgt gataatgaaa agacaggttg
661 caaagcccgg gaactaaaat cagtttatgt ggatgcagta ggacaatttc ttaaactgat
721 ttttcaccaa aaccatgtca acaaatacaa catatataat caggttgctt tggttgccat
781 aaatatcatt ggagaccctg cagatttcag tgatgaaagc aatactgcct ctcgagagaa
841 gttgattgac cactaccttg ggcacaacag cgaggaccct gctctagaag gaacgtacgc
901 caggaaatct gactatatct ctccgctaga tgacttagct tttgatatgt accaagatcc
961 agaagttgca cagatcatac gaaaattaga tgaaagaaaa cgggaagctg tccaaaagga
1021 acgctatgat tatgccaaga aactaaaaca agccattgct gatttgcaaa aggttggtga
1081 acgccttggg aggtatgagg tagagaaacg ctgtgccgtg gagaaggaag actacgatct
1141 cgccaaggag aagaagcagc agatggagca gtatcgtgcc gaggtgtacg agcagctgga
1201 gctgcacagc ctcctggatg ccgagctgat gcgaagacct tttgatttgc ccctccagcc
1261 cctcgctcgt tctggcagtc cttgccacca aaagccaatg ccctcactac cacaactgga
1321 agaaagagga acagaaaacc agtttgcaga acctttcctt caggaaaagc cttcatcata
1381 ttctctaact atttctcctc agcattctgc agtagacccg ttactccctg ccacagatcc
1441 tcatccaaag atcaatgcag agtccctgcc ctacgatgag cggcctcttc cagctattcg
1501 taagcattat ggggaggcag tggtggagcc ggaaatgagt aatgcagaca tcagcgatgc
1561 tcggagggga ggcatgttag gggagccaga gcccttaacc gagaaggcct tgagagaagc
1621 cagctctgcc atcgatgtgt tgggagaaac cttggttgct gaggcctatt gtaagacgtg
1681 gtcctaccga gaggatgcac tgcttgcctt gtctaagaag ttaatggaaa tgcctgttgg
1741 aaccccaaaa gaagatttaa agaacacact gagagcatcc gtctttctcg ttagaagagc
1801 cataaaggac attgtgacct ccgtttttca ggcttctttg aaattgttga aaatgatcat
1861 tacacaatat attcctaaac ataaactgag taaacttgaa acagctcact gtgtggagag
1921 gaccattccc gttttgctca ccagaactgg agattcttct gcccgcctcc gcgtcacagc
1981 tgcaaatttt attcaggaaa tggccttgtt taaagaagtt aagtctctcc aaattattcc
2041 atcctacctg gtgcagccat tgaaagcaaa ctcttcagtt cacctggcaa tgagtcagat
2101 gggcctcctg gcccggctgc tgaaagacct gggcactggc agctcgggct tcaccattga
2161 caacgtgatg aagttttcag tgagtgccct ggagcataga gtgtatgagg tccgcgagac
2221 ggcggttcga attattttgg acatgtacag acagcaccag gcttccatcc tggagtacct
2281 tcctccagac gacagcaaca cacgcaggaa cattctctac aaaacaattt ttgagggatt
2341 tgctaaaata gatggcagag ctacagatgc tgagatgagg gcacggagaa aagcggctac
2401 agaagaagca gaaaaacaaa agaaagaaga aataaaagct ttacaagggc agctggcagc
2461 actgaaagaa attcaggctg aagttcagga aaaagaaagt gatgctgtga agccaaagaa
2521 tcaggacatt caaggaggga aagcagcccc tgctgaagct ctgggaatcc cggatgagca
2581 ctatctagat aatttgtgta ttttttgtgg ggaaaggagt gaatccttca cagaggaagg
2641 tctggatctc cactactgga agcactgtct catgctgaca agatgtgacc actgcaaaca
2701 ggtggtcgag atatccagtc tgacggagca cttgctgacg gaatgtgaca aaaaagacgg
2761 gtttggaaag tgttaccgtt gcagtgaggc tgttttcaag gaagagctgc ccagacacat
2821 aaaacacaag gattgcaacc ctgccaaacc ggagaagctg gcaaaccggt gtcccctgtg
2881 tcatgagaac ttcagccctg gagaagaggc atggaaagct cacctgatgg gcccagccgg
2941 ctgcacgatg aacctgcgca agacacacat tctgcagaag gccccggcac tgcagccagg
3001 gaaaagctca gctgtggccg catcaggccc cttggggtca aaggccggaa gcaagatccc
3061 caccccgaag ggcggactga gcaagagctc cagcaggacg tacgccaagc gctgacgcgg
3121 cgctcgggct ccttggtctc tgtgagggat ggagcgggtc tcctgattct acaccatctc
3181 tccagaactc tctggccttg gtggccccat gctctggctg ctgtccccag ctccccgccg
3241 tgcacgcctc ttacgcgtct gtgccgtcag ctctcgtgca aacgatatgg atgcagctaa
3301 ccaaagatcc tgcgtgcagt gccaggacct ggccgcactg tacattaagc cttcagggct
3361 gtctcaggcc ttccttagaa tcagagaagg aagcgtcctg tttggagaga gccagagagc
3421 accgccggga ggcgctcgcg caaggccacg gtcagcacag gcacggtccc gctttcctta
3481 gtgcttggag caatttccat aaaacattca ccagaaacct tttgcacatc ggtctctgcc
3541 acacgcagta gaatttccgc agggctgtgg ctcggccagc agcggttcca ggagagtggc
3601 ggtgcgcacg ggcctccagc cgtgccttcc ccctgcaggc cccgtctgct gggcctgctg
3661 cccagtgcac tcagccccag gtagcagaac tcacgttccc actatagcaa gaaataaagg
3721 caaaagagaa catctttttt ttaatcgtag tttttttgag aattggtccc acctcagccg
3781 caccttgctg gatgcttctc cagtagtgct gcccctgtga caggcatcag ctccctgctg
3841 gaactgaggt agacacaggt gtgggccctt cccgtgcctt tgctcagagg cgcttcactt
3901 tctccacact ttcgaattcc taaagacatg tggaggaagt cactgttaaa tgaatttcca
3961 cctgatcacc ctgtgttcac agcaggcaga agcccactgg tatgggcctc ccgccccttc
4021 cacatccatg ttgtgattgg atccataagt ttactttctt caaagagttg ataggatgtt
4081 taaaacatca acacattgct taaaatgatg aaaccaaccc tcaaaaaaca gtctcctaac
4141 cagccatccc ctcctgtggg agtgagctgg gggttttgtc catagctttg gttgggcctg
4201 tgtcacatcc aggcagccat gtggagggag tcagggtctg tctggaagca tccaccctct
4261 cgctgcccca gcctgtgctc ccaggggcct aggctaccat ggactgaagg gcagtcccct
4321 cccacctggt gcccagggct tctgcttgcc tcgctgatgt tgcatgggca gacttcaaaa
4381 aggatagtta gaaaggtttg ggttgatgga gtttgcatta atgcaattag tgtataaata
4441 tgttttaatt gccaaccgtg tgaaacaaca aaatatctaa aaactaatcc cgatttgaac
4501 aatgtactcc ctggcctgga tacattaata accataaatt tgcatgaatt aatctccacg
4561 tttggtaaac taatacctct ggttgactga gaatactgag taagatataa gacctaccag
4621 gaacctttaa gaatatgctc tgctcagtgt tgtttgtctg cttgtttgcg acggagtctc
4681 actgtgtcgc ccgggctgca gtgcaatggc gtgatcttgg ctcacagtaa cctccacctc
4741 ctgggttcaa gcaattctcc tgcctcagcc tccctagtag ctgggattac aggtgcacac
4801 caccatgctc ggctaatttt ttctattttt agtagagatg gggtttcacc atgttggcca
4861 ggctggtctc gaactcgtga cctcataatc tgcccacctt ggcctcccaa agtgctggga
4921 ttacaggcgt gagccaccac gcccaggtta aatgtgttta taaggagaga ggaggccagg
4981 cgcggtggct cacgctgtaa tcccagcact ttgggaggcc gaggcgggcg gaccacctga
5041 ggtcaggagt tcgagaccag cctggccaac atggtgaaac cccatctcta ctaaaaatac
5101 aaaaatgagc caggcgtggt ggcctgtagt cccagctact tgagaggctg aggcaggaaa
5161 attgcttgaa cccgggaggt ggaggttgca ttgagcccac atcatgccat tgcactccag
5221 cccaggcgac agagcgagac tccgtctcga aaaaaaaaaa aagtataagg agagaaataa
5281 ctttaaagtt tattagacaa aacagagtat agatgccaag atgtctgtaa aatgattttt
5341 tctggtttta aagagatgtt ggccattatt ttctaatcca tttttaaaat acagacaaaa
5401 cacttcttta aacagaacaa gaatgagaaa agttaaccaa ggaattattc ttttctcacc
5461 aatcaacact tttaagaaat atatatatat atatacacac atatacacat gccttctata
5521 tattgtaact taaagaaaat acttataaaa agacttcatt tttagtgatt gacaagcaaa
5581 cgggttcatt taaaacaggt tcctcttttg ttagttacag ggggtttttt tgttgttttt
5641 ttgtttttgt ttttgttttg cgggggtggt ggggtttgag acggagtctt gctctgttgc
5701 ctaggctgga gtgcagtggc gcgatcttgg ccccctgcaa cctccgcctc ccgggttcga
5761 gcaattctcc tgcctcagcc tcccgagtag ctgggattac aggcgtgtgt caccacgcct
5821 ggctaatttt tttgtatttt tagtagagac ggggtttcac catattggcc aggctggtct
5881 caaactcctg accttgtgat ccacccacct cggcctccca aagtgctgga attacaggca
5941 tgagccaccg cgcccggccc aatcatgtgt ttttgttgaa atgatcctac cagtgattag
6001 tggctattga gagttttaca gggttataca ttgttaaggg accaagaatc aagtacaaaa
6061 aattaaaaag gaactgtaaa atcccttggt cattcataaa taaatatcta aattaggaat
6121 actaattaat tgaattttca ctcatgagta tgttctgaat atttaatatt tatttctatt
6181 attttcatat gttaagatat tccattaaat ctaacttaaa agaattgtat gtataaattg
6241 gcattaggat acaaatgtaa atgtttttaa tgaaattttg caacttttta atattttaac
6301 atagttttct atttgtcttt atttcaagta ccagaattac aaaatatcta agtaatatat
6361 ttttgttgtc gttttagggc ttaagggtta attcacccag agtatattaa tataataaaa
6421 agatcactaa a
//